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4AUT
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CRYSTAL STRUCTURE OF THE TUBERCULOSIS DRUG TARGET DECAPRENYL- PHOSPHORYL-BETA-D-RIBOFURANOSE-2-OXIDOREDUCTASE (DPRE1) FROM MYCOBACTERIUM SMEGMATIS
Descriptor:DECAPRENYL-PHOSPHORYL-BETA-D-RIBOFURANOSE-2-OXIDOREDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Neres, J., Pojer, F., Molteni, E., Chiarelli, L.R., Dhar, N., Boy-Rottger, S., Buroni, S., Fullam, E., Degiacomi, G., Lucarelli, A., Read, R.J., Zanoni, G., Edmondson, D.E., De Rossi, E., Pasca, M., Riccardi, G., Mattevi, A., Dyson, P.J., Cole, S.T., Binda, C.
Deposit date:2012-05-21
Release date:2012-09-05
Last modified:2012-09-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium Tuberculosis.
Sci. Transl. Med., 4, 2012
2V57
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CRYSTAL STRUCTURE OF THE TETR-LIKE TRANSCRIPTIONAL REGULATOR LFRR FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH PROFLAVINE
Descriptor:TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR, PROFLAVIN, ISOPROPYL ALCOHOL, ...
Authors:Bellinzoni, M., Buroni, S., Riccardi, G., De Rossi, E., Alzari, P.M.
Deposit date:2008-10-02
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Plasticity and Distinct Drug-Binding Modes of Lfrr, a Mycobacterial Efflux Pump Regulator.
J.Bacteriol., 191, 2009
2WGB
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CRYSTAL STRUCTURE OF THE TETR-LIKE TRANSCRIPTIONAL REGULATOR LFRR FROM MYCOBACTERIUM SMEGMATIS
Descriptor:TETR FAMILY TRANSCRIPTIONAL REPRESSOR LFRR, SULFATE ION
Authors:Bellinzoni, M., Buroni, S., Riccardi, G., De Rossi, E., Alzari, P.M.
Deposit date:2009-04-16
Release date:2009-10-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Plasticity and Distinct Drug-Binding Modes of Lfrr, a Mycobacterial Efflux Pump Regulator.
J.Bacteriol., 191, 2009
5FUS
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CRYSTAL STRUCTURE OF B. CENOCEPACIA DFSA
Descriptor:PUTATIVE ENOYL COA HYDRATASE, SULFATE ION, GLYCEROL, ...
Authors:Spadaro, F., Scoffone, V.C., Chiarelli, L.R., Fumagalli, M., Buroni, S., Riccardi, G., Forneris, F.
Deposit date:2016-01-29
Release date:2016-06-01
Last modified:2016-06-29
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:The Crystal Structure of Burkholderia Cenocepacia Dfsa Provides Insights Into Substrate Recognition and Quorum Sensing Fatty Acid Biosynthesis.
Biochemistry, 55, 2016
4NXI
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RV2466C MEDIATES THE ACTIVATION OF TP053 TO KILL REPLICATING AND NON-REPLICATING MYCOBACTERIUM TUBERCULOSIS
Descriptor:Uncharacterized protein, MAGNESIUM ION, 1,2-ETHANEDIOL
Authors:Albesa-Jove, D., Urresti, S., Comino, N., Guerin, M.E.
Deposit date:2013-12-09
Release date:2014-10-22
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis.
Acs Chem.Biol., 9, 2014
4F4Q
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CRYSTAL STRUCTURE OF M. SMEGMATIS DPRE1 IN COMPLEX WITH FAD AND COVALENTLY BOUND BTZ043
Descriptor:DprE1, 8-(hydroxyamino)-2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Neres, J., Pojer, F., Molteni, E., Chiarelli, L., Riccardi, G., Mattevi, A., Cole, S.T., Binda, C.
Deposit date:2012-05-11
Release date:2012-09-05
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.619 Å)
Cite:Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis.
Sci Transl Med, 4, 2012
2WZV
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CRYSTAL STRUCTURE OF THE FMN-DEPENDENT NITROREDUCTASE NFNB FROM MYCOBACTERIUM SMEGMATIS
Descriptor:NFNB PROTEIN, FLAVIN MONONUCLEOTIDE, PHOSPHATE ION, ...
Authors:Bellinzoni, M., Manina, G., Riccardi, G., Alzari, P.M.
Deposit date:2009-12-03
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Biological and Structural Characterization of the Mycobacterium Smegmatis Nitroreductase Nfnb, and its Role in Benzothiazinone Resistance
Mol.Microbiol., 77, 2010
2WZW
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CRYSTAL STRUCTURE OF THE FMN-DEPENDENT NITROREDUCTASE NFNB FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH NADPH
Descriptor:NFNB PROTEIN, FLAVIN MONONUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Bellinzoni, M., Manina, G., Riccardi, G., Alzari, P.M.
Deposit date:2009-12-03
Release date:2010-07-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Biological and Structural Characterization of the Mycobacterium Smegmatis Nitroreductase Nfnb, and its Role in Benzothiazinone Resistance
Mol.Microbiol., 77, 2010