Author results

5FJB
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CYCLOPHILIN A STABILIZE HIV-1 CAPSID THROUGH A NOVEL NON- CANONICAL BINDING SITE
Descriptor:GAG POLYPROTEIN, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
Authors:Liu, C., Perilla, J.R., Ning, J., Lu, M., Hou, G., Ramalhu, R., Bedwell, G.J., Ahn, J., Shi, J., Gronenborn, A.M., Prevelige Jr, P.E., Rousso, I., Aiken, C., Polenova, T., Schulten, K., Zhang, P.
Deposit date:2015-10-07
Release date:2016-03-16
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Cyclophilin a Stabilizes the HIV-1 Capsid Through a Novel Non-Canonical Binding Site.
Nat.Commun., 7, 2016
5K79
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STRUCTURE AND ANTI-HIV ACTIVITY OF CYT-CVNH, A NEW CYANOVIRIN-N HOMOLOG
Descriptor:Cyanovirin-N domain protein, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL
Authors:Matei, E., Basu, R., Furey, W., Shi, J., Calnan, C., Aiken, C., Gronenborn, A.M.
Deposit date:2016-05-25
Release date:2016-07-20
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and Glycan Binding of a New Cyanovirin-N Homolog.
J.Biol.Chem., 291, 2016
3J34
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STRUCTURE OF HIV-1 CAPSID PROTEIN BY CRYO-EM
Descriptor:capsid protein
Authors:Zhao, G., Perilla, J.R., Yufenyuy, E., Meng, X., Chen, B., Ning, J., Ahn, J., Gronenborn, A.M., Schulten, K., Aiken, C., Zhang, P.
Deposit date:2013-02-23
Release date:2013-05-29
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (8.6 Å)
Cite:Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics.
Nature, 497, 2013
3LHC
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CRYSTAL STRUCTURE OF CYANOVIRIN-N SWAPPING DOMAIN B MUTANT
Descriptor:Cyanovirin-N, SODIUM ION, PHOSPHATE ION
Authors:Matei, E., Zheng, A., Furey, W., Rose, J., Aiken, C., Gronenborn, A.M.
Deposit date:2010-01-21
Release date:2010-02-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Anti-HIV activity of defective cyanovirin-N mutants is restored by dimerization.
J.Biol.Chem., 285, 2010
4J93
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HIV-1 CAPSID IN COMPLEX WITH INHIBITOR BI-1
Descriptor:Gag protein, 4-{2-[5-(3-chlorophenyl)-1H-pyrazol-4-yl]-1-[3-(1H-imidazol-1-yl)propyl]-1H-benzimidazol-5-yl}benzoic acid, (4S)-3-phenyl-4-(pyridin-3-yl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one
Authors:Lemke, C.T.
Deposit date:2013-02-15
Release date:2013-07-10
Last modified:2013-10-09
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes.
Antimicrob.Agents Chemother., 57, 2013
2KOD
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A HIGH-RESOLUTION NMR STRUCTURE OF THE DIMERIC C-TERMINAL DOMAIN OF HIV-1 CA
Descriptor:HIV-1 CA C-terminal domain
Authors:Byeon, I.-J.L., Jung, J., Ahn, J., concel, J., Gronenborn, A.M.
Deposit date:2009-09-18
Release date:2009-11-24
Last modified:2012-03-21
Method:SOLUTION NMR
Cite:Structural convergence between Cryo-EM and NMR reveals intersubunit interactions critical for HIV-1 capsid function.
Cell(Cambridge,Mass.), 139, 2009
3J3Q
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ATOMIC-LEVEL STRUCTURE OF THE ENTIRE HIV-1 CAPSID
Descriptor:capsid protein
Authors:Perilla, J.R., Zhao, G., Zhang, P., Schulten, K.J.
Deposit date:2013-04-12
Release date:2013-05-29
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY
Cite:Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics.
Nature, 497, 2013
3J3Y
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ATOMIC-LEVEL STRUCTURE OF THE ENTIRE HIV-1 CAPSID (186 HEXAMERS + 12 PENTAMERS)
Descriptor:capsid protein
Authors:Perilla, J.R., Zhao, G., Zhang, P., Schulten, K.J.
Deposit date:2013-05-06
Release date:2013-05-29
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY
Cite:Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics.
Nature, 497, 2013
3J4F
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STRUCTURE OF HIV-1 CAPSID PROTEIN BY CRYO-EM
Descriptor:capsid protein
Authors:Zhao, G., Perilla, J.R., Meng, X., Schulten, K., Zhang, P.
Deposit date:2013-07-11
Release date:2013-07-24
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (8.6 Å)
Cite:Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics.
Nature, 497, 2013
3NTE
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CRYSTAL STRUCTURE OF THE WILD-TYPE FULL-LENGTH HIV-1 CAPSID PROTEIN
Descriptor:HIV-1 capsid protein, IODIDE ION, Tri-iodode Anion, ...
Authors:Betts, L., Yeh, J.I.
Deposit date:2010-07-03
Release date:2010-12-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding.
J.Mol.Biol., 406, 2011
4B3N
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CRYSTAL STRUCTURE OF RHESUS TRIM5ALPHA PRY/SPRY DOMAIN
Descriptor:MALTOSE-BINDING PERIPLASMIC PROTEIN, TRIPARTITE MOTIF-CONTAINING PROTEIN 5, MALTOSE, ...
Authors:Yang, H., Ji, X., Zhao, Q., Xiong, Y.
Deposit date:2012-07-25
Release date:2012-10-24
Last modified:2017-03-15
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural Insight Into HIV-1 Capsid Recognition by Rhesus Trim5Alpha
Proc.Natl.Acad.Sci.USA, 109, 2012
4FBO
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CRYSTAL STRUCTURE OF THE PSEUDOMONAS FLUORESCENS AGGLUTININ (PFA)
Descriptor:Pseudomonas fluorescens agglutinin
Authors:Koharudin, L.M.I., Gronenborn, A.M.
Deposit date:2012-05-23
Release date:2012-08-15
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights into the Anti-HIV Activity of the Oscillatoria agardhii Agglutinin Homolog Lectin Family.
J.Biol.Chem., 287, 2012
4FBR
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CRYSTAL STRUCTURE OF THE MYXOCOCCUS XANTHUS HEMAGGLUTININ (MBHA)
Descriptor:Myxobacterial hemagglutinin
Authors:Koharudin, L.M.I., Gronenborn, A.M.
Deposit date:2012-05-23
Release date:2012-08-15
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Insights into the Anti-HIV Activity of the Oscillatoria agardhii Agglutinin Homolog Lectin Family.
J.Biol.Chem., 287, 2012
4FBV
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CRYSTAL STRUCTURE OF THE MYXOCOCCUS XANTHUS HEMAGGLUTININ IN COMPLEX WITH A3,A6-MANNOPENTAOSE
Descriptor:Myxobacterial hemagglutinin, BETA-D-MANNOSE, ALPHA-D-MANNOSE, ...
Authors:Koharudin, L.M.I., Gronenborn, A.M.
Deposit date:2012-05-23
Release date:2012-08-15
Last modified:2012-10-17
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structural Insights into the Anti-HIV Activity of the Oscillatoria agardhii Agglutinin Homolog Lectin Family.
J.Biol.Chem., 287, 2012
4U0A
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HEXAMERIC HIV-1 CA IN COMPLEX WITH CPSF6 PEPTIDE, P6 CRYSTAL FORM
Descriptor:Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6, CHLORIDE ION
Authors:Price, A.J., Jacques, D.A., James, L.C.
Deposit date:2014-07-11
Release date:2014-11-12
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0B
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HEXAMER HIV-1 CA IN COMPLEX WITH CPSF6 PEPTIDE, P212121 CRYSTAL FORM
Descriptor:Capsid protein p24, Cleavage and polyadenylation specificity factor subunit 6
Authors:Price, A.J., Jacques, D.A., James, L.C.
Deposit date:2014-07-11
Release date:2014-11-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0C
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HEXAMERIC HIV-1 CA IN COMPLEX WITH NUP153 PEPTIDE, P6 CRYSTAL FORM
Descriptor:Capsid protein p24, Nuclear pore complex protein Nup153
Authors:Price, A.J., Jacques, D.A., James, L.C.
Deposit date:2014-07-11
Release date:2014-11-12
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0D
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HEXAMERIC HIV-1 CA IN COMPLEX WITH NUP153 PEPTIDE, P212121 CRYSTAL FORM
Descriptor:Gag polyprotein, Nuclear pore complex protein Nup153, CHLORIDE ION
Authors:Price, A.J., Jacques, D.A., James, L.C.
Deposit date:2014-07-11
Release date:2014-11-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0E
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HEXAMERIC HIV-1 CA IN COMPLEX WITH PF3450074
Descriptor:Capsid protein p24, CHLORIDE ION, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE
Authors:Price, A.J., Jacques, D.A., James, L.C.
Deposit date:2014-07-11
Release date:2014-11-12
Method:X-RAY DIFFRACTION (2.043 Å)
Cite:Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4U0F
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HEXAMERIC HIV-1 CA IN COMPLEX WITH BI-2
Descriptor:Capsid protein p24, 1,2-ETHANEDIOL, (4S)-4-(4-hydroxyphenyl)-3-phenyl-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-one
Authors:Price, A.J., Jacques, D.A., James, L.C.
Deposit date:2014-07-11
Release date:2014-11-12
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.
Plos Pathog., 10, 2014
4WHJ
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MYXOVIRUS RESISTANCE PROTEIN 2 (MXB)
Descriptor:Interferon-induced GTP-binding protein Mx2
Authors:Xiong, Y., Fribourgh, J.L., Nguyen, H.C.
Deposit date:2014-09-22
Release date:2014-10-29
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Insight into HIV-1 Restriction by MxB.
Cell Host Microbe, 16, 2014
4XRO
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DISULFIDE STABILIZED HIV-1 CA HEXAMER 4MUT (S41A, Q67H, V165I, L172I)
Descriptor:Capsid protein p24
Authors:Price, A.J., James, L.C.
Deposit date:2015-01-21
Release date:2015-07-15
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
J.Virol., 89, 2015
4XRQ
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DISULFIDE STABILIZED HIV-1 CA HEXAMER 4MUT (S41A, Q67H, V165I, L172I) IN COMPLEX WITH PF-3450074
Descriptor:Capsid protein p24, N-METHYL-NALPHA-[(2-METHYL-1H-INDOL-3-YL)ACETYL]-N-PHENYL-L-PHENYLALANINAMIDE
Authors:Price, A.J., James, L.C.
Deposit date:2015-01-21
Release date:2015-07-15
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:HIV-1 Resistance to the Capsid-Targeting Inhibitor PF74 Results in Altered Dependence on Host Factors Required for Virus Nuclear Entry.
J.Virol., 89, 2015
5UP4
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STRUCTURE OF THE HIV-1 CAPSID PROTEIN AND SPACER PEPTIDE 1 BY CRYO-EM
Descriptor:HIV-1 Capsid Protein and spacer peptide 1
Authors:Perilla, J.R., Schirra, R., Zhang, P., Schulten, K.
Deposit date:2017-02-01
Release date:2017-12-06
Last modified:2017-12-13
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Quenching protein dynamics interferes with HIV capsid maturation.
Nat Commun, 8, 2017