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5HIF
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CRYSTAL STRUCTURE OF A RECONSTRUCTED LACTONASE ANCESTOR, ANC1-MPH, OF THE BACTERIAL METHYL PARATHION HYDROLASE, MPH.
Descriptor:reconstructed lactonase ancestor, Anc1-MPH, ZINC ION, ...
Authors:Baier, F., Carr, P.D., Jackson, C.J.
Deposit date:2016-01-11
Release date:2017-02-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:to be published
To Be Published
6C2C
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THE MOLECULAR BASIS FOR THE FUNCTIONAL EVOLUTION OF AN ORGANOPHOSPHATE HYDROLYSING ENZYME
Descriptor:dihydrocoumarin hydrolase, AncDHCH1, ZINC ION, ...
Authors:Hong, N.-S., Jackson, C.J., Carr, P.D., Tokuriki, N., Baier, F., Yang, G.
Deposit date:2018-01-08
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (1.597 Å)
Cite:Higher-order epistatic networks underlie the evolutionary fitness landscape of a xenobiotic-degrading enzyme
Biorxiv, 2019
5EH9
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INDIRECT CONTRIBUTIONS OF MUTATIONS UNDERLIE OPTIMIZATION OF NEW ENZYME FUNCTION
Descriptor:N-acyl homoserine lactonase AiiA, ZINC ION, GLYCEROL, ...
Authors:Hong, N.-S., Jackson, C.J., Tokuriki, N., Yang, G., Baier, F.
Deposit date:2015-10-28
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects.
Biochemistry, 55, 2016
5JQJ
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DIRECTED EVOLUTIONARY CHANGES IN MBL SUPER FAMILY - NDM-1 ROUND 10 CRYSTAL-1
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Hong, N.-S., Jackson, C.J., Carr, P.D.
Deposit date:2016-05-05
Release date:2017-05-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Enzyme evolvability is contingent on the initial sequence background
To Be Published
5K4M
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DIRECTED EVOLUTIONARY CHANGES IN MBL SUPER FAMILY - NDM-1 ROUND 10 CRYSTAL-3
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Hong, N.-S., Jackson, C.J., Carr, P.D.
Deposit date:2016-05-20
Release date:2017-04-26
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Enzyme evolvability is contingent on the initial sequence background
To Be Published
6BM9
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DIRECTED EVOLUTIONARY CHANGES IN MBL SUPER FAMILY - VIM-2 ROUND 10
Descriptor:Metallo-beta-lactamase, ZINC ION, GLYCEROL
Authors:Hong, N.-S., Jackson, C.J., Carr, P.D.
Deposit date:2017-11-13
Release date:2018-11-21
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes.
Elife, 8, 2019
5EHT
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INDIRECT CONTRIBUTIONS OF MUTATIONS UNDERLIE OPTIMIZATION OF NEW ENZYME FUNCTION
Descriptor:N-acyl homoserine lactonase, ZINC ION, GLYCEROL
Authors:Jackson, C.J., Hong, N.-S.
Deposit date:2015-10-28
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects.
Biochemistry, 55, 2016