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2Z4T
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CRYSTAL STRUCTURE OF VIBRIONACEAE PHOTOBACTERIUM SP. JT-ISH-224 2,6-SIALYLTRANSFERASE IN A TERNARY COMPLEX WITH DONOR PRODUCT CMP AND ACCEPTER SUBSTRATE LACTOSE
Descriptor:Beta-galactoside alpha-2,6-sialyltransferase, ALPHA-LACTOSE, PHOSPHATE ION, ...
Authors:Kakuta, Y., Okino, N., Kajiwara, H., Ichikawa, M., Takakura, Y., Ito, M., Yamamoto, T.
Deposit date:2007-06-25
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of Vibrionaceae Photobacterium sp. JT-ISH-224 alpha2,6-sialyltransferase in a ternary complex with donor product CMP and acceptor substrate lactose: catalytic mechanism and substrate recognition
Glycobiology, 18, 2008
2ZOX
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CRYSTAL STRUCTURE OF THE COVALENT INTERMEDIATE OF HUMAN CYTOSOLIC BETA-GLUCOSIDASE
Descriptor:Cytosolic beta-glucosidase, ALPHA-D-GLUCOSE, 4'-NITROPHENYL-ALPHA-D-GLUCOPYRANOSIDE, ...
Authors:Noguchi, J., Hayashi, Y., Baba, Y., Okino, N., Kimura, M., Ito, M., Kakuta, Y.
Deposit date:2008-06-17
Release date:2008-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the covalent intermediate of human cytosolic beta-glucosidase
Biochem.Biophys.Res.Commun., 374, 2008
2ZWI
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CRYSTAL STRUCTURE OF ALPHA/BETA-GALACTOSIDE ALPHA-2,3-SIALYLTRANSFERASE FROM A LUMINOUS MARINE BACTERIUM, PHOTOBACTERIUM PHOSPHOREUM
Descriptor:Alpha-/beta-galactoside alpha-2,3-sialyltransferase, CYTIDINE-5'-MONOPHOSPHATE, ZINC ION, ...
Authors:Iwatani, T., Okino, N., Sakakura, M., Kajiwara, H., Ichikawa, M., Takakura, Y., Kimura, M., Ito, M., Yamamoto, T., Kakuta, Y.
Deposit date:2008-12-05
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of alpha/beta-galactoside alpha2,3-sialyltransferase from a luminous marine bacterium, Photobacterium phosphoreum
Febs Lett., 583, 2009
3VKK
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CRYSTAL STRUCTURE OF THE COVALENT INTERMEDIATE OF HUMAN CYTOSOLIC BETA-GLUCOSIDASE-MANNOSE COMPLEX
Descriptor:Cytosolic beta-glucosidase, GLYCEROL, CHLORIDE ION, ...
Authors:Noguchi, J., Hayashi, Y., Okino, N., Ito, M., Kimura, M., Kakuta, Y.
Deposit date:2011-11-17
Release date:2012-11-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for inhibition mechanism of human cytosolic beta-glucosidase by monnoside
To be Published
5LVU
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XIAF (APO) FROM STREPTOMYCES SP.
Descriptor:XiaF protein, SULFATE ION
Authors:Kugel, S., Baunach, M., Baer, P., Ishida-Ito, M., Sundaram, S., Xu, Z., Groll, M., Hertweck, C.
Deposit date:2016-09-14
Release date:2017-06-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification.
Nat Commun, 8, 2017
5LVW
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XIAF (FADH2) FROM STREPTOMYCES SP.
Descriptor:XiaF protein, FLAVIN-ADENINE DINUCLEOTIDE, INDOLE, ...
Authors:Kugel, S., Baunach, M., Baer, P., Ishida-Ito, M., Sundaram, S., Xu, Z., Groll, M., Hertweck, C.
Deposit date:2016-09-14
Release date:2017-06-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification.
Nat Commun, 8, 2017
5MR6
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XIAF FROM STREPTOMYCES SP. IN COMPLEX WITH FADH2 AND GLYCEROL
Descriptor:XiaF protein, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL
Authors:Kugel, S., Baunach, M., Baer, P., Ishida-Ito, M., Sundaram, S., Xu, Z., Groll, M., Hertweck, C.
Deposit date:2016-12-21
Release date:2017-06-28
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Cryptic indole hydroxylation by a non-canonical terpenoid cyclase parallels bacterial xenobiotic detoxification.
Nat Commun, 8, 2017
2E9L
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NEUTRAL BETA-GLYCOSYLCERAMIDASE (KLOTHO-RELATED PROTE:KLRP) COMPLEX WITH GLUCOSE AND FATTY ACIDS
Descriptor:Cytosolic beta-glucosidase, BETA-D-GLUCOSE, PALMITIC ACID, ...
Authors:Kakuta, Y., Hayashi, Y., Okino, N., Ito, M.
Deposit date:2007-01-25
Release date:2007-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase.
J.Biol.Chem., 282, 2007
2E9M
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CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC NEUTRAL BETA-GLYCOSYLCERAMIDASE (KLOTHO-RELATED PROTE:KLRP) COMPLEX WITH GALACTOSE AND FATTY ACIDS
Descriptor:Cytosolic beta-glucosidase, BETA-D-GALACTOSE, PALMITIC ACID, ...
Authors:Kakuta, Y., Hayashi, Y., Okino, N., Ito, M.
Deposit date:2007-01-25
Release date:2007-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase.
J.Biol.Chem., 282, 2007
2ZSC
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TAMAVIDIN2, NOVEL AVIDIN-LIKE BIOTIN-BINDING PROTEINS FROM AN EDIBLE MUSHROOM
Descriptor:Tamavidin2, GLYCEROL, BIOTIN, ...
Authors:Kakuta, Y., Okino, N., Ito, M., Yamamoto, T., Takakura, Y.
Deposit date:2008-09-05
Release date:2009-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Tamavidins--novel avidin-like biotin-binding proteins from the Tamogitake mushroom
Febs J., 276, 2009
2ZWS
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CRYSTAL STRUCTURE ANALYSIS OF NEUTRAL CERAMIDASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:Neutral ceramidase, ZINC ION, MAGNESIUM ION, ...
Authors:Kakuta, Y., Okino, N., Inoue, T., Okano, H., Ito, M.
Deposit date:2008-12-17
Release date:2009-03-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase.
J.Biol.Chem., 284, 2009
2ZXC
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CERAMIDASE COMPLEXED WITH C2
Descriptor:Neutral ceramidase, ZINC ION, N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)heptadec-3-en-1-yl]acetamide, ...
Authors:Okano, H., Inoue, T., Okino, N., Kakuta, Y., Matsumura, H., Ito, M.
Deposit date:2008-12-22
Release date:2009-02-03
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mechanistic insights into the hydrolysis and synthesis of ceramide by neutral ceramidase.
J.Biol.Chem., 284, 2009
3GH4
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CRYSTAL STRUCTURE OF BETA-HEXOSAMINIDASE FROM PAENIBACILLUS SP. TS12
Descriptor:beta-hexosaminidase, SULFATE ION, ACETIC ACID
Authors:Sumida, T., Ishii, R., Yanagisawa, T., Yokoyama, S., Ito, M., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2009-03-03
Release date:2009-07-07
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular cloning and crystal structural analysis of a novel beta-N-acetylhexosaminidase from Paenibacillus sp. TS12 capable of degrading glycosphingolipids
J.Mol.Biol., 392, 2009
3GH5
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CRYSTAL STRUCTURE OF BETA-HEXOSAMINIDASE FROM PAENIBACILLUS SP. TS12 IN COMPLEX WITH GLCNAC
Descriptor:beta-hexosaminidase, SULFATE ION, N-ACETYL-D-GLUCOSAMINE
Authors:Sumida, T., Ishii, R., Yanagisawa, T., Yokoyama, S., Ito, M., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2009-03-03
Release date:2009-07-07
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular cloning and crystal structural analysis of a novel beta-N-acetylhexosaminidase from Paenibacillus sp. TS12 capable of degrading glycosphingolipids
J.Mol.Biol., 392, 2009
3GH7
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CRYSTAL STRUCTURE OF BETA-HEXOSAMINIDASE FROM PAENIBACILLUS SP. TS12 IN COMPLEX WITH GALNAC
Descriptor:beta-hexosaminidase, SULFATE ION, N-ACETYL-D-GALACTOSAMINE
Authors:Sumida, T., Ishii, R., Yanagisawa, T., Yokoyama, S., Ito, M., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2009-03-03
Release date:2009-07-07
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Molecular cloning and crystal structural analysis of a novel beta-N-acetylhexosaminidase from Paenibacillus sp. TS12 capable of degrading glycosphingolipids
J.Mol.Biol., 392, 2009
6CKX
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STRUCTURE OF CDK12/CYCK IN COMPLEX WITH A SMALL MOLECULE INHIBITOR N-(4-(1-METHYL-1H-PYRAZOL-4-YL)PHENYL)-N-((1R,4R)-4-(QUINAZOLIN-2-YLAMINO)CYCLOHEXYL)ACETAMIDE
Descriptor:Cyclin-dependent kinase 12, Cyclin-K, MAGNESIUM ION, ...
Authors:Klein, M.G.
Deposit date:2018-03-01
Release date:2018-08-29
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.
J. Med. Chem., 61, 2018
3VPL
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CRYSTAL STRUCTURE OF A 2-FLUOROXYLOTRIOSYL COMPLEX OF THE VIBRIO SP. AX-4 BETA-1,3-XYLANASE
Descriptor:Beta-1,3-xylanase XYL4, 2-deoxy-2-fluoro-beta-D-xylopyranose, BETA-D-XYLOPYRANOSE, ...
Authors:Watanabe, N., Sakaguchi, K.
Deposit date:2012-03-05
Release date:2013-03-06
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The crystal structure of a 2-fluoroxylotriosyl complex of the Vibrio sp. AX-4 beta-1,3-xylanase at 1.2 A resolution
To be Published
1FHG
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HIGH RESOLUTION REFINEMENT OF TELOKIN
Descriptor:TELOKIN
Authors:Tomchick, D.R., Minor, W., Kiyatkin, A., Lewinski, K., Somlyo, A.V., Somlyo, A.P.
Deposit date:2000-08-01
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution.
J.Mol.Biol., 227, 1992
1LOP
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CYCLOPHILIN A COMPLEXED WITH SUCCINYL-ALA-PRO-ALA-P-NITROANILIDE
Descriptor:CYCLOPHILIN A, SUCCINYL-ALA-PRO-ALA-P-NITROANILIDE
Authors:Konno, M.
Deposit date:1996-06-17
Release date:1996-12-23
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The substrate-binding site in Escherichia coli cyclophilin A preferably recognizes a cis-proline isomer or a highly distorted form of the trans isomer.
J.Mol.Biol., 256, 1996
2IBX
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INFLUENZA VIRUS (VN1194) H5 HA
Descriptor:Hemagglutinin, N-ACETYL-D-GLUCOSAMINE
Authors:Yamada, S., Russell, R.J., Gamblin, S.J., Skehel, J.J., Kawaoka, Y.
Deposit date:2006-09-12
Release date:2006-11-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors.
Nature, 444, 2006
3KC6
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CRYSTAL STRUCTURE OF THE LARGE C-TERMINAL DOMAIN OF POLYMERASE BASIC PROTEIN 2 FROM INFLUENZA VIRUS A/VIET NAM/1203/2004 (H5N1)
Descriptor:Polymerase PB2, 1,2-ETHANEDIOL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-10-20
Release date:2010-03-09
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
3KHW
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CRYSTAL STRUCTURE OF THE LARGE C-TERMINAL DOMAIN OF POLYMERASE BASIC PROTEIN 2 FROM INFLUENZA VIRUS A/MEXICO/INDRE4487/2009(H1N1)
Descriptor:Polymerase PB2, GLYCEROL
Authors:Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-10-31
Release date:2010-03-09
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
3L56
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CRYSTAL STRUCTURE OF THE LARGE C-TERMINAL DOMAIN OF POLYMERASE BASIC PROTEIN 2 FROM INFLUENZA VIRUS A/VIET NAM/1203/2004 (H5N1)
Descriptor:Polymerase PB2
Authors:Staker, B.L., Edwards, T., Eric, S., Raymond, A., Stewart, L., Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2009-12-21
Release date:2010-03-09
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Biological and structural characterization of a host-adapting amino acid in influenza virus.
Plos Pathog., 6, 2010
3WXA
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X-RAY CRYSTAL STRUCTURAL ANALYSIS OF THE COMPLEX BETWEEN ALG-2 AND SEC31A PEPTIDE
Descriptor:Programmed cell death protein 6, Protein transport protein Sec31A, ZINC ION
Authors:Takahashi, T., Suzuki, H., Kawasaki, M., Shibata, H., Wakatsuki, S., Maki, M.
Deposit date:2014-07-29
Release date:2015-03-11
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structural Analysis of the Complex between Penta-EF-Hand ALG-2 Protein and Sec31A Peptide Reveals a Novel Target Recognition Mechanism of ALG-2
Int J Mol Sci, 16, 2015
5URJ
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CRYSTAL STRUCTURE OF HUMAN BRR2 IN COMPLEX WITH T-3905516
Descriptor:U5 small nuclear ribonucleoprotein 200 kDa helicase, GLYCEROL, 6-benzyl-3-[(2R)-2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-1-benzopyran-7-yl]-4,6-dihydropyrido[4,3-d]pyrimidine-2,7(3H,8H)-dione
Authors:Klein, M.G., Tjhen, R., Qin, L.
Deposit date:2017-02-10
Release date:2017-07-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2.
J. Med. Chem., 60, 2017
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