5D2N
 
 | Crystal structure of C25-NLV-HLA-A2 complex | Descriptor: | ASN-LEU-VAL-PRO-MET-VAL-ALA-THR-VAL, Beta-2-microglobulin, C25 alpha, ... | Authors: | Mariuzza, R.A, Yang, X. | Deposit date: | 2015-08-05 | Release date: | 2015-10-07 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Structural Basis for Clonal Diversity of the Public T Cell Response to a Dominant Human Cytomegalovirus Epitope. J.Biol.Chem., 290, 2015
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1NBY
 
 | Crystal Structure of HyHEL-63 complexed with HEL mutant K96A | Descriptor: | Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain | Authors: | Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J. | Deposit date: | 2002-12-04 | Release date: | 2003-04-01 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen Biochemistry, 42, 2003
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1NDG
 
 | Crystal structure of Fab fragment of antibody HyHEL-8 complexed with its antigen lysozyme | Descriptor: | ACETIC ACID, Lysozyme C, antibody kappa light chain, ... | Authors: | Mariuzza, R.A, Li, Y, Li, H, Yang, F, Smith-Gill, S.J. | Deposit date: | 2002-12-09 | Release date: | 2003-06-03 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray snapshots of the maturation of an antibody response to a protein antigen Nat.Struct.Biol., 10, 2003
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1NBZ
 
 | Crystal Structure of HyHEL-63 complexed with HEL mutant K97A | Descriptor: | Lysozyme C, antibody kappa light chain, immunoglobulin gamma 1 chain | Authors: | Mariuzza, R.A, Li, Y, Urrutia, M, Smith-Gill, S.J. | Deposit date: | 2002-12-04 | Release date: | 2003-04-01 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Dissection of binding interactions in the complex between the anti-lysozyme antibody HyHEL-63 and its antigen Biochemistry, 42, 2003
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1NDM
 
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1JCK
 
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7RM4
 
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1DVF
 
 | IDIOTOPIC ANTIBODY D1.3 FV FRAGMENT-ANTIIDIOTOPIC ANTIBODY E5.2 FV FRAGMENT COMPLEX | Descriptor: | FV D1.3, FV E5.2, ZINC ION | Authors: | Braden, B.C, Fields, B.A, Ysern, X, Dall'Acqua, W, Goldbaum, F.A, Poljak, R.J, Mariuzza, R.A. | Deposit date: | 1996-04-13 | Release date: | 1996-08-17 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of an Fv-Fv idiotope-anti-idiotope complex at 1.9 A resolution. J.Mol.Biol., 264, 1996
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8TXQ
 
 | CryoEM structure of non-neutralizing antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2 | Descriptor: | CBH-4B Heavy chain, CBH-4B Light chain, envelope glycoprotein E2 | Authors: | Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A. | Deposit date: | 2023-08-24 | Release date: | 2024-08-28 | Last modified: | 2025-07-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers. Commun Biol, 8, 2025
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8TZY
 
 | CryoEM structure of non-neutralizing bivalent antibody CBH-4B in complex with Hepatitis C virus envelope glycoprotein E2 | Descriptor: | CBH4B Heavy chain, CBH4B Light chain, envelope glycoprotein E2 | Authors: | Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A. | Deposit date: | 2023-08-28 | Release date: | 2024-09-04 | Last modified: | 2025-07-09 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers. Commun Biol, 8, 2025
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8U9Y
 
 | CryoEM structure of neutralizing antibody HC84.26 in complex with Hepatitis C virus envelope glycoprotein E2_New interface | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... | Authors: | Shahid, S, Liqun, J, Liu, Y, Hasan, S.S, Mariuzza, R.A. | Deposit date: | 2023-09-20 | Release date: | 2024-09-25 | Last modified: | 2025-07-09 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers. Commun Biol, 8, 2025
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2G9H
 
 | Crystal Structure of Staphylococcal Enterotoxin I (SEI) in Complex with a Human MHC class II Molecule | Descriptor: | 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HLA class II histocompatibility antigen, ... | Authors: | Fernandez, M.M, Guan, R, Malchiodi, E.L, Mariuzza, R.A. | Deposit date: | 2006-03-06 | Release date: | 2006-07-11 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of staphylococcal enterotoxin I (SEI) in complex with a human major histocompatibility complex class II molecule. J.Biol.Chem., 281, 2006
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1JWU
 
 | Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1 (HA peptide 306-318) with the superantigen SEC3 Variant 3B2 | Descriptor: | Enterotoxin type C-3, HA peptide, HLA class II histocompatibility antigen, ... | Authors: | Sundberg, E.J, Andersen, P.S, Schlievert, P.M, Karjalainen, K, Mariuzza, R.A. | Deposit date: | 2001-09-05 | Release date: | 2003-07-08 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity
maturation Structure, 11, 2003
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8YJ3
 
 | N17.1.2 recognition of NRAS neoantigens | Descriptor: | tcr alpha, tcr beta | Authors: | Wu, D.C, Mariuzza, R.A. | Deposit date: | 2024-02-29 | Release date: | 2024-12-04 | Method: | X-RAY DIFFRACTION (3.503 Å) | Cite: | Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens. Sci Adv, 10, 2024
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8YIV
 
 | N17.1.2 recognition of NRAS neoantigens | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | Authors: | Wu, D.C, Mariuzza, R.A. | Deposit date: | 2024-02-29 | Release date: | 2024-12-04 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens. Sci Adv, 10, 2024
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8YJ2
 
 | N17.1.2 recognition of NRAS neoantigens | Descriptor: | Beta-2-microglobulin, ILE-LEU-ASP-THR-ALA-GLY-ARG-GLU-GLU-TYR, human leukocyte antigen, ... | Authors: | Wu, D.C, Mariuzza, R.A. | Deposit date: | 2024-02-29 | Release date: | 2024-12-04 | Method: | X-RAY DIFFRACTION (2.261 Å) | Cite: | Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens. Sci Adv, 10, 2024
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7RD2
 
 | Co-crystal structure of Chaetomium glucosidase with compound 2 | Descriptor: | (2R,3R,4R,5S)-1-{[4-({4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-nitroanilino}methyl)phenyl]methyl}-2-(hydroxymethyl)piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chaetomium alpha glucosidase, ... | Authors: | Karade, S.S, Mariuzza, R.A. | Deposit date: | 2021-07-09 | Release date: | 2023-02-22 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum alpha-Glucosidase I with Anti-SARS-CoV-2 Activity. J.Med.Chem., 66, 2023
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3C8J
 
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6VQO
 
 | T cell receptor-p53-HLA-A2 complex | Descriptor: | Beta-2-microglobulin, MHC class I antigen, T-cell receptor 1a2, ... | Authors: | Wu, D, Gallagher, D.T, Pierce, B.G, Mariuzza, R.A. | Deposit date: | 2020-02-05 | Release date: | 2020-06-17 | Last modified: | 2024-11-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen. Nat Commun, 11, 2020
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6VR1
 
 | Complex of HLA-A2, a class I MHC, with a p53 peptide | Descriptor: | Beta-2-microglobulin, Cellular tumor antigen p53 peptide, MHC class I antigen | Authors: | Wu, D, Pierce, B.G, Gallagher, D.T, Mariuzza, R.A. | Deposit date: | 2020-02-06 | Release date: | 2020-06-10 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen. Nat Commun, 11, 2020
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6VTH
 
 | p53-specific T cell receptor | Descriptor: | SULFATE ION, T-cell Receptor 12-6, Alfa chain, ... | Authors: | Wu, D, Gallagher, D.T, Gowthaman, R, Pierce, B.G, Mariuzza, R.A. | Deposit date: | 2020-02-12 | Release date: | 2020-06-17 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Structural basis for oligoclonal T cell recognition of a shared p53 cancer neoantigen. Nat Commun, 11, 2020
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8FWH
 
 | Crystal structure of bivalent antibody Fab fragment of Anti-human LAG3 (22D2) | Descriptor: | 1,2-ETHANEDIOL, Anti-human LAG3 (22D2) heavy chain, Anti-human LAG3 (22D2) light chain | Authors: | Mishra, A.K, Agnihotri, P, Mariuzza, R.A. | Deposit date: | 2023-01-22 | Release date: | 2023-09-06 | Last modified: | 2024-11-20 | Method: | X-RAY DIFFRACTION (2.833 Å) | Cite: | CryoEM structure of a therapeutic antibody (favezelimab) bound to human LAG3 determined using a bivalent Fab as fiducial marker. Structure, 31, 2023
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8GOP
 
 | SARS-CoV-2 specific private TCR RLQ7 | Descriptor: | SARS-CoV-2 specific private TCR RLQ7 alpha, SARS-CoV-2 specific private TCR RLQ7 beta | Authors: | Wu, D, Mariuzza, R.A. | Deposit date: | 2022-08-25 | Release date: | 2023-03-01 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural insights into protection against a SARS-CoV-2 spike variant by T cell receptor (TCR) diversity. J.Biol.Chem., 299, 2023
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8GOM
 
 | SARS-CoV-2 specific private TCR RLQ7 in complex with RLQ-HLA-A2 | Descriptor: | Beta-2-microglobulin, MHC class I antigen, SARS-CoV-2 specific private TCR RLQ7 alpha, ... | Authors: | Wu, D, Mariuzza, R.A. | Deposit date: | 2022-08-25 | Release date: | 2023-03-01 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2.783 Å) | Cite: | Structural insights into protection against a SARS-CoV-2 spike variant by T cell receptor (TCR) diversity. J.Biol.Chem., 299, 2023
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8GON
 
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