Author results

1H24
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CDK2/CYCLINA IN COMPLEX WITH A 9 RESIDUE RECRUITMENT PEPTIDE FROM E2F
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, TRANSCRIPTION FACTOR E2F1
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H25
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CDK2/CYCLIN A IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM RETINOBLASTOMA-ASSOCIATED PROTEIN
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-ASSOCIATED PROTEIN
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H26
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P53
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CELLULAR TUMOR ANTIGEN P53
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H27
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P27
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, CYCLIN-DEPENDENT KINASE INHIBITOR 1B
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
1H28
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CDK2/CYCLINA IN COMPLEX WITH AN 11-RESIDUE RECRUITMENT PEPTIDE FROM P107
Descriptor:CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, RETINOBLASTOMA-LIKE PROTEIN 1
Authors:Tews, I., Cheng, K.Y., Lowe, E.D., Noble, M.E.M., Brown, N.R., Gul, S., Gamblin, S., Johnson, L.N.
Deposit date:2002-07-31
Release date:2003-02-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Specificity Determinants of Recruitment Peptides Bound to Phospho-Cdk2/Cyclin A
Biochemistry, 41, 2002
5LS6
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STRUCTURE OF HUMAN POLYCOMB REPRESSIVE COMPLEX 2 (PRC2) WITH INHIBITOR
Descriptor:Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ...
Authors:Zhang, Y., Justin, N., Chen, S., Wilson, J., Gamblin, S.
Deposit date:2016-08-22
Release date:2017-02-22
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (3.47 Å)
Cite:Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016
2WR0
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STRUCTURES OF INFLUENZA H2 HEMAGGLUTININS
Descriptor:HEMAGGLUTININ, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Liu, J., Stevens, D., Haire, L., Coombs, P., Russell, R., Gamblin, S., Skehel, J.
Deposit date:2009-08-28
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:From the Cover: Structures of Receptor Complexes Formed by Hemagglutinins from the Asian Influenza Pandemic of 1957.
Proc.Natl.Acad.Sci.USA, 106, 2009
4CPL
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STRUCTURE OF THE NEURAMINIDASE FROM THE B/BRISBANE/60/2008 VIRUS.
Descriptor:NEURAMINIDASE, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Escuret, V., Casalegno, J.S., Cattle, N., Ferraris, O., Sabatier, M., Frobert, E., Caro, V., Skehel, J.J., Gamblin, S.J., Valla, F., Valette, M., Ottmann, M., McCauley, J.W., Daniels, R.S., Lina, B.
Deposit date:2014-02-07
Release date:2014-05-14
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses.
J.Infect.Dis., 210, 2014
4CPM
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STRUCTURE OF THE NEURAMINIDASE FROM THE B/BRISBANE/60/2008 VIRUS IN COMPLEX WITH OSELTAMIVIR
Descriptor:NEURAMINIDASE, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Escuret, V., Casalegno, J.S., Cattle, N., Ferraris, O., Sabatier, M., Frobert, E., Caro, V., Skehel, J.J., Gamblin, S.J., Valla, F., Valette, M., Ottmann, M., McCauley, J.W., Daniels, R.S., Lina, B.
Deposit date:2014-02-07
Release date:2014-05-14
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses.
J.Infect.Dis., 210, 2014
4CPN
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STRUCTURE OF THE NEURAMINIDASE FROM THE B/BRISBANE/60/2008 VIRUS IN COMPLEX WITH ZANAMIVIR
Descriptor:NEURAMINIDASE, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Escuret, V., Casalegno, J.S., Cattle, N., Ferraris, O., Sabatier, M., Frobert, E., Caro, V., Skehel, J.J., Gamblin, S.J., Valla, F., Valette, M., Ottmann, M., McCauley, J.W., Daniels, R.S., Lina, B.
Deposit date:2014-02-08
Release date:2014-05-14
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses.
J.Infect.Dis., 210, 2014
4CPO
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STRUCTURE OF THE NEURAMINIDASE FROM THE B/LYON/CHU/15.216/2011 VIRUS
Descriptor:NEURAMINIDASE, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:Vachieri, S.G., Collins, P.J., Escuret, V., Casalegno, J.S., Cattle, N., Ferraris, O., Sabatier, M., Frobert, E., Caro, V., Skehel, J.J., Gamblin, S.J., Valla, F., Valette, M., Ottmann, M., McCauley, J.W., Daniels, R.S., Lina, B.
Deposit date:2014-02-08
Release date:2014-05-14
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses.
J.Infect.Dis., 210, 2014
4CPY
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STRUCTURE OF THE NEURAMINIDASE FROM THE B/LYON/CHU/15.216/2011 VIRUS IN COMPLEX WITH OSELTAMIVIR
Descriptor:NEURAMINIDASE, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Escuret, V., Casalegno, J.S., Cattle, N., Ferraris, O., Sabatier, M., Frobert, E., Caro, V., Skehel, J.J., Gamblin, S.J., Valla, F., Valette, M., Ottmann, M., McCauley, J.W., Daniels, R.S., Lina, B.
Deposit date:2014-02-09
Release date:2014-05-14
Last modified:2019-10-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses.
J.Infect.Dis., 210, 2014
4CPZ
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STRUCTURE OF THE NEURAMINIDASE FROM THE B/LYON/CHU/15.216/2011 VIRUS IN COMPLEX WITH ZANAMIVIR
Descriptor:NEURAMINIDASE, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Vachieri, S.G., Collins, P.J., Escuret, V., Casalegno, J.S., Cattle, N., Ferraris, O., Sabatier, M., Frobert, E., Caro, V., Skehel, J.J., Gamblin, S.J., Valla, F., Valette, M., Ottmann, M., McCauley, J.W., Daniels, R.S., Lina, B.
Deposit date:2014-02-09
Release date:2014-05-14
Last modified:2019-10-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Novel I221 L Substitution in Neuraminidase Confers High Level Resistance to Oseltamivir in Influenza B Viruses.
J.Infect.Dis., 210, 2014
5M5G
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CRYSTAL STRUCTURE OF THE CHAETOMIUM THERMOPHILUM POLYCOMB REPRESSIVE COMPLEX 2 (PRC2)
Descriptor:putative polycomb protein EED, Putative uncharacterized protein, HISTONE H3 11-Mer peptide, ...
Authors:Zhang, Y., Justin, N., Wilson, J., Gamblin, S.
Deposit date:2016-10-21
Release date:2017-01-11
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".
Science, 354, 2016
2WF5
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STRUCTURE OF BETA-PHOSPHOGLUCOMUTASE INHIBITED WITH GLUCOSE-6-PHOSPHATE AND TRIFLUOROMAGNESATE
Descriptor:BETA-PHOSPHOGLUCOMUTASE, BETA-D-GLUCOSE-6-PHOSPHATE, MAGNESIUM ION, ...
Authors:Bowler, M.W., Baxter, N.J., Webster, C.E., Hounslow, A.M., Cliff, M.J., Williams, N.H., Hollfelder, F., Gamblin, S., Blackburn, G.M., Waltho, J.P.
Deposit date:2009-04-03
Release date:2009-09-15
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF-3 rather than by phosphoranes.
Proc. Natl. Acad. Sci. U.S.A., 107, 2010