Author results

1M1L
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HUMAN SUPPRESSOR OF FUSED (N-TERMINAL DOMAIN)
Descriptor:Suppressor of Fused
Authors:Merchant, M., Vajdos, F.F., Ultsch, M., Maun, H.R., Wendt, U., Cannon, J., Lazarus, R.A., de Vos, A.M., de Sauvage, F.J.
Deposit date:2002-06-19
Release date:2004-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Suppressor of fused regulates Gli activity through a dual binding mechanism
Mol.Cell.Biol., 24, 2004
4JV7
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CO-CRYSTAL STRUCTURE OF MDM2 WITH INHIBITOR (2S,5R,6S)-2-BENZYL-5,6-BIS(4-BROMOPHENYL)-4-METHYLMORPHOLIN-3-ONE
Descriptor:E3 ubiquitin-protein ligase Mdm2, (2S,5R,6S)-2-benzyl-5,6-bis(4-bromophenyl)-4-methylmorpholin-3-one, SULFATE ION
Authors:Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.
Deposit date:2013-03-25
Release date:2013-05-01
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
J.Med.Chem., 56, 2013
4JV9
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CO-CRYSTAL STRUCTURE OF MDM2 WITH INHIBITOR (2S,5R,6S)-2-BENZYL-5,6-BIS(4-CHLOROPHENYL)-4-METHYLMORPHOLIN-3-ONE
Descriptor:E3 ubiquitin-protein ligase Mdm2, (2S,5R,6S)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one, SULFATE ION
Authors:Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.
Deposit date:2013-03-25
Release date:2013-05-01
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
J.Med.Chem., 56, 2013
4JVE
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CO-CRYSTAL STRUCTURE OF MDM2 WITH INHIBITOR (2R,3E)-2-[(2S,3R,6S)-2,3-BIS(4-CHLOROPHENYL)-6-(4-FLUOROBENZYL)-5-OXOMORPHOLIN-4-YL]PENT-3-ENOIC ACID
Descriptor:E3 ubiquitin-protein ligase Mdm2, (2R,3E)-2-[(2S,3R,6S)-2,3-bis(4-chlorophenyl)-6-(4-fluorobenzyl)-5-oxomorpholin-4-yl]pent-3-enoic acid
Authors:Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.
Deposit date:2013-03-25
Release date:2013-05-01
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
J.Med.Chem., 56, 2013
4JVR
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CO-CRYSTAL STRUCTURE OF MDM2 WITH INHIBITOR (2'S,3R,4'S,5'R)-N-(2-AMINOETHYL)-6-CHLORO-4'-(3-CHLORO-2-FLUOROPHENYL)-2'-(2,2-DIMETHYLPROPYL)-2-OXO-1,2-DIHYDROSPIRO[INDOLE-3,3'-PYRROLIDINE]-5'-CARBOXAMIDE
Descriptor:E3 ubiquitin-protein ligase Mdm2, (2'S,3R,4'S,5'R)-N-(2-aminoethyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
Authors:Huang, X., Gonzalez-Lopez de Turiso, F., Sun, D., Yosup, R., Bartberger, M.D., Beck, H.P., Cannon, J., Shaffer, P., Oliner, J.D., Olson, S.H., Medina, J.C.
Deposit date:2013-03-26
Release date:2013-05-01
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Rational Design and Binding Mode Duality of MDM2-p53 Inhibitors.
J.Med.Chem., 56, 2013
4BL8
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CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN SUPPRESSOR OF FUSED (SUFU)
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG, MALTOSE
Authors:Karlstrom, M., Finta, C., Cherry, A.L., Toftgard, R., Jovine, L.
Deposit date:2013-05-02
Release date:2013-11-27
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013
4BL9
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CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN SUPPRESSOR OF FUSED (SUFU) MUTANT LACKING A REGULATORY SUBDOMAIN (CRYSTAL FORM I)
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG, MALTOSE
Authors:Cherry, A.L., Finta, C., Karlstrom, M., Toftgard, R., Jovine, L.
Deposit date:2013-05-02
Release date:2013-11-27
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013
4BLA
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CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN SUPPRESSOR OF FUSED (SUFU) MUTANT LACKING A REGULATORY SUBDOMAIN (CRYSTAL FORM II)
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG
Authors:Cherry, A.L., Finta, C., Karlstrom, M., Toftgard, R., Jovine, L.
Deposit date:2013-05-02
Release date:2013-11-27
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013
4BLB
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CRYSTAL STRUCTURE OF A HUMAN SUPPRESSOR OF FUSED (SUFU)-GLI1P COMPLEX
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG, ZINC FINGER PROTEIN GLI1, ...
Authors:Cherry, A.L., Finta, C., Karlstrom, M., De Sanctis, D., Toftgard, R., Jovine, L.
Deposit date:2013-05-02
Release date:2013-11-27
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013
4BLD
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CRYSTAL STRUCTURE OF A HUMAN SUPPRESSOR OF FUSED (SUFU)-GLI3P COMPLEX
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG, TRANSCRIPTIONAL ACTIVATOR GLI3, ...
Authors:Cherry, A.L., Finta, C., Karlstrom, M., De Sanctis, D., Toftgard, R., Jovine, L.
Deposit date:2013-05-02
Release date:2013-11-27
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Acta Crystallogr.,Sect.D, 69, 2013