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4A0D
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STRUCTURE OF UNLIGANDED HUMAN PARG CATALYTIC DOMAIN
Descriptor:POLY(ADP-RIBOSE) GLYCOHYDROLASE, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL, ...
Authors:Brassington, C., Ellston, J., Hassall, G., Holdgate, G., McAlister, M., Overman, R., Smith, G., Tucker, J.A., Watson, M.
Deposit date:2011-09-08
Release date:2012-10-17
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1G
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STRUCTURE OF UNLIGANDED HUMAN PARG CATALYTIC DOMAIN
Descriptor:POLY(ADP-RIBOSE) GLYCOHYDROLASE, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, SULFATE ION
Authors:Brassington, C., Ellston, J., Hassall, G., Holdgate, G., McAlister, M., Overman, R., Smith, G., Tucker, J.A., Watson, M.
Deposit date:2012-07-10
Release date:2012-12-19
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1H
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STRUCTURE OF HUMAN PARG CATALYTIC DOMAIN IN COMPLEX WITH ADP-RIBOSE
Descriptor:POLY(ADP-RIBOSE) GLYCOHYDROLASE, BETA-MERCAPTOETHANOL, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, ...
Authors:Brassington, C., Ellston, J., Hassall, G., Holdgate, G., McAlister, M., Smith, G., Tucker, J.A., Watson, M.
Deposit date:2012-07-10
Release date:2012-12-19
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1I
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STRUCTURE OF HUMAN PARG CATALYTIC DOMAIN IN COMPLEX WITH OA-ADP-HPD
Descriptor:POLY(ADP-RIBOSE) GLYCOHYDROLASE, (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL, ...
Authors:Brassington, C., Ellston, J., Hassall, G., Holdgate, G., Johnson, T., McAlister, M., Smith, G., Tucker, J.A., Watson, M.
Deposit date:2012-07-10
Release date:2012-12-19
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1J
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STRUCTURE OF HUMAN PARG CATALYTIC DOMAIN IN COMPLEX WITH ADP-HPD
Descriptor:POLY(ADP-RIBOSE) GLYCOHYDROLASE, GLYCEROL, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, ...
Authors:Brassington, C., Ellston, J., Hassall, G., Holdgate, G., McAlister, M., Overman, R., Smith, G., Tucker, J.A., Watson, M.
Deposit date:2012-07-10
Release date:2012-12-19
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
5AD2
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BIVALENT BINDING TO BET BROMODOMAINS
Descriptor:BROMODOMAIN-CONTAINING PROTEIN 4, (3R)-4-(2-{4-[1-(3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy}ethyl)-1,3-dimethyl-2-piperazinone
Authors:Waring, M.J., Chen, H., Rabow, A.A., Walker, G., Bobby, R., Boiko, S., Bradbury, R.H., Callis, R., Dale, I., Daniels, D., Flavell, L., Holdgate, G., Jowitt, T.A., Kikhney, A., McAlister, M., Ogg, D., Patel, J., Petteruti, P., Robb, G.R., Robers, M., Stratton, N., Svergun, D.I., Wang, W., Whittaker, D.
Deposit date:2015-08-19
Release date:2016-09-28
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Potent and Selective Bivalent Inhibitors of Bet Bromodomains
Nat.Chem.Biol., 12, 2016
5AD3
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BIVALENT BINDING TO BET BROMODOMAINS
Descriptor:BROMODOMAIN-CONTAINING PROTEIN 4, 3-methoxy-N-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-N-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine
Authors:Waring, M.J., Chen, H., Rabow, A.A., Walker, G., Bobby, R., Boiko, S., Bradbury, R.H., Callis, R., Dale, I., Daniels, D., Flavell, L., Holdgate, G., Jowitt, T.A., Kikhney, A., McAlister, M., Ogg, D., Patel, J., Petteruti, P., Robb, G.R., Robers, M., Stratton, N., Svergun, D.I., Wang, W., Whittaker, D.
Deposit date:2015-08-19
Release date:2016-09-28
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Potent and Selective Bivalent Inhibitors of Bet Bromodomains
Nat.Chem.Biol., 12, 2016
1H70
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DDAH FROM PSEUDOMONAS AERUGINOSA. C249S MUTANT COMPLEXED WITH CITRULLINE
Descriptor:NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE, CITRULLINE
Authors:Murray-Rust, J., Leiper, J., McAlister, M., Phelan, J., Tilley, S., Santamaria, J., Vallance, P., McDonald, N.
Deposit date:2001-06-30
Release date:2001-08-02
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase.
Nat. Struct. Biol., 8, 2001
3ZEW
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CRYSTAL STRUCTURE OF EPHB4 IN COMPLEX WITH STAUROSPORINE
Descriptor:EPHRIN TYPE-B RECEPTOR 4, STAUROSPORINE, SULFATE ION
Authors:Debreczeni, J.E., Overman, R., Truman, C., McAlister, M., Attwood, T.K.
Deposit date:2012-12-07
Release date:2013-12-25
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Completing the Structural Family Portrait of the Human Ephb Tyrosine Kinase Domains
Protein Sci., 23, 2014
3ZFM
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CRYSTAL STRUCTURE OF EPHB2
Descriptor:EPHRIN TYPE-B RECEPTOR 2
Authors:Debreczeni, J.E., Overman, R., Truman, C., McAlister, M., Attwood, T.K.
Deposit date:2012-12-12
Release date:2014-01-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Completing the Structural Family Portrait of the Human Ephb Tyrosine Kinase Domains
Protein Sci., 23, 2014
3ZFX
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CRYSTAL STRUCTURE OF EPHB1
Descriptor:EPHRIN TYPE-B RECEPTOR 1, SULFATE ION
Authors:Debreczeni, J.E., Overman, R., Truman, C., McAlister, M., Attwood, T.K.
Deposit date:2012-12-12
Release date:2014-01-08
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Completing the Structural Family Portrait of the Human Ephb Tyrosine Kinase Domains
Protein Sci., 23, 2014
3ZFY
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CRYSTAL STRUCTURE OF EPHB3
Descriptor:EPHRIN TYPE-B RECEPTOR 3
Authors:Debreczeni, J.E., Overman, R., Truman, C., McAlister, M., Attwood, T.K.
Deposit date:2012-12-12
Release date:2014-01-08
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Completing the Structural Family Portrait of the Human Ephb Tyrosine Kinase Domains
Protein Sci., 23, 2014
2VWU
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EPHB4 KINASE DOMAIN INHIBITOR COMPLEX
Descriptor:EPHRIN TYPE-B RECEPTOR 4, N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine
Authors:Read, J., Brassington, C.A., Green, I., McCall, E.J., Valentine, A.L., Barratt, D., Rowsell, S., Packer, M., McAlister, M.
Deposit date:2008-06-27
Release date:2008-07-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines
Bioorg.Med.Chem.Lett., 18, 2008
1GNU
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GABA(A) RECEPTOR ASSOCIATED PROTEIN GABARAP
Descriptor:GABARAP, NICKEL (II) ION
Authors:Knight, D., Harris, R., Moss, S., Driscoll, P.C., Keep, N.H.
Deposit date:2001-10-09
Release date:2001-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The X-Ray Crystal Structure and Putative Ligand-Derived Peptide Binding Properties of Gamma-Aminobutyric Acid Receptor Type a Receptor-Associated Protein
J.Biol.Chem., 277, 2002
4IWV
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CRYSTALS STRUCTURE OF HUMAN GLUCOKINASE IN COMPLEX WITH SMALL MOLECULE ACTIVATOR
Descriptor:Glucokinase isoform 3, SODIUM ION, ALPHA-D-GLUCOSE, ...
Authors:Ogg, D.J., Hargreaves, D., Gerhardt, S., Flavell, L., McAlister, M.
Deposit date:2013-01-24
Release date:2013-04-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets the discovery of AZD3651 and AZD9485
To be Published