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4GS3
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DIMERIC STRUCTURE OF THE N-TERMINAL DOMAIN OF PRIB PROTEIN FROM THERMOANAEROBACTER TENCONGENSIS SOLVED AB INITIO
Descriptor:Single-stranded DNA-binding protein
Authors:Liebschner, D., Brzezinski, K., Dauter, M., Dauter, Z., Nowak, M., Kur, J., Olszewski, M.
Deposit date:2012-08-27
Release date:2012-09-19
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Dimeric structure of the N-terminal domain of PriB protein from Thermoanaerobacter tengcongensis solved ab initio.
Acta Crystallogr.,Sect.D, 68, 2012
5M11
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STRUCTURAL AND FUNCTIONAL PROBING OF PORZ, AN ESSENTIAL BACTERIAL SURFACE COMPONENT OF THE TYPE-IX SECRETION SYSTEM OF HUMAN ORAL-MICROBIOMIC PORPHYROMONAS GINGIVALIS.
Descriptor:Immunoreactive 84kD antigen PG93, CALCIUM ION, ZINC ION, ...
Authors:Lasica, A.M., Goulas, T., Mizgalska, D., Zhou, X., Ksiazek, M., Madej, M., Guo, Y., Guevara, T., Nowak, M., Potempa, B., Goel, A., Sztukowska, M., Prabhakar, A.T., Bzowska, M., Widziolek, M., Thogersen, I.B., Enghild, J.J., Simonian, M., Kulczyk, A.W., Nguyen, K.-A., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2016-10-07
Release date:2016-11-09
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Sci Rep, 6, 2016
6HVH
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 1
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-(oxan-4-yl)pyridine-4-carboxamide, PYROPHOSPHATE 2-, ...
Authors:Banaszak, K., Jakubiec, K., Bialas, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-10-11
Release date:2018-11-14
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.
ChemMedChem, 14, 2019
6HVI
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 2
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 8-[3-(dimethylamino)phenyl]-~{N}-(4-methylsulfonylpyridin-3-yl)quinoxalin-6-amine, PYROPHOSPHATE 2-, ...
Authors:Banaszak, K., Sowinska, M., Gondela, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-10-11
Release date:2018-11-14
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.
ChemMedChem, 14, 2019
6HVJ
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 3
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 8-(3-methyl-1-benzofuran-5-yl)-~{N}-(4-methylsulfonylpyridin-3-yl)quinoxalin-6-amine, FRUCTOSE-6-PHOSPHATE, ...
Authors:Banaszak, K., Pawlik, H., Bialas, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-10-11
Release date:2018-11-14
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Discovery and Structure-Activity Relationships of N-Aryl 6-Aminoquinoxalines as Potent PFKFB3 Kinase Inhibitors.
ChemMedChem, 14, 2019
6IBX
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 5
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpiperidin-3-yl]pyridine-4-carboxamide, PYROPHOSPHATE 2-, ...
Authors:Banaszak, K., Pawlik, H., Bialas, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-12-01
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Bioorg. Med. Chem. Lett., 29, 2019
6IBY
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 6
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpyrrolidin-3-yl]pyridine-4-carboxamide, PYROPHOSPHATE 2-, ...
Authors:Banaszak, K., Pawlik, H., Bialas, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-12-01
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Bioorg. Med. Chem. Lett., 29, 2019
6IBZ
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 7
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, PHOSPHATE ION, CITRATE ANION, ...
Authors:Banaszak, K., Tomczyk, M., Guzik, P., Fabritius, C.H., Nowak, M.
Deposit date:2018-12-01
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Bioorg. Med. Chem. Lett., 29, 2019
6IC0
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HUMAN PFKFB3 IN COMPLEX WITH A N-ARYL 6-AMINOQUINOXALINE INHIBITOR 4
Descriptor:6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-pyrimidin-5-yl-pyridine-4-carboxamide, PYROPHOSPHATE 2-, ...
Authors:Banaszak, K., Pawlik, H., Bialas, A., Fabritius, C.H., Nowak, M.
Deposit date:2018-12-01
Release date:2019-01-23
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Bioorg. Med. Chem. Lett., 29, 2019
5AG8
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CRYSTAL STRUCTURE OF A MUTANT (665I6H) OF THE C-TERMINAL DOMAIN OF RGPB
Descriptor:GINGIPAIN R2, SULFATE ION, GLYCEROL
Authors:de Diego, I., Ksiazek, M., Mizgalska, D., Golik, P., Szmigielski, B., Nowak, M., Nowakowska, Z., Potempa, B., Koneru, L., Nguyen, K.A., Enghild, J., Thogersen, I.B., Dubin, G., Gomis-Ruth, F.X., Potempa, J.
Deposit date:2015-01-29
Release date:2016-04-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Outer-Membrane Export Signal of Porphyromonas Gingivalis Type Ix Secretion System (T9Ss) is a Conserved C-Terminal Beta-Sandwich Domain.
Sci.Rep., 6, 2016
5AG9
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CRYSTAL STRUCTURE OF A MUTANT (665SXA) C-TERMINAL DOMAIN OF RGPB
Descriptor:Gingipain R2, SULFATE ION
Authors:de Diego, I., Ksiazek, M., Mizgalska, D., Golik, P., Szmigielski, B., Nowak, M., Nowakowska, Z., Potempa, B., Koneru, L., Nguyen, K.A., Enghild, J., Thogersen, I.B., Dubin, G., Gomis-Ruth, F.X., Potempa, J.
Deposit date:2015-01-29
Release date:2016-04-06
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal beta-sandwich domain.
Sci Rep, 6, 2016
5HFS
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CRYSTAL STRUCTURE OF C-TERMINAL DOMAIN OF CARGO PROTEINS OF TYPE IX SECRETION SYSTEM
Descriptor:Gingipain R2, CALCIUM ION, ZINC ION
Authors:Golik, P., Szmigielski, B., Ksiazek, M., Nowakowska, Z., Mizgalska, D., Nowak, M., Dubin, G., Potempa, J.
Deposit date:2016-01-07
Release date:2016-04-06
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal beta-sandwich domain.
Sci Rep, 6, 2016
5MUN
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STRUCTURAL INSIGHT INTO ZYMOGENIC LATENCY OF GINGIPAIN K FROM PORPHYROMONAS GINGIVALIS.
Descriptor:Lys-gingipain W83, AZIDE ION
Authors:Pomowski, A., Uson, I., Nowakovska, Z., Veillard, F., Sztukowska, M.N., Guevara, T., Goulas, T., Mizgalska, D., Nowak, M., Potempa, B., Huntington, J.A., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2017-01-13
Release date:2017-02-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.
J. Biol. Chem., 292, 2017
6I9A
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PORPHYROMONAS GINGIVALIS GINGIPAIN K (KGP) IN COMPLEX WITH INHIBITOR KYT-36
Descriptor:Lys-gingipain W83, UNKNOWN ATOM OR ION, SODIUM ION, ...
Authors:Gomis-Ruth, F.X., Guevara, T., Rofdriguez-Banqueri, A.
Deposit date:2018-11-22
Release date:2019-03-13
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor.
Sci Rep, 9, 2019