Author results

2PNT
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN GRASP (GRP1) IN COMPLEX WITH THE C-TERMINAL PEPTIDE OF THE METABOTROPIC GLUTAMATE RECEPTOR TYPE 1
Descriptor:General receptor for phosphoinositides 1-associated scaffold protein, CHLORIDE ION
Authors:Elkins, J., Papagrigoriou, E., Cooper, C., Gileadi, C., Uppenberg, J., Bray, J., von Delft, F., Pike, A.C.W., Ugochukwu, E., Umeano, C., Gileadi, O., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2007-04-25
Release date:2007-05-08
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.148 Å)
Cite:Crystal structure of the PDZ domain of human GRASP (GRP1) in complex with the C-terminal peptide of the metabotropic glutamate receptor type 1.
To be Published
2V90
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CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF INTESTINE- AND KIDNEY- ENRICHED PDZ DOMAIN IKEPP (PDZD3)
Descriptor:PDZ DOMAIN-CONTAINING PROTEIN 3, SULFATE ION
Authors:Uppenberg, J., Gileadi, C., Phillips, C., Elkins, J., Bunkoczi, G., Cooper, C., Pike, A.C.W., Salah, E., Ugochukwu, E., Arrowsmith, C.H., Edwards, A., Sundstrom, M., Weigelt, J., Doyle, D.A.
Deposit date:2007-08-16
Release date:2007-08-28
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the 3Rd Pdz Domain of Intestine- and Kidney-Enriched Pdz Domain Ikepp (Pdzd3)
To be Published
2VZ5
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STRUCTURE OF THE PDZ DOMAIN OF TAX1 (HUMAN T-CELL LEUKEMIA VIRUS TYPE I) BINDING PROTEIN 3
Descriptor:TAX1-BINDING PROTEIN 3, IMIDAZOLE, ZINC ION, ...
Authors:Murray, J.W., Shafqat, N., Yue, W., Pilka, E., Johannsson, C., Salah, E., Cooper, C., Elkins, J.M., Pike, A.C., Roos, A., Filippakopoulos, P., von Delft, F., Wickstroem, M., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Oppermann, U.
Deposit date:2008-07-30
Release date:2008-08-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.738 Å)
Cite:The Structure of the Pdz Domain of Tax1BP
To be Published
2W4F
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CRYSTAL STRUCTURE OF THE FIRST PDZ DOMAIN OF HUMAN SCRIB1
Descriptor:PROTEIN LAP4, 1,2-ETHANEDIOL
Authors:Hozjan, V., Pilka, E.S., Roos, A.K., W Yue, W., Phillips, C., Bray, J., Cooper, C., Salah, E., Elkins, J.M., Muniz, J.R.C., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., von Delft, F., Bountra, C., Doyle, D.A., Oppermann, U.
Deposit date:2008-11-25
Release date:2008-12-09
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal Structure of the First Pdz Domain of Human Scrib1
To be Published
2XZZ
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CRYSTAL STRUCTURE OF THE HUMAN TRANSGLUTAMINASE 1 BETA-BARREL DOMAIN
Descriptor:PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE K
Authors:Vollmar, M., Krysztofinska, E., Krojer, T., Yue, W.W., Cooper, C., Kavanagh, K., Allerston, C., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-11-30
Release date:2011-01-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of the Human Transglutaminase 1 Beta-Barrel Domain
To be Published
3MDY
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CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE-1B (BMPR1B) IN COMPLEX WITH FKBP12 AND LDN-193189
Descriptor:Bone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Authors:Chaikuad, A., Sanvitale, C., Mahajan, P., Daga, N., Cooper, C., Krojer, T., Alfano, I., Knapp, S., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-03-31
Release date:2010-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189
To be Published
3OOM
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CRYSTAL STRUCTURE OF THE ACVR1 KINASE DOMAIN IN COMPLEX WITH THE IMIDAZO[1,2-B]PYRIDAZINE INHIBITOR K00507
Descriptor:Activin receptor type-1, PHOSPHATE ION, 1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone, ...
Authors:Chaikuad, A., Sanvitale, C., Cooper, C., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Allerston, C., Krojer, T., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-10-13
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507
To be Published
4DYM
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CRYSTAL STRUCTURE OF THE ACVR1 KINASE DOMAIN IN COMPLEX WITH THE IMIDAZO[1,2-B]PYRIDAZINE INHIBITOR K00135
Descriptor:Activin receptor type-1, SULFATE ION, 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, ...
Authors:Chaikuad, A., Sanvitale, C., Cooper, C., Canning, P., Mahajan, P., Daga, N., Petrie, K., Alfano, I., Gileadi, O., Fedorov, O., Krojer, T., Filippakopoulos, P., Muniz, J.R.C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2012-02-29
Release date:2012-03-21
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135
To be Published
2JIK
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CRYSTAL STRUCTURE OF PDZ DOMAIN OF SYNAPTOJANIN-2 BINDING PROTEIN
Descriptor:SYNAPTOJANIN-2 BINDING PROTEIN
Authors:Tickle, J., Phillips, C., Pike, A.C.W., Cooper, C., Salah, E., Elkins, J., Turnbull, A.P., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D.
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal Structure of Pdz Domain of Synaptojanin-2 Binding Protein
To be Published
2JIN
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CRYSTAL STRUCTURE OF PDZ DOMAIN OF SYNAPTOJANIN-2 BINDING PROTEIN
Descriptor:SYNAPTOJANIN-2 BINDING PROTEIN, SODIUM ION, SULFATE ION
Authors:Tickle, J., Phillips, C., Pike, A.C.W., Cooper, C., Salah, E., Elkins, J., Turnbull, A.P., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D.
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Pdz Domain of Synaptojanin-2 Binding Protein
To be Published
2REY
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN DISHEVELLED 2 (HOMOLOGOUS TO DROSOPHILA DSH)
Descriptor:Segment polarity protein dishevelled homolog DVL-2
Authors:Papagrigoriou, E., Gileadi, C., Elkins, J., Cooper, C., Ugochukwu, E., Turnbull, A., Pike, A.C.W., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2007-09-27
Release date:2007-10-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the PDZ domains of human dishevelled 2 (homologous to Drosophila dsh).
To be Published
2VRF
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CRYSTAL STRUCTURE OF THE HUMAN BETA-2-SYNTROPHIN PDZ DOMAIN
Descriptor:BETA-2-SYNTROPHIN, 1,2-ETHANEDIOL
Authors:Sun, Z., Roos, A.K., Pike, A.C.W., Pilka, E.S., Cooper, C., Elkins, J.M., Murray, J., Arrowsmith, C.H., Doyle, D., Edwards, A., von Delft, F., Bountra, C., Oppermann, U.
Deposit date:2008-03-31
Release date:2008-04-22
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Human Beta-2-Syntrophin Pdz Domain
To be Published
3GGE
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF PDZ DOMAIN-CONTAINING PROTEIN GIPC2
Descriptor:PDZ domain-containing protein GIPC2, SULFATE ION, GLYCEROL
Authors:Chaikuad, A., Hozjan, V., Yue, W., Cooper, C., Elkins, J., Pike, A.C.W., Roos, A.K., Filippakopoulos, P., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2009-02-27
Release date:2009-03-24
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the PDZ domain of PDZ domain-containing protein GIPC2
To be Published
4A64
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN CUL4B AT 2.57A RESOLUTION
Descriptor:CULLIN-4B, 1,2-ETHANEDIOL
Authors:Vollmar, M., Ayinampudi, V., Cooper, C., Guo, K., Krojer, T., Muniz, J.R.C., von Delft, F., Weigelt, J., Arrowsmith, C.H., Bountra, C., Edwards, A., Bullock, A.
Deposit date:2011-10-31
Release date:2012-02-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Crystal Structure of the N-Terminal Domain of Human Cul4B at 2.57A Resolution
To be Published
3II0
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CRYSTAL STRUCTURE OF HUMAN GLUTAMATE OXALOACETATE TRANSAMINASE 1 (GOT1)
Descriptor:Aspartate aminotransferase, cytoplasmic, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Ugochukwu, E., Pilka, E., Cooper, C., Bray, J.E., Yue, W.W., Muniz, J., Chaikuad, A., von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Kavanagh, K.L., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2009-07-31
Release date:2009-08-11
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of human Glutamate oxaloacetate transaminase 1 (GOT1)
To be Published
2JIL
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CRYSTAL STRUCTURE OF 2ND PDZ DOMAIN OF GLUTAMATE RECEPTOR INTERACTING PROTEIN-1 (GRIP1)
Descriptor:GLUTAMATE RECEPTOR INTERACTING PROTEIN-1, THIOCYANATE ION, 1,2-ETHANEDIOL
Authors:Tickle, J., Elkins, J., Pike, A.C.W., Cooper, C., Salah, E., Papagrigoriou, E., von Delft, F., Edwards, A., Arrowsmith, C.H., Weigelt, J., Sundstrom, M., Doyle, D.
Deposit date:2007-06-28
Release date:2007-07-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of 2Nd Pdz Domain of Glutamate Receptor Interacting Protein-1 (Grip1)
To be Published
2OBV
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CRYSTAL STRUCTURE OF THE HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 1 IN COMPLEX WITH THE PRODUCT
Descriptor:S-adenosylmethionine synthetase isoform type-1, SODIUM ION, S-ADENOSYLMETHIONINE, ...
Authors:Pilka, E.S., Shafqat, N., Kavanagh, K.L., Cooper, C., Hozjan, V., Turnbull, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-12-20
Release date:2007-01-02
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product.
To be Published
2PN8
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CRYSTAL STRUCTURE OF HUMAN PEROXIREDOXIN 4 (THIOREDOXIN PEROXIDASE)
Descriptor:Peroxiredoxin-4
Authors:Pilka, E.S., Kavanagh, K.L., Cooper, C., von Delft, F., Sundstrom, M., Arrowsmith, C.A., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-04-24
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human peroxiredoxin 4 (thioredoxin peroxidase).
To be Published
2Q9V
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CRYSTAL STRUCTURE OF THE C890S MUTANT OF THE 4TH PDZ DOMAIN OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
Authors:Pilka, E.S., Hozjan, V., Kavanagh, K.L., Papagrigoriou, E., Cooper, C., Elkins, J.M., Doyle, D.A., von Delft, F., Sundstrom, M., Arrowsmith, C.A., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-06-14
Release date:2007-06-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the C890S mutant of the 4th PDZ domain of human membrane associated guanylate kinase.
To be Published
2R4H
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CRYSTAL STRUCTURE OF A C1190S MUTANT OF THE 6TH PDZ DOMAIN OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, HISTIDINE
Authors:Ugochukwu, E., Pilka, E.S., Hozjan, V., Kavanagh, K.L., Cooper, C., Pike, A.C.W., Elkins, J.M., Doyle, D.A., von Delft, F., Sundstrom, M., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-08-31
Release date:2007-10-16
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of a C1190S mutant of the 6th PDZ domain of human membrane associated guanylate kinase.
To be Published
3B84
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CRYSTAL STRUCTURE OF THE HUMAN BTB DOMAIN OF THE KRUEPPEL RELATED ZINC FINGER PROTEIN 3 (HKR3)
Descriptor:Zinc finger and BTB domain-containing protein 48, UNKNOWN, 1,2-ETHANEDIOL
Authors:Filippakopoulos, P., Bullock, A., Cooper, C., Keates, T., Salah, E., Pilka, E., Pike, A.C.W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2007-10-31
Release date:2007-11-20
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal Structure of the Human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3).
To be Published
3BPU
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CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF HUMAN MEMBRANE ASSOCIATED GUANYLATE KINASE, C677S AND C709S DOUBLE MUTANT
Descriptor:Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1, ZINC ION
Authors:Pilka, E.S., Hozjan, V., Cooper, C., Pike, A.C.W., Elkins, J., Doyle, D.A., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-12-19
Release date:2008-01-08
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of the 3rd PDZ domain of human membrane associated guanylate kinase, C677S and C709S double mutant.
To be Published
6FV3
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CRYSTAL STRUCTURE OF N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE DEACETYLASE FROM MYCOBACTERIUM SMEGMATIS.
Descriptor:N-acetylglucosamine-6-phosphate deacetylase, ZINC ION
Authors:Ahangar, M.S., Furze, C.M., Guy, C.S., Cooper, C., Maskew, K.S., Graham, B., Cameron, A.D., Fullam, E.
Deposit date:2018-02-28
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural and functional determination of homologs of theMycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).
J. Biol. Chem., 293, 2018
6FV4
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THE STRUCTURE OF N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE DEACETYLASE D267A MUTANT FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE
Descriptor:N-acetylglucosamine-6-phosphate deacetylase, ZINC ION, N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE, ...
Authors:Ahangar, M.S., Furze, C.M., Guy, C.S., Cooper, C., Maskew, K.S., Graham, B., Cameron, A.D., Fullam, E.
Deposit date:2018-03-01
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.974 Å)
Cite:Structural and functional determination of homologs of theMycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).
J. Biol. Chem., 293, 2018
3EPU
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CRYSTAL STRUCTURE OF STM2138, A NOVEL VIRULENCE CHAPERONE IN SALMONELLA
Descriptor:STM2138 Virulence Chaperone
Authors:Zhang, K., Andres, S.N., Hannemann, M., Coombes, B., Junop, M.
Deposit date:2008-09-30
Release date:2009-09-29
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis and quantitative proteomic interactome of a novel virulence chaperone in Salmonella
To be Published
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