4RRW

Crystal Structure of Apo Murine Cyclooxygenase-2

Summary for 4RRW

Related4RRX 4RRY 4RRZ 4RS0
DescriptorProstaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid, ... (4 entities in total)
Functional Keywordsprostaglandin-endoperoxide synthase, glycosylation, membrane, oxidoreductase
Biological sourceMus musculus (mouse)
Cellular locationMicrosome membrane; Peripheral membrane protein Q05769
Total number of polymer chains4
Total molecular weight274237.3
Authors
Xu, S.,Blobaum, A.L.,Banerjee, S.,Marnett, L.J. (deposition date: 2014-11-06, release date: 2015-04-08, Last modification date: 2015-06-03)
Primary citation
Blobaum, A.L.,Xu, S.,Rowlinson, S.W.,Duggan, K.C.,Banerjee, S.,Kudalkar, S.N.,Birmingham, W.R.,Ghebreselasie, K.,Marnett, L.J.
Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290:12793-12803, 2015
PubMed: 25825493 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M114.635987
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.569 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.218201.6%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report