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2VAL
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CRYSTAL STRUCTURE OF AN ESCHERICHIA COLI TRNAGLY MICROHELIX AT 2.0 ANGSTROM RESOLUTION
Descriptor:5'-R(*GP*CP*GP*GP*GP*AP*AP)-3', 5'-R(*UP*UP*CP*CP*CP*GP*CP)-3', MAGNESIUM ION
Authors:Forster, C., Brauer, A.B.E., Perbandt, M., Lehmann, D., Furste, J.P., Betzel, C., Erdmann, V.A.
Deposit date:2007-09-03
Release date:2007-10-16
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of an Escherichia Coli Trnagly Microhelix at 2.0 Angstrom Resolution
Biochem.Biophys.Res.Commun., 363, 2007
6T8U
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COMPLEMENT FACTOR B IN COMPLEX WITH 5-BROMO-3-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-7-METHYL-1H-INDOL-4-AMINE
Descriptor:Complement factor B, 5-bromanyl-3-chloranyl-~{N}-(1~{H}-imidazol-2-yl)-7-methyl-1~{H}-indol-4-amine, SULFATE ION
Authors:Mainolfi, N., Ehara, T., Karki, R.G., Anderson, K., Mac Sweeney, A., Wiesmann, C., Adams, C., Liao, S.-M., Argikar, U.A., Jendza, K., Zhang, C., Powers, J., Klosowski, D.W., Crowley, M., Kawanami, T., Ding, J., April, M., Forster, C., Serrano-Wu, M., Capparelli, M., Ramqaj, R., Solovay, C., Cumin, F., Smith, T.M., Ferrara, L., Lee, W., Long, D., Prentiss, M., De Erkenez, A., Yang, L., Fang, L., Sellner, H., Sirockin, F., Valeur, E., Erbel, P., Ramage, P., Gerhartz, B., Schubart, A., Flohr, S., Gradoux, N., Feifel, R., Vogg, B., Maibaum, J., Eder, J., Sedrani, R., Harrison, R.A., Mogi, M., Jaffee, B.D., Adams, C.M.
Deposit date:2019-10-25
Release date:2020-03-04
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 2020
6T8V
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COMPLEMENT FACTOR B IN COMPLEX WITH (S)-5,7-DIMETHYL-4-((2-PHENYLPIPERIDIN-1-YL)METHYL)-1H-INDOLE
Descriptor:Complement factor B, SULFATE ION, 4-[(2~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, ...
Authors:Mainolfi, N., Ehara, T., Karki, R.G., Anderson, K., Mac Sweeney, A., Wiesmann, C., Adams, C., Mainolfi, N., Liao, S.-M., Argikar, U.A., Jendza, K., Zhang, C., Powers, J., Klosowski, D.W., Crowley, M., Kawanami, T., Ding, J., April, M., Forster, C., Serrano-Wu, M., Capparelli, M., Ramqaj, R., Solovay, C., Cumin, F., Smith, T.M., Ferrara, L., Lee, W., Long, D., Prentiss, M., De Erkenez, A., Yang, L., Fang, L., Sellner, H., Sirockin, F., Valeur, E., Erbel, P., Ramage, P., Gerhartz, B., Schubart, A., Flohr, S., Gradoux, N., Feifel, R., Vogg, B., Wiesmann, C., Maibaum, J., Eder, J., Sedrani, R., Harrison, R.A., Mogi, M., Jaffee, B.D., Adams, C.M.
Deposit date:2019-10-25
Release date:2020-03-04
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 2020
6T8W
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COMPLEMENT FACTOR B IN COMPLEX WITH (-)-4-(1-((5,7-DIMETHYL-1H-INDOL-4-YL)METHYL)PIPERIDIN-2-YL)BENZOIC ACID
Descriptor:Complement factor B, SULFATE ION, 5,7-dimethyl-4-[[(2~{S})-2-phenylpiperidin-1-yl]methyl]-1~{H}-indole, ...
Authors:Mainolfi, N., Ehara, T., Karki, R.G., Anderson, K., Sweeney, A.M., Wiesmann, C., Adams, C., Mainolfi, N., Liao, S.M., Argikar, U.A., Jendza, K., Zhang, C., Powers, J., Klosowski, D.W., Crowley, M., Kawanami, T., Ding, J., April, M., Forster, C., Wu, M.S., Capparelli, M., Ramqaj, R., Solovay, C., Cumin, F., Smith, T.M., Ferrara, L., Lee, W., Long, D., Prentiss, M., Erkenez, A.D., Yang, L., Fang, L., Sellner, H., Sirockin, F., Valeur, E., Erbel, P., Ramage, P., Gerhartz, B., Schubart, A., Flohr, S., Gradoux, N., Feifel, R., Vogg, B., Wiesmann, C., Maibaum, J., Eder, J., Sedrani, R., Harrison, R.A., Mogi, M., Jaffee, B.D., Adams, C.M.
Deposit date:2019-10-25
Release date:2020-03-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J.Med.Chem., 2020
3GVN
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THE 1.2 ANGSTROEM CRYSTAL STRUCTURE OF AN E.COLI TRNASER ACCEPTOR STEM MICROHELIX REVEALS TWO MAGNESIUM BINDING SITES
Descriptor:5'-R(*GP*GP*UP*GP*AP*GP*G)-3', 5'-R(*CP*CP*UP*CP*AP*CP*C)-3', MAGNESIUM ION
Authors:Eichert, A., Furste, J.P., Schreiber, A., Perbandt, M., Betzel, C., Erdmann, V.A., Forster, C.
Deposit date:2009-03-31
Release date:2009-07-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The 1.2A crystal structure of an E. coli tRNASer)acceptor stem microhelix reveals two magnesium binding sites.
Biochem.Biophys.Res.Commun., 386, 2009
2V6W
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TRNASER ACCEPTOR STEM: CONFORMATION AND HYDRATION OF A MICROHELIX IN A CRYSTAL STRUCTURE AT 1.8 ANGSTROM RESOLUTION
Descriptor:5'-R(*GP*GP*AP*GP*AP*GP*AP)-3', 5'-R(*UP*CP*UP*CP*UP*CP*CP)-3'
Authors:Foerster, C., Brauer, A.B.E., Brode, S., Fuerste, J.P., Betzel, C., Erdmann, V.A.
Deposit date:2007-07-23
Release date:2007-11-06
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Trnaser Acceptor Stem: Conformation and Hydration of a Microhelix in a Crystal Structure at 1.8 A Resolution.
Acta Crystallogr.,Sect.D, 63, 2007
2W89
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CRYSTAL STRUCTURE OF THE E.COLI TRNAARG AMINOACYL STEM ISSOACCEPTOR RR-1660 AT 2.0 ANGSTROEM RESOLUTION
Descriptor:5'-R(*GP*CP*AP*UP*CP*CP*GP)-3', 5'-R(*CP*GP*GP*AP*UP*GP*CP)-3', GLYCEROL
Authors:Eichert, A., Schreiber, A., Fuerste, J.P., Perbandt, M., Betzel, C., Erdmann, V.A., Foerster, C.
Deposit date:2009-01-15
Release date:2009-11-17
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the E. Coli tRNA(Arg) Aminoacyl Stem Isoacceptor Rr-1660 at 2.0 A Resolution.
Biochem.Biophys.Res.Commun., 385, 2009
2X2Q
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CRYSTAL STRUCTURE OF AN 'ALL LOCKED' LNA DUPLEX AT 1.9 ANGSTROM RESOLUTION
Descriptor:LOCKED NUCLEIC ACID DERIVED FROM TRNA SER ACCEPTOR STEM MICROHELIX, COBALT HEXAMMINE(III), MAGNESIUM ION, ...
Authors:Eichert, A., Behling, K., Fuerste, J.P., Betzel, C., Erdmann, V.A., Foerster, C.
Deposit date:2010-01-15
Release date:2011-02-16
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Crystal Structure of an 'All Locked' Nucleic Acid Duplex.
Nucleic Acids Res., 38, 2010
2XSL
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THE CRYSTAL STRUCTURE OF A THERMUS THERMOPHILUS TRNAGLY ACCEPTOR STEM MICROHELIX AT 1.6 ANGSTROEM RESOLUTION
Descriptor:5'-R(*GP*CP*GP*GP*GP*AP*G)-3', 5'-R(*CP*UP*CP*CP*CP*GP*C)-3'
Authors:Oberthuer, D., Eichert, A., Erdmann, V.A., Fuerste, J.P., Betzel, C., Foerster, C.
Deposit date:2010-10-29
Release date:2011-08-10
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:The Crystal Structure of a Thermus Thermophilus tRNA(Gly) Acceptor Stem Microhelix at 1.6 A Resolution.
Biochem.Biophys.Res.Commun., 404, 2011