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2A3J
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BU of 2a3j by Molmil
Structure of URNdesign, a complete computational redesign of human U1A protein
Descriptor: U1 small nuclear ribonucleoprotein A
Authors:Varani, G, Dobson, N, Dantas, G, Baker, D.
Deposit date:2005-06-24
Release date:2006-06-06
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:High-Resolution Structural Validation of the Computational Redesign of Human U1A Protein
Structure, 14, 2006
7SHX
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BU of 7shx by Molmil
A functional SNP regulates E-cadherin expression by dynamically remodeling the 3D structure of a promoter-associated non-coding RNA transcript, NMR, minimized average structure
Descriptor: RNA (94-MER)
Authors:Sharma, S, Varani, G.
Deposit date:2021-10-11
Release date:2022-10-19
Last modified:2022-11-16
Method:SOLUTION NMR
Cite:A functional SNP regulates E-cadherin expression by dynamically remodeling the 3D structure of a promoter-associated non-coding RNA transcript.
Nucleic Acids Res., 50, 2022
7K4L
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BU of 7k4l by Molmil
DENV1 SLA bottom stem RNA (DenvBS)
Descriptor: DenvSLA RNA
Authors:Sun, Y.T, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-09-15
Release date:2021-09-29
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution NMR Structure of Denv1 5'UTR SLA region
To Be Published
6MXQ
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BU of 6mxq by Molmil
Solution structure of a c-JUN 5' UTR stem-loop associated with specialized cap-dependent translation initiation
Descriptor: RNA C-JUN TL
Authors:Walker, M, Shortridge, M, Varani, G.
Deposit date:2018-10-31
Release date:2020-05-06
Last modified:2020-11-18
Method:SOLUTION NMR
Cite:Structure of the RNA Specialized Translation Initiation Element that Recruits eIF3 to the 5'-UTR of c-Jun.
J.Mol.Biol., 432, 2020
4M3O
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BU of 4m3o by Molmil
Crystal structure of K.lactis Rtr1 NTD
Descriptor: KLLA0F12672p, ZINC ION
Authors:Hsu, P.L, Yang, W, Zheng, N, Varani, G.
Deposit date:2013-08-06
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rtr1 Is a Dual Specificity Phosphatase That Dephosphorylates Tyr1 and Ser5 on the RNA Polymerase II CTD.
J.Mol.Biol., 426, 2014
1AUD
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BU of 1aud by Molmil
U1A-UTRRNA, NMR, 31 STRUCTURES
Descriptor: RNA 3UTR, U1A 102
Authors:Allain, F.H.-T, Gubser, C.C, Howe, P.W.A, Nagai, K, Neuhaus, D, Varani, G.
Deposit date:1997-08-22
Release date:1998-02-25
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Structural basis of the RNA-binding specificity of human U1A protein.
EMBO J., 16, 1997
6NOA
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BU of 6noa by Molmil
Solution Structure of the RNA element that recruits eIF3 to the 5'-UTR of c-Jun and regulates specialized translation initiation (apical loop)
Descriptor: C-JUN SL1
Authors:Walker, M, Shortridge, M, Varani, G.
Deposit date:2019-01-16
Release date:2020-07-22
Last modified:2020-11-18
Method:SOLUTION NMR
Cite:Structure of the RNA Specialized Translation Initiation Element that Recruits eIF3 to the 5'-UTR of c-Jun.
J.Mol.Biol., 432, 2020
7UMD
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BU of 7umd by Molmil
DENV1 SLA three-way junction RNA (DenvSLAsh)
Descriptor: RNA (40-MER)
Authors:Sun, Y.T, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-04-06
Release date:2022-07-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of the dengue virus RNA promoter.
Rna, 28, 2022
7UMC
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BU of 7umc by Molmil
DENV1 SLA RNA (DenvSLATL)
Descriptor: RNA (70-MER)
Authors:Sun, Y.T, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-04-06
Release date:2022-07-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of the dengue virus RNA promoter.
Rna, 28, 2022
7UME
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BU of 7ume by Molmil
DENV1 SLA top stemloop RNA (DenvTSL)
Descriptor: RNA (28-MER)
Authors:Sun, Y.T, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2022-04-06
Release date:2022-07-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of the dengue virus RNA promoter.
Rna, 28, 2022
6PK9
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BU of 6pk9 by Molmil
Solution Structure of lncRNA (LINK-A) 20-nt Hexaloop Hairpin
Descriptor: RNA (5'-R(*GP*GP*AP*GP*GP*GP*UP*AP*GP*AP*CP*UP*CP*GP*CP*UP*CP*UP*CP*C)-3')
Authors:Amado, A.Y, Walker, M, Varani, G.
Deposit date:2019-06-28
Release date:2020-07-01
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure of the lncRNA LINK-A Hexaloop Hairpin in PI(3,4,5)P3 Interaction
To Be Published
7VRL
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BU of 7vrl by Molmil
Solution structure of Rbfox RRM bound to a non-cognate RNA
Descriptor: RNA (5'-R(*UP*GP*CP*AP*UP*AP*U)-3'), RNA binding protein fox-1 homolog 1
Authors:Yang, F, Varani, G.
Deposit date:2021-10-23
Release date:2022-10-26
Last modified:2023-02-22
Method:SOLUTION NMR
Cite:Two distinct binding modes provide the RNA-binding protein RbFox with extraordinary sequence specificity.
Nat Commun, 14, 2023
6U79
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BU of 6u79 by Molmil
Solution NMR structure of 5' UTR stem loop B from West Nile Virus
Descriptor: 5' UTR region stem loop
Authors:Sharma, S, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2019-09-01
Release date:2020-08-26
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR structure of Dengue West Nile viruses stem-loop B: A key cis-acting element for flavivirus replication.
Biochem.Biophys.Res.Commun., 531, 2020
6W3M
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BU of 6w3m by Molmil
Solution NMR Structure of 5'UTR Stem Loop B in DENV4 Flavivirus.
Descriptor: RNA (41-MER)
Authors:Sharma, S, Varani, G, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-03-09
Release date:2020-09-23
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR structure of Dengue West Nile viruses stem-loop B: A key cis-acting element for flavivirus replication.
Biochem.Biophys.Res.Commun., 531, 2020
3ZV0
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BU of 3zv0 by Molmil
Structure of the SHQ1P-CBF5P complex
Descriptor: GLYCEROL, H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 4, PROTEIN SHQ1
Authors:Walbott, H, Machado-Pinilla, R, Liger, D, Blaud, M, Rety, S, Grozdanov, P.N, Godin, K, vanTilbeurgh, H, Varani, G, Meier, U.T, Leulliot, N.
Deposit date:2011-07-22
Release date:2011-11-30
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The H/Aca Rnp Assembly Factor Shq1 Functions as an RNA Mimic.
Genes Dev., 25, 2011
3ZUZ
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BU of 3zuz by Molmil
Structure of Shq1p C-terminal domain
Descriptor: ISOPROPYL ALCOHOL, PROTEIN SHQ1
Authors:Walbott, H, Machado-Pinilla, R, Liger, D, Blaud, M, Rety, S, Grozdanov, P.N, Godin, K, vanTilbeurgh, H, Varani, G, Meier, U.T, Leulliot, N.
Deposit date:2011-07-22
Release date:2011-11-30
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The H/Aca Rnp Assembly Factor Shq1 Functions as an RNA Mimic.
Genes Dev., 25, 2011
2FEY
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BU of 2fey by Molmil
The structure of stem loop IV of Tetrahymena telomerase RNA
Descriptor: stem-loop IV of Tetrahymena telomerase RNA
Authors:Chen, Y, Fender, J, Legassie, J.D, Jarstfer, M.B, Bryan, T.M, Varani, G.
Deposit date:2005-12-16
Release date:2006-06-27
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Structure of stem-loop IV of Tetrahymena telomerase RNA.
Embo J., 25, 2006
1DZ5
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BU of 1dz5 by Molmil
The NMR structure of the 38KDa U1A protein-PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein
Descriptor: PIE, RNA (5'-R(*GP*AP*GP*AP*CP*AP*UP*UP*GP*CP*AP*CP*CP* CP*GP*GP*AP*GP*UP*CP*UP*C)-3'), U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
Authors:Varani, L, Gunderson, S.I, Mattaj, I.W, Kay, L.E, Neuhaus, D, Varani, G.
Deposit date:2000-02-16
Release date:2000-03-29
Last modified:2013-05-15
Method:SOLUTION NMR
Cite:The NMR Structure of the 38kDa U1A Protein-Pie RNA Complex Reveals the Basis of Cooperativity in Regulation of Polyadenylation by Human U1A Protein
Nat.Struct.Biol., 7, 2000
1EI2
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BU of 1ei2 by Molmil
STRUCTURAL BASIS FOR RECOGNITION OF THE RNA MAJOR GROOVE IN THE TAU EXON 10 SPLICING REGULATORY ELEMENT BY AMINOGLYCOSIDE ANTIBIOTICS
Descriptor: NEOMYCIN, TAU EXON 10 SRE RNA
Authors:Varani, L, Spillantini, M.G, Goedert, M, Varani, G.
Deposit date:2000-02-23
Release date:2000-03-06
Last modified:2017-02-01
Method:SOLUTION NMR
Cite:Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics.
Nucleic Acids Res., 28, 2000
1ANR
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BU of 1anr by Molmil
CIS-ACTING RNA REGULATORY ELEMENT (HIV-1 TAR), NMR, 20 STRUCTURES
Descriptor: RNA REGULATORY ELEMENT TAR
Authors:Aboul-Ela, F, Varani, G, Karn, J.
Deposit date:1996-07-06
Release date:1997-01-11
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge.
Nucleic Acids Res., 24, 1996
1QC8
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BU of 1qc8 by Molmil
NMR STRUCTURE OF TAU EXON 10 SPLICING REGULATORY ELEMENT RNA
Descriptor: TAU EXON 10 SPLICING REGULATORY ELEMENT RNA
Authors:Varani, L, Spillantini, M.G, Klug, A, Goedert, M, Varani, G.
Deposit date:1999-05-18
Release date:1999-08-31
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17.
Proc.Natl.Acad.Sci.USA, 96, 1999
1UUD
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BU of 1uud by Molmil
NMR structure of a synthetic small molecule, rbt203, bound to HIV-1 TAR RNA
Descriptor: N-[2-(2-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-4-METHOXYPHENOXY)ETHYL]GUANIDINE, RNA (5'-(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP *CP*CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C) -3')
Authors:Davis, B, Afshar, M, Varani, G, Karn, J, Murchie, A.I.H, Lentzen, G, Drysdale, M.J, Potter, A.J, Bower, J, Aboul-Ela, F.
Deposit date:2003-12-18
Release date:2004-03-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots"
J.Mol.Biol., 336, 2004
1UUI
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BU of 1uui by Molmil
NMR structure of a synthetic small molecule, rbt158, bound to HIV-1 TAR RNA
Descriptor: 4-[AMINO(IMINO)METHYL]-1-[2-(3-AMMONIOPROPOXY)-5-METHOXYBENZYL]PIPERAZIN-1-IUM, 5'-R(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP*CP* CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C)-3'
Authors:Davis, B, Afshar, M, Varani, G, Karn, J, Murchie, A.I.H, Lentzen, G, Drysdale, M.J, Potter, A.J, Bower, J, Aboul-Ela, F.
Deposit date:2003-12-19
Release date:2004-02-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Rational Design of Inhibitors of HIV-1 Tar RNA Through the Stabilisation of Electrostatic "Hot Spots"
J.Mol.Biol., 336, 2004
1ARJ
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BU of 1arj by Molmil
ARG-BOUND TAR RNA, NMR
Descriptor: ARGININE, TAR RNA
Authors:Aboul-Ela, F, Varani, G, Karn, J.
Deposit date:1995-08-30
Release date:1996-11-08
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:The structure of the human immunodeficiency virus type-1 TAR RNA reveals principles of RNA recognition by Tat protein.
J.Mol.Biol., 253, 1995
2OSR
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BU of 2osr by Molmil
NMR Structure of RRM-2 of Yeast NPL3 Protein
Descriptor: Nucleolar protein 3
Authors:Deka, P, Bucheli, M, Skrisovska, L, Allain, F.H, Moore, C, Buratowski, S, Varani, G.
Deposit date:2007-02-06
Release date:2007-12-18
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals.
J.Mol.Biol., 375, 2008

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