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6BLI
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BU of 6bli by Molmil
RSV G peptide bound to Fab CB002.5
Descriptor: CB002.5 Fab Heavy Chain, CB002.5 Fab Light Chain, Major surface glycoprotein G
Authors:Jones, H.G, McLellan, J.S, Langedijk, J.P.
Deposit date:2017-11-10
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.
PLoS Pathog., 14, 2018
1BRV
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BU of 1brv by Molmil
SOLUTION NMR STRUCTURE OF THE IMMUNODOMINANT REGION OF PROTEIN G OF BOVINE RESPIRATORY SYNCYTIAL VIRUS, 48 STRUCTURES
Descriptor: PROTEIN G
Authors:Doreleijers, J.F, Langedijk, J.P.M, Hard, K, Rullmann, J.A.C, Boelens, R, Schaaper, W.M, Van Oirschot, J.T, Kaptein, R.
Deposit date:1996-03-29
Release date:1997-06-05
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the immunodominant region of protein G of bovine respiratory syncytial virus.
Biochemistry, 35, 1996
6BLH
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BU of 6blh by Molmil
RSV G central conserved region bound to Fab CB017.5
Descriptor: 1,2-ETHANEDIOL, Fab CB017.5 heavy chain, Fab CB017.5 light chain, ...
Authors:Jones, H.G, McLellan, J.S, Langedijk, J.P.
Deposit date:2017-11-10
Release date:2018-02-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.
PLoS Pathog., 14, 2018
5KWW
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BU of 5kww by Molmil
Crystal Structure of Inhibitor JNJ-53718678 In Complex with Prefusion RSV F Glycoprotein
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[[5-chloranyl-1-(3-methylsulfonylpropyl)indol-2-yl]methyl]-1-[2,2,2-tris(fluoranyl)ethyl]imidazo[4,5-c]pyridin-2-one, ...
Authors:McLellan, J.S, Battles, M.B, Arnoult, E, Roymans, D, Langedijk, J.P.
Deposit date:2016-07-19
Release date:2017-08-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor.
Nat Commun, 8, 2017
5C6B
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BU of 5c6b by Molmil
Crystal Structure of Prefusion-stabilized RSV F variant SC-TM
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CHLORIDE ION, Fusion glycoprotein F0,Fibritin, ...
Authors:McLellan, J.S, Langedijk, J.P.M.
Deposit date:2015-06-22
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism.
Nat Commun, 6, 2015
5C69
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BU of 5c69 by Molmil
Crystal Structure of Prefusion-stabilized RSV F variant PR-DM
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CHLORIDE ION, Fusion glycoprotein F0,Fibritin, ...
Authors:McLellan, J.S, Langedijk, J.P.M.
Deposit date:2015-06-22
Release date:2015-09-23
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism.
Nat Commun, 6, 2015
5EA6
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BU of 5ea6 by Molmil
Crystal Structure of Inhibitor BTA-9881 in Complex with Prefusion RSV F Glycoprotein
Descriptor: (9~{b}~{R})-9~{b}-(4-chlorophenyl)-1-pyridin-3-ylcarbonyl-2,3-dihydroimidazo[5,6]pyrrolo[1,2-~{a}]pyridin-5-one, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
5EA5
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BU of 5ea5 by Molmil
Crystal Structure of Inhibitor TMC-353121 in Complex with Prefusion RSV F Glycoprotein
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol, D(-)-TARTARIC ACID, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
5EA8
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BU of 5ea8 by Molmil
Crystal Structure of Prefusion RSV F Glycoprotein Fusion Inhibitor Resistance Mutant D489Y
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, D(-)-TARTARIC ACID, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
5EA4
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BU of 5ea4 by Molmil
Crystal Structure of Inhibitor JNJ-49153390 in Complex with Prefusion RSV F Glycoprotein
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 3-[[5-bromanyl-1-(3-methylsulfonylpropyl)benzimidazol-2-yl]methyl]-1-cyclopropyl-imidazo[4,5-c]pyridin-2-one, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
5EA3
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BU of 5ea3 by Molmil
Crystal Structure of Inhibitor JNJ-2408068 in Complex with Prefusion RSV F Glycoprotein
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[2-[[1-(2-azanylethyl)piperidin-4-yl]amino]-4-methyl-benzimidazol-1-yl]methyl]-6-methyl-pyridin-3-ol, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Langedijk, J.P, Roymans, D.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
5EA7
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BU of 5ea7 by Molmil
Crystal Structure of Inhibitor BMS-433771 in Complex with Prefusion RSV F Glycoprotein
Descriptor: 1-cyclopropyl-3-[[1-(4-oxidanylbutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.851 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
6VKM
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BU of 6vkm by Molmil
Crystal Structure of Stabilized GP from Makona Variant of Ebola Virus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Virion spike glycoprotein
Authors:Gilman, M.S.A, Rutten, L, Langedijk, J.P.M, McLellan, J.S.
Deposit date:2020-01-21
Release date:2020-04-15
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers.
Cell Rep, 30, 2020
7A4N
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BU of 7a4n by Molmil
Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and V987P)(S-closed trimer)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin
Authors:Rutten, L, Renault, L.L.R, Juraszek, J, Langedijk, J.P.M.
Deposit date:2020-08-20
Release date:2020-11-04
Last modified:2021-01-27
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Stabilizing the closed SARS-CoV-2 spike trimer.
Nat Commun, 12, 2021
7AD1
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BU of 7ad1 by Molmil
Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and V987P)(One up trimer)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Envelope glycoprotein,Spike glycoprotein,Envelope glycoprotein,SARS-CoV-2 S protein
Authors:Rutten, L, Renault, L.L.R, Juraszek, J, Langedijk, J.P.M.
Deposit date:2020-09-14
Release date:2020-11-04
Last modified:2021-01-27
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Stabilizing the closed SARS-CoV-2 spike trimer.
Nat Commun, 12, 2021
7QA4
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BU of 7qa4 by Molmil
Crystal structure of stabilized H3N2 A/Hong Kong/1/1968 Hemagglutinin at 2.2 Angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:Milder, F.J, Langedijk, J.P.M.
Deposit date:2021-11-16
Release date:2022-02-02
Last modified:2022-03-30
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions.
Proc.Natl.Acad.Sci.USA, 119, 2022
8FU7
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BU of 8fu7 by Molmil
Structure of Covid Spike variant deltaN135 in fully closed form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Yu, X, Juraszek, J, Rutten, L, Bakkers, M.J.G, Blokland, S, Van den Broek, N.J.F, Verwilligen, A.Y.W, Abeywickrema, P, Vingerhoets, J, Neefs, J, Bakhash, S.A.M, Roychoudhury, P, Greninger, A, Sharma, S, Langedijk, J.P.M.
Deposit date:2023-01-16
Release date:2023-04-05
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike.
Plos Pathog., 19, 2023
8FU9
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BU of 8fu9 by Molmil
Structure of Covid Spike variant deltaN25 with one erect RBD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Yu, X, Juraszek, J, Rutten, L, Bakkers, M.J.G, Blokland, S, Van den Broek, N.J.F, Verwilligen, A.Y.W, Abeywickrema, P, Vingerhoets, J, Neefs, J, Bakhash, S.A.M, Roychoudhury, P, Greninger, A, Sharma, S, Langedijk, J.P.M.
Deposit date:2023-01-16
Release date:2023-04-05
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike.
Plos Pathog., 19, 2023
8FU8
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BU of 8fu8 by Molmil
Structure of Covid Spike variant deltaN135 with one erect RBD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Yu, X, Juraszek, J, Rutten, L, Bakkers, M.J.G, Blokland, S, Van den Broek, N.J.F, Verwilligen, A.Y.W, Abeywickrema, P, Vingerhoets, J, Neefs, J, Bakhash, S.A.M, Roychoudhury, P, Greninger, A, Sharma, S, Langedijk, J.P.M.
Deposit date:2023-01-16
Release date:2023-04-05
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (3.08 Å)
Cite:Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike.
Plos Pathog., 19, 2023
8VT2
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BU of 8vt2 by Molmil
cryo-EM structure of HMPV (MPV-2c)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Prefusion of HMPV (MPV-2c), ...
Authors:Yu, X, Langedijk, J.P.M.
Deposit date:2024-01-25
Release date:2024-07-31
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer.
Nat Commun, 15, 2024
8VT3
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BU of 8vt3 by Molmil
cryo-EM structure of HMPV (MPV-2cREKR)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Prefusion of HMPV (MPV-2cREKR), ...
Authors:Yu, X, Langedijk, J.P.M.
Deposit date:2024-01-25
Release date:2024-07-31
Last modified:2024-08-07
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Efficacious human metapneumovirus vaccine based on AI-guided engineering of a closed prefusion trimer.
Nat Commun, 15, 2024
3ZTN
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BU of 3ztn by Molmil
STRUCTURE OF INFLUENZA A NEUTRALIZING ANTIBODY SELECTED FROM CULTURES OF SINGLE HUMAN PLASMA CELLS IN COMPLEX WITH HUMAN H1 INFLUENZA HAEMAGGLUTININ.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FI6V3 ANTIBODY LIGHT CHAIN, ...
Authors:Hubbard, P.A, Ritchie, A.J, Corti, D, Voss, J.E, Gamblin, S.J, Codoni, G, Macagno, A, Jarrossay, D, Pinna, D, Minola, A, Vanzetta, F, Silacci, C, Fernandez-Rodriguez, B.M, Agatic, G, Giacchetto-Sasselli, I, Vachieri, S.G, Sallusto, F, Collins, P.J, Haire, L.F, Temperton, N, Langedijk, J.P.M, Skehel, J.J, Lanzavecchia, A.
Deposit date:2011-07-12
Release date:2011-08-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.001 Å)
Cite:A Neutralizing Antibody Selected from Plasma Cells that Binds to Group 1 and Group 2 Influenza a Hemagglutinins.
Science, 333, 2011
8V5A
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BU of 8v5a by Molmil
Prefusion-stabilized Respirovirus type 3 Fusion protein
Descriptor: Camelid nanobody 4C06, Fusion glycoprotein F0
Authors:Johnson, N.V, McLellan, J.S.
Deposit date:2023-11-30
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein.
Nat Commun, 15, 2024
4B50
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BU of 4b50 by Molmil
Crystal structure of the HIV-1 gp41 MPER-specific llama VHH 2H10
Descriptor: 2H10 LLAMA VHH
Authors:Lutje Hulsik, D, Sabin, C, Macheboeuf, P, Weissenhorn, W.
Deposit date:2012-08-02
Release date:2013-03-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A Gp41 Mper-Specific Llama Vhh Requires a Hydrophobic Cdr3 for Neutralization But not for Antigen Recognition.
Plos Pathog., 9, 2013
6WIX
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BU of 6wix by Molmil
Crystal Structure of HIV-1 MI369 RnS-DS.SOSIP Prefusion Env Trimer in Complex with Human Antibodies 3H109L and 35O22 at 3.5 Angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Lai, Y.-T, Olia, A, Kwong, P.D.
Deposit date:2020-04-10
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains.
Cell Rep, 33, 2020

 

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