2NXB | | CRYSTAL STRUCTURE OF HUMAN BROMODOMAIN CONTAINING PROTEIN 3 (BRD3) | | Descriptor: | Bromodomain-containing protein 3, SODIUM ION, 1,2-ETHANEDIOL | | Authors: | Filippakopoulos, P., Bullock, A., Cooper, C., Keates, K., Berridge, G., Pike, A., Bunkoczi, G., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-11-17 | | Release date: | 2006-12-12 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
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2OBV | | CRYSTAL STRUCTURE OF THE HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 1 IN COMPLEX WITH THE PRODUCT | | Descriptor: | S-adenosylmethionine synthetase isoform type-1, SODIUM ION, S-ADENOSYLMETHIONINE, ... | | Authors: | Pilka, E.S., Shafqat, N., Kavanagh, K.L., Cooper, C., Hozjan, V., Turnbull, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2006-12-20 | | Release date: | 2007-01-02 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product.
To be Published
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2OO1 | | CRYSTAL STRUCTURE OF THE BROMO DOMAIN 2 OF HUMAN BROMODOMAIN CONTAINING PROTEIN 3 (BRD3) | | Descriptor: | Bromodomain-containing protein 3, SODIUM ION, 1,2-ETHANEDIOL, ... | | Authors: | Filippakopoulos, P., Bullock, A., Papagrigoriou, E., Keates, T., Cooper, C., Smee, C., Ugochukwu, E., Debreczeni, J., von Delft, F., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Knapp, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-01-25 | | Release date: | 2007-02-13 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell(Cambridge,Mass.), 149, 2012
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2PN8 | | CRYSTAL STRUCTURE OF HUMAN PEROXIREDOXIN 4 (THIOREDOXIN PEROXIDASE) | | Descriptor: | Peroxiredoxin-4 | | Authors: | Pilka, E.S., Kavanagh, K.L., Cooper, C., von Delft, F., Sundstrom, M., Arrowsmith, C.A., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-04-24 | | Release date: | 2007-05-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase).
To be Published
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2PNT | | CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN GRASP (GRP1) IN COMPLEX WITH THE C-TERMINAL PEPTIDE OF THE METABOTROPIC GLUTAMATE RECEPTOR TYPE 1 | | Descriptor: | General receptor for phosphoinositides 1-associated scaffold protein, CHLORIDE ION | | Authors: | Elkins, J., Papagrigoriou, E., Cooper, C., Gileadi, C., Uppenberg, J., Bray, J., von Delft, F., Pike, A.C.W., Ugochukwu, E., Umeano, C., Gileadi, O., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-04-25 | | Release date: | 2007-05-08 | | Last modified: | 2017-10-18 | | Method: | X-RAY DIFFRACTION (2.148 Å) | | Cite: | Crystal structure of the PDZ domain of human GRASP (GRP1) in complex with the C-terminal peptide of the metabotropic glutamate receptor type 1.
To be Published
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2Q9V | | CRYSTAL STRUCTURE OF THE C890S MUTANT OF THE 4TH PDZ DOMAIN OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE | | Descriptor: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 | | Authors: | Pilka, E.S., Hozjan, V., Kavanagh, K.L., Papagrigoriou, E., Cooper, C., Elkins, J.M., Doyle, D.A., von Delft, F., Sundstrom, M., Arrowsmith, C.A., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-06-14 | | Release date: | 2007-06-26 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of the C890S mutant of the 4th PDZ domain of human membrane associated guanylate kinase.
To be Published
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2JII | | STRUCTURE OF VACCINIA RELATED KINASE 3 | | Descriptor: | SERINE/THREONINE-PROTEIN KINASE VRK3 MOLECULE: VACCINIA RELATED KINASE 3, 1,2-ETHANEDIOL | | Authors: | Bunkoczi, G., Eswaran, J., Pike, A.C.W., Uppenberg, J., Ugochukwu, E., von Delft, F., Cooper, C., Salah, E., Savitsky, P., Burgess-Brown, N., Keates, T., Fedorov, O., Sobott, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S. | | Deposit date: | 2007-06-28 | | Release date: | 2007-07-10 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site.
Structure, 17, 2009
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2JIK | | CRYSTAL STRUCTURE OF PDZ DOMAIN OF SYNAPTOJANIN-2 BINDING PROTEIN | | Descriptor: | SYNAPTOJANIN-2 BINDING PROTEIN | | Authors: | Tickle, J., Phillips, C., Pike, A.C.W., Cooper, C., Salah, E., Elkins, J., Turnbull, A.P., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D. | | Deposit date: | 2007-06-28 | | Release date: | 2007-07-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Crystal Structure of Pdz Domain of Synaptojanin-2 Binding Protein
To be Published
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2JIL | | CRYSTAL STRUCTURE OF 2ND PDZ DOMAIN OF GLUTAMATE RECEPTOR INTERACTING PROTEIN-1 (GRIP1) | | Descriptor: | GLUTAMATE RECEPTOR INTERACTING PROTEIN-1, THIOCYANATE ION, 1,2-ETHANEDIOL | | Authors: | Tickle, J., Elkins, J., Pike, A.C.W., Cooper, C., Salah, E., Papagrigoriou, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D. | | Deposit date: | 2007-06-28 | | Release date: | 2007-07-10 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal Structure of 2Nd Pdz Domain of Glutamate Receptor Interacting Protein-1 (Grip1)
To be Published
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2JIN | | CRYSTAL STRUCTURE OF PDZ DOMAIN OF SYNAPTOJANIN-2 BINDING PROTEIN | | Descriptor: | SYNAPTOJANIN-2 BINDING PROTEIN, SODIUM ION, SULFATE ION | | Authors: | Tickle, J., Phillips, C., Pike, A.C.W., Cooper, C., Salah, E., Elkins, J., Turnbull, A.P., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D. | | Deposit date: | 2007-06-28 | | Release date: | 2007-07-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal Structure of Pdz Domain of Synaptojanin-2 Binding Protein
To be Published
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2V62 | | STRUCTURE OF VACCINIA-RELATED KINASE 2 | | Descriptor: | SERINE/THREONINE-PROTEIN KINASE VRK2, MAGNESIUM ION, SUCCINIC ACID, ... | | Authors: | Bunkoczi, G., Eswaran, J., Cooper, C., Fedorov, O., Keates, T., Rellos, P., Salah, E., Savitsky, P., Ugochukwu, E., von Delft, F., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Knapp, S. | | Deposit date: | 2007-07-13 | | Release date: | 2007-08-21 | | Last modified: | 2011-11-30 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of the Pseudokinase Vrk3 Reveals a Degraded Catalytic Site, a Highly Conserved Kinase Fold, and a Putative Regulatory Binding Site.
Structure, 17, 2009
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2V90 | | CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF INTESTINE- AND KIDNEY- ENRICHED PDZ DOMAIN IKEPP (PDZD3) | | Descriptor: | PDZ DOMAIN-CONTAINING PROTEIN 3, SULFATE ION | | Authors: | Uppenberg, J., Gileadi, C., Phillips, C., Elkins, J., Bunkoczi, G., Cooper, C., Pike, A.C.W., Salah, E., Ugochukwu, E., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Doyle, D.A. | | Deposit date: | 2007-08-16 | | Release date: | 2007-08-28 | | Last modified: | 2018-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of the 3Rd Pdz Domain of Intestine- and Kidney-Enriched Pdz Domain Ikepp (Pdzd3)
To be Published
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2R4H | | CRYSTAL STRUCTURE OF A C1190S MUTANT OF THE 6TH PDZ DOMAIN OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE | | Descriptor: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, HISTIDINE | | Authors: | Ugochukwu, E., Pilka, E.S., Hozjan, V., Kavanagh, K.L., Cooper, C., Pike, A.C.W., Elkins, J.M., Doyle, D.A., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-08-31 | | Release date: | 2007-10-16 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase.
To be Published
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2REY | | CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN DISHEVELLED 2 (HOMOLOGOUS TO DROSOPHILA DSH) | | Descriptor: | Segment polarity protein dishevelled homolog DVL-2 | | Authors: | Papagrigoriou, E., Gileadi, C., Elkins, J., Cooper, C., Ugochukwu, E., Turnbull, A., Pike, A.C.W., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Doyle, D., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-09-27 | | Release date: | 2007-10-23 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structure of the PDZ domains of human dishevelled 2 (homologous to Drosophila dsh).
To be Published
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3B84 | | CRYSTAL STRUCTURE OF THE HUMAN BTB DOMAIN OF THE KRUEPPEL RELATED ZINC FINGER PROTEIN 3 (HKR3) | | Descriptor: | Zinc finger and BTB domain-containing protein 48, UNKNOWN, 1,2-ETHANEDIOL | | Authors: | Filippakopoulos, P., Bullock, A., Cooper, C., Keates, T., Salah, E., Pilka, E., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-10-31 | | Release date: | 2007-11-20 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Crystal Structure of the Human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3).
To be Published
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3BKB | | CRYSTAL STRUCTURE OF HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V-FES) | | Descriptor: | Proto-oncogene tyrosine-protein kinase Fes/Fps, SULFATE ION, 1,2-ETHANEDIOL, ... | | Authors: | Filippakopoulos, P., Salah, E., Fedorov, O., Cooper, C., Ugochukwu, E., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-12-06 | | Release date: | 2007-12-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134, 2008
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3BPU | | CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE, C677S AND C709S DOUBLE MUTANT | | Descriptor: | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, ZINC ION | | Authors: | Pilka, E.S., Hozjan, V., Cooper, C., Pike, A.C.W., Elkins, J., Doyle, D.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2007-12-19 | | Release date: | 2008-01-08 | | Last modified: | 2017-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structure of the 3rd PDZ domain of human membrane associated guanylate kinase, C677S and C709S double mutant.
To be Published
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3CBL | | CRYSTAL STRUCTURE OF HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V-FES) IN COMPLEX WITH STAUROSPORINE AND A CONSENSUS PEPTIDE | | Descriptor: | Proto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, STAUROSPORINE | | Authors: | Filippakopoulos, P., Salah, E., Cooper, C., Picaud, S.S., Elkins, J.M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2008-02-22 | | Release date: | 2008-03-04 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134, 2008
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3CD3 | | CRYSTAL STRUCTURE OF PHOSPHORYLATED HUMAN FELINE SARCOMA VIRAL ONCOGENE HOMOLOGUE (V-FES) IN COMPLEX WITH STAUROSPORINE AND A CONSENSUS PEPTIDE | | Descriptor: | Proto-oncogene tyrosine-protein kinase Fes/Fps, Synthetic peptide, CHLORIDE ION, ... | | Authors: | Filippakopoulos, P., Salah, E., Cooper, C., Picaud, S.S., Elkins, J.M., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC) | | Deposit date: | 2008-02-26 | | Release date: | 2008-03-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Structural Coupling of SH2-Kinase Domains Links Fes and Abl Substrate Recognition and Kinase Activation
Cell(Cambridge,Mass.), 134, 2008
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2VRF | | CRYSTAL STRUCTURE OF THE HUMAN BETA-2-SYNTROPHIN PDZ DOMAIN | | Descriptor: | BETA-2-SYNTROPHIN, 1,2-ETHANEDIOL | | Authors: | Sun, Z., Roos, A.K., Pike, A.C.W., Pilka, E.S., Cooper, C., Elkins, J.M., Murray, J., Arrowsmith, C.H., Doyle, D., Edwards, A., von Delft, F., Bountra, C., Oppermann, U. | | Deposit date: | 2008-03-31 | | Release date: | 2008-04-22 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of the Human Beta-2-Syntrophin Pdz Domain
To be Published
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2VSP | | CRYSTAL STRUCTURE OF THE FOURTH PDZ DOMAIN OF PDZ DOMAIN-CONTAINING PROTEIN 1 | | Descriptor: | PDZ DOMAIN-CONTAINING PROTEIN 1 | | Authors: | Yue, W.W., Shafqat, N., Pilka, E.S., Johansson, C., Murray, J.W., Elkins, J., Roos, A., Cooper, C., Phillips, C., Salah, E., von Delft, F., Doyle, D., Edwards, A., Wikstrom, M., Arrowsmith, C., Bountra, C., Oppermann, U. | | Deposit date: | 2008-04-28 | | Release date: | 2009-03-03 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | Crystal Structure of the Fourth Pdz Domain of Pdz Domain-Containing Protein 1
To be Published
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2VZ5 | | STRUCTURE OF THE PDZ DOMAIN OF TAX1 (HUMAN T-CELL LEUKEMIA VIRUS TYPE I) BINDING PROTEIN 3 | | Descriptor: | TAX1-BINDING PROTEIN 3, IMIDAZOLE, ZINC ION, ... | | Authors: | Murray, J.W., Shafqat, N., Yue, W., Pilka, E., Johannsson, C., Salah, E., Cooper, C., Elkins, J.M., Pike, A.C., Roos, A., Filippakopoulos, P., von Delft, F., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Oppermann, U. | | Deposit date: | 2008-07-30 | | Release date: | 2008-08-12 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.738 Å) | | Cite: | The Structure of the Pdz Domain of Tax1BP
To be Published
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3EPU | | CRYSTAL STRUCTURE OF STM2138, A NOVEL VIRULENCE CHAPERONE IN SALMONELLA | | Descriptor: | STM2138 Virulence Chaperone | | Authors: | Zhang, K., Andres, S.N., Hannemann, M., Coombes, B., Junop, M. | | Deposit date: | 2008-09-30 | | Release date: | 2009-09-29 | | Last modified: | 2013-02-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural analysis and quantitative proteomic
interactome of a novel virulence chaperone in Salmonella
To be Published
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2W4F | | CRYSTAL STRUCTURE OF THE FIRST PDZ DOMAIN OF HUMAN SCRIB1 | | Descriptor: | PROTEIN LAP4, 1,2-ETHANEDIOL | | Authors: | Hozjan, V., Pilka, E.S., Roos, A.K., W Yue, W., Phillips, C., Bray, J., Cooper, C., Salah, E., Elkins, J.M., Muniz, J.R.C., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., von Delft, F., Bountra, C., Doyle, D.A., Oppermann, U. | | Deposit date: | 2008-11-25 | | Release date: | 2008-12-09 | | Last modified: | 2018-01-24 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Crystal Structure of the First Pdz Domain of Human Scrib1
To be Published
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3GGE | | CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF PDZ DOMAIN-CONTAINING PROTEIN GIPC2 | | Descriptor: | PDZ domain-containing protein GIPC2, SULFATE ION, GLYCEROL | | Authors: | Chaikuad, A., Hozjan, V., Yue, W., Cooper, C., Elkins, J., Pike, A.C.W., Roos, A.K., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC) | | Deposit date: | 2009-02-27 | | Release date: | 2009-03-24 | | Last modified: | 2018-01-31 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the PDZ domain of PDZ domain-containing protein GIPC2
To be Published
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