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5F1R
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THE TRANSCRIPTIONAL REGULATOR PRFA FROM LISTERIA MONOCYTOGENES IN COMPLEX WITH A RING-FUSED 2-PYRIDONE (C10)
Descriptor:Listeriolysin regulatory protein, (3~{R})-8-cyclopropyl-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid
Authors:Begum, A., Grundstrom, C., Good, J.A.D., Andersson, C., ALmqvist, F., Johansson, J., Sauer, U.H., Sauer-Eriksson, A.E.
Deposit date:2015-11-30
Release date:2016-03-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Attenuating Listeria monocytogenes Virulence by Targeting the Regulatory Protein PrfA.
Cell Chem Biol, 23, 2016
1H15
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X-RAY CRYSTAL STRUCTURE OF HLA-DRA1*0101/DRB5*0101 COMPLEXED WITH A PEPTIDE FROM EPSTEIN BARR VIRUS DNA POLYMERASE
Descriptor:HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, DR BETA 1 CHAIN, ...
Authors:Lang, H., Jacobsen, H., Ikemizu, S., Andersson, C., Harlos, K., Madsen, L., Hjorth, P., Sondergaard, L., Svejgaard, A., Wucherpfennig, K., Stuart, D.I., Bell, J.I., Jones, E.Y., Fugger, L.
Deposit date:2002-07-02
Release date:2002-10-03
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A Functional and Structural Basis for Tcr Cross-Reactivity in Multiple Sclerosis
Nat.Immunol., 3, 2002
4CTH
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NEPRILYSIN VARIANT G399V,G714K IN COMPLEX WITH PHOSPHORAMIDON
Descriptor:NEPRILYSIN, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Webster, C.I., Burrell, M., Olsson, L., Fowler, S.B., Digby, S., Sandercock, A., Snijder, A., Tebbe, J., Haupts, U., Grudzinska, J., Jermutus, L., Andersson, C.
Deposit date:2014-03-13
Release date:2014-08-13
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Engineering Neprilysin Activity and Specificity to Create a Novel Therapeutic for Alzheimer'S Disease.
Plos One, 9, 2014
5OV9
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CRYSTAL STRUCTURE OF ACETYLCHOLINESTERASE IN COMPLEX WITH CRYSTAL VIOLET
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, 2-(2-METHOXYETHOXY)ETHANOL, ...
Authors:Allgardsson, A., Andersson, C.D., Akfur, C., Worek, F., Linusson, A., Ekstrom, F.
Deposit date:2017-08-28
Release date:2017-09-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet.
Molecules, 22, 2017
4W1O
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PDE4D COMPLEXED WITH INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, N-(3,5-dichloropyridin-4-yl)-3-[(3-ethyl-1,2-oxazol-5-yl)methoxy]-4-methoxybenzamide, ZINC ION
Authors:Sorensen, M.D.
Deposit date:2014-08-14
Release date:2014-11-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis
J.Med.Chem, 57, 2014
4WCU
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PDE4 COMPLEXED WITH INHIBITOR
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, N-benzyl-2-{6-[(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide, ZINC ION, ...
Authors:Sorensen, M.D.
Deposit date:2014-09-05
Release date:2014-10-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis.
J. Med. Chem., 57, 2014
6EUT
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THE TRANSCRIPTIONAL REGULATOR PRFA FROM LISTERIA MONOCYTOGENES IN COMPLEX WITH A RING-FUSED 2-PYRIDONE (KSK67)
Descriptor:Listeriolysin regulatory protein, (3~{R})-8-cyclopropyl-7-[(4-methylnaphthalen-1-yl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-3-carboxylic acid, SODIUM ION, ...
Authors:Begum, A., Hall, M., Grundstrom, C., Kulen, M., Lindgren, M., Johansson, J., Almqvist, F., Sauer, U.H., Sauer-Eriksson, A.E.
Deposit date:2017-10-31
Release date:2018-05-02
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018
6EUU
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THE TRANSCRIPTIONAL REGULATOR PRFA FROM LISTERIA MONOCYTOGENES IN COMPLEX WITH A RING-FUSED 2-PYRIDONE (KSK29)
Descriptor:Listeriolysin positive regulatory factor A, SODIUM ION, ISOPROPYL ALCOHOL, ...
Authors:Begum, A., Hall, M., Grundstrom, C., Kulen, M., Lindgren, M., Johansson, J., Almqvist, F., Sauer, U.H., Sauer-Eriksson, A.E.
Deposit date:2017-10-31
Release date:2018-05-02
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018
6EUZ
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THE TRANSCRIPTIONAL REGULATOR PRFA FROM LISTERIA MONOCYTOGENES IN COMPLEX WITH A RING-FUSED 2-PYRIDONE (MK37)
Descriptor:Listeriolysin positive regulatory factor A, ISOPROPYL ALCOHOL, SODIUM ION, ...
Authors:Begum, A., Hall, M., Grundstrom, C., Kulen, M., Lindgren, M., Johansson, J., Almqvist, F., Sauer, U.H., Sauer-Eriksson, A.E.
Deposit date:2017-10-31
Release date:2018-05-02
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018
6EV0
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THE TRANSCRIPTIONAL REGULATOR PRFA FROM LISTERIA MONOCYTOGENES IN COMPLEX WITH A RING-FUSED 2-PYRIDONE (AC129)
Descriptor:Listeriolysin regulatory protein, [(3~{R})-3-carboxy-7-(naphthalen-1-ylmethyl)-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium, ISOPROPYL ALCOHOL, ...
Authors:Begum, A., Hall, M., Grundstrom, C., Cairns, A.G., Kulen, M., Lindgren, M., Johansson, J., Almqvist, F., Sauer, U.H., Sauer-Eriksson, A.E.
Deposit date:2017-10-31
Release date:2018-05-02
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018
6EXK
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THE TRANSCRIPTIONAL REGULATOR PRFA FROM LISTERIA MONOCYTOGENES IN COMPLEX WITH A RING-FUSED 2-PYRIDONE (MK206) - UNFOLDED HTH MOTIF
Descriptor:Listeriolysin regulatory protein, [(3~{R})-3-carboxy-7-[(4-methylnaphthalen-1-yl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium, SODIUM ION, ...
Authors:Hall, M., Grundstrom, C., Begum, A., Kulen, M., Lindgren, M., Johansson, J., Almqvist, F., Sauer, U.H., Sauer-Eriksson, A.E.
Deposit date:2017-11-08
Release date:2018-05-02
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018
6EXL
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THE TRANSCRIPTIONAL REGULATOR PRFA FROM LISTERIA MONOCYTOGENES IN COMPLEX WITH A RING-FUSED 2-PYRIDONE (MK206) - FOLDED HTH MOTIF
Descriptor:Listeriolysin positive regulatory factor A, [(3~{R})-3-carboxy-7-[(4-methylnaphthalen-1-yl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium, SODIUM ION, ...
Authors:Hall, M., Grundstrom, C., Begum, A., Kulen, M., Lindgren, M., Johansson, J., Almqvist, F., Sauer, U.H., Sauer-Eriksson, A.E.
Deposit date:2017-11-08
Release date:2018-05-02
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018
6EXM
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THE TRANSCRIPTIONAL REGULATOR PRFA FROM LISTERIA MONOCYTOGENES IN COMPLEX WITH A RING-FUSED 2-PYRIDONE (MK202)
Descriptor:Listeriolysin positive regulatory factor A, [(3~{R})-3-carboxy-7-[(2,3-dimethylphenyl)methyl]-5-oxidanylidene-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridin-8-yl]-dimethyl-azanium, SODIUM ION, ...
Authors:Grundstrom, C., Begum, A., Hall, M., Kulen, M., Lindgren, M., Johansson, J., Almqvist, F., Sauer, U.H., Sauer-Eriksson, A.E.
Deposit date:2017-11-08
Release date:2018-05-02
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure-Based Design of Inhibitors Targeting PrfA, the Master Virulence Regulator of Listeria monocytogenes.
J. Med. Chem., 61, 2018