Author results

3J9B
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ELECTRON CRYO-MICROSCOPY OF AN RNA POLYMERASE
Descriptor:Polymerase, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ...
Authors:Chang, S.H., Sun, D.P., Liang, H.H., Wang, J., Li, J., Guo, L., Wang, X.L., Guan, C.C., Boruah, B.M., Yuan, L.M., Feng, F., Yang, M.R., Wojdyla, J., Wang, J.W., Wang, M.T., Wang, H.W., Liu, Y.F.
Deposit date:2014-12-16
Release date:2015-02-18
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 angstrom Resolution.
Mol.Cell, 2015
4J0U
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CRYSTAL STRUCTURE OF IFIT5/ISG58
Descriptor:Interferon-induced protein with tetratricopeptide repeats 5
Authors:Liu, Y., Liang, H., Feng, F., Yuan, L., Wang, Y.E., Crowley, C., Lv, Z., Li, J., Zeng, S., Cheng, G.
Deposit date:2013-01-31
Release date:2013-02-13
Method:X-RAY DIFFRACTION (1.969 Å)
Cite:Crystal Structure of IFIT5
To be Published
4W98
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ACINETOBACTER BAUMANNII SDF NDK
Descriptor:Nucleoside diphosphate kinase
Authors:Hu, Y., Feng, F., Liang, H., Liu, Y.
Deposit date:2014-08-27
Release date:2015-06-17
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Structural and Functional Characterization of Acinetobacter baumannii Nucleoside Diphosphate Kinase
Prog.Biochem.Biophys., 42, 2015
4WJA
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CRYSTAL STRUCTURE OF PAXX
Descriptor:Uncharacterized protein C9orf142
Authors:Xing, M., Yang, M., Huo, W., Feng, F., Wei, L., Ning, S., Yan, Z., Li, W., Wang, Q., Hou, M., Dong, C., Guo, R., Gao, G., Ji, J., Lan, L., Liang, H., Xu, D.
Deposit date:2014-09-29
Release date:2015-03-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway.
Nat Commun, 6, 2015
5LS2
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RECEPTOR MEDIATED CHITIN PERCEPTION IN LEGUMES IS FUNCTIONALLY SEPERABLE FROM NOD FACTOR PERCEPTION
Descriptor:LysM type receptor kinase, SULFATE ION, N-ACETYL-D-GLUCOSAMINE
Authors:Bozsoki, Z., Cheng, J., Feng, F., Gysel, K., Andersen, K.R., Oldroyd, G., Blaise, M., Radutoiu, S., Stougaard, J.
Deposit date:2016-08-22
Release date:2017-08-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Receptor-mediated chitin perception in legume roots is functionally separable from Nod factor perception.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
4WBF
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ACINETOBACTER BAUMANNII SDF NDK
Descriptor:Nucleoside diphosphate kinase
Authors:Hu, Y., Liu, Y.
Deposit date:2014-09-03
Release date:2015-06-17
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural and Functional Characterization of Acinetobacter baumannii Nucleoside Diphosphate Kinase
Prog.Biochem.Biophys., 42, 2015
5I5N
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF MATRIX PROTEIN OF THOGOTO VIRUS AT ACIDIC PH.
Descriptor:Matrix protein
Authors:Liu, Y., Liang, H., Yang, M.
Deposit date:2016-02-15
Release date:2016-08-17
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.418 Å)
Cite:pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating
J.Gen.Virol., 97, 2016
5I5O
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CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF MATRIX PROTEIN OF THOGOTO VIRUS AT NEUTRAL PH.
Descriptor:Matrix protein
Authors:Liu, Y., Liang, H., Yang, M.
Deposit date:2016-02-15
Release date:2016-08-17
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.682 Å)
Cite:pH-dependent conformational changes of a Thogoto virus matrix protein reveal mechanisms of viral assembly and uncoating
J.Gen.Virol., 97, 2016
5VAL
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BRAF IN COMPLEX WITH N-(3-(TERT-BUTYL)PHENYL)-4-METHYL-3-(6-MORPHOLINOPYRIMIDIN-4-YL)BENZAMIDE
Descriptor:Serine/threonine-protein kinase B-raf, N-(3-tert-butylphenyl)-4-methyl-3-[6-(morpholin-4-yl)pyrimidin-4-yl]benzamide
Authors:Mamo, M., Appleton, B.A.
Deposit date:2017-03-27
Release date:2017-06-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
J. Med. Chem., 60, 2017
5VAM
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BRAF IN COMPLEX WITH RAF709
Descriptor:Serine/threonine-protein kinase B-raf, N-{2-methyl-5'-(morpholin-4-yl)-6'-[(oxan-4-yl)oxy][3,3'-bipyridin]-5-yl}-3-(trifluoromethyl)benzamide
Authors:Mamo, M., Appleton, B.A.
Deposit date:2017-03-27
Release date:2017-06-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
J. Med. Chem., 60, 2017
6E4X
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HUMAN ANTIBODY S5V2-29 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ A/TEXAS/50/2012 (H3N2)
Descriptor:Hemagglutinin, S5V2-29 light chain, S5V2-29 heavy chain, ...
Authors:McCarthy, K.R., Harrison, S.C.
Deposit date:2018-07-18
Release date:2019-05-22
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.
Cell, 177, 2019
6E56
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HUMAN ANTIBODY H2214 IN COMPLEX WITH INFLUENZA HEMAGGLUTININ A/AICHI/2/1968 (X-31) (H3N2)
Descriptor:Hemagglutinin, antibody H2214 heavy chain, antibody H2214 light chain, ...
Authors:McCarthy, K.R., Harrison, S.C.
Deposit date:2018-07-19
Release date:2019-05-22
Last modified:2019-12-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism.
Cell, 177, 2019
6N0P
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BRAF IN COMPLEX WITH N-(3-(2-(2-HYDROXYETHOXY)-6-MORPHOLINOPYRIDIN-4-YL)-4-METHYLPHENYL)-2-(TRIFLUOROMETHYL)ISONICOTINAMIDE (LXH254)
Descriptor:Serine/threonine-protein kinase B-raf, N-{3-[2-(2-hydroxyethoxy)-6-(morpholin-4-yl)pyridin-4-yl]-4-methylphenyl}-2-(trifluoromethyl)pyridine-4-carboxamide
Authors:Mamo, M., Appleton, B.A.
Deposit date:2018-11-07
Release date:2019-09-04
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
J.Med.Chem., 2019
6N0Q
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BRAF IN COMPLEX WITH N-(4-METHYL-3-(1-METHYL-2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOL-5-YL)PHENYL)-3-(TRIFLUOROMETHYL)BENZAMIDE.
Descriptor:Serine/threonine-protein kinase B-raf, N-[4-methyl-3-(1-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide
Authors:Mamo, M., Appleton, B.A.
Deposit date:2018-11-07
Release date:2019-10-23
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
J.Med.Chem., 2019