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3NT1
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HIGH RESOLUTION STRUCTURE OF NAPROXEN:COX-2 COMPLEX.
Descriptor:Prostaglandin-endoperoxide synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Duggan, K.C., Musee, J., Walters, M.J., Harp, J.M., Kiefer, J.R., Oates, J.A., Marnett, L.J.
Deposit date:2010-07-02
Release date:2010-09-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
J.Biol.Chem., 285, 2010
3NTB
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STRUCTURE OF 6-METHYLTHIO NAPROXEN ANALOG BOUND TO MCOX-2.
Descriptor:Prostaglandin-endoperoxide synthase 2, PROTOPORPHYRIN IX CONTAINING FE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Duggan, K.C., Musee, J., Walters, M.J., Harp, J.M., Kiefer, J.R., Oates, J.A., Marnett, L.J.
Deposit date:2010-07-03
Release date:2010-09-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
J.Biol.Chem., 285, 2010
3Q7D
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STRUCTURE OF (R)-NAPROXEN BOUND TO MCOX-2.
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Duggan, K.C., Hermanson, D.J., Musee, J., Prusakiewicz, J.J., Scheib, J., Carter, B.D., Banerjee, S., Marnett, L.J.
Deposit date:2011-01-04
Release date:2011-11-09
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2.
Nat.Chem.Biol., 7, 2011
3RR3
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STRUCTURE OF (R)-FLURBIPROFEN BOUND TO MCOX-2
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Duggan, K.C., Hermanson, D.J., Musee, J., Prusakiewicz, J.J., Scheib, J., Carter, B.D., Banerjee, S., Oates, J.A., Marnett, L.J.
Deposit date:2011-04-28
Release date:2011-11-09
Last modified:2012-03-21
Method:X-RAY DIFFRACTION (2.842 Å)
Cite:(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2.
Nat.Chem.Biol., 7, 2011
4RRW
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CRYSTAL STRUCTURE OF APO MURINE CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.569 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRX
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CRYSTAL STRUCTURE OF APO MURINE V89W CYCLOOXYGENASE-2 COMPLEXED WITH LUMIRACOXIB
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRY
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CRYSTAL STRUCTURE OF APO MURINE H90W CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.429 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRZ
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CRYSTAL STRUCTURE OF APO MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH LUMIRACOXIB
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.569 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RS0
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CRYSTAL STRUCTURE OF MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH S-IBUPROFEN
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.807 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015