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1EPF
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CRYSTAL STRUCTURE OF THE TWO N-TERMINAL IMMUNOGLOBULIN DOMAINS OF THE NEURAL CELL ADHESION MOLECULE (NCAM)
Descriptor:PROTEIN (NEURAL CELL ADHESION MOLECULE), CALCIUM ION
Authors:Kasper, C., Rasmussen, H., Kastrup, J.S., Ikemizu, S., Jones, E.Y., Berezin, V., Bock, E., Larsen, I.K.
Deposit date:2000-03-29
Release date:2000-10-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis of cell-cell adhesion by NCAM.
Nat.Struct.Biol., 7, 2000
1MQD
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X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-DES-ME-AMPA AT 1.46 A RESOLUTION. CRYSTALLIZATION IN THE PRESENCE OF LITHIUM SULFATE.
Descriptor:Glutamate receptor subunit 2, SULFATE ION, (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID, ...
Authors:Kasper, C., Lunn, M.-L., Liljefors, T., Gouaux, E., Egebjerg, J., Kastrup, J.S.
Deposit date:2002-09-16
Release date:2003-07-01
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:GluR2 ligand-binding core complexes: Importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists.
FEBS Lett., 531, 2002
1MS7
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X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-DES-ME-AMPA AT 1.97 A RESOLUTION, CRYSTALLIZATION IN THE PRESENCE OF ZINC ACETATE
Descriptor:Glutamate receptor subunit 2, ZINC ION, (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID
Authors:Kasper, C., Lunn, M.-L., Liljefors, T., Gouaux, E., Egebjerg, J., Kastrup, J.S.
Deposit date:2002-09-19
Release date:2003-07-08
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists
FEBS Lett., 531, 2002
2CMO
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THE STRUCTURE OF A MIXED GLUR2 LIGAND-BINDING CORE DIMER IN COMPLEX WITH (S)-GLUTAMATE AND THE ANTAGONIST (S)-NS1209
Descriptor:GLUTAMATE RECEPTOR 2, SULFATE ION, 2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC ACID, ...
Authors:Kasper, C., Pickering, D.S., Mirza, O., Olsen, L., Kristensen, A.S., Greenwood, J.R., Liljefors, T., Schousboe, A., Watjen, F., Gajhede, M., Sigurskjold, B.W., Kastrup, J.S.
Deposit date:2006-05-11
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Structure of a Mixed Glur2 Ligand-Binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-Ns1209.
J.Mol.Biol., 357, 2006
3FAS
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X-RAY STRUCTURE OF IGLUR4 FLIP LIGAND-BINDING CORE (S1S2) IN COMPLEX WITH (S)-GLUTAMATE AT 1.40A RESOLUTION
Descriptor:Glutamate receptor 4, GLUTAMIC ACID, SULFATE ION, ...
Authors:Kasper, C., Frydenvang, K., Naur, P., Gajhede, M., Kastrup, J.S.
Deposit date:2008-11-18
Release date:2008-12-09
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4
Febs Lett., 582, 2008
3FAT
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X-RAY STRUCTURE OF IGLUR4 FLIP LIGAND-BINDING CORE (S1S2) IN COMPLEX WITH (S)-AMPA AT 1.90A RESOLUTION
Descriptor:Glutamate receptor 4, (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, SULFATE ION, ...
Authors:Kasper, C., Frydenvang, K., Naur, P., Gajhede, M., Kastrup, J.S.
Deposit date:2008-11-18
Release date:2008-12-09
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4
Febs Lett., 582, 2008
1QZ1
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CRYSTAL STRUCTURE OF THE IG 1-2-3 FRAGMENT OF NCAM
Descriptor:Neural cell adhesion molecule 1, 140 kDa isoform
Authors:Soroka, V., Kolkova, K., Kastrup, J.S., Diederichs, K., Breed, J., Kiselyov, V.V., Poulsen, F.M., Larsen, I.K., Welte, W., Berezin, V., Bock, E., Kasper, C.
Deposit date:2003-09-15
Release date:2003-11-04
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion
Structure, 11, 2003
1SYH
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X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 1.85 A RESOLUTION.
Descriptor:Glutamate receptor 2, (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID
Authors:Frandsen, A., Pickering, D.S., Vestergaard, B., Kasper, C., Nielsen, B.B., Greenwood, J.R., Campiani, G., Gajhede, M., Schousboe, A., Kastrup, J.S.
Deposit date:2004-04-01
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2.
Mol.Pharmacol., 67, 2005
1SYI
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X-RAY STRUCTURE OF THE Y702F MUTANT OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 2.1 A RESOLUTION.
Descriptor:Glutamate receptor 2, (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID
Authors:Frandsen, A., Pickering, D.S., Vestergaard, B., Kasper, C., Nielsen, B.B., Greenwood, J.R., Campiani, G., Gajhede, M., Schousboe, A., Kastrup, J.S.
Deposit date:2004-04-01
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2.
Mol.Pharmacol., 67, 2005
1XHY
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X-RAY STRUCTURE OF THE Y702F MUTANT OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH KAINATE AT 1.85 A RESOLUTION
Descriptor:Glutamate receptor, SULFATE ION, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE
Authors:Frandsen, A., Pickering, D.S., Vestergaard, B., Kasper, C., Nielsen, B.B., Greenwood, J.R., Campiani, G., Gajhede, M., Schousboe, A., Kastrup, J.S.
Deposit date:2004-09-21
Release date:2005-03-22
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Tyr702 Is an Important Determinant of Agonist Binding and Domain Closure of the Ligand-Binding Core of GluR2.
Mol.Pharmacol., 67, 2005
3OJW
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DISULFIDE CROSSLINKED CYTOCHROME P450 REDUCTASE INACTIVE
Descriptor:NADPH-cytochrome P450 reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Xia, C., Hamdane, D., Shen, A., Choi, V., Kasper, C., Zhang, H., Im, S.-C., Waskell, L., Kim, J.-J.P.
Deposit date:2010-08-23
Release date:2011-02-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding.
J.Biol.Chem., 286, 2011
3OJX
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DISULFIDE CROSSLINKED CYTOCHROME P450 REDUCTASE INACTIVE
Descriptor:NADPH-Cytochrome P450 Reductase, FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Xia, C., Hamdane, D., Shen, A., Choi, V., Kasper, C., Zhang, H., Im, S.-C., Waskell, L., Kim, J.-J.P.
Deposit date:2010-08-23
Release date:2011-02-23
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding.
J.Biol.Chem., 286, 2011
2ANJ
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CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y450W) MUTANT IN COMPLEX WITH THE PARTIAL AGONIST KAINIC ACID AT 2.1 A RESOLUTION
Descriptor:Glutamate receptor 2, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE
Authors:Holm, M.M., Naur, P., Vestergaard, B., Geballe, M.T., Gajhede, M., Kastrup, J.S., Traynelis, S.F., Egebjerg, J.
Deposit date:2005-08-11
Release date:2005-08-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2: a mutagenic, kinetic, and crystallographic study
J.Biol.Chem., 280, 2005
2P2A
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X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-BN-TET-AMPA AT 2.26A RESOLUTION
Descriptor:Glutamate receptor 2, SULFATE ION, GLUTAMIC ACID, ...
Authors:Frydenvang, K., Kastrup, J.S., Gajhede, M.
Deposit date:2007-03-07
Release date:2007-06-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
J.Med.Chem., 50, 2007