Author results

6XE6
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STRUCTURE OF HUMAN DISPATCHED-1 (DISP1)
分子名称:Protein dispatched homolog 1, CHOLESTEROL HEMISUCCINATE, N-ACETYL-D-GLUCOSAMINE
著者Chen, H., Liu, Y., Li, X.
登録日2020-06-12
公開日2020-07-08
実験手法ELECTRON MICROSCOPY (4.54 Å)
主引用文献Structure of Human Dispatched-1 (DISP1)
To Be Published
6LON
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CRYSTAL STRUCTURE OF HPSG
分子名称:PFL2/glycerol dehydratase family glycyl radical enzyme, (2~{S})-2,3-bis(oxidanyl)propane-1-sulfonic acid, GLYCEROL, ...
著者Liu, J., Zhang, Y., Yuchi, Z.
登録日2020-01-06
公開日2020-06-24
最終更新日2020-07-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate.
Proc.Natl.Acad.Sci.USA, 2020
6W1G
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CRYSTAL STRUCTURE OF THE HYDROXYGLUTARATE SYNTHASE FROM PSEUDOMONAS PUTIDA
分子名称:Hydroxyglutarate synthase, NICKEL (II) ION
著者Pereira, J.H., Thompson, M.G., Blake-Hedges, J.M., Keasling, J.D., Adams, P.D.
登録日2020-03-04
公開日2020-06-24
実験手法X-RAY DIFFRACTION (1.14 Å)
主引用文献An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism.
Nat Commun, 11, 2020
6W1H
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CRYSTAL STRUCTURE OF THE HYDROXYGLUTARATE SYNTHASE IN COMPLEX WITH 2-OXOADIPATE FROM PSEUDOMONAS PUTIDA
分子名称:Hydroxyglutarate synthase, NICKEL (II) ION, 2-OXOADIPIC ACID
著者Pereira, J.H., Thompson, M.G., Blake-Hedges, J.M., Keasling, J.D., Adams, P.D.
登録日2020-03-04
公開日2020-06-24
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism.
Nat Commun, 11, 2020
6W1K
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CRYSTAL STRUCTURE OF THE HYDROXYGLUTARATE SYNTHASE IN COMPLEX WITH 2-OXOADIPATE FROM ORYZA SATIVA
分子名称:Hydroxyglutarate synthase, NICKEL (II) ION, 2-OXOADIPIC ACID, ...
著者Pereira, J.H., Thompson, M.G., Blake-Hedges, J.M., Keasling, J.D., Adams, P.D.
登録日2020-03-04
公開日2020-06-24
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism.
Nat Commun, 11, 2020
6XZ8
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STRUCTURE OF ALDOSTERONE SYNTHASE (CYP11B2) IN COMPLEX WITH N-[(1R)-1-[5-(6-CHLORO-1,1-DIMETHYL-3-OXO-ISOINDOLIN-2-YL)-3-PYRIDYL]ETHYL]METHANESULFONAMIDE
分子名称:Cytochrome P450 11B2, mitochondrial, HEME C, ...
著者Kuglstatter, A., Joseph, C., Benz, J.
登録日2020-02-03
公開日2020-06-24
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
J.Med.Chem., 2020
6XZ9
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STRUCTURE OF ALDOSTERONE SYNTHASE (CYP11B2) IN COMPLEX WITH 5-CHLORO-3,3-DIMETHYL-2-[5-[1-(1-METHYLPYRAZOLE-4-CARBONYL)AZETIDIN-3-YL]OXY-3-PYRIDYL]ISOINDOLIN-1-ONE
分子名称:Cytochrome P450 11B2, mitochondrial, HEME C, ...
著者Kuglstatter, A., Joseph, C., Benz, J.
登録日2020-02-03
公開日2020-06-24
実験手法X-RAY DIFFRACTION (2.77 Å)
主引用文献Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
J.Med.Chem., 2020
7BTA
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CRYSTAL STRUCTURE OF RHEB D60K MUTANT BOUND TO GDP
分子名称:GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION
著者Zhang, C., Zhang, T., Ding, J.
登録日2020-03-31
公開日2020-06-17
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
J Mol Cell Biol, 2020
7BTC
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CRYSTAL STRUCTURE OF RHEB Y35N MUTANT BOUND TO GDP
分子名称:GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE
著者Zhang, C., Zhang, T., Ding, J.
登録日2020-04-01
公開日2020-06-17
実験手法X-RAY DIFFRACTION (2.101 Å)
主引用文献Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
J Mol Cell Biol, 2020
7BTD
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CRYSTAL STRUCTURE OF RHEB Y35N MUTANT BOUND TO GPPNHP
分子名称:GTP-binding protein Rheb, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Zhang, C., Zhang, T., Ding, J.
登録日2020-04-01
公開日2020-06-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
J Mol Cell Biol, 2020
7BWN
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CRYSTAL STRUCTURE OF A DESIGNED PROTEIN HETEROCATENANE
分子名称:Chimera of Green fluorescent protein and p53dim, Cellular tumor antigen p53
著者Liu, Y.J., Duan, Z.L., Fang, J., Zhang, F., Xiao, J.Y., Zhang, W.B.
登録日2020-04-15
公開日2020-06-17
最終更新日2020-06-24
実験手法X-RAY DIFFRACTION (2.396 Å)
主引用文献Cellular Synthesis and Crystal Structure of a Designed Protein Heterocatenane.
Angew.Chem.Int.Ed.Engl., 2020
6JHP
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CRYSTAL STRUCTURE OF THE GLYCOSIDE HYDROLASE FAMILY 36 ALPHA-GALACTOSIDASE FROM PAECILOMYCES THERMOPHILA
分子名称:Alpha-galactosidase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Liu, Y., Huang, P., Ma, J., Jiang, Z.
登録日2019-02-18
公開日2020-05-20
実験手法X-RAY DIFFRACTION (2.559 Å)
主引用文献Crystal structure and phylogenetic analysis of the glycoside hydrolase family 36 alpha-galactosidase from Paecilomyces thermophila
To be published
7BZ5
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STRUCTURE OF COVID-19 VIRUS SPIKE RECEPTOR-BINDING DOMAIN COMPLEXED WITH A NEUTRALIZING ANTIBODY
分子名称:Spike protein S1, Heavy chain of B38, Light chain of B38, ...
著者Wu, Y., Qi, J., Gao, F.
登録日2020-04-26
公開日2020-05-13
最終更新日2020-06-24
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2.
Science, 368, 2020
6VBN
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CRYSTAL STRUCTURE OF HTDO2 BOUND TO INHIBITOR GNE1
分子名称:Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, 1,5-anhydro-2,3-dideoxy-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-D-threo-pentitol
著者Harris, S.F., Oh, A.
登録日2019-12-19
公開日2020-05-06
実験手法X-RAY DIFFRACTION (3.18 Å)
主引用文献Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
Acs Med.Chem.Lett., 11, 2020
6L0O
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WH DOMAIN OF HUMAN MCM8
分子名称:DNA helicase MCM8, SULFATE ION
著者Liu, Y., Li, J., Liu, L., Zeng, H.
登録日2019-09-26
公開日2020-04-29
最終更新日2020-06-03
実験手法X-RAY DIFFRACTION (1.21 Å)
主引用文献Crystal structure of the winged-helix domain of MCM8.
Biochem.Biophys.Res.Commun., 526, 2020
6JWD
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STRUCTURE OF RET G-QUADRUPLEX IN COMPLEX WITH BERBERINE
分子名称:DNA (5'-D(*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3'), BERBERINE
著者Wang, F., Wang, C., Liu, Y., Lan, W.X., Li, Y.M., Wang, R.X., Cao, C.
登録日2019-04-19
公開日2020-04-22
実験手法SOLUTION NMR
主引用文献Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR.
Chem.Commun.(Camb.), 56, 2020
6P9V
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CRYSTAL STRUCTURE OF HMAT MUTANT K289L
分子名称:S-adenosylmethionine synthase isoform type-2, ADENOSINE, POTASSIUM ION, ...
著者Miller, M.D., Xu, W., Huber, T.D., Clinger, J.A., Liu, Y., Thorson, J.S., Philips Jr., G.N.
登録日2019-06-10
公開日2020-04-22
実験手法X-RAY DIFFRACTION (2.051 Å)
主引用文献Methionine Adenosyltransferase Engineering to Enable Bioorthogonal Platforms for AdoMet-Utilizing Enzymes.
Acs Chem.Biol., 15, 2020
6KNY
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STRUCTURE OF AMUC_1100 WITHOUT TRANSMEMBRANE REGION FROM AKKERMANSIA MUCINIPHILA
分子名称:Protein Amuc_1100
著者Mou, L.Q., Xiao, Q.J., Deng, D.
登録日2019-08-07
公開日2020-04-15
最終更新日2020-04-22
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of monomeric Amuc_1100 from Akkermansia muciniphila.
Acta Crystallogr.,Sect.F, 76, 2020
6JPI
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CRYSTAL STRUCTURE OF PA4674 IN COMPLEX WITH ITS OPERATOR DNA (28BP) FROM PSEUDOMONAS AERUGINOSA
分子名称:HTH cro/C1-type domain-containing protein, DNA (28-MER)
著者Liu, Y., Gao, Z., Zhang, H., Dong, Y.
登録日2019-03-27
公開日2020-04-01
実験手法X-RAY DIFFRACTION (3.143 Å)
主引用文献Crystal structure of PA4674 in complex with its operator DNA (28bp) from Pseudomonas aeruginosa
To Be Published
6V3N
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CRYSTAL STRUCTURE OF CDYL2 IN COMPLEX WITH H3K27ME3
分子名称:Chromodomain Y-like protein 2, ACE-GLN-LEU-ALA-THR-LYS-ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA-THR-TYR-NH2, UNKNOWN ATOM OR ION
著者Qin, S., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
登録日2019-11-26
公開日2020-04-01
最終更新日2020-06-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 2020
6OAI
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CRYSTAL STRUCTURE OF P[6] ROTAVIRUS VP8* COMPLEXED WITH LNFPI
分子名称:Protease-sensitive outer capsid protein, 6-deoxy-alpha-L-galactopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->3)-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose
著者Xu, S., Liu, Y., Jiang, X., Kennedy, M.A.
登録日2019-03-16
公開日2020-03-18
最終更新日2020-04-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular basis of P[II] major human rotavirus VP8* domain recognition of histo-blood group antigens.
Plos Pathog., 16, 2020
6PPO
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RHINOVIRUS C15 COMPLEXED WITH DOMAIN I OF RECEPTOR CDHR3
分子名称:Capsid protein VP1, Capsid protein VP3, Capsid protein VP2, ...
著者Sun, Y., Watters, K., Klose, T., Palmenberg, A.C.
登録日2019-07-08
公開日2020-03-11
最終更新日2020-04-15
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structure of rhinovirus C15a bound to its cadherin-related protein 3 receptor.
Proc.Natl.Acad.Sci.USA, 117, 2020
6PSF
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RHINOVIRUS C15 COMPLEXED WITH DOMAINS I AND II OF RECEPTOR CDHR3
分子名称:Capsid protein VP1, Capsid protein VP3, Capsid protein VP2, ...
著者Sun, Y., Watters, K., Klose, T., Palmenberg, A.C.
登録日2019-07-12
公開日2020-03-11
最終更新日2020-04-15
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Cryo-EM structure of rhinovirus C15a bound to its cadherin-related protein 3 receptor.
Proc.Natl.Acad.Sci.USA, 117, 2020
6JWE
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STRUCTURE OF RET G-QUADRUPLEX IN COMPLEX WITH COLCHICINE
分子名称:DNA (5'-D(*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3'), N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide
著者Wang, F., Wang, C., Liu, Y., Lan, W.X., Li, Y.M., Wang, R.X., Cao, C.
登録日2019-04-20
公開日2020-02-26
最終更新日2020-03-04
実験手法SOLUTION NMR
主引用文献Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR.
Chem.Commun.(Camb.), 56, 2020
6L3F
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THE STRUCTURE OF UTP:RNA URIDYLYLTRANSFERASE 1 (URT1) IN IN ARABIDOPSIS
分子名称:UTP:RNA uridylyltransferase 1
著者Lingru, Z.
登録日2019-10-10
公開日2020-01-29
最終更新日2020-04-01
実験手法X-RAY DIFFRACTION (1.975 Å)
主引用文献Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
Biochem.Biophys.Res.Commun., 524, 2020