6KTQ | | CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HOMOCITRATE SYNTHASE FROM SULFOLOBUS ACIDOCALDARIUS (SAHCS(DRAM)) IN COMPLEX WITH ALPHA-KETOGLUTARATE/ZN2+/COA | | Descriptor: | Homocitrate synthase, ZINC ION, 2-OXOGLUTARIC ACID, ... | | Authors: | Suzuki, T., Tomita, T., Kuzuyama, T., Nishiyama, M. | | Deposit date: | 2019-08-28 | | Release date: | 2020-09-02 | | Last modified: | 2020-09-23 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Involvement of subdomain II in the recognition of acetyl-CoA revealed by the crystal structure of homocitrate synthase from Sulfolobus acidocaldarius.
Febs J., 2020
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3SSI | |
4WJ3 | | CRYSTAL STRUCTURE OF THE ASPARAGINE TRANSAMIDOSOME FROM PSEUDOMONAS AERUGINOSA | | Descriptor: | Glutamyl-tRNA(Gln) amidotransferase subunit A, Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, Glutamyl-tRNA(Gln) amidotransferase subunit C, ... | | Authors: | Suzuki, T., Nakamura, A., Kato, K., Tanaka, I., Yao, M. | | Deposit date: | 2014-09-29 | | Release date: | 2014-12-31 | | Last modified: | 2020-02-05 | | Method: | X-RAY DIFFRACTION (3.705 Å) | | Cite: | Structure of the Pseudomonas aeruginosa transamidosome reveals unique aspects of bacterial tRNA-dependent asparagine biosynthesis
Proc.Natl.Acad.Sci.USA, 112, 2015
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4WJ4 | | CRYSTAL STRUCTURE OF NON-DISCRIMINATING ASPARTYL-TRNA SYNTHETASE FROM PSEUDOMONAS AERUGINOSA COMPLEXED WITH TRNA(ASN) AND ASPARTIC ACID | | Descriptor: | Aspartate--tRNA(Asp/Asn) ligase, 76mer-tRNA, ASPARTIC ACID | | Authors: | Suzuki, T., Nakamura, A., Kato, K., Tanaka, I., Yao, M. | | Deposit date: | 2014-09-29 | | Release date: | 2014-12-31 | | Last modified: | 2020-02-05 | | Method: | X-RAY DIFFRACTION (3.294 Å) | | Cite: | Structure of the Pseudomonas aeruginosa transamidosome reveals unique aspects of bacterial tRNA-dependent asparagine biosynthesis
Proc.Natl.Acad.Sci.USA, 112, 2015
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5UD5 | |
5V6X | |
3WLU | | CRYSTAL STRUCTURE OF HUMAN GALECTIN-9 NCRD WITH SELENOLACTOSE | | Descriptor: | Galectin-9, 2-(trimethylsilyl)ethyl 4-O-beta-D-galactopyranosyl-6-Se-methyl-6-seleno-beta-D-glucopyranoside | | Authors: | Makyio, H., Suzuki, T., Ando, H., Yamada, Y., Ishida, H., Kiso, M., Wakatsuki, S., Kato, R. | | Deposit date: | 2013-11-14 | | Release date: | 2014-11-05 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Expanded potential of seleno-carbohydrates as a molecular tool for X-ray structural determination of a carbohydrate-protein complex with single/multi-wavelength anomalous dispersion phasing
Bioorg.Med.Chem., 22, 2014
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6L3R | | CRYSTAL STRUCTURE OF RIBONUCLEOTIDE REDUCTASE R1 SUBUNIT, RRM1 IN COMPLEX WITH 4-BROMO-N-((1S,2R)-2-(NAPHTHALEN-1-YL)-1-(5-OXO-4,5-DIHYDRO-1,3,4-OXADIAZOL-2-YL)PROPYL)BENZENESULFONAMIDE | | Descriptor: | Ribonucleoside-diphosphate reductase large subunit, THYMIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Miyahara, S., Chong, K.T., Suzuki, T. | | Deposit date: | 2019-10-15 | | Release date: | 2020-10-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published
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6L7L | | CRYSTAL STRUCTURE OF RIBONUCLEOTIDE REDUCTASE R1 SUBUNIT, RRM1 IN COMPLEX WITH 5-CHLORO-2-(N-((1S,2R)-2-(2,3-DIHYDRO-1H-INDEN-4-YL)-1-(5-OXO-4,5-DIHYDRO-1,3,4-OXADIAZOL-2-YL)PROPYL)SULFAMOYL)BENZAMIDE | | Descriptor: | Ribonucleoside-diphosphate reductase large subunit, MAGNESIUM ION, THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Miyahara, S., Chong, K.T., Suzuki, T. | | Deposit date: | 2019-11-01 | | Release date: | 2020-11-04 | | Method: | X-RAY DIFFRACTION (2.171 Å) | | Cite: | TAS1553, a novel small molecule ribonucleotide reductase (RNR) subunit interaction inhibitor, displays remarkable anti-tumor activity
To be published
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5Y5N | | CRYSTAL STRUCTURE OF HUMAN SIRTUIN 2 IN COMPLEX WITH A SELECTIVE INHIBITOR | | Descriptor: | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, 2-[[3-(2-phenylethoxy)phenyl]amino]benzamide | | Authors: | Mellini, P., Itoh, Y., Tsumoto, H., Li, Y., Suzuki, M., Tokuda, N., Kakizawa, T., Miura, Y., Takeuchi, J., Lahtela-Kakkonen, M., Suzuki, T. | | Deposit date: | 2017-08-09 | | Release date: | 2017-09-06 | | Last modified: | 2019-12-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Potent mechanism-based sirtuin-2-selective inhibition by anin situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site.
Chem Sci, 8, 2017
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1WLE | | CRYSTAL STRUCTURE OF MAMMALIAN MITOCHONDRIAL SERYL-TRNA SYNTHETASE COMPLEXED WITH SERYL-ADENYLATE | | Descriptor: | Seryl-tRNA synthetase, SERYL ADENYLATE | | Authors: | Chimnaronk, S., Jeppesen, M.G., Suzuki, T., Nyborg, J., Watanabe, K. | | Deposit date: | 2004-06-25 | | Release date: | 2005-09-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Dual-mode recognition of noncanonical tRNAs(Ser) by seryl-tRNA synthetase in mammalian mitochondria
Embo J., 24, 2005
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2ZW9 | | CRYSTAL STRUCTURE OF TRNA WYBUTOSINE SYNTHESIZING ENZYME TYW4 | | Descriptor: | Leucine carboxyl methyltransferase 2, S-ADENOSYLMETHIONINE | | Authors: | Suzuki, Y., Noma, A., Suzuki, T., Ishitani, R., Nureki, O. | | Deposit date: | 2008-12-01 | | Release date: | 2009-06-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.
Nucleic Acids Res., 37, 2009
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2ZWA | | CRYSTAL STRUCTURE OF TRNA WYBUTOSINE SYNTHESIZING ENZYME TYW4 | | Descriptor: | Leucine carboxyl methyltransferase 2, S-ADENOSYL-L-HOMOCYSTEINE, CITRIC ACID, ... | | Authors: | Suzuki, Y., Noma, A., Suzuki, T., Ishitani, R., Nureki, O. | | Deposit date: | 2008-12-01 | | Release date: | 2009-06-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.
Nucleic Acids Res., 37, 2009
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2ZZK | | CRYSTAL STRUCTURE OF TRNA WYBUTOSINE SYNTHESIZING ENZYME TYW4 | | Descriptor: | Leucine carboxyl methyltransferase 2, CITRIC ACID, TETRAETHYLENE GLYCOL | | Authors: | Suzuki, Y., Noma, A., Suzuki, T., Ishitani, R., Nureki, O. | | Deposit date: | 2009-02-17 | | Release date: | 2009-06-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.706 Å) | | Cite: | Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4.
Nucleic Acids Res., 37, 2009
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5GVO | | SOLUTION NMR STRUCTURE OF A NEW LASSO PEPTIDE SPHAERICIN | | Descriptor: | Uncharacterized protein | | Authors: | Hemmi, H., Kodani, S., Inoue, Y., Suzuki, M., Dohra, H., Suzuki, T., Ohnishi-Kameyama, M. | | Deposit date: | 2016-09-06 | | Release date: | 2017-04-05 | | Method: | SOLUTION NMR | | Cite: | Sphaericin, a Lasso Peptide from the Rare Actinomycete Planomonospora sphaerica
Eur.J.Org.Chem., 2017
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1WTG | | HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH ETHYLSULFONAMIDE-D-BIPHENYLALANINE-GLN-P-AMINOBENZAMIDINE | | Descriptor: | Coagulation factor VII, Tissue factor, beta-D-glucopyranose, ... | | Authors: | Kadono, S., Sakamoto, S., Kikuchi, Y., Oh-Eda, M., Yabuta, N., Kitazawa, K., Yoshihashi, T., Suzuki, T., Koga, T., Hattori, K., Shiraishi, T., Kodama, M., Haramura, H., Ono, Y., Esaki, T., Sato, H., Watanabe, Y., Itoh, S., Ohta, M., Kozono, T. | | Deposit date: | 2004-11-23 | | Release date: | 2005-11-23 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor
Biochem.Biophys.Res.Commun., 326, 2005
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1WUN | | HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH ETHYLSULFONAMIDE-D-TRP-GLN-P-AMINOBENZAMIDINE | | Descriptor: | Coagulation factor VII, Tissue factor, beta-D-glucopyranose, ... | | Authors: | Kadono, S., Sakamoto, A., Kikuchi, Y., Oh-eda, M., Yabuta, N., Yoshihashi, K., Kitazawa, T., Suzuki, T., Koga, T., Hattori, K., Shiraishi, T., Haramura, M., Kodama, H., Ono, Y., Esaki, T., Sato, H., Watanabe, Y., Itoh, S., Ohta, M., Kozono, T. | | Deposit date: | 2004-12-08 | | Release date: | 2005-12-08 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor
Biochem.Biophys.Res.Commun., 327, 2005
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1WV7 | | HUMAN FACTOR VIIA-TISSUE FACTOR COMPLEXED WITH ETHYLSULFONAMIDE-D-5-PROPOXY-TRP-GLN-P-AMINOBENZAMIDINE | | Descriptor: | Coagulation factor VII, Tissue factor, beta-D-glucopyranose, ... | | Authors: | Kadono, S., Sakamoto, A., Kikuchi, Y., Oh-eda, M., Yabuta, N., Yoshihashi, K., Kitazawa, T., Suzuki, T., Koga, T., Hattori, K., Shiraishi, T., Haramura, M., Kodama, H., Ono, Y., Esaki, T., Sato, H., Watanabe, Y., Itoh, S., Ohta, M., Kozono, T. | | Deposit date: | 2004-12-11 | | Release date: | 2005-12-11 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor
Biochem.Biophys.Res.Commun., 327, 2005
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4ZY3 | | CRYSTAL STRUCTURE OF KEAP1 IN COMPLEX WITH A SMALL CHEMICAL COMPOUND, K67 | | Descriptor: | Kelch-like ECH-associated protein 1, FORMIC ACID, N,N'-[2-(2-oxopropyl)naphthalene-1,4-diyl]bis(4-ethoxybenzenesulfonamide) | | Authors: | Fukutomi, T., Iso, T., Suzuki, T., Takagi, K., Mizushima, T., Komatsu, M., Yamamoto, M. | | Deposit date: | 2015-05-21 | | Release date: | 2016-05-25 | | Last modified: | 2020-02-19 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
Nat Commun, 7, 2016
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2E4M | | CRYSTAL STRUCTURE OF HEMAGGLUTININ SUBCOMPONENT COMPLEX (HA-33/HA-17) FROM CLOSTRIDIUM BOTULINUM SEROTYPE D STRAIN 4947 | | Descriptor: | Main hemagglutinin component, HA-17 | | Authors: | Hasegawa, K., Watanabe, T., Suzuki, T., Yamano, A., Niwa, K., Ohyama, T. | | Deposit date: | 2006-12-13 | | Release date: | 2007-06-19 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A Novel Subunit Structure of Clostridium botulinum Serotype D Toxin Complex with Three Extended Arms
J.Biol.Chem., 282, 2007
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2VQE | | MODIFIED URIDINES WITH C5-METHYLENE SUBSTITUENTS AT THE FIRST POSITION OF THE TRNA ANTICODON STABILIZE U-G WOBBLE PAIRING DURING DECODING | | Descriptor: | 16S RRNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ... | | Authors: | Kurata, S., Weixlbaumer, A., Ohtsuki, T., Shimazaki, T., Wada, T., Kirino, Y., Takai, K., Watanabe, K., Ramakrishnan, V., Suzuki, T. | | Deposit date: | 2008-03-13 | | Release date: | 2008-04-29 | | Last modified: | 2018-11-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Modified Uridines with C5-Methylene Substituents at the First Position of the tRNA Anticodon Stabilize U.G Wobble Pairing During Decoding.
J.Biol.Chem., 283, 2008
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2VQF | | MODIFIED URIDINES WITH C5-METHYLENE SUBSTITUENTS AT THE FIRST POSITION OF THE TRNA ANTICODON STABILIZE U-G WOBBLE PAIRING DURING DECODING | | Descriptor: | 16S RRNA, 30S RIBOSOMAL PROTEIN S2, 30S RIBOSOMAL PROTEIN S3, ... | | Authors: | Kurata, S., Weixlbaumer, A., Ohtsuki, T., Shimazaki, T., Wada, T., Kirino, Y., Takai, K., Watanabe, K., Ramakrishnan, V., Suzuki, T. | | Deposit date: | 2008-03-14 | | Release date: | 2008-04-29 | | Last modified: | 2018-11-21 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Modified Uridines with C5-Methylene Substituents at the First Position of the tRNA Anticodon Stabilize U.G Wobble Pairing During Decoding.
J.Biol.Chem., 283, 2008
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3WY9 | | CRYSTAL STRUCTURE OF A COMPLEX OF THE ARCHAEAL RIBOSOMAL STALK PROTEIN AP1 AND THE GDP-BOUND ARCHAEAL ELONGATION FACTOR AEF1ALPHA | | Descriptor: | Elongation factor 1-alpha, 50S ribosomal protein L12, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Ito, K., Honda, T., Suzuki, T., Miyoshi, T., Murakami, R., Yao, M., Uchiumi, T. | | Deposit date: | 2014-08-22 | | Release date: | 2014-12-24 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Molecular insights into the interaction of the ribosomal stalk protein with elongation factor 1 alpha
Nucleic Acids Res., 2014
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3WYA | | CRYSTAL STRUCTURE OF GDP-BOUND EF1ALPHA FROM PYROCOCCUS HORIKOSHII | | Descriptor: | Elongation factor 1-alpha, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Ito, K., Honda, T., Suzuki, T., Miyoshi, T., Murakami, R., Yao, M., Uchiumi, T. | | Deposit date: | 2014-08-22 | | Release date: | 2014-12-24 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Molecular insights into the interaction of the ribosomal stalk protein with elongation factor 1 alpha
Nucleic Acids Res., 2014
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5B2H | | CRYSTAL STRUCTURE OF HA33 FROM CLOSTRIDIUM BOTULINUM SEROTYPE C STRAIN YOICHI | | Descriptor: | HA-33, TRIETHYLENE GLYCOL | | Authors: | Akiyama, T., Hayashi, S., Matsumoto, T., Hasegawa, K., Yamano, A., Suzuki, T., Niwa, K., Watanabe, T., Sagane, Y., Yajima, S. | | Deposit date: | 2016-01-15 | | Release date: | 2016-06-15 | | Last modified: | 2020-02-26 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Conformational divergence in the HA-33/HA-17 trimer of serotype C and D botulinum toxin complex
Biochem.Biophys.Res.Commun., 476, 2016
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