Author results

2IY5
  • Download 2iy5
  • View 2iy5
Molmil generated image of 2iy5
PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH TRNA AND A PHENYLALANYL-ADENYLATE ANALOG
Descriptor:PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN, PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN, TRNAPHE, ...
Authors:Moor, N., Kotik-Kogan, O., Tworowski, D., Sukhanova, M., Safro, M.
Deposit date:2006-07-12
Release date:2006-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The Crystal Structure of the Ternary Complex of Phenylalanyl-tRNA Synthetase with tRNA(Phe) and a Phenylalanyl-Adenylate Analogue Reveals a Conformational Switch of the Cca End.
Biochemistry, 45, 2006
4CMS
  • Download 4cms
  • View 4cms
Molmil generated image of 4cms
X-RAY ANALYSES OF ASPARTIC PROTEINASES IV. STRUCTURE AND REFINEMENT AT 2.2 ANGSTROMS RESOLUTION OF BOVINE CHYMOSIN
Descriptor:CHYMOSIN B
Authors:Newman, M., Frazao, C., Khan, G., Tickle, I.J., Blundell, T.L., Safro, M., Andreeva, N., Zdanov, A.
Deposit date:1991-11-01
Release date:1991-11-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray analyses of aspartic proteinases. IV. Structure and refinement at 2.2 A resolution of bovine chymosin.
J.Mol.Biol., 221, 1991
1EIY
  • Download 1eiy
  • View 1eiy
Molmil generated image of 1eiy
THE CRYSTAL STRUCTURE OF PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH COGNATE TRNAPHE
Descriptor:TRNA(PHE), PHENYLALANYL-TRNA SYNTHETASE
Authors:Goldgur, Y., Mosyak, L., Reshetnikova, L., Ankilova, V., Safro, M.
Deposit date:2000-02-29
Release date:2000-03-06
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The crystal structure of phenylalanyl-tRNA synthetase from thermus thermophilus complexed with cognate tRNAPhe.
Structure, 5, 1997
2AMC
  • Download 2amc
  • View 2amc
Molmil generated image of 2amc
CRYSTAL STRUCTURE OF PHENYLALANYL-TRNA SYNTHETASE COMPLEXED WITH L-TYROSINE
Descriptor:Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, MAGNESIUM ION, ...
Authors:Kotik-Kogan, O., Moor, N., Tworowski, D., Safro, M.
Deposit date:2005-08-09
Release date:2005-12-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Discrimination of L-Phenylalanine from L-Tyrosine by Phenylalanyl-tRNA Synthetase
Structure, 13, 2005
3CMQ
  • Download 3cmq
  • View 3cmq
Molmil generated image of 3cmq
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL PHENYLALANINE TRNA SYNTHETASE
Descriptor:Phenylalanyl-tRNA synthetase, mitochondrial, MAGNESIUM ION, ...
Authors:Klipcan, L., Levin, I.L., Kessler, N., Moor, N., Finarov, I., Safro, M.
Deposit date:2008-03-24
Release date:2008-07-01
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The tRNA-Induced Conformational Activation of Human Mitochondrial Phenylalanyl-tRNA Synthetase.
Structure, 16, 2008
5MGH
  • Download 5mgh
  • View 5mgh
Molmil generated image of 5mgh
CRYSTAL STRUCTURE OF PATHOGENIC MUTANTS OF HUMAN MITOCHODNRIAL PHERS
Descriptor:Phenylalanine--tRNA ligase, mitochondrial, PHENYLALANINE
Authors:Kartvelishvili, E., Tworowski, D., Vernon, H., Chrzanowska-Lightowlers, Z., Moor, N., Wang, J., Wong, L.-J., Safro, M.
Deposit date:2016-11-21
Release date:2017-05-03
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2.
Protein Sci., 26, 2017
5MGU
  • Download 5mgu
  • View 5mgu
Molmil generated image of 5mgu
KINETIC AND STRUCTURAL CHANGES IN HSMTPHERS, INDUCED BY PATHOGENIC MUTATIONS IN HUMAN FARS2
Descriptor:Phenylalanine--tRNA ligase, mitochondrial, PHENYLALANINE
Authors:Kartvelishvili, E., Tworowski, D., Vernon, H., Chrzanowska-Lightowlers, Z., Moor, N., Wang, J., Wong, L.-J., Safro, M.
Deposit date:2016-11-22
Release date:2017-05-03
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2.
Protein Sci., 26, 2017
5MGV
  • Download 5mgv
  • View 5mgv
Molmil generated image of 5mgv
KINETIC AND STRUCTURAL CHANGES IN HSMTPHERS, INDUCED BY PATHOGENIC MUTATIONS IN HUMAN FARS2
Descriptor:Phenylalanine--tRNA ligase, mitochondrial
Authors:Kartvelishvili, E., Tworowski, D., Vernon, H., Chrzanowska-Lightowlers, Z., Moor, N., Wang, J., Wong, L.-J., Safro, M.
Deposit date:2016-11-22
Release date:2017-05-03
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2.
Protein Sci., 26, 2017
5MGW
  • Download 5mgw
  • View 5mgw
Molmil generated image of 5mgw
KINETIC AND STRUCTURAL CHANGES IN HSMTPHERS, INDUCED BY PATHOGENIC MUTATIONS IN HUMAN FARS2
Descriptor:Phenylalanine--tRNA ligase, mitochondrial, PHENYLALANINE
Authors:Kartvelishvili, E., Tworowski, D., Vernon, H., Chrzanowska-Lightowlers, Z., Moor, N., Wang, J., Wong, L.-J., Safro, M.
Deposit date:2016-11-22
Release date:2017-05-03
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Kinetic and structural changes in HsmtPheRS, induced by pathogenic mutations in human FARS2.
Protein Sci., 26, 2017
1PYS
  • Download 1pys
  • View 1pys
Molmil generated image of 1pys
PHENYLALANYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS
Descriptor:PHENYLALANYL-TRNA SYNTHETASE, MAGNESIUM ION
Authors:Safro, M., Mosyak, L., Goldgur, Y., Reshetnikova, L., Delarue, M.
Deposit date:1996-11-14
Release date:1997-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of phenylalanyl-tRNA synthetase from Thermus thermophilus.
Nat.Struct.Biol., 2, 1995
3TUP
  • Download 3tup
  • View 3tup
Molmil generated image of 3tup
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL PHERS COMPLEXED WITH TRNAPHE IN THE ACTIVE OPEN STATE
Descriptor:Phenylalanyl-tRNA synthetase, mitochondrial, Thermus thermophilus tRNAPhe
Authors:Safro, M., Klipcan, L., Moor, N., Finarov, I., Kessler, N., Sukhanova, M.
Deposit date:2011-09-17
Release date:2011-11-23
Last modified:2012-02-01
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal Structure of Human Mitochondrial PheRS Complexed with tRNA(Phe) in the Active "Open" State.
J.Mol.Biol., 415, 2012
4TVA
  • Download 4tva
  • View 4tva
Molmil generated image of 4tva
UNIVERSAL PATHWAY FOR POST-TRANSFER EDITING REACTIONS: INSIGHT FROM CRYSTAL STRUCTURE OF TTHPHERS WITH PUROMYCINE
Descriptor:Phenylalanine--tRNA ligase alpha subunit, Phenylalanine--tRNA ligase beta subunit, PHENYLALANINE, ...
Authors:Safro, M., Klipcan, L., Tworowski, D., Peretz, M.
Deposit date:2014-06-26
Release date:2015-03-18
Last modified:2015-10-07
Method:X-RAY DIFFRACTION (2.597 Å)
Cite:Universal pathway for posttransfer editing reactions: Insights from the crystal structure of TtPheRS with puromycin.
Proc.Natl.Acad.Sci.USA, 112, 2015
3TEH
  • Download 3teh
  • View 3teh
Molmil generated image of 3teh
CRYSTAL STRUCTURE OF THERMUS THERMOPHILUS PHENYLALANYL-TRNA SYNTHETASE COMPLEXED WITH L-DOPA
Descriptor:Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain, 3,4-DIHYDROXYPHENYLALANINE
Authors:Safro, M., Klipcan, L., Moor, N.
Deposit date:2011-08-14
Release date:2011-11-23
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (2.8524 Å)
Cite:Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNA(Phe) with 3,4-Dihydroxy-L-Phenylalanine.
Chem.Biol., 18, 2011
1JJC
  • Download 1jjc
  • View 1jjc
Molmil generated image of 1jjc
CRYSTAL STRUCTURE AT 2.6A RESOLUTION OF PHENYLALANYL-TRNA SYNTHETASE COMPLEXED WITH PHENYLALANYL-ADENYLATE IN THE PRESENCE OF MANGANESE
Descriptor:PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN, PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN, ADENOSINE-5'-[PHENYLALANINYL-PHOSPHATE], ...
Authors:Safro, M.G., Fishman, R., Moor, N., Ankilova, V.
Deposit date:2001-07-04
Release date:2001-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure at 2.6 A resolution of phenylalanyl-tRNA synthetase complexed with phenylalanyl-adenylate in the presence of manganese.
Acta Crystallogr.,Sect.D, 57, 2001
3TEG
  • Download 3teg
  • View 3teg
Molmil generated image of 3teg
BACTERIAL AND EUKARYOTIC PHENYLALANYL-TRNA SYNTHETASES CATALYZE MISAMINOACYLATION OF TRNAPHE WITH 3,4-DIHYDROXY-L-PHENYLALANINE (L-DOPA)
Descriptor:Phenylalanyl-tRNA synthetase, mitochondrial, 3,4-DIHYDROXYPHENYLALANINE
Authors:Moor, N., Klipcan, L., Safro, M.
Deposit date:2011-08-14
Release date:2011-11-23
Method:X-RAY DIFFRACTION (2.2044 Å)
Cite:Bacterial and Eukaryotic Phenylalanyl-tRNA Synthetases Catalyze Misaminoacylation of tRNA(Phe) with 3,4-Dihydroxy-L-Phenylalanine.
Chem.Biol., 18, 2011
1B70
  • Download 1b70
  • View 1b70
Molmil generated image of 1b70
PHENYLALANYL TRNA SYNTHETASE COMPLEXED WITH PHENYLALANINE
Descriptor:PHENYLALANYL-TRNA SYNTHETASE, MAGNESIUM ION, PHENYLALANINE
Authors:Reshetnikova, L., Moor, N., Lavrik, O., Vassylyev, D.G.
Deposit date:1999-01-26
Release date:2000-02-09
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue
J.Mol.Biol., 287, 1999
1B7Y
  • Download 1b7y
  • View 1b7y
Molmil generated image of 1b7y
PHENYLALANYL TRNA SYNTHETASE COMPLEXED WITH PHENYLALANINYL-ADENYLATE
Descriptor:PROTEIN (PHENYLALANYL-TRNA SYNTHETASE), MAGNESIUM ION, ADENOSINE-5'-[PHENYLALANINOL-PHOSPHATE]
Authors:Reshetnikova, L., Moor, N., Lavrik, O., Vassylyev, D.G.
Deposit date:1999-01-26
Release date:2000-01-26
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of phenylalanyl-tRNA synthetase complexed with phenylalanine and a phenylalanyl-adenylate analogue.
J.Mol.Biol., 287, 1999
3CMS
  • Download 3cms
  • View 3cms
Molmil generated image of 3cms
ENGINEERING ENZYME SUB-SITE SPECIFICITY: PREPARATION, KINETIC CHARACTERIZATION AND X-RAY ANALYSIS AT 2.0-ANGSTROMS RESOLUTION OF VAL111PHE SITE-MUTATED CALF CHYMOSIN
Descriptor:CHYMOSIN B
Authors:Newman, M., Frazao, C., Shearer, A., Tickle, I.J., Blundell, T.L.
Deposit date:1990-02-26
Release date:1992-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Engineering enzyme subsite specificity: preparation, kinetic characterization, and X-ray analysis at 2.0-A resolution of Val111Phe site-mutated calf chymosin.
Biochemistry, 29, 1990
1CZI
  • Download 1czi
  • View 1czi
Molmil generated image of 1czi
CHYMOSIN COMPLEX WITH THE INHIBITOR CP-113972
Descriptor:CHYMOSIN, CP-113972 (NORSTATINE-S-METHYL CYSTEINE-IODO-PHENYLALANINE-PROLINE)
Authors:Groves, M.R., Dhanaraj, V., Pitts, J.E., Badasso, M., Hoover, D., Nugent, P., Blundell, T.L.
Deposit date:1997-01-15
Release date:1997-04-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A 2.3 A resolution structure of chymosin complexed with a reduced bond inhibitor shows that the active site beta-hairpin flap is rearranged when compared with the native crystal structure.
Protein Eng., 11, 1998