Author results

1MFG
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THE STRUCTURE OF ERBIN PDZ DOMAIN BOUND TO THE CARBOXY-TERMINAL TAIL OF THE ERBB2 RECEPTOR
Descriptor:Erb-B2 INTERACTING PROTEIN, Erb-B2 carboxyl-terminal fragment
Authors:Birrane, G., Chung, J., Ladias, J.A.
Deposit date:2002-08-10
Release date:2003-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Novel mode of ligand recognition by the erbin PDZ domain
J.Biol.Chem., 278, 2003
1MFL
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THE STRUCTURE OF ERBIN PDZ DOMAIN BOUND TO THE CARBOXY-TERMINAL TAIL OF THE ERBB2 RECEPTOR
Descriptor:Erb-B2 INTERACTING PROTEIN, PHOSPHORYLATED Erb-B2 carboxyl-terminal fragment.
Authors:Birrane, G., Chung, J., Ladias, J.A.
Deposit date:2002-08-12
Release date:2003-01-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Novel mode of ligand recognition by the erbin PDZ domain
J.Biol.Chem., 278, 2003
2NTE
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CRYSTAL STRUCTURE OF THE BARD1 BRCT DOMAINS
Descriptor:BRCA1-associated RING domain protein 1, SULFATE ION, CHLORIDE ION, ...
Authors:Birrane, G., Varma, A.K., Soni, A., Ladias, J.A.A.
Deposit date:2006-11-07
Release date:2007-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the BARD1 BRCT domains.
Biochemistry, 46, 2007
3BYA
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STRUCTURE OF A CALMODULIN COMPLEX
Descriptor:Calmodulin, Glutamate [NMDA] receptor subunit zeta-1 peptide, CALCIUM ION
Authors:Birrane, G., Soni, A., Ladias, J.A.A.
Deposit date:2008-01-15
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of a Calmodulin Complex
To be Published
3CMY
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STRUCTURE OF A HOMEODOMAIN IN COMPLEX WITH DNA
Descriptor:Paired box protein Pax-3, 5'-D(*DAP*DCP*DAP*DTP*DAP*DAP*DP*DCP*DGP*DAP*DTP*DTP*DAP*DC)-3', 5'-D(*DTP*DGP*DTP*DAP*DAP*DTP*DCP*DGP*DAP*DTP*DTP*DAP*DTP*DG)-3', ...
Authors:Birrane, G., Ladias, J.A.A., Soni, A.
Deposit date:2008-03-24
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for DNA Recognition by the Human PAX3 Homeodomain.
Biochemistry, 48, 2009
3QGO
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STRUCTURE OF THERMOLYSIN IN COMPLEX WITH L-PHENYLALANINE METHYLESTER
Descriptor:Thermolysin, CALCIUM ION, ZINC ION, ...
Authors:Birrane, G., Bhyravbhatla, B., Navia, M.
Deposit date:2011-01-24
Release date:2012-01-04
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Synthesis of Aspartame by Thermolysin: An X-ray Structural Study.
ACS MED.CHEM.LETT., 5, 2014
3QH1
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STRUCTURE OF THERMOLYSIN IN COMPLEX WITH N-BENZYLOXYCARBONYL-L-ASPARTIC ACID
Descriptor:Thermolysin, CALCIUM ION, ZINC ION, ...
Authors:Birrane, G., Bhyravbhatla, B., Navia, M.
Deposit date:2011-01-25
Release date:2012-01-04
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Synthesis of Aspartame by Thermolysin: An X-ray Structural Study.
ACS MED.CHEM.LETT., 5, 2014
3QH5
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STRUCTURE OF THERMOLYSIN IN COMPLEX WITH N-CARBOBENZYLOXY-L-ASPARTIC ACID AND L-PHENYLALANINE METHYL ESTER
Descriptor:Thermolysin, CALCIUM ION, ZINC ION, ...
Authors:Birrane, G., Bhyravbhatla, B., Navia, M.
Deposit date:2011-01-25
Release date:2012-01-04
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Synthesis of Aspartame by Thermolysin: An X-ray Structural Study.
ACS MED.CHEM.LETT., 5, 2014
4LG0
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STRUCTURE OF A TERNARY FOXO1-ETS1 DNA COMPLEX
Descriptor:Forkhead box protein O1, Protein C-ets-1, DNA (5'-D(*DTP*DTP*DCP*DAP*DCP*DGP*DGP*DTP*DTP*DTP*DCP*DCP*DTP*DGP*DTP*DTP*DAP*DTP*DTP*DGP*DT)-3'), ...
Authors:Birrane, G., Choy, W.C., Datta, D., Geiger, C.A., Grant, M.A.
Deposit date:2013-06-27
Release date:2014-07-02
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structure of a ternary FOXO1-ETS1 DNA complex
To be Published
4R2Z
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MOLECULAR ANALYSIS OF THE PDZ4 DOMAIN OF MOUSE PDZK1
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF3, GLYCEROL, 2-(2-METHOXYETHOXY)ETHANOL
Authors:Birrane, G., Kocher, O., Krieger, M.
Deposit date:2014-08-13
Release date:2015-08-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Analysis of the PDZ4 domain from Mouse PDZK1
To be Published
4XWH
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CRYSTAL STRUCTURE OF THE HUMAN N-ACETYL-ALPHA-GLUCOSAMINIDASE
Descriptor:Alpha-N-acetylglucosaminidase, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Birrane, G., Meiyappan, M., Dassier, A.
Deposit date:2015-01-28
Release date:2016-02-03
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural characterization of the alpha-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B.
J.Struct.Biol., 205, 2019
6E7K
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STRUCTURE OF THE LIPOPROTEIN LIPASE GPIHBP1 COMPLEX THAT MEDIATES PLASMA TRIGLYCERIDE HYDROLYSIS
Descriptor:Lipoprotein lipase, Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1, CALCIUM ION, ...
Authors:Birrane, G., Meiyappan, M.
Deposit date:2018-07-26
Release date:2018-12-19
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6O31
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CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4
Descriptor:Alpha-actinin-4
Authors:Birrane, G., Feng, D.
Deposit date:2019-02-25
Release date:2020-02-26
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4
To Be Published
6OA6
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CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4
Descriptor:Alpha-actinin-4, GLYCEROL
Authors:Birrane, G., Feng, D.
Deposit date:2019-03-15
Release date:2020-03-18
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:CRYSTAL STRUCTURE OF THE ACTIN-BINDING DOMAIN OF HUMAN ALPHA-ACTININ-4
To Be Published
2ING
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X-RAY STRUCTURE OF THE BRCA1 BRCT MUTANT M1775K
Descriptor:Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION
Authors:Birrane, G., Soni, A., Ladias, J.A.A.
Deposit date:2006-10-07
Release date:2007-09-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.
Eur.J.Hum.Genet., 16, 2008
4F8K
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MOLECULAR ANALYSIS OF THE INTERACTION BETWEEN THE PROSTACYCLIN RECEPTOR AND THE FIRST PDZ DOMAIN OF PDZK1
Descriptor:Na(+)/H(+) exchange regulatory cofactor NHE-RF3, Prostacyclin receptor
Authors:Kocher, O., Birrane, G., Kinsella, B.T., Mulvaney, E.P.
Deposit date:2012-05-17
Release date:2013-02-27
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular Analysis of the Prostacyclin Receptor's Interaction with the PDZ1 Domain of Its Adaptor Protein PDZK1.
Plos One, 8, 2013
6N63
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CRYSTAL STRUCTURE OF AN IRON BINDING PROTEIN
Descriptor:ENCAPSULIN CARGO PROTEIN, GLYCOLIC ACID, ACETATE ION, ...
Authors:Birrane, G., Geissen, T.W.
Deposit date:2018-11-24
Release date:2019-07-17
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Large protein organelles form a new iron sequestration system with high storage capacity.
Elife, 8, 2019
1Q9H
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3-DIMENSIONAL STRUCTURE OF NATIVE CEL7A FROM TALAROMYCES EMERSONII
Descriptor:cellobiohydrolase I catalytic domain, N-ACETYL-D-GLUCOSAMINE
Authors:Grassick, A., Thompson, R., Murray, P.G., Collins, C.M., Byrnes, L., Tuohy, M.G., Birrane, G., Higgins, T.M.
Deposit date:2003-08-25
Release date:2004-11-09
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii
Eur.J.Biochem., 271, 2004
1G9O
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FIRST PDZ DOMAIN OF THE HUMAN NA+/H+ EXCHANGER REGULATORY FACTOR
Descriptor:NHE-RF
Authors:Karthikeyan, S., Leung, T., Birrane, G., Webster, G., Ladias, J.A.A.
Deposit date:2000-11-26
Release date:2001-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains.
J.Mol.Biol., 308, 2001
5D8J
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DEVELOPMENT OF A THERAPEUTIC MONOCLONAL ANTIBODY TARGETING SECRETED AP2 TO TREAT TYPE 2 DIABETES.
Descriptor:Fatty acid-binding protein, adipocyte, HA3 Fab Heavy Chain, ...
Authors:Doyle, C., Birrane, G.
Deposit date:2015-08-17
Release date:2016-01-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.
Sci Transl Med, 7, 2015
1DLK
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CRYSTAL STRUCTURE ANALYSIS OF DELTA-CHYMOTRYPSIN BOUND TO A PEPTIDYL CHLOROMETHYL KETONE INHIBITOR
Descriptor:Thrombin light chain, Thrombin heavy chain, peptidic inhibitor, ...
Authors:Mac Sweeney, A., Birrane, G., Walsh, M.A., O'Connell, T., Malthouse, J.P.G.
Deposit date:1999-12-10
Release date:2000-05-03
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor.
Acta Crystallogr.,Sect.D, 56, 2000
1Y98
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STRUCTURE OF THE BRCT REPEATS OF BRCA1 BOUND TO A CTIP PHOSPHOPEPTIDE.
Descriptor:Breast cancer type 1 susceptibility protein, CtIP PHOSPHORYLATED PEPTIDE, COBALT (II) ION, ...
Authors:Varma, A.K., Brown, R.S., Birrane, G., Ladias, J.A.A.
Deposit date:2004-12-14
Release date:2005-08-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Cell Cycle Checkpoint Control by the BRCA1-CtIP Complex.
Biochemistry, 44, 2005
2HO2
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STRUCTURE OF HUMAN FE65-WW DOMAIN IN COMPLEX WITH HMENA PEPTIDE.
Descriptor:Amyloid beta A4 protein-binding family B member 1, Protein enabled homolog, GLYCEROL
Authors:Meiyappan, M., Birrane, G., Ladias, J.A.
Deposit date:2006-07-13
Release date:2007-07-10
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Structural Basis for Polyproline Recognition by the FE65 WW Domain.
J.Mol.Biol., 372, 2007
2I53
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CRYSTAL STRUCTURE OF CYCLIN K
Descriptor:Cyclin K, ACETATE ION
Authors:Baek, K., Brown, R.S., Birrane, G., Ladias, J.A.A.
Deposit date:2006-08-23
Release date:2007-01-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structure of Human Cyclin K, a Positive Regulator of Cyclin-dependent Kinase 9.
J.Mol.Biol., 366, 2007
2IDH
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CRYSTAL STRUCTURE OF HUMAN FE65 WW DOMAIN
Descriptor:Amyloid beta A4 protein-binding family B member 1, SULFATE ION, TETRAETHYLENE GLYCOL
Authors:Meiyappan, M., Birrane, G., Ladias, J.A.A.
Deposit date:2006-09-15
Release date:2007-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structural Basis for Polyproline Recognition by the FE65 WW Domain.
J.Mol.Biol., 372, 2007
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