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2O48
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CRYSTAL STRUCTURE OF MAMMALIAN DIMERIC DIHYDRODIOL DEHYDROGENASE
Descriptor:Dimeric dihydrodiol dehydrogenase, SULFATE ION, P-HYDROXYACETOPHENONE, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2006-12-04
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis.
Proteins, 70, 2008
2O4U
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CRYSTAL STRUCTURE OF MAMMALIAN DIMERIC DIHYDRODIOL DEHYDROGENASE
Descriptor:Dimeric dihydrodiol dehydrogenase, PHOSPHATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2006-12-04
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of dimeric dihydrodiol dehydrogenase apoenzyme and inhibitor complex: probing the subunit interface with site-directed mutagenesis.
Proteins, 70, 2008
2POQ
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DIMERIC DIHYDRODIOL DEHYDROGENASE COMPLEXED WITH INHIBITOR, ISOASCORBIC ACID
Descriptor:Dimeric dihydrodiol dehydrogenase, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2007-04-27
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure of monkey dimeric dihydrodiol dehydrogenase in complex with isoascorbic acid.
Acta Crystallogr.,Sect.D, 64, 2008
3CV7
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CRYSTAL STRUCTURE OF PORCINE ALDEHYDE REDUCTASE TERNARY COMPLEX
Descriptor:Alcohol dehydrogenase, SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2008-04-18
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.412 Å)
Cite:Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: Implications for inhibitor binding and selectivity
Arch.Biochem.Biophys., 479, 2008
3FX4
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PORCINE ALDEHYDE REDUCTASE IN TERNARY COMPLEX WITH INHIBITOR
Descriptor:Alcohol dehydrogenase [NADP+], SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2009-01-20
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structure of Aldehyde Reductase in Ternary Complex with a 5-Arylidene-2,4-thiazolidinedione Aldose Reductase Inhibitor
To be Published
4FIO
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CRYSTAL STRUCTURE OF METHENYLTETRAHYDROMETHANOPTERIN CYCLOHYDROLASE FROM METHANOBREVIBACTER RUMINANTIUM
Descriptor:Methenyltetrahydromethanopterin cyclohydrolase, ETHYL ACETATE, ISOPROPYL ALCOHOL
Authors:Carbone, V., Schofield, L.R., Beattie, A.K., Sutherland-Smith, A.J., Ronimus, R.S.
Deposit date:2012-06-10
Release date:2013-07-24
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:The Crystal Structure of Methenyltetrahydromethanopterin Cyclohydrolase from Methanobrevibacter ruminantium: Implications for substrate binding of N5-formyl-5,6,7,8-tetrahydro-methanopterin
To be Published, 2012
4RFL
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CRYSTAL STRUCTURE OF G1PDH WITH NADPH FROM METHANOCALDOCOCCUS JANNASCHII
Descriptor:Glycerol-1-phosphate dehydrogenase [NAD(P)+], NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ...
Authors:Carbone, V., Ronimus, R.S., Schofield, L.R., Sutherland-Smith, A.J.
Deposit date:2014-09-26
Release date:2015-07-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Evolution of the Archaeal Lipid Synthesis Enzyme sn-Glycerol-1-phosphate Dehydrogenase.
J.Biol.Chem., 290, 2015
4RGQ
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CRYSTAL STRUCTURE OF THE METHANOCALDOCOCCUS JANNASCHII G1PDH WITH NADPH AND DHAP
Descriptor:Glycerol-1-phosphate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ...
Authors:Carbone, V., Ronimus, R.S., Schofield, L.R., Sutherland-Smith, A.J.
Deposit date:2014-09-30
Release date:2015-07-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Structure and Evolution of the Archaeal Lipid Synthesis Enzyme sn-Glycerol-1-phosphate Dehydrogenase.
J.Biol.Chem., 290, 2015
4RGV
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CRYSTAL STRUCTURE OF THE METHANOCALDOCOCCUS JANNASCHII G1PDH
Descriptor:Glycerol-1-phosphate dehydrogenase, MAGNESIUM ION, ZINC ION
Authors:Carbone, V., Ronimus, R.S., Schofield, L.R., Sutherland-Smith, A.J.
Deposit date:2014-09-30
Release date:2015-07-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structure and Evolution of the Archaeal Lipid Synthesis Enzyme sn-Glycerol-1-phosphate Dehydrogenase.
J.Biol.Chem., 290, 2015
6DNT
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UDP-N-ACETYLGLUCOSAMINE 4-EPIMERASE FROM METHANOBREVIBACTER RUMINANTIUM M1 IN COMPLEX WITH UDP-N-ACETYLMURAMIC ACID
Descriptor:NAD-dependent epimerase/dehydratase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (2R)-2-{[(2R,3R,4R,5S,6R)-3-(acetylamino)-2-{[(S)-{[(R)-{[(2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]oxy}-5-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl]oxy}propanoic acid, ...
Authors:Carbone, V., Schofield, L.R., Sang, C., Sutherland-Smith, A.J., Ronimus, R.S.
Deposit date:2018-06-07
Release date:2018-10-03
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural determination of archaeal UDP-N-acetylglucosamine 4-epimerase from Methanobrevibacter ruminantium M1 in complex with the bacterial cell wall intermediate UDP-N-acetylmuramic acid.
Proteins, 86, 2018
3H4G
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STRUCTURE OF ALDEHYDE REDUCTASE HOLOENZYME IN COMPLEX WITH POTENT ALDOSE REDUCTASE INHIBITOR FIDARESTAT: IMPLICATIONS FOR INHIBITOR BINDING AND SELECTIVITY
Descriptor:Alcohol dehydrogenase [NADP+], SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Carbone, V., El-Kabbani, O.
Deposit date:2009-04-20
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
J.Med.Chem., 48, 2005
1PR9
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HUMAN L-XYLULOSE REDUCTASE HOLOENZYME
Descriptor:L-XYLULOSE REDUCTASE, POTASSIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Ishikura, S., Darmanin, C., Carbone, V., Chung, R.P.-T., Usami, N., Hara, A.
Deposit date:2003-06-20
Release date:2004-02-24
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of human L-xylulose reductase holoenzyme: probing the role of Asn107 with site-directed mutagenesis
Proteins, 55, 2004
1WNT
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STRUCUTRE OF THE TETRAMERIC FORM OF HUMAN L-XYLULOSE REDUCTASE
Descriptor:L-xylulose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:El-Kabbani, O., Carbone, V., Darmanin, C., Ishikura, S., Hara, A.
Deposit date:2004-08-09
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the tetrameric form of human L-Xylulose reductase: Probing the inhibitor-binding site with molecular modeling and site-directed mutagenesis
Proteins, 60, 2005
2P5N
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CRYSTAL STRUCTURE OF MOUSE 17-ALPHA HYDROXYSTEROID DEHYDROGENASE IN COMPLEX WITH COENZYME NADPH
Descriptor:Aldo-keto reductase family 1, member C21, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:El-Kabbani, O., Dhagat, U.
Deposit date:2007-03-15
Release date:2007-10-09
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) holoenzyme from an orthorhombic crystal form: an insight into the bifunctionality of the enzyme.
Acta Crystallogr.,Sect.F, 63, 2007
3BCJ
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH 2S4R (STEREOISOMER OF FIDARESTAT, 2S4S) AT 0.78 A
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ...
Authors:Zhao, H.T., El-Kabbani, O.
Deposit date:2007-11-13
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.78 Å)
Cite:Unusual Binding Mode of the 2S4R Stereoisomer of the Potent Aldose Reductase Cyclic Imide Inhibitor Fidarestat (2S4S) in the 15 K Crystal Structure of the Ternary Complex Refined at 0.78 A Resolution: Implications for the Inhibition Mechanism
J.Med.Chem., 51, 2008