5LBT

Structure of the human quinone reductase 2 (NQO2) in complex with imiquimod

Summary for 5LBT

• Entry DOI: 10.2210/pdb5lbt/pdb
• Descriptor: Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
• Functional Keywords: quinone reductase 2 ribosyldihydronicotinamide dehydrogenase, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P16083
• Total number of polymer chains: 2
• Total formula weight: 56502.12

Authors

Schneider, S.,Gross, O. (deposition date: 2016-06-17, release date: 2016-07-27, Last modification date: 2024-01-10)

• Primary citation: Gross, C.,Mishra, R.,Schneider, K.,Medard, G.,Wettmarshausen, J.,Dittlein, D.,Gorka, O.,Koenig, P.-A.,Fromm, S.,Magnani, G.,Cikovic, T.,Hartjes, L.,Smollich, J.,Robertson, A.,Cooper, M.,Schmidt-Supprian, M.,Schuster, M.,Schroder, K.,Broz, P.,Traidl-Hoffmann, C.,Kuester, B.,Ruland, J.,Schneider, S.,Perocchi, F.,Gross, O.; Imiquimod Inhibits Mitochondrial Complex I and Induces K+ efflux-independent Nlrp3 Inflammasome Activation via Nek7; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.75 Å)