Author results

6E7K
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STRUCTURE OF THE LIPOPROTEIN LIPASE GPIHBP1 COMPLEX THAT MEDIATES PLASMA TRIGLYCERIDE HYDROLYSIS
Descriptor:Lipoprotein lipase, Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1, CALCIUM ION, ...
Authors:Birrane, G., Meiyappan, M.
Deposit date:2018-07-26
Release date:2018-12-19
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5UEF
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RNA PRIMER-TEMPLATE COMPLEX WITH GUANOSINE DINUCLEOTIDE P(5')G(3')P(5')G LIGAND
Descriptor:RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3'), RNA (5'-R(P*GP*G)-3')
Authors:Zhang, W., Tam, C.P., Szostak, J.W.
Deposit date:2017-01-02
Release date:2017-07-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UEG
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RNA PRIMER-TEMPLATE COMPLEX WITH GUANOSINE DINUCLEOTIDE G(5')PPPP(5')G LIGAND
Descriptor:RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3'), [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl] hydrogen phosphate
Authors:Zhang, W., Tam, C.P., Szostak, J.W.
Deposit date:2017-01-02
Release date:2017-07-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UED
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RNA PRIMER-TEMPLATE COMPLEX WITH GUANOSINE DINUCLEOTIDE LIGAND G(5')PP(5')G
Descriptor:RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3'), [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate
Authors:Zhang, W., Tam, C.P., Szostak, J.W.
Deposit date:2017-01-01
Release date:2017-07-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5UEE
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RNA PRIMER-TEMPLATE COMPLEX WITH GUANOSINE DINUCLEOTIDE LIGAND G(5')PPP(5')G
Descriptor:RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3'), DIGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Zhang, W., Tam, C.P., Szostak, J.W.
Deposit date:2017-01-01
Release date:2017-07-05
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5HUZ
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SOLUTION STRUCTURE OF COILED COIL DOMAIN OF MYOSIN BINDING SUBUNIT OF MYOSIN LIGHT CHAIN PHOSPHATASE
Descriptor:Protein phosphatase 1 regulatory subunit 12A
Authors:Sharma, A.K., Birrane, G., Anklin, C., Rigby, A.C., Pollak, M., Alper, S.L.
Deposit date:2016-01-27
Release date:2016-03-02
Last modified:2016-08-10
Method:SOLUTION NMR
Cite:To be published
To Be Published
5D8J
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DEVELOPMENT OF A THERAPEUTIC MONOCLONAL ANTIBODY TARGETING SECRETED AP2 TO TREAT TYPE 2 DIABETES.
Descriptor:Fatty acid-binding protein, adipocyte, HA3 Fab Heavy Chain, ...
Authors:Doyle, C., Birrane, G.
Deposit date:2015-08-17
Release date:2016-01-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
Sci Transl Med, 7, 2015
5C0N
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DEVELOPMENT OF A MONOCLONAL ANTIBODY TARGETING SECRETED AP2 TO TREAT DIABETES AND FATTY LIVER DISEASE
Descriptor:Fatty acid-binding protein, adipocyte, Fab CA33 Heavy chain, ...
Authors:Doyle, C.
Deposit date:2015-06-12
Release date:2015-06-24
Last modified:2016-01-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
Sci Transl Med, 7, 2015
4XWH
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CRYSTAL STRUCTURE OF THE HUMAN N-ACETYL-ALPHA-GLUCOSAMINIDASE
Descriptor:Alpha-N-acetylglucosaminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Birrane, G., Meiyappan, M., Dassier, A.
Deposit date:2015-01-28
Release date:2016-02-03
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Crystal Structure of N-acetylglucosaminidase
To Be Published
4R2Z
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MOLECULAR ANALYSIS OF THE PDZ4 DOMAIN OF MOUSE PDZK1
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF3, GLYCEROL, 2-(2-METHOXYETHOXY)ETHANOL
Authors:Birrane, G., Kocher, O., Krieger, M.
Deposit date:2014-08-13
Release date:2015-08-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Analysis of the PDZ4 domain from Mouse PDZK1
To be Published
4LG0
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STRUCTURE OF A TERNARY FOXO1-ETS1 DNA COMPLEX
Descriptor:Forkhead box protein O1, Protein C-ets-1, DNA (5'-D(*DTP*DTP*DCP*DAP*DCP*DGP*DGP*DTP*DTP*DTP*DCP*DCP*DTP*DGP*DTP*DTP*DAP*DTP*DTP*DGP*DT)-3'), ...
Authors:Birrane, G., Choy, W.C., Datta, D., Geiger, C.A., Grant, M.A.
Deposit date:2013-06-27
Release date:2014-07-02
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structure of a ternary FOXO1-ETS1 DNA complex
To be Published
4F8K
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MOLECULAR ANALYSIS OF THE INTERACTION BETWEEN THE PROSTACYCLIN RECEPTOR AND THE FIRST PDZ DOMAIN OF PDZK1
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF3, Prostacyclin receptor
Authors:Kocher, O., Birrane, G., Kinsella, B.T., Mulvaney, E.P.
Deposit date:2012-05-17
Release date:2013-02-27
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Analysis of the Prostacyclin Receptor's Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1.
Plos One, 8, 2013
3R68
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MOLECULAR ANALYSIS OF THE PDZ3 DOMAIN OF PDZK1
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF3, ACETATE ION, 1,2-ETHANEDIOL, ...
Authors:Kocher, O., Birrane, G., Krieger, M.
Deposit date:2011-03-21
Release date:2011-05-18
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Identification of the PDZ3 Domain of the Adaptor Protein PDZK1 as a Second, Physiologically Functional Binding Site for the C Terminus of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I.
J.Biol.Chem., 286, 2011
3R69
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MOLECULAR ANALYSIS OF THE INTERACTION OF THE HDL-RECEPTOR SR-BI WITH THE PDZ3 DOMAIN OF ITS ADAPTOR PROTEIN PDZK1
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF3, Scavenger receptor class B member 1, CITRIC ACID
Authors:Kocher, O., Birrane, G., Krieger, M.
Deposit date:2011-03-21
Release date:2011-05-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.499 Å)
Cite:Identification of the PDZ3 Domain of the Adaptor Protein PDZK1 as a Second, Physiologically Functional Binding Site for the C Terminus of the High Density Lipoprotein Receptor Scavenger Receptor Class B Type I.
J.Biol.Chem., 286, 2011
3QH1
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STRUCTURE OF THERMOLYSIN IN COMPLEX WITH N-BENZYLOXYCARBONYL-L-ASPARTIC ACID
Descriptor:Thermolysin, CALCIUM ION, ZINC ION, ...
Authors:Birrane, G., Bhyravbhatla, B., Navia, M.
Deposit date:2011-01-25
Release date:2012-01-04
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Synthesis of Aspartame by Thermolysin: An X-ray Structural Study.
ACS MED.CHEM.LETT., 5, 2014
3QH5
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STRUCTURE OF THERMOLYSIN IN COMPLEX WITH N-CARBOBENZYLOXY-L-ASPARTIC ACID AND L-PHENYLALANINE METHYL ESTER
Descriptor:Thermolysin, CALCIUM ION, ZINC ION, ...
Authors:Birrane, G., Bhyravbhatla, B., Navia, M.
Deposit date:2011-01-25
Release date:2012-01-04
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Synthesis of Aspartame by Thermolysin: An X-ray Structural Study.
ACS MED.CHEM.LETT., 5, 2014
3QGO
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STRUCTURE OF THERMOLYSIN IN COMPLEX WITH L-PHENYLALANINE METHYLESTER
Descriptor:Thermolysin, CALCIUM ION, ZINC ION, ...
Authors:Birrane, G., Bhyravbhatla, B., Navia, M.
Deposit date:2011-01-24
Release date:2012-01-04
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Synthesis of Aspartame by Thermolysin: An X-ray Structural Study.
ACS MED.CHEM.LETT., 5, 2014
3NGH
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MOLECULAR ANALYSIS OF THE INTERACTION OF THE HDL RECEPTOR SR-BI WITH THE ADAPTOR PROTEIN PDZK1
Descriptor:PDZ domain-containing protein 1
Authors:Kocher, O., Birrane, G., Krieger, M., Ladias, J.A.
Deposit date:2010-06-11
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:In vitro and in vivo analysis of the binding of the C terminus of the HDL receptor scavenger receptor class B, type I (SR-BI), to the PDZ1 domain of its adaptor protein PDZK1.
J.Biol.Chem., 285, 2010
2KG2
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SOLUTION STRUCTURE OF A PDZ PROTEIN
Descriptor:Tax1-binding protein 3
Authors:Durney, M.A., Birrane, G., Anklin, C., Soni, A., Ladias, J.A.A.
Deposit date:2009-03-02
Release date:2010-01-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the human Tax-interacting protein-1.
J.Biomol.Nmr, 45, 2009
3CMY
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STRUCTURE OF A HOMEODOMAIN IN COMPLEX WITH DNA
Descriptor:Paired box protein Pax-3, 5'-D(*DAP*DCP*DAP*DTP*DAP*DAP*DP*DCP*DGP*DAP*DTP*DTP*DAP*DC)-3', 5'-D(*DTP*DGP*DTP*DAP*DAP*DTP*DCP*DGP*DAP*DTP*DTP*DAP*DTP*DG)-3', ...
Authors:Birrane, G., Ladias, J.A.A., Soni, A.
Deposit date:2008-03-24
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for DNA Recognition by the Human PAX3 Homeodomain.
Biochemistry, 48, 2009
3BYA
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STRUCTURE OF A CALMODULIN COMPLEX
Descriptor:Calmodulin, Glutamate [NMDA] receptor subunit zeta-1 peptide, CALCIUM ION
Authors:Birrane, G., Soni, A., Ladias, J.A.A.
Deposit date:2008-01-15
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of a Calmodulin Complex
To be Published
2OEI
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CRYSTAL STRUCTURE OF HUMAN FE65-WW DOMAIN IN COMPLEX WITH HUMAN MENA PEPTIDE
Descriptor:Amyloid beta A4 protein-binding family B member 1, poly-proline peptide
Authors:Meiyappan, M., Birrane, G., Ladias, J.A.A.
Deposit date:2006-12-29
Release date:2007-07-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural Basis for Polyproline Recognition by the FE65 WW Domain.
J.Mol.Biol., 372, 2007
2NTE
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CRYSTAL STRUCTURE OF THE BARD1 BRCT DOMAINS
Descriptor:BRCA1-associated RING domain protein 1, SULFATE ION, CHLORIDE ION, ...
Authors:Birrane, G., Varma, A.K., Soni, A., Ladias, J.A.A.
Deposit date:2006-11-07
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the BARD1 BRCT domains.
Biochemistry, 46, 2007
2ING
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X-RAY STRUCTURE OF THE BRCA1 BRCT MUTANT M1775K
Descriptor:Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
Authors:Birrane, G., Soni, A., Ladias, J.A.A.
Deposit date:2006-10-07
Release date:2007-09-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.
Eur.J.Hum.Genet., 16, 2008
2IDH
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CRYSTAL STRUCTURE OF HUMAN FE65 WW DOMAIN
Descriptor:Amyloid beta A4 protein-binding family B member 1, SULFATE ION, TETRAETHYLENE GLYCOL
Authors:Meiyappan, M., Birrane, G., Ladias, J.A.A.
Deposit date:2006-09-15
Release date:2007-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural Basis for Polyproline Recognition by the FE65 WW Domain.
J.Mol.Biol., 372, 2007
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