Author results

2BKD
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STRUCTURE OF THE N-TERMINAL DOMAIN OF FRAGILE X MENTAL RETARDATION PROTEIN
Descriptor:FRAGILE X MENTAL RETARDATION 1 PROTEIN
Authors:Ramos, A., Hollingworth, D., Adinolfi, S., Castets, M., Kelly, G., Frenkiel, T.A., Bardoni, B., Pastore, A.
Deposit date:2005-02-15
Release date:2006-01-18
Last modified:2018-03-28
Method:SOLUTION NMR
Cite:The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction.
Structure, 14, 2006
1EKZ
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NMR STRUCTURE OF THE COMPLEX BETWEEN THE THIRD DSRBD FROM DROSOPHILA STAUFEN AND A RNA HAIRPIN
Descriptor:STAUFEN DOUBLE-STRANDED RNA BINDING DOMAIN, MATERNAL EFFECT PROTEIN (STAUFEN)
Authors:Ramos, A., Grunert, S., Bycroft, M., St Johnston, D., Varani, G.
Deposit date:2000-03-11
Release date:2000-08-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:RNA recognition by a Staufen double-stranded RNA-binding domain.
EMBO J., 19, 2000
1IKD
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ACCEPTOR STEM, NMR, 30 STRUCTURES
Descriptor:TRNA ALA ACCEPTOR STEM
Authors:Ramos, A., Varani, G.
Deposit date:1996-11-15
Release date:1997-04-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the acceptor stem of Escherichia coli tRNA Ala: role of the G3.U70 base pair in synthetase recognition.
Nucleic Acids Res., 25, 1997
5G1N
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ASPARTATE TRANSCARBAMOYLASE DOMAIN OF HUMAN CAD BOUND TO PALA
Descriptor:CAD PROTEIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, 1,2-ETHANEDIOL
Authors:Ruiz-Ramos, A., Grande-Garcia, A., Moreno-Morcillo, M.D., Ramon-Maiques, S.
Deposit date:2016-03-29
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala.
Structure, 24, 2016
5G1O
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ASPARTATE TRANSCARBAMOYLASE DOMAIN OF HUMAN CAD IN APO FORM
Descriptor:CAD PROTEIN, 1,2-ETHANEDIOL, GLYCEROL
Authors:Ruiz-Ramos, A., Grande-Garcia, A., Moreno-Morcillo, M.D., Ramon-Maiques, S.
Deposit date:2016-03-29
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala.
Structure, 24, 2016
5G1P
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ASPARTATE TRANSCARBAMOYLASE DOMAIN OF HUMAN CAD BOUND TO CARBAMOYL PHOSPHATE
Descriptor:CAD PROTEIN, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER
Authors:Ruiz-Ramos, A., Grande-Garcia, A., Moreno-Morcillo, M.D., Ramon-Maiques, S.
Deposit date:2016-03-29
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala.
Structure, 24, 2016
2N8M
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ZIPCODE-BINDING-PROTEIN-1 KH3(DD)KH4 DOMAINS IN COMPLEX WITH THE KH4 RNA TARGET
Descriptor:Insulin-like growth factor 2 mRNA-binding protein 1, RNA (5'-R(P*UP*CP*GP*GP*AP*CP*U)-3')
Authors:Nicastro, G., Ramos, A., Candel, A., Hollingworth, D.
Deposit date:2015-10-21
Release date:2017-01-25
Method:SOLUTION NMR
Cite:Zipcode-binding-protein-1 KH3(DD)KH4 domains in complex with the RNA target UCGGACU
To be Published
5CQU
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MONOCLINIC COMPLEX STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH A BENZOTRIAZOLE-BASED INHIBITOR GENERATED BY CLICK-CHEMISTRY
Descriptor:Casein kinase II subunit alpha, 4-[4-[2-[4,5,6,7-tetrakis(bromanyl)benzotriazol-2-yl]ethyl]-1,2,3-triazol-1-yl]butan-1-amine, SULFATE ION, ...
Authors:Niefind, K., Schnitzler, A., Swider, R., Maslyk, M., Ramos, A.
Deposit date:2015-07-22
Release date:2015-09-09
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Synthesis, Biological Activity and Structural Study of New Benzotriazole-Based Protein Kinase CK2 Inhibitors
Rsc Adv, 5, 2015
5CQW
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TETRAGONAL COMPLEX STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH A BENZOTRIAZOLE-BASED INHIBITOR GENERATED BY CLICK-CHEMISTRY
Descriptor:Casein kinase II subunit alpha, 4-[4-[2-[4,5,6,7-tetrakis(bromanyl)benzotriazol-2-yl]ethyl]-1,2,3-triazol-1-yl]butan-1-amine, SULFATE ION, ...
Authors:Niefind, K., Schnitzler, A., Swider, R., Maslyk, M., Ramos, A.
Deposit date:2015-07-22
Release date:2015-09-09
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Synthesis, Biological Activity and Structural Study of New Benzotriazole-Based Protein Kinase CK2 Inhibitors
Rsc Adv, 5, 2015
2JVZ
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SOLUTION NMR STRUCTURE OF THE SECOND AND THIRD KH DOMAINS OF KSRP
Descriptor:Far upstream element-binding protein 2
Authors:Diaz-Moreno, I., Hollingworth, D., Garcia-Mayoral, M.F., Kelly, G., Cukier, C.D., Ramos, A.
Deposit date:2007-09-28
Release date:2009-02-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR Structure of the Second and Third KH Domains of KSRP
To be Published, 2007
2N8L
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ZIPCODE-BINDING-PROTEIN-1 KH3KH4(DD) DOMAINS IN COMPLEX WITH THE KH3 RNA TARGET
Descriptor:Insulin-like growth factor 2 mRNA-binding protein 1, RNA (5'-R(P*GP*CP*AP*CP*AP*CP*CP*C)-3')
Authors:Nicastro, G., Candel, A.M., Ramos, A., Hollingworth, D.
Deposit date:2015-10-21
Release date:2017-01-25
Method:SOLUTION NMR
Cite:Zipcode-binding-protein-1 KH3KH4(DD) domains in complex with the RNA target GCACACCC
To be Published
4B8T
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RNA BINDING PROTEIN SOLUTION STRUCTURE OF THE THIRD KH DOMAIN OF KSRP IN COMPLEX WITH THE G-RICH TARGET SEQUENCE.
Descriptor:KH-TYPE SPLICING REGULATORY PROTEIN, 5'-R(*AP*GP*GP*GP*UP)-3'
Authors:Nicastro, G., Garcia-Mayoral, M.F., Hollingworth, D., Kelly, G., Martin, S.R., Briata, P., Gherzi, R., Ramos, A.
Deposit date:2012-08-30
Release date:2012-11-07
Last modified:2013-01-16
Method:SOLUTION NMR
Cite:Noncanonical G Recognition Mediates Ksrp Regulation of Let-7 Biogenesis
Nat.Struct.Mol.Biol., 19, 2012
6ES4
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A CRYPTIC RNA-BINDING DOMAIN MEDIATES SYNCRIP RECOGNITION AND EXOSOMAL PARTITIONING OF MIRNA TARGETS
Descriptor:Syncrip, isoform K, SULFATE ION, ...
Authors:Hobor, F., Dallmann, A., Ball, N.J., Cicchini, C., Battistelli, C., Ogrodowicz, R.W., Christodoulou, E., Martin, S.R., Castello, A., Tripodi, M., Taylor, I.A., Ramos, A.
Deposit date:2017-10-19
Release date:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets.
Nat Commun, 9, 2018
3COI
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CRYSTAL STRUCTURE OF P38DELTA KINASE
Descriptor:Mitogen-activated protein kinase 13
Authors:Atwell, S., Burley, S.K., Houle, A., Ramos, A., Sauder, J.M., New York SGX Research Center for Structural Genomics (NYSGXRC)
Deposit date:2008-03-28
Release date:2008-04-15
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal structure of p38delta kinase.
To be Published
1XBA
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CRYSTAL STRUCTURE OF APO SYK TYROSINE KINASE DOMAIN
Descriptor:Tyrosine-protein kinase SYK
Authors:Atwell, S., Adams, J.M., Badger, J., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Nienaber, V.L., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G.
Deposit date:2004-08-30
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
J.Biol.Chem., 279, 2004
1XBB
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CRYSTAL STRUCTURE OF THE SYK TYROSINE KINASE DOMAIN WITH GLEEVEC
Descriptor:Tyrosine-protein kinase SYK, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
Authors:Nienaber, V.L., Atwell, S., Adams, J.M., Badger, J., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G.
Deposit date:2004-08-30
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase
J.Biol.Chem., 279, 2004
1XBC
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CRYSTAL STRUCTURE OF THE SYK TYROSINE KINASE DOMAIN WITH STAUROSPORIN
Descriptor:Tyrosine-protein kinase SYK, STAUROSPORINE
Authors:Badger, J., Atwell, S., Adams, J.M., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Nienaber, V.L., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G.
Deposit date:2004-08-30
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase
J.Biol.Chem., 279, 2004
2BF0
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CRYSTAL STRUCTURE OF THE RPR OF PCF11
Descriptor:PCF11, CALCIUM ION
Authors:Noble, C.G., Hollingworth, D., Martin, S.R., Adeniran, V.E., Smerdon, S.J., Kelly, G., Taylor, I.A., Ramos, A.
Deposit date:2004-12-02
Release date:2005-01-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Key Features of the Interaction between Pcf11 Cid and RNA Polymerase II Ctd.
Nat.Struct.Mol.Biol., 12, 2005
2KXF
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SOLUTION STRUCTURE OF THE FIRST TWO RRM DOMAINS OF FBP-INTERACTING REPRESSOR (FIR)
Descriptor:Poly(U)-binding-splicing factor PUF60
Authors:Cukier, C.D., Ramos, A., Hollingworth, D., Diaz-Moreno, I., Kelly, G.
Deposit date:2010-05-04
Release date:2010-08-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Molecular basis of FIR-mediated c-myc transcriptional control
Nat.Struct.Mol.Biol., 2010
2KXH
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SOLUTION STRUCTURE OF THE FIRST TWO RRM DOMAINS OF FIR IN THE COMPLEX WITH FBP NBOX PEPTIDE
Descriptor:Poly(U)-binding-splicing factor PUF60, peptide of Far upstream element-binding protein 1
Authors:Cukier, C.D., Ramos, A., Hollingworth, D., Diaz-Moreno, I., Kelly, G.
Deposit date:2010-05-05
Release date:2010-08-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Molecular basis of FIR-mediated c-myc transcriptional control
Nat.Struct.Mol.Biol., 2010
2OPU
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SOLUTION NMR STRUCTURE OF THE FIRST DOMAIN OF KSRP
Descriptor:KHSRP protein
Authors:Diaz-Moreno, I., Ramos, A., Garcia-Mayoral, M.F., Hollingworth, D.
Deposit date:2007-01-30
Release date:2008-02-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Phosphorylation-mediated unfolding of a KH domain regulates KSRP localization via 14-3-3 binding.
Nat.Struct.Mol.Biol., 16, 2009
2OPV
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SOLUTION NMR STRUCTURE OF THE SECOND DOMAIN OF KSRP
Descriptor:KHSRP protein
Authors:Diaz-Moreno, I., Ramos, A., Garcia-Mayoral, M.F., Hollingworth, D.
Deposit date:2007-01-30
Release date:2008-02-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The NMR Structures of the N-terminal Domains of KSRP
To be Published
2X1A
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STRUCTURE OF RNA15 RRM WITH RNA BOUND (G)
Descriptor:MRNA 3'-END-PROCESSING PROTEIN RNA15, 5'-R(*GP*UP*UP*GP*UP)-3', MAGNESIUM ION
Authors:Pancevac, C., Goldstone, D.C., Ramos, A., Taylor, I.A.
Deposit date:2010-01-06
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of the RNA15 Rrm-RNA Complex Reveals the Molecular Basis of Gu Specificity in Transcriptional 3-End Processing Factors.
Nucleic Acids Res., 38, 2010
2X1B
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STRUCTURE OF RNA15 RRM
Descriptor:MRNA 3'-END-PROCESSING PROTEIN RNA15, PHOSPHATE ION
Authors:Pancevac, C., Goldstone, D.C., Ramos, A., Taylor, I.A.
Deposit date:2010-01-06
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the RNA15 Rrm-RNA Complex Reveals the Molecular Basis of Gu Specificity in Transcriptional 3-End Processing Factors.
Nucleic Acids Res., 38, 2010
2X1F
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STRUCTURE OF RNA15 RRM WITH BOUND RNA (GU)
Descriptor:MRNA 3'-END-PROCESSING PROTEIN RNA15, 5'-R(*GP*UP*UP*GP*UP)-3'
Authors:Pancevac, C., Goldstone, D.C., Ramos, A., Taylor, I.A.
Deposit date:2010-01-06
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the RNA15 Rrm-RNA Complex Reveals the Molecular Basis of Gu Specificity in Transcriptional 3-End Processing Factors.
Nucleic Acids Res., 38, 2010