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1O41
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78300.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2-FORMYL-6-METHOXYPHENYL DIHYDROGEN PHOSPHATE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O42
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU81843.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-O-PHOSPHONOTYROSINAMIDE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O43
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82129.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [4-((1Z)-2-(ACETYLAMINO)-3-{[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]AMINO}-3-OXOPROP-1-ENYL)-2-FORMYLPHENYL]ACETIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O44
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85052
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXY-PHENYL}-MALONIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O45
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU84687.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3-FORMYL-O-PHOSPHONOTYROSINAMIDE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O46
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-METHOXYCARBONYL-PHENYL}-2-FLUORO-MALONIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O47
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82209.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-4-[DIFLUORO(PHOSPHONO)METHYL]PHENYLALANINAMIDE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O48
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85053.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 5-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXYMETHYL-BENZOIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O49
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85493.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, {4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-PHOSPHONO-PHENOXY}-ACETIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4A
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82197.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-FORMYL-BENZOIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4B
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU83876.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3,4-DIPHOSPHONOPHENYLALANINAMIDE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4C
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, PHOSPHATE ION
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4D
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78262.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2-FORMYLPHENYL DIHYDROGEN PHOSPHATE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4E
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78299.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2,6-DIFORMYL-4-METHYLPHENYL DIHYDROGEN PHOSPHATE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4F
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79073.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 1,2,3,4-TETRAHYDROQUINOLIN-8-YL DIHYDROGEN PHOSPHATE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4G
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH DPI59.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, HYDROXY(1-NAPHTHYL)METHYLPHOSPHONIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4H
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79072.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2-CYANOQUINOLIN-8-YL DIHYDROGEN PHOSPHATE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4I
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4J
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH ISO24.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4K
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PASBN.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, BENZYL 2-FORMYLPHENYL HYDROGEN PHOSPHATE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4L
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, CITRIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4M
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH MALONICACID.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, MALONIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4N
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH OXALIC ACID.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, OXALIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4O
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHENYLPHOSPHATE.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, PHENYL DIHYDROGEN PHOSPHATE
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4P
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78791.
Descriptor:PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, 2-PHENYLMALONIC ACID
Authors:Lange, G., Loenze, P., Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
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