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Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer)
Descriptor:	NACHT, LRR and PYD domains-containing protein 3
Authors:	Andreeva, L, Rawson, S, Wu, H.
Deposit date:	2021-01-17
Release date:	2021-12-15
Last modified:	2022-04-27
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. Cell, 184, 2021

Crystal structure of mouse cGAS in complex with 39 bp DNA
Descriptor:	Cyclic GMP-AMP synthase, DNA (36-MER), DNA (37-MER), ...
Authors:	Andreeva, L, Kostrewa, D, Hopfner, K.-P.
Deposit date:	2017-02-15
Release date:	2017-09-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3.6 Å)
Cite:	cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders. Nature, 549, 2017

Cryo-EM structure of NLRP3 bound to NEK7
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 3, ...
Authors:	Sharif, H, Wang, L, Wang, W.L, Wu, H.
Deposit date:	2019-01-18
Release date:	2019-06-19
Last modified:	2024-03-20
Method:	ELECTRON MICROSCOPY (3.8 Å)
Cite:	Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature, 570, 2019