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1GA7
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CRYSTAL STRUCTURE OF THE ADP-RIBOSE PYROPHOSPHATASE IN COMPLEX WITH GD+3
Descriptor:HYPOTHETICAL 23.7 KDA PROTEIN IN ICC-TOLC INTERGENIC REGION, GADOLINIUM ION
Authors:Gabelli, S.B., Bianchet, M.A., Bessman, M.J., Amzel, L.M.
Deposit date:2000-11-29
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family.
Nat.Struct.Biol., 8, 2001
1G0S
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THE CRYSTAL STRUCTURE OF THE E.COLI ADP-RIBOSE PYROPHOSPHATASE
Descriptor:HYPOTHETICAL 23.7 KDA PROTEIN IN ICC-TOLC INTERGENIC REGION
Authors:Gabelli, S.B., Bianchet, M.A., Bessman, M.J., Amzel, L.M.
Deposit date:2000-10-08
Release date:2001-05-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family.
Nat.Struct.Biol., 8, 2001
1G9Q
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COMPLEX STRUCTURE OF THE ADPR-ASE AND ITS SUBSTRATE ADP-RIBOSE
Descriptor:HYPOTHETICAL 23.7 KDA PROTEIN IN ICC-TOLC INTERGENIC REGION, ADENOSINE-5-DIPHOSPHORIBOSE
Authors:Gabelli, S.B., Bianchet, M.A., Bessman, M.J., Amzel, L.M.
Deposit date:2000-11-27
Release date:2001-05-02
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family.
Nat.Struct.Biol., 8, 2001
1KHZ
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STRUCTURE OF THE ADPR-ASE IN COMPLEX WITH AMPCPR AND MG
Descriptor:ADP-ribose pyrophosphatase, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Gabelli, S.B., Bianchet, M.A., Bessman, M.J., Amzel, L.M.
Deposit date:2001-12-01
Release date:2002-10-09
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolase.
Biochemistry, 41, 2002
1RYA
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CRYSTAL STRUCTURE OF THE E. COLI GDP-MANNOSE MANNOSYL HYDROLASE IN COMPLEX WITH GDP AND MG
Descriptor:GDP-mannose mannosyl hydrolase, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Gabelli, S.B., Bianchet, M.A., Legler, P.M., Mildvan, A.S., Amzel, L.M.
Deposit date:2003-12-20
Release date:2004-06-22
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure and mechanism of GDP-mannose glycosyl hydrolase, a Nudix enzyme that cleaves at carbon instead of phosphorus.
Structure, 12, 2004
1YHK
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TRYPANOSOMA CRUZI FARNESYL DIPHOSPHATE SYNTHASE
Descriptor:farnesyl pyrophosphate synthase, SULFATE ION
Authors:Gabelli, S.B., McLellan, J.S., Montalvetti, A., Oldfield, E., Docampo, R., Amzel, L.M.
Deposit date:2005-01-09
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design.
Proteins, 62, 2005
1YHL
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STRUCTURE OF THE COMPLEX OF TRYPANOSOMA CRUZI FARNESYL DIPHOSPHATE SYNTHASE WITH RISEDRONATE, DMAPP AND MG+2
Descriptor:farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ...
Authors:Gabelli, S.B., McLellan, J.S., Montalvetti, A., Oldfield, E., Docampo, R., Amzel, L.M.
Deposit date:2005-01-09
Release date:2005-12-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design.
Proteins, 62, 2005
1YHM
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STRUCTURE OF THE COMPLEX OF TRYPANOSOMA CRUZI FARNESYL DISPHOSPHATE SYNTHASE WITH ALENDRONATE, ISOPENTENYL DIPHOSPHATE AND MG+2
Descriptor:farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ...
Authors:Gabelli, S.B., McLellan, J.S., Montalvetti, A., Oldfield, E., Docampo, R., Amzel, L.M.
Deposit date:2005-01-09
Release date:2005-12-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design.
Proteins, 62, 2005
2GT2
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STRUCTURE OF THE E. COLI GDP-MANNOSE MANNOSYL HYDROLASE
Descriptor:GDP-mannose mannosyl hydrolase
Authors:Gabelli, S.B., Bianchet, M.A., Azurmendi, H.F., MIldvan, A.S., Amzel, L.M.
Deposit date:2006-04-27
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction.
Biochemistry, 45, 2006
2GT4
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CRYSTAL STRUCTURE OF THE Y103F MUTANT OF THE GDP-MANNOSE MANNOSYL HYDROLASE IN COMPLEX WITH GDP-MANNOSE AND MG+2
Descriptor:GDP-mannose mannosyl hydrolase, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE, ...
Authors:Gabelli, S.B., Bianchet, M.A., Azurmendi, H.F., Mildvan, A.S., Amzel, L.A.
Deposit date:2006-04-27
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction.
Biochemistry, 45, 2006
2O1C
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STRUCTURE OF THE E. COLI DIHYDRONEOPTERIN TRIPHOSPHATE PYROPHOSPHOHYDROLASE
Descriptor:dATP pyrophosphohydrolase, SULFATE ION, PYROPHOSPHATE
Authors:Gabelli, S.B., Bianchet, M.A., Amzel, L.M.
Deposit date:2006-11-28
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis.
Structure, 15, 2007
2O5W
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STRUCTURE OF THE E. COLI DIHYDRONEOPTERIN TRIPHOSPHATE PYROPHOSPHOHYDROLASE IN COMPLEX WITH SM+3 AND PYROPHOSPHATE
Descriptor:dATP pyrophosphohydrolase, SULFATE ION, SAMARIUM (III) ION, ...
Authors:Gabelli, S.B., Bianchet, M.A., Amzel, L.M.
Deposit date:2006-12-06
Release date:2007-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis.
Structure, 15, 2007
4OVN
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VOLTAGE-GATED SODIUM CHANNEL 1.5 (NAV1.5) C-TERMINAL DOMAIN IN COMPLEX WITH CALMODULIN POISED FOR ACTIVATION
Descriptor:Calmodulin, Sodium channel protein type 5 subunit alpha, MAGNESIUM ION, ...
Authors:Gabelli, S.B., Bianchet, M.A., Boto, A., Jakoncic, J., Tomaselli, G.F., Amzel, L.M.
Deposit date:2013-12-10
Release date:2014-12-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Regulation of the NaV1.5 cytoplasmic domain by calmodulin.
Nat Commun, 5, 2014
3NLS
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CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH KNI-10772
Descriptor:Protease, GLYCEROL, UREA, ...
Authors:Gabelli, S.B., Kawasaki, Y., Freire, E., Amzel, L.M.
Deposit date:2010-06-21
Release date:2011-09-07
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structure of HIV-1 Protease in Complex with KNI-10772
To be Published
4HXX
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PYRIDINYLPYRIMIDINES SELECTIVELY INHIBIT HUMAN METHIONINE AMINOPEPTIDASE-1
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Gabelli, S.B., Zhang, F., Liu, J., Amzel, L.M.
Deposit date:2012-11-12
Release date:2013-04-03
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.
Bioorg.Med.Chem., 21, 2013
4IU6
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HUMAN METHIONINE AMINOPEPTIDASE IN COMPLEX WITH FZ1: PYRIDINYLQUINAZOLINES SELECTIVELY INHIBIT HUMAN METHIONINE AMINOPEPTIDASE-1
Descriptor:Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ...
Authors:Gabelli, S.B., Zhang, F., Miller, M., Liu, J., Amzel, L.M.
Deposit date:2013-01-19
Release date:2013-05-01
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
J.Med.Chem., 56, 2013
4OVU
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CRYSTAL STRUCTURE OF P110ALPHA IN COMPLEX WITH NISH2 OF P85ALPHA
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha
Authors:Gabelli, S.B., Vogelstein, B., Miller, M.S., Amzel, L.M.
Deposit date:2014-01-14
Release date:2014-09-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Structural basis of nSH2 regulation and lipid binding in PI3K alpha.
Oncotarget, 5, 2014
4OVV
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CRYSTAL STRUCTURE OF PI3KALPHA IN COMPLEX WITH DIC4-PIP2
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, (2R)-3-{[(R)-HYDROXY{[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIHYDROXY-4,5-BIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}PHOSPHORYL]OXY}PROPANE-1,2-DIYL DIBUTANOATE, ...
Authors:Gabelli, S.B., Vogelstein, B., Miller, M., Amzel, L.M.
Deposit date:2014-01-14
Release date:2014-09-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural basis of nSH2 regulation and lipid binding in PI3K alpha.
Oncotarget, 5, 2014
5C7Q
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CRYSTAL STRUCTURE OF THE BDELLOVIBRIO BACTERIOVORUS NUCLEOSIDE DIPHOSPHATE SUGAR HYDROLASE
Descriptor:NudF protein, SULFATE ION, GLYCEROL, ...
Authors:Gabelli, S.B., de la Pena, A.H., Suarez, A., Amzel, L.M.
Deposit date:2015-06-24
Release date:2016-01-20
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.
Plos One, 10, 2015
5C7T
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CRYSTAL STRUCTURE OF THE BDELLOVIBRIO BACTERIOVORUS NUCLEOSIDE DIPHOSPHATE SUGAR HYDROLASE IN COMPLEX WITH ADP-RIBOSE
Descriptor:NudF protein, ADENOSINE-5-DIPHOSPHORIBOSE, SULFATE ION, ...
Authors:Gabelli, S.B., de la Pena, A.H., Suarez, A., Amzel, L.M.
Deposit date:2015-06-24
Release date:2016-01-20
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.
Plos One, 10, 2015
5C8L
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CRYSTAL STRUCTURE OF THE BDELLOVIBRIO BACTERIOVORUS NUCLEOSIDE DIPHOSPHATE SUGAR HYDROLASE
Descriptor:NudF protein, ALPHA-D-GLUCOSE, SULFATE ION, ...
Authors:Gabelli, S.B., de la Pena, A.H., Suarez, A., Amzel, L.M.
Deposit date:2015-06-25
Release date:2016-01-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus.
Plos One, 10, 2015
5SW8
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CRYSTAL STRUCTURE OF PI3KALPHA IN COMPLEX WITH FRAGMENTS 7 AND 11
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Gabelli, S.B., Vogelstein, B., Miller, M.S., Amzel, L.M.
Deposit date:2016-08-08
Release date:2017-02-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
Bioorg. Med. Chem., 25, 2017
5SWG
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CRYSTAL STRUCTURE OF PI3KALPHA IN COMPLEX WITH FRAGMENTS 5 AND 21
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 1H-benzimidazol-2-amine, ...
Authors:Gabelli, S.B., Vogelstein, B., Miller, M.S., Amzel, L.M.
Deposit date:2016-08-08
Release date:2017-02-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
Bioorg. Med. Chem., 25, 2017
5SWO
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CRYSTAL STRUCTURE OF PI3KALPHA IN COMPLEX WITH FRAGMENTS 4 AND 19
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, CHLORIDE ION, ...
Authors:Gabelli, S.B., Vogelstein, B., Miller, M.S., Amzel, L.M.
Deposit date:2016-08-08
Release date:2017-02-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
Bioorg. Med. Chem., 25, 2017
5SWP
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CRYSTAL STRUCTURE OF PI3KALPHA IN COMPLEX WITH FRAGMENTS 6 AND 24
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, tert-butyl 4-aminopiperidine-1-carboxylate, ...
Authors:Gabelli, S.B., Vogelstein, B., Miller, M.S., Amzel, L.M.
Deposit date:2016-08-08
Release date:2017-02-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.41 Å)
Cite:Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
Bioorg. Med. Chem., 25, 2017