Author results

2XMY
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DISCOVERY AND CHARACTERISATION OF 2-ANILINO-4-(THIAZOL-5-YL) PYRIMIDINE TRANSCRIPTIONAL CDK INHIBITORS AS ANTICANCER AGENTS
Descriptor:CELL DIVISION PROTEIN KINASE 2, 4-[4-(3,4-DIMETHYL-2-OXO-2,3-DIHYDRO-THIAZOL-5-YL)-PYRIMIDIN-2-YLAMINO]-N-(2-METHOXY-ETHYL)-BENZENESULFONAMIDE
Authors:Wang, S., Griffiths, G., Midgley, C.A., Barnett, A.L., Cooper, M., Grabarek, J., Ingram, L., Jackson, W., Kontopidis, G., McClue, S.J., McInnes, C., McLachlan, J., Meades, C., Mezna, M., Stuart, I., Thomas, M.P., Zheleva, D.I., Lane, D.P., Jackson, R.C., Glover, D.M., Blake, D.G., Fischer, P.M.
Deposit date:2010-07-29
Release date:2010-11-10
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Characterisation of 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents
Chem.Biol., 17, 2010
2XNB
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DISCOVERY AND CHARACTERISATION OF 2-ANILINO-4-(THIAZOL-5-YL) PYRIMIDINE TRANSCRIPTIONAL CDK INHIBITORS AS ANTICANCER AGENTS
Descriptor:CELL DIVISION PROTEIN KINASE 2, 3,4-DIMETHYL-5-(2-{[(1Z)-4-PIPERAZIN-1-YLCYCLOHEXA-2,4-DIEN-1-YLIDENE]AMINO}PYRIMIDIN-4-YL)-1,3-THIAZOL-2(3H)-ONE
Authors:Wang, S., Griffiths, G., Midgley, C.A., Barnett, A.L., Cooper, M., Grabarek, J., Ingram, L., Jackson, W., Kontopidis, G., McClue, S.J., McInnes, C., McLachlan, J., Meades, C., Mezna, M., Stuart, I., Thomas, M.P., Zheleva, D.I., Lane, D.P., Jackson, R.C., Glover, D.M., Blake, D.G., Fischer, P.M.
Deposit date:2010-08-01
Release date:2010-11-10
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery and Characterisation of 2-Anilino-4-(Thiazol-5-Yl)Pyrimidine Transcriptional Cdk Inhibitors as Anticancer Agents
Chem.Biol., 17, 2010
5LBT
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STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH IMIQUIMOD
Descriptor:Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Schneider, S., Gross, O.
Deposit date:2016-06-17
Release date:2016-07-27
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Imiquimod Inhibits Mitochondrial Complex I and Induces K+ efflux-independent Nlrp3 Inflammasome Activation via Nek7
To Be Published
5LBU
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STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH TO CL097
Descriptor:Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Schneider, S., Gross, O.
Deposit date:2016-06-17
Release date:2016-07-27
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Imiquimod Inhibits Mitochondrial Complex I and Induces K+ efflux-independent Nlrp3 Inflammasome Activation via Nek7
To Be Published
5TPL
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CRYSTAL STRUCTURE OF DH270.3 (UNLIGANDED) FROM THE DH270 BROADLY NEUTRALIZING N332-GLYCAN DEPENDENT LINEAGE
Descriptor:DH270.3 Fab light chain, DH270.3 Fab heavy chain
Authors:Fera, D., Harrison, S.C.
Deposit date:2016-10-20
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5TPP
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CRYSTAL STRUCTURE OF DH270.5 (UNLIGANDED) FROM THE DH270 BROADLY NEUTRALIZING N332-GLYCAN DEPENDENT LINEAGE
Descriptor:DH270.5 Fab heavy chain, DH270.5 Fab light chain, SODIUM ION, ...
Authors:Fera, D., Harrison, S.C.
Deposit date:2016-10-20
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5TQA
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CRYSTAL STRUCTURE OF DH270.6 (UNLIGANDED) FROM THE DH270 BROADLY NEUTRALIZING N332-GLYCAN DEPENDENT LINEAGE
Descriptor:DH270.6 Fab heavy chain, DH270.6 Fab light chain
Authors:Fera, D., Harrison, S.C.
Deposit date:2016-10-23
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.723 Å)
Cite:Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5TRP
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CRYSTAL STRUCTURE OF THE UNLIGANDED DH270 COOPERATING LINEAGE MEMBER DH272
Descriptor:DH272 Fab heavy chain, DH272 Fab light chain, SULFATE ION, ...
Authors:Fera, D., Harrison, S.C.
Deposit date:2016-10-27
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.692 Å)
Cite:Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5U0R
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CRYSTAL STRUCTURE OF DH270.UCA1 (UNLIGANDED) FROM THE DH270 BROADLY NEUTRALIZING N332-GLYCAN DEPENDENT LINEAGE
Descriptor:DH270.UCA1 heavy chain, DH270.UCA1 light chain, SULFATE ION
Authors:Fera, D., Harrison, S.C.
Deposit date:2016-11-26
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.295 Å)
Cite:Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5U0U
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CRYSTAL STRUCTURE OF DH270.1 (UNLIGANDED, SINGLE-CHAIN FV) FROM THE DH270 BROADLY NEUTRALIZING N332-GLYCAN DEPENDENT LINEAGE
Descriptor:DH270.1 single-chain variable fragment
Authors:Fera, D., Harrison, S.C.
Deposit date:2016-11-27
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.428 Å)
Cite:Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5U15
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CRYSTAL STRUCTURE OF DH270.UCA3 (UNLIGANDED) FROM THE DH270 BROADLY NEUTRALIZING N332-GLYCAN DEPENDENT LINEAGE
Descriptor:DH270.UCA3 heavy chain, DH270.UCA3 light chain
Authors:Fera, D., Harrison, S.C.
Deposit date:2016-11-27
Release date:2017-03-15
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017