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6T58
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STRUCTURE DETERMINATION OF THE TRANSACTIVATION DOMAIN OF P53 IN COMPLEX WITH S100A4 USING ANNEXIN A2 AS A CRYSTALLIZATION CHAPERONE
Descriptor:Cellular tumor antigen p53,Protein S100-A4,Protein S100-A4,Annexin A2, GLYCEROL, CALCIUM ION
Authors:Ecsedi, P., Gogl, G., Nyitray, L.
Deposit date:2019-10-15
Release date:2020-05-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure Determination of the Transactivation Domain of p53 in Complex with S100A4 Using Annexin A2 as a Crystallization Chaperone
Structure, 2020
6TWZ
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14-3-3 SIGMA COMPLEXED WITH A PHOSPHORYLATED 16E6 PEPTIDE
Descriptor:14-3-3 protein sigma, phosphorylated 16E6 peptide, D(-)-TARTARIC ACID, ...
Authors:Gogl, G., Cousido-Siah, A., Sluchanko, N.N., Trave, G.
Deposit date:2020-01-13
Release date:2020-05-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study.
Structure, 2020
6TWQ
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MAGI1_2 COMPLEXED WITH A 16E6 PEPTIDE
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,Annexin A2, THR-ARG-ARG-GLU-THR-GLN-LEU, ...
Authors:Gogl, G., Cousido-Siah, A., Trave, G.
Deposit date:2020-01-13
Release date:2020-04-01
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study.
Structure, 2020
6TWU
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MAGI1_2 COMPLEXED WITH A PHOSPHOMIMETIC 16E6 PEPTIDE
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,Annexin A2, Protein E6, ...
Authors:Gogl, G., Cousido-Siah, A., Trave, G.
Deposit date:2020-01-13
Release date:2020-04-01
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study.
Structure, 2020
6TWX
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MAGI1_2 COMPLEXED WITH A PHOSPHORYLATED 16E6 PEPTIDE
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,Annexin A2, 16E6 peptide, ...
Authors:Gogl, G., Cousido-Siah, A., Trave, G.
Deposit date:2020-01-13
Release date:2020-04-01
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study.
Structure, 2020
6TWY
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MAGI1_2 COMPLEXED WITH A PHOSPHOMIMETIC RSK1 PEPTIDE
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,Annexin A2, Phosphomimetic RSK1 peptide, ...
Authors:Gogl, G., Cousido-Siah, A., Trave, G.
Deposit date:2020-01-13
Release date:2020-04-01
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study.
Structure, 2020
5NCL
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CRYSTAL STRUCTURE OF THE CBK1-MOB2 KINASE-COACTIVATOR COMPLEX WITH AN SSD1 PEPTIDE
Descriptor:Serine/threonine-protein kinase CBK1, CBK1 kinase activator protein MOB2, Protein SSD1, ...
Authors:Gogl, G., Remenyi, A., Parker, B., Weiss, E.
Deposit date:2017-03-06
Release date:2018-05-16
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface.
Biochemistry, 2020
5NCM
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CRYSTAL STRUCTURE CBK1(NTR)-MOB2 COMPLEX
Descriptor:CBK1 kinase activator protein MOB2, Serine/threonine-protein kinase CBK1, ZINC ION
Authors:Gogl, G., Remenyi, A., Parker, B., Weiss, E.
Deposit date:2017-03-06
Release date:2018-05-16
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface.
Biochemistry, 2020
5NCN
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CRYSTAL STRUCTURE DBF2(NTR)-MOB1 COMPLEX
Descriptor:DBF2 kinase activator protein MOB1, Cell cycle protein kinase DBF2, ZINC ION, ...
Authors:Gogl, G., Remenyi, A., Parker, B., Weiss, E.
Deposit date:2017-03-06
Release date:2018-05-16
Last modified:2020-05-06
Method:X-RAY DIFFRACTION (3.501 Å)
Cite:Ndr/Lats Kinases Bind Specific Mob-Family Coactivators through a Conserved and Modular Interface.
Biochemistry, 2020
5NP2
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ABL1 SH3 PTYR89/134
Descriptor:Tyrosine-protein kinase ABL1
Authors:Mero, B., Radnai, L., Gogl, G., Leveles, I., Buday, L.
Deposit date:2017-04-13
Release date:2018-05-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.
J.Biol.Chem., 294, 2019
5NP3
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ABL2 SH3
Descriptor:Abelson tyrosine-protein kinase 2
Authors:Mero, B., Radnai, L., Gogl, G., Leveles, I., Buday, L.
Deposit date:2017-04-13
Release date:2018-05-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.
J.Biol.Chem., 294, 2019
5NP5
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ABL2 SH3 PTYR116/161
Descriptor:Abelson tyrosine-protein kinase 2, SULFATE ION
Authors:Mero, B., Radnai, L., Gogl, G., Leveles, I., Buday, L.
Deposit date:2017-04-13
Release date:2018-05-16
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.
J.Biol.Chem., 294, 2019
5N7D
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MAGI-1 COMPLEXED WITH A RSK1 PEPTIDE
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,Annexin A2, Ribosomal protein S6 kinase alpha-1, ...
Authors:Gogl, G., Nyitray, L.
Deposit date:2017-02-20
Release date:2017-11-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dynamic control of RSK complexes by phosphoswitch-based regulation.
FEBS J., 285, 2018
5N7F
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MAGI-1 COMPLEXED WITH A PRSK1 PEPTIDE
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,Annexin A2, Ribosomal protein S6 kinase alpha-1, ...
Authors:Gogl, G., Nyitray, L.
Deposit date:2017-02-20
Release date:2017-11-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dynamic control of RSK complexes by phosphoswitch-based regulation.
FEBS J., 285, 2018
5N7G
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MAGI-1 COMPLEXED WITH A SYNTHETIC PRSK1 PEPTIDE
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1,Annexin A2, Ribosomal protein S6 kinase alpha-1, ...
Authors:Gogl, G., Nyitray, L.
Deposit date:2017-02-20
Release date:2017-11-08
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Dynamic control of RSK complexes by phosphoswitch-based regulation.
FEBS J., 285, 2018
5LPU
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CRYSTAL STRUCTURE OF ANNEXIN A2 COMPLEXED WITH S100A4
Descriptor:Annexin A2, Protein S100-A4, CALCIUM ION, ...
Authors:Ecsedi, P., Gogl, G., Kiss, B., Nyitray, L.
Deposit date:2016-08-15
Release date:2017-07-05
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.
Structure, 25, 2017
5LPX
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CRYSTAL STRUCTURE OF PKC PHOSPHORYLATION-MIMICKING MUTANT (S26E) ANNEXIN A2
Descriptor:Annexin A2, CALCIUM ION, GLYCEROL
Authors:Ecsedi, P., Gogl, G., Kiss, B., Nyitray, L.
Deposit date:2016-08-15
Release date:2017-07-05
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.
Structure, 25, 2017
5LQ0
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CRYSTAL STRUCTURE OF TYR24 PHOSPHORYLATED ANNEXIN A2 AT 2.9 A RESOLUTION
Descriptor:Annexin A2, CALCIUM ION
Authors:Ecsedi, P., Gogl, G., Kiss, B., Nyitray, L.
Deposit date:2016-08-15
Release date:2017-07-05
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.
Structure, 25, 2017
5LQ2
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CRYSTAL STRUCTURE OF TYR24 PHOSPHORYLATED ANNEXIN A2 AT 3.4 A RESOLUTION
Descriptor:Annexin A2, CALCIUM ION
Authors:Ecsedi, P., Gogl, G., Kiss, B., Nyitray, L.
Deposit date:2016-08-15
Release date:2017-07-05
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Regulation of the Equilibrium between Closed and Open Conformations of Annexin A2 by N-Terminal Phosphorylation and S100A4-Binding.
Structure, 25, 2017
5CSF
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S100B-RSK1 CRYSTAL STRUCTURE A
Descriptor:Protein S100-B, Ribosomal protein S6 kinase alpha-1, CALCIUM ION
Authors:Gogl, G., Nyitray, L.
Deposit date:2015-07-23
Release date:2015-11-11
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.
J.Biol.Chem., 291, 2016
5CSI
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S100B-RSK1 CRYSTAL STRUCTURE A'
Descriptor:Protein S100-B, Ribosomal protein S6 kinase alpha-1, CALCIUM ION
Authors:Gogl, G., Nyitray, L.
Deposit date:2015-07-23
Release date:2015-11-11
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.
J.Biol.Chem., 291, 2016
5CSJ
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S100B-RSK1 CRYSTAL STRUCTURE B
Descriptor:Protein S100-B, Ribosomal protein S6 kinase alpha-1, CALCIUM ION, ...
Authors:Gogl, G., Nyitray, L.
Deposit date:2015-07-23
Release date:2015-11-11
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.
J.Biol.Chem., 291, 2016
5CSN
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S100B-RSK1 CRYSTAL STRUCTURE C
Descriptor:Protein S100-B, Ribosomal protein S6 kinase alpha-1, CALCIUM ION
Authors:Gogl, G., Nyitray, L.
Deposit date:2015-07-23
Release date:2015-11-11
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY.
J.Biol.Chem., 291, 2016
4QSY
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SHP2 SH2 DOMAIN IN COMPLEX WITH GAB1 PEPTIDE
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, GRB2-associated-binding protein 1
Authors:Gogl, G., Remenyi, A.
Deposit date:2014-07-06
Release date:2015-07-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective targeting of GAB adapter protein SHP2 tyrosine phosphatase interaction attenuates ERK signaling
To be Published
4NIF
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HETERODIMERIC STRUCTURE OF ERK2 AND RSK1
Descriptor:Ribosomal protein S6 kinase alpha-1, Mitogen-activated protein kinase 1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Gogl, G., Remenyi, A.
Deposit date:2013-11-06
Release date:2014-11-12
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural assembly of the signaling competent ERK2-RSK1 heterodimeric protein kinase complex
Proc.Natl.Acad.Sci.USA, 112, 2015
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