Author results

2A3J
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STRUCTURE OF URNDESIGN, A COMPLETE COMPUTATIONAL REDESIGN OF HUMAN U1A PROTEIN
Descriptor:U1 small nuclear ribonucleoprotein A
Authors:Varani, G., Dobson, N., Dantas, G., Baker, D.
Deposit date:2005-06-24
Release date:2006-06-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High-Resolution Structural Validation of the Computational Redesign of Human U1A Protein
Structure, 14, 2006
1DZ5
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THE NMR STRUCTURE OF THE 38KDA U1A PROTEIN-PIE RNA COMPLEX REVEALS THE BASIS OF COOPERATIVITY IN REGULATION OF POLYADENYLATION BY HUMAN U1A PROTEIN
Descriptor:U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A, PIE, RNA (5'-R(*GP*AP*GP*AP*CP*AP*UP*UP*GP*CP*AP*CP*CP* CP*GP*GP*AP*GP*UP*CP*UP*C)-3')
Authors:Varani, L., Gunderson, S.I., Mattaj, I.W., Kay, L.E., Neuhaus, D., Varani, G.
Deposit date:2000-02-16
Release date:2000-03-29
Last modified:2013-05-15
Method:SOLUTION NMR
Cite:The NMR Structure of the 38kDa U1A Protein-Pie RNA Complex Reveals the Basis of Cooperativity in Regulation of Polyadenylation by Human U1A Protein
Nat.Struct.Biol., 7, 2000
1EI2
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STRUCTURAL BASIS FOR RECOGNITION OF THE RNA MAJOR GROOVE IN THE TAU EXON 10 SPLICING REGULATORY ELEMENT BY AMINOGLYCOSIDE ANTIBIOTICS
Descriptor:TAU EXON 10 SRE RNA, NEOMYCIN
Authors:Varani, L., Spillantini, M.G., Goedert, M., Varani, G.
Deposit date:2000-02-23
Release date:2000-03-06
Last modified:2017-02-01
Method:SOLUTION NMR
Cite:Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics.
Nucleic Acids Res., 28, 2000
1QC8
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NMR STRUCTURE OF TAU EXON 10 SPLICING REGULATORY ELEMENT RNA
Descriptor:TAU EXON 10 SPLICING REGULATORY ELEMENT RNA
Authors:Varani, L., Spillantini, M.G., Klug, A., Goedert, M., Varani, G.
Deposit date:1999-05-18
Release date:1999-08-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17.
Proc.Natl.Acad.Sci.USA, 96, 1999
1AUD
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U1A-UTRRNA, NMR, 31 STRUCTURES
Descriptor:RNA 3UTR, U1A 102
Authors:Allain, F.H.-T., Gubser, C.C., Howe, P.W.A., Nagai, K., Neuhaus, D., Varani, G.
Deposit date:1997-08-22
Release date:1998-02-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis of the RNA-binding specificity of human U1A protein.
EMBO J., 16, 1997
1UUD
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NMR STRUCTURE OF A SYNTHETIC SMALL MOLECULE, RBT203, BOUND TO HIV-1 TAR RNA
Descriptor:RNA (5'-(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP *CP*CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C) -3'), N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE
Authors:Davis, B., Afshar, M., Varani, G., Karn, J., Murchie, A.I.H., Lentzen, G., Drysdale, M.J., Potter, A.J., Bower, J., Aboul-Ela, F.
Deposit date:2003-12-18
Release date:2004-03-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots"
J.Mol.Biol., 336, 2004
1UUI
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NMR STRUCTURE OF A SYNTHETIC SMALL MOLECULE, RBT158, BOUND TO HIV-1 TAR RNA
Descriptor:5'-R(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP*CP* CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C)-3', 4-[AMINO(IMINO)METHYL]-1-[2-(3-AMMONIOPROPOXY)-5-METHOXYBENZYL]PIPERAZIN-1-IUM
Authors:Davis, B., Afshar, M., Varani, G., Karn, J., Murchie, A.I.H., Lentzen, G., Drysdale, M.J., Potter, A.J., Bower, J., Aboul-Ela, F.
Deposit date:2003-12-19
Release date:2004-02-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots"
J.Mol.Biol., 336, 2004
1ANR
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CIS-ACTING RNA REGULATORY ELEMENT (HIV-1 TAR), NMR, 20 STRUCTURES
Descriptor:RNA REGULATORY ELEMENT TAR
Authors:Aboul-Ela, F., Varani, G., Karn, J.
Deposit date:1996-07-06
Release date:1997-01-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge.
Nucleic Acids Res., 24, 1996
1HLX
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P1 HELIX NUCLEIC ACIDS (DNA/RNA) RIBONUCLEIC ACID
Descriptor:RNA (5'-R(*GP*GP*GP*AP*UP*AP*AP*CP*UP*UP*CP*GP*GP*UP*UP*GP*UP*CP*CP*C)-3')
Authors:Allain, F.H.-T., Varani, G.
Deposit date:1995-05-03
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the P1 helix from group I self-splicing introns.
J.Mol.Biol., 250, 1995
1QYS
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CRYSTAL STRUCTURE OF TOP7: A COMPUTATIONALLY DESIGNED PROTEIN WITH A NOVEL FOLD
Descriptor:TOP7
Authors:Kuhlman, B., Dantas, G., Ireton, G.C., Varani, G., Stoddard, B.L., Baker, D.
Deposit date:2003-09-11
Release date:2003-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
Science, 302, 2003
6BE7
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN8.1
Descriptor:DDPT(DPR)(DAR)Q(DGN)
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, D.
Deposit date:2017-10-24
Release date:2018-01-03
Last modified:2018-01-17
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BE9
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN7.1
Descriptor:T(DLY)NDT(DSG)(DPR)
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, B.
Deposit date:2017-10-24
Release date:2017-12-27
Last modified:2018-01-17
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BEN
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN8.2
Descriptor:(DAR)Q(DPR)(DGN)R(DGL)PQ
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, B.
Deposit date:2017-10-25
Release date:2017-12-27
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BEO
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN9.1
Descriptor:(DPR)PY(DHI)PKDL(DGN)
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, D.
Deposit date:2017-10-25
Release date:2017-12-27
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BEQ
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN10.1
Descriptor:AAR(DVA)(DPR)R(DLE)(DTH)PE
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, D.
Deposit date:2017-10-25
Release date:2018-01-10
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BER
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN10.2
Descriptor:E(DVA)DP(DGL)(DHI)(DPR)N(DAL)(DPR)
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, D.
Deposit date:2017-10-25
Release date:2017-12-27
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BES
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN11_SS
Descriptor:(DAL)Q(DPR)(DCY)(DLY)DS(DTY)(DCY)P(DSN)
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, D.
Deposit date:2017-10-25
Release date:2017-12-27
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BET
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN12_SS
Descriptor:H(DPR)(DVA)CIP(DPR)E(DLY)VC(DGL)
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, D.
Deposit date:2017-10-25
Release date:2017-12-27
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BEU
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN14_SS
Descriptor:(DCY)N(DVA)(DPR)DVYC(DPR)(DSG)KY(DVA)(DPR)
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, D.
Deposit date:2017-10-25
Release date:2017-12-27
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BEW
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN7.2
Descriptor:(DHI)P(DAS)(DGN)(DSN)(DGL)P
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, D.
Deposit date:2017-10-25
Release date:2017-12-27
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BF3
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN7.3A
Descriptor:QDP(DPR)K(2TL)(DAS)
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, D.
Deposit date:2017-10-25
Release date:2018-01-10
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
6BF5
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SOLUTION STRUCTURE OF DE NOVO MACROCYCLE DESIGN7.3A
Descriptor:QDP(DPR)K(DTH)(DAS)
Authors:Shortridge, M.D., Hosseinzadeh, P., Pardo-Avila, F., Varani, G., Baker, D.
Deposit date:2017-10-25
Release date:2018-01-10
Method:SOLUTION NMR
Cite:Comprehensive computational design of ordered peptide macrocycles.
Science, 358, 2017
1ARJ
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ARG-BOUND TAR RNA, NMR
Descriptor:TAR RNA, ARGININE
Authors:Aboul-Ela, F., Varani, G., Karn, J.
Deposit date:1995-08-30
Release date:1996-11-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein.
J.Mol.Biol., 253, 1995
1EKZ
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NMR STRUCTURE OF THE COMPLEX BETWEEN THE THIRD DSRBD FROM DROSOPHILA STAUFEN AND A RNA HAIRPIN
Descriptor:STAUFEN DOUBLE-STRANDED RNA BINDING DOMAIN, MATERNAL EFFECT PROTEIN (STAUFEN)
Authors:Ramos, A., Grunert, S., Bycroft, M., St Johnston, D., Varani, G.
Deposit date:2000-03-11
Release date:2000-08-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:RNA recognition by a Staufen double-stranded RNA-binding domain.
EMBO J., 19, 2000
1FHT
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RNA-BINDING DOMAIN OF THE U1A SPLICEOSOMAL PROTEIN U1A117, NMR, 43 STRUCTURES
Descriptor:U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
Authors:Allain, F.H.-T., Gubser, C.C., Howe, P.W.A., Nagai, K., Neuhaus, D., Varani, G.
Deposit date:1996-02-21
Release date:1996-07-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding.
J.Mol.Biol., 257, 1996