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3TUC
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CRYSTAL STRUCTURE OF SYK KINASE DOMAIN WITH 1-BENZYL-N-(5-(6,7-DIMETHOXYQUINOLIN-4-YLOXY)PYRIDIN-2-YL)-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE
Descriptor:Tyrosine-protein kinase SYK, 1-benzyl-N-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-2-oxo-1,2-dihydropyridine-3-carboxamide
Authors:Lovering, F., McDonald, J., Whitlock, G., Glossop, P., Phillips, C., Sabnis, Y., Ryan, M., Fitz, L., Lee, J., Chang, J.S., Han, S., Kurumbail, R., Thorarenson, A.
Deposit date:2011-09-16
Release date:2012-08-29
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of Type-II Inhibitors Using Kinase Structures.
Chem.Biol.Drug Des., 80, 2012
3TUD
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CRYSTAL STRUCTURE OF SYK KINASE DOMAIN WITH N-(4-METHYL-3-(8-METHYL-7-OXO-2-(PHENYLAMINO)-7,8-DIHYDROPYRIDO[2,3-D]PYRIMIDIN-6-YL)PHENYL)-3-(TRIFLUOROMETHYL)BENZAMIDE
Descriptor:Tyrosine-protein kinase SYK, N-{4-methyl-3-[8-methyl-7-oxo-2-(phenylamino)-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl]phenyl}-3-(trifluoromethyl)benzamide
Authors:Lovering, F., McDonald, J., Whitlock, G., Glossop, P., Phillips, C., Sabnis, Y., Ryan, M., Fitz, L., Lee, J., Chang, J.S., Han, S., Kurumbail, R., Thorarenson, A.
Deposit date:2011-09-16
Release date:2012-08-29
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Identification of Type-II Inhibitors Using Kinase Structures.
Chem.Biol.Drug Des., 80, 2012
1XJD
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CRYSTAL STRUCTURE OF PKC-THETA COMPLEXED WITH STAUROSPORINE AT 2A RESOLUTION
Descriptor:Protein kinase C, theta type, STAUROSPORINE
Authors:Xu, Z.B.
Deposit date:2004-09-23
Release date:2004-10-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Catalytic domain crystal structure of protein kinase C-theta (PKCtheta)
J.Biol.Chem., 279, 2004
3FXY
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ACIDIC MAMMALIAN CHINASE, CATALYTIC DOMAIN
Descriptor:Acidic mammalian chitinase
Authors:Olland, A.M.
Deposit date:2009-01-21
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.
Protein Sci., 18, 2009
3FY1
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THE ACIDIC MAMMALIAN CHITINASE CATALYTIC DOMAIN IN COMPLEX WITH METHYLALLOSAMIDIN
Descriptor:Acidic mammalian chitinase, METHYL N-ACETYL ALLOSAMINE, N-ACETYL-D-ALLOSAMINE, ...
Authors:Olland, A.M.
Deposit date:2009-01-21
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Triad of polar residues implicated in pH specificity of acidic mammalian chitinase.
Protein Sci., 18, 2009
3TUB
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CRYSTAL STRUCTURE OF SYK KINASE DOMAIN WITH 1-(5-(6,7-DIMETHOXYQUINOLIN-4-YLOXY)PYRIDIN-2-YL)-3-((1R,2S)-2-PHENYLCYCLOPROPYL)UREA
Descriptor:Tyrosine-protein kinase SYK, 1-{5-[(6,7-dimethoxyquinolin-4-yl)oxy]pyridin-2-yl}-3-[(1R,2S)-2-phenylcyclopropyl]urea
Authors:Han, S.
Deposit date:2011-09-16
Release date:2012-08-29
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Identification of Type-II Inhibitors Using Kinase Structures.
Chem.Biol.Drug Des., 80, 2012
5C26
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CRYSTAL STRUCTURE OF SYK IN COMPLEX WITH COMPOUND 1
Descriptor:Tyrosine-protein kinase SYK, GLU-VAL-PTR-GLU-SER-PRO, 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzamide
Authors:Han, S., Chang, J.
Deposit date:2015-06-15
Release date:2015-10-07
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP).
Chemmedchem, 11, 2016
5C27
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CRYSTAL STRUCTURE OF SYK IN COMPLEX WITH COMPOUND 2
Descriptor:Tyrosine-protein kinase SYK, GLU-VAL-TYR-GLU-SER, 3-{8-[(3,4-dimethoxyphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}-N-[4-(methylcarbamoyl)phenyl]benzamide, ...
Authors:Han, S., Chang, J.
Deposit date:2015-06-15
Release date:2015-10-07
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free-Energy Perturbation (FEP).
Chemmedchem, 11, 2016