2MSR
| Solution structure of LEDGF/p75 IBD in complex with MLL1 peptide (140-160) | Descriptor: | Histone-lysine N-methyltransferase 2A, PC4 and SFRS1-interacting protein | Authors: | Cermakova, K, Tesina, P, Demeulemeester, J, El Ashkar, S, Mereau, H, Schwaller, J, Rezacova, P, Veverka, V, De Rijck, J. | Deposit date: | 2014-08-05 | Release date: | 2014-08-20 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Validation and Structural Characterization of the LEDGF/p75-MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia. Cancer Res., 74, 2014
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4IKF
| PFV intasome with inhibitor MB-76 | Descriptor: | 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', AMMONIUM ION, ... | Authors: | Taltynov, O, Demeulemeester, J, Desimmie, B.A, Suchaud, V, Billamboz, M, Lion, C, Bailly, F, Debyser, Z, Cotelle, P, Christ, F, Strelkov, S.V. | Deposit date: | 2012-12-26 | Release date: | 2013-04-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | 2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance. Acs Chem.Biol., 8, 2013
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2N3A
| Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404) | Descriptor: | PC4 and SFRS1-interacting protein, Pogo transposable element with ZNF domain | Authors: | Tesina, P, Cermakova, K, Horejsi, M, Prochazkova, K, Fabry, M, Sharma, S, Christ, F, Demeulemeester, J, Debyser, Z, De Rijck, J, Veverka, V, Rezacova, P. | Deposit date: | 2015-05-26 | Release date: | 2015-08-19 | Method: | SOLUTION NMR | Cite: | Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif. Nat Commun, 6, 2015
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5YI9
| Solution structure of the LEDGF/p75 IBD - JPO2 (aa 56-91) complex | Descriptor: | PC4 and SFRS1-interacting protein,Cell division cycle-associated 7-like protein | Authors: | Veverka, V. | Deposit date: | 2017-10-03 | Release date: | 2018-08-15 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6ZV4
| Human TFIIS N-terminal domain in complex with IWS1 | Descriptor: | Transcription elongation factor A protein 1,Protein IWS1 homolog | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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6ZUZ
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6ZV2
| TFIIS N-terminal domain (TND) from human PPP1R10 | Descriptor: | Serine/threonine-protein phosphatase 1 regulatory subunit 10 | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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4OL0
| Crystal structure of transportin-SR2, a karyopherin involved in human disease, in complex with Ran | Descriptor: | GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Tsirkone, V.G, Strelkov, S.V. | Deposit date: | 2014-01-23 | Release date: | 2014-04-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran. Acta Crystallogr.,Sect.F, 70, 2014
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6ZV3
| TFIIS N-terminal domain (TND) from human MED26 | Descriptor: | Mediator of RNA polymerase II transcription subunit 26 | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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6ZV0
| TFIIS N-terminal domain (TND) from human LEDGF/p75 | Descriptor: | PC4 and SFRS1-interacting protein | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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6ZUY
| Human TFIIS N-terminal domain (TND) | Descriptor: | Transcription elongation factor A protein 1 | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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6ZV1
| TFIIS N-terminal domain (TND) from human IWS1 | Descriptor: | Protein IWS1 homolog | Authors: | Veverka, V. | Deposit date: | 2020-07-23 | Release date: | 2021-12-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | A ubiquitous disordered protein interaction module orchestrates transcription elongation. Science, 374, 2021
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6EMO
| Solution structure of the LEDGF/p75 IBD - JPO2 (aa 1-32) complex | Descriptor: | PC4 and SFRS1-interacting protein,LEDGF/p75 IBD-JPO2 M1 | Authors: | Veverka, V. | Deposit date: | 2017-10-03 | Release date: | 2018-07-25 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6EMR
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6EMQ
| Solution structure of the LEDGF/p75 IBD - MLL1 (aa 111-160) complex | Descriptor: | PC4 and SFRS1-interacting protein,Histone-lysine N-methyltransferase 2A | Authors: | Veverka, V. | Deposit date: | 2017-10-03 | Release date: | 2018-08-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6EMP
| Solution structure of the LEDGF/p75 IBD - POGZ (aa 1370-1404) complex | Descriptor: | PC4 and SFRS1-interacting protein,Pogo transposable element with ZNF domain | Authors: | Veverka, V. | Deposit date: | 2017-10-03 | Release date: | 2018-07-25 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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