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3PSR
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BU of 3psr by Molmil
HUMAN PSORIASIN (S100A7) CA2+ BOUND FORM (CRYSTAL FORM I)
Descriptor: CALCIUM ION, PSORIASIN, ZINC ION
Authors:Brodersen, D.E, Nyborg, J, Kjeldgaard, M.
Deposit date:1998-09-17
Release date:1999-06-15
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states.
Biochemistry, 38, 1999
2PSR
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BU of 2psr by Molmil
HUMAN PSORIASIN (S100A7) CA2+ AND ZN2+ BOUND FORM (CRYSTAL FORM II)
Descriptor: CALCIUM ION, PSORIASIN, ZINC ION
Authors:Brodersen, D.E, Nyborg, J, Kjeldgaard, M.
Deposit date:1998-09-17
Release date:1999-06-15
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states.
Biochemistry, 38, 1999
1PSR
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BU of 1psr by Molmil
HUMAN PSORIASIN (S100A7)
Descriptor: HOLMIUM ATOM, PSORIASIN
Authors:Brodersen, D.E, Etzerodt, M, Madsen, P, Celis, J, Thoegersen, H.C, Nyborg, J, Kjeldgaard, M.
Deposit date:1997-11-27
Release date:1999-01-13
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing.
Structure, 6, 1998
1HNW
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BU of 1hnw by Molmil
STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH TETRACYCLINE
Descriptor: 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
Authors:Brodersen, D.E, Clemons Jr, W.M, Carter, A.P, Morgan-Warren, R, Wimberly, B.T, Ramakrishnan, V.
Deposit date:2000-12-08
Release date:2001-02-21
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Cell(Cambridge,Mass.), 103, 2000
1HNX
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BU of 1hnx by Molmil
STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH PACTAMYCIN
Descriptor: 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
Authors:Brodersen, D.E, Clemons Jr, W.M, Carter, A.P, Morgan-Warren, R, Wimberly, B.T, Ramakrishnan, V.
Deposit date:2000-12-08
Release date:2001-02-21
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Cell(Cambridge,Mass.), 103, 2000
1HNZ
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BU of 1hnz by Molmil
STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH HYGROMYCIN B
Descriptor: 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
Authors:Brodersen, D.E, Clemons Jr, W.M, Carter, A.P, Morgan-Warren, R, Wimberly, B.T, Ramakrishnan, V.
Deposit date:2000-12-08
Release date:2001-02-21
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.
Cell(Cambridge,Mass.), 103, 2000
4FXI
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BU of 4fxi by Molmil
Crystal structure of the isolated E. coli RelE toxin, P21 form
Descriptor: SULFATE ION, mRNA interferase RelE
Authors:Brodersen, D.E, Boggild, A, Sofos, N.
Deposit date:2012-07-03
Release date:2012-08-29
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.8003 Å)
Cite:The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity.
Structure, 20, 2012
4XB6
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BU of 4xb6 by Molmil
Structure of the E. coli C-P lyase core complex
Descriptor: Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, ...
Authors:Brodersen, D.E.
Deposit date:2014-12-16
Release date:2015-08-19
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural insights into the bacterial carbon-phosphorus lyase machinery.
Nature, 525, 2015
6YES
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BU of 6yes by Molmil
Crystal structure of type I-D CRISPR-Cas nuclease Cas10d
Descriptor: CRISPR-associated protein, CscA, ZINC ION
Authors:Brodersen, D.E, Van, L.B, Manav, M.C.
Deposit date:2020-03-25
Release date:2020-10-28
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Structural basis for inhibition of an archaeal CRISPR-Cas type I-D large subunit by an anti-CRISPR protein.
Nat Commun, 11, 2020
4FXE
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BU of 4fxe by Molmil
Crystal structure of the intact E. coli RelBE toxin-antitoxin complex
Descriptor: Antitoxin RelB, SULFATE ION, mRNA interferase RelE
Authors:Brodersen, D.E, Boggild, A, Sofos, N.
Deposit date:2012-07-03
Release date:2012-08-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7503 Å)
Cite:The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity.
Structure, 20, 2012
4FXH
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BU of 4fxh by Molmil
Crystal structure of the isolated E. coli RelE toxin, P212121 form
Descriptor: SULFATE ION, mRNA interferase RelE
Authors:Brodersen, D.E, Boggild, A, Sofos, N.
Deposit date:2012-07-03
Release date:2012-08-29
Last modified:2024-11-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity.
Structure, 20, 2012
4V4T
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BU of 4v4t by Molmil
Crystal structure of the whole ribosomal complex with a stop codon in the A-site.
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Petry, S, Brodersen, D.E, Murphy IV, F.V, Dunham, C.M, Selmer, M, Tarry, M.J, Kelley, A.C, Ramakrishnan, V.
Deposit date:2005-10-12
Release date:2014-07-09
Last modified:2024-12-25
Method:X-RAY DIFFRACTION (6.46 Å)
Cite:Crystal Structures of the Ribosome in Complex with Release Factors RF1 and RF2 Bound to a Cognate Stop Codon.
Cell(Cambridge,Mass.), 123, 2005
6ZI1
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BU of 6zi1 by Molmil
Crystal structure of the isolated H. influenzae VapD toxin (D7N mutant)
Descriptor: Endoribonuclease VapD
Authors:Bertelsen, M.B, Senissar, M, Nielsen, M.H, Bisiak, F, Cunha, M.V, Molinaro, A.L, Daines, D.A, Brodersen, D.E.
Deposit date:2020-06-24
Release date:2020-10-14
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System.
Structure, 29, 2021
6ZI0
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BU of 6zi0 by Molmil
Crystal structure of the isolated H. influenzae VapD toxin (wildtype)
Descriptor: Endoribonuclease VapD
Authors:Bertelsen, M.B, Senissar, M, Nielsen, M.H, Bisiak, F, Cunha, M.V, Molinaro, A.L, Daines, D.A, Brodersen, D.E.
Deposit date:2020-06-24
Release date:2020-10-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Toxin Inhibition in the VapXD Toxin-Antitoxin System.
Structure, 29, 2021
6EX0
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BU of 6ex0 by Molmil
Crystal structure of RelP (SAS2) from Staphylococcus aureus bound to pppGpp in the post-catalytic state
Descriptor: FE (II) ION, GTP pyrophosphokinase, guanosine 5'-(tetrahydrogen triphosphate) 3'-(trihydrogen diphosphate)
Authors:Manav, M.C, Brodersen, D.E.
Deposit date:2017-11-07
Release date:2018-01-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Structural basis for (p)ppGpp synthesis by theStaphylococcus aureussmall alarmone synthetase RelP.
J. Biol. Chem., 293, 2018
7Z18
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BU of 7z18 by Molmil
E. coli C-P lyase bound to a PhnK ABC dimer and ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, ...
Authors:Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
Deposit date:2022-02-24
Release date:2022-05-25
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (1.98 Å)
Cite:Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
7Z19
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BU of 7z19 by Molmil
E. coli C-P lyase bound to a single PhnK ABC domain
Descriptor: Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, ...
Authors:Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
Deposit date:2022-02-24
Release date:2022-05-25
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
7Z17
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BU of 7z17 by Molmil
E. coli C-P lyase bound to a PhnK ABC dimer in an open conformation
Descriptor: Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, ...
Authors:Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
Deposit date:2022-02-24
Release date:2022-05-25
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
7Z15
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BU of 7z15 by Molmil
E. coli C-P lyase bound to a PhnK/PhnL dual ABC dimer and ADP + Pi
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, ...
Authors:Amstrup, S.K, Sofos, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
Deposit date:2022-02-24
Release date:2022-06-22
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (1.93 Å)
Cite:Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
7Z16
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BU of 7z16 by Molmil
E. coli C-P lyase bound to PhnK/PhnL dual ABC dimer with AMPPNP and PhnK E171Q mutation
Descriptor: Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P lyase, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI, ...
Authors:Amstrup, S.K, Sofus, N, Karlsen, J.L, Skjerning, R.B, Boesen, T, Enghild, J.J, Hove-Jensen, B, Brodersen, D.E.
Deposit date:2022-02-24
Release date:2022-06-22
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.09 Å)
Cite:Structural remodelling of the carbon-phosphorus lyase machinery by a dual ABC ATPase.
Nat Commun, 14, 2023
6EWZ
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BU of 6ewz by Molmil
Crystal structure of RelP (SAS2) from Staphylococcus aureus bound to AMPCPP and GTP in the pre-catalytic state
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, FE (III) ION, GTP pyrophosphokinase, ...
Authors:Manav, M.C, Brodersen, D.E.
Deposit date:2017-11-07
Release date:2018-01-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structural basis for (p)ppGpp synthesis by theStaphylococcus aureussmall alarmone synthetase RelP.
J. Biol. Chem., 293, 2018
1FJG
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BU of 1fjg by Molmil
STRUCTURE OF THE THERMUS THERMOPHILUS 30S RIBOSOMAL SUBUNIT IN COMPLEX WITH THE ANTIBIOTICS STREPTOMYCIN, SPECTINOMYCIN, AND PAROMOMYCIN
Descriptor: 16S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, 30S RIBOSOMAL PROTEIN S11, ...
Authors:Carter, A.P, Clemons Jr, W.M, Brodersen, D.E, Wimberly, B.T, Morgan-Warren, R.J, Ramakrishnan, V.
Deposit date:2000-08-08
Release date:2000-09-25
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics
Nature, 407, 2000
7QOE
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BU of 7qoe by Molmil
Structure of a small alarmone hydrolase from Leptospira levettii
Descriptor: HDc domain-containing protein, MANGANESE (II) ION
Authors:Bisiak, F, Brodersen, D.E, Chrenkova, A.
Deposit date:2021-12-23
Release date:2022-07-13
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response.
J.Biol.Chem., 298, 2022
7QOD
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BU of 7qod by Molmil
Native structure of a small alarmone hydrolase (RelH) from Corynebacterium glutamicum
Descriptor: Guanosine polyphosphate pyrophosphohydrolases/synthetases, MANGANESE (II) ION, TETRAETHYLENE GLYCOL
Authors:Bisiak, F, Brodersen, D.E, Chrenkova, A.
Deposit date:2021-12-23
Release date:2022-07-13
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural variations between small alarmone hydrolase dimers support different modes of regulation of the stringent response.
J.Biol.Chem., 298, 2022
9H6A
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BU of 9h6a by Molmil
Crystal structure of the E. coli F-plasmid VapBC toxin-antitoxin complex
Descriptor: Antitoxin, tRNA(fMet)-specific endonuclease VapC
Authors:Hollingshead, S, McVicker, G, Nielsen, M.R, Zhang, Y, Pilla, G, Jones, R.A, Thomas, J.C, Johansen, S.E.H, Exley, R.M, Brodersen, D.E, Tang, C.M.
Deposit date:2024-10-24
Release date:2024-12-18
Last modified:2025-02-12
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system.
Mbio, 16, 2025

 

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