Author results

4PQE
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CRYSTAL STRUCTURE OF HUMAN ACETYLCHOLINESTERASE
Descriptor:Acetylcholinesterase
Authors:Dym, O., Unger, T., Toker, L., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2014-03-02
Release date:2015-04-08
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of Human Acetylcholinesterase
To be Published
1S0W
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1B LACTAMSE/ B LACTAMASE INHIBITOR
Descriptor:beta-lactamase TEM, Beta-lactamase inhibitory protein, CALCIUM ION
Authors:Schreiber, G., Reichman, D., Israel Structural Proteomics Center (ISPC)
Deposit date:2004-01-05
Release date:2004-02-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The modular architecture of protein-protein binding interfaces.
Proc.Natl.Acad.Sci.USA, 102, 2005
1U65
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ACHE W. CPT-11
Descriptor:Acetylcholinesterase, BETA-L-FUCOSE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Harel, M., Hyatt, J.L., Brumshtein, B., Morton, C.L., Wadkins, R.W., Silman, I., Sussman, J.L., Potter, P.M., Israel Structural Proteomics Center (ISPC)
Deposit date:2004-07-29
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action
Mol.Pharmacol., 67, 2005
1XXM
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THE MODULAR ARCHITECTURE OF PROTEIN-PROTEIN BINDING SITE
Descriptor:Beta-lactamase TEM, Beta-lactamase inhibitory protein, CALCIUM ION
Authors:Reichmann, D., Rahat, O., Albeck, S., Meged, R., Dym, O., Schreiber, G., Israel Structural Proteomics Center (ISPC)
Deposit date:2004-11-07
Release date:2005-01-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The modular architecture of protein-protein binding interfaces
Proc.Natl.Acad.Sci.USA, 102, 2005
1Y7V
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X-RAY STRUCTURE OF HUMAN ACID-BETA-GLUCOSIDASE COVALENTLY BOUND TO CONDURITOL B EPOXIDE
Descriptor:Glucosylceramidase, N-ACETYL-D-GLUCOSAMINE, SULFATE ION, ...
Authors:Premkumar, L., Sawkar, A.R., Boldin-Adamsky, S., Toker, L., Silman, I., Kelly, J.W., Futerman, A.H., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2004-12-10
Release date:2005-04-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease.
J.Biol.Chem., 280, 2005
1Y7W
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CRYSTAL STRUCTURE OF A HALOTOLERANT CARBONIC ANHYDRASE FROM DUNALIELLA SALINA
Descriptor:Halotolerant alpha-type carbonic anhydrase (dCA II), SODIUM ION, ZINC ION, ...
Authors:Premkumar, L., Greenblatt, H.M., Bageshwar, U.K., Savchenko, T., Gokhman, I., Sussman, J.L., Zamir, A., Israel Structural Proteomics Center (ISPC)
Deposit date:2004-12-10
Release date:2005-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Three-dimensional structure of a halotolerant algal carbonic anhydrase predicts halotolerance of a mammalian homolog.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZGB
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CRYSTAL STRUCTURE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AN (R)-TACRINE(10)-HUPYRIDONE INHIBITOR.
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, (5R)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE
Authors:Haviv, H., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-04-21
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase
J.Am.Chem.Soc., 127, 2005
1ZGC
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CRYSTAL STRUCTURE OF TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH AN (RS)-TACRINE(10)-HUPYRIDONE INHIBITOR.
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, (5S)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE
Authors:Haviv, H., Wong, D.M., Greenblatt, H.M., Carlier, P.R., Pang, Y.P., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-04-21
Release date:2005-08-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase
J.Am.Chem.Soc., 127, 2005
2B5R
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1B LACTAMASE / B LACTAMASE INHIBITOR
Descriptor:Beta-lactamase TEM, Beta-lactamase inhibitory protein
Authors:Rahat, O., Albeck, S., Meged, R., Dym, O., Screiber, G., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-09-29
Release date:2006-04-11
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Binding Hot Spots in the TEM1-BLIP Interface in Light of its Modular Architecture.
J.Mol.Biol., 102, 2006
2B83
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A SINGLE AMINO ACID SUBSTITUTION IN THE CLOSTRIDIUM BEIJERINCKII ALCOHOL DEHYDROGENASE IS CRITICAL FOR THERMOSTABILIZATION
Descriptor:NADP-dependent alcohol dehydrogenase, ZINC ION
Authors:Goihberg, E., Dym, O., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-10-06
Release date:2006-09-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:A single proline substitution is critical for the thermostabilization of Clostridium beijerinckii alcohol dehydrogenase.
Proteins, 66, 2006
2F1O
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CRYSTAL STRUCTURE OF NQO1 WITH DICOUMAROL
Descriptor:NAD(P)H dehydrogenase [quinone] 1, BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE], FLAVIN-ADENINE DINUCLEOTIDE
Authors:Shaul, Y., Asher, G., Dym, O., Tsvetkov, P., Adler, J., Israel Structural Proteomics Center (ISPC)
Deposit date:2005-11-15
Release date:2006-05-16
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol.
Biochemistry, 45, 2006
2NVB
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CONTRIBUTION OF PRO275 TO THE THERMOSTABILITY OF THE ALCOHOL DEHYDROGENASES (ADHS)
Descriptor:NADP-dependent alcohol dehydrogenase, ZINC ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Goihberg, E., Tel-Or, S., Peretz, M., Frolow, F., Dym, O., Burstein, Y., Israel Structural Proteomics Center (ISPC)
Deposit date:2006-11-12
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Thermal stabilization of the protozoan Entamoeba histolytica alcohol dehydrogenase by a single proline substitution
Proteins, 72, 2008
2RCI
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HIGH-RESOLUTION CRYSTAL STRUCTURE OF ACTIVATED CYT2BA MONOMER FROM BACILLUS THURINGIENSIS SUBSP. ISRAELENSIS
Descriptor:Type-2Ba cytolytic delta-endotoxin
Authors:Dym, O., Israel Structural Proteomics Center (ISPC)
Deposit date:2007-09-20
Release date:2008-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-resolution crystal structure of activated Cyt2Ba monomer from Bacillus thuringiensis subsp. israelensis.
J.Mol.Biol., 380, 2008
2RKX
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THE 3D STRUCTURE OF CHAIN D, CYCLASE SUBUNIT OF IMIDAZOLEGLYCEROL_EVOLVEDCEROLPHOSPHATE SYNTHASE
Descriptor:Cyclase subunit of imidazoleglycerol_evolvedcerolphosphate synthase
Authors:Tawfik, D., Khersonsky, O., Albeck, S., Dym, O., Israel Structural Proteomics Center (ISPC)
Deposit date:2007-10-18
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Kemp elimination catalysts by computational enzyme design.
Nature, 453, 2008
3BTN
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CRYSTAL STRUCTURE OF ANTIZYME INHIBITOR, AN ORNITHINE DECARBOXYLASE HOMOLOGOUS PROTEIN
Descriptor:Antizyme inhibitor 1
Authors:Dym, O., Unger, T., Albeck, S., Kahana, C., Israel Structural Proteomics Center (ISPC)
Deposit date:2007-12-30
Release date:2008-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystallographic and biochemical studies revealing the structural basis for antizyme inhibitor function.
Protein Sci., 17, 2008
3BTP
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CRYSTAL STRUCTURE OF AGROBACTERIUM TUMEFACIENS VIRE2 IN COMPLEX WITH ITS CHAPERONE VIRE1: A NOVEL FOLD AND IMPLICATIONS FOR DNA BINDING
Descriptor:Single-strand DNA-binding protein, Protein virE1, AMMONIUM ION, ...
Authors:Dym, O., Albeck, S., Unger, T., Elbaum, M., Israel Structural Proteomics Center (ISPC)
Deposit date:2007-12-30
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Agrobacterium virulence complex VirE1-VirE2 reveals a flexible protein that can accommodate different partners.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3D3M
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THE CRYSTAL STRUCTURE OF THE C-TERMINAL REGION OF DEATH ASSOCIATED PROTEIN 5(DAP5)
Descriptor:Eukaryotic translation initiation factor 4 gamma 2
Authors:Dym, O., Israel Structural Proteomics Center (ISPC)
Deposit date:2008-05-12
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of the C-terminal DAP5/p97 domain sheds light on the molecular basis for its processing by caspase cleavage.
J.Mol.Biol., 383, 2008
3GKL
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FOLLOWING EVOLUTIONARY PATHS TO HIGH AFFINITY AND SELECTIVITY PROTEIN-PROTEIN INTERACTIONS USING COLICIN7 AND IMMUNITY PROTEINS
Descriptor:Colicin-E9 immunity protein, Colicin-E7, ZINC ION
Authors:Dym, O., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2009-03-11
Release date:2009-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Following evolutionary paths to high affinity and selectivity protein-protein interactions
To be Published
3HQJ
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STRUCTURE-FUNCTION ANALYSIS OF MYCOBACTERIUM TUBERCULOSIS ACYL CARRIER PROTEIN SYNTHASE (ACPS).
Descriptor:Holo-[acyl-carrier-protein] synthase, MAGNESIUM ION, COENZYME A
Authors:Dym, O., Albeck, S., Peleg, Y., Schwarz, A., Shakked, Z., Burstein, Y., Zimhony, O., Israel Structural Proteomics Center (ISPC)
Deposit date:2009-06-07
Release date:2009-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-function analysis of the acyl carrier protein synthase (AcpS) from Mycobacterium tuberculosis.
J.Mol.Biol., 393, 2009
3JXV
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CRYSTAL STRUCTURE OF THE 3 FKBP DOMAINS OF WHEAT FKBP73
Descriptor:70 kDa peptidyl-prolyl isomerase
Authors:Dym, O., Breiman, A., Israel Structural Proteomics Center (ISPC)
Deposit date:2009-09-21
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain.
J Struct Funct Genomics, 11, 2010
3JYM
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CRYSTAL STRUCTURE OF THE 3 FKBP DOMAINS OF WHEAT FKBP73
Descriptor:FK506-binding protein (FKBP) from wheat
Authors:Dym, O., Breiman, A., Israel Structural Proteomics Center (ISPC)
Deposit date:2009-09-22
Release date:2010-06-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain
J.STRUCT.FUNCT.GENOM., 11, 2010
3KIF
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THE CRYSTAL STRUCTURES OF TWO FRAGMENTS TRUNCATED FROM 5-BLADED BETA-PROPELLER LECTIN, TACHYLECTIN-2 (LIB1-B7-18 AND LIB2-D2-15)
Descriptor:5-bladed beta-propeller lectin, 2-ACETAMIDO-2-DEOXY-D-GLUCONO-1,5-LACTONE, SULFATE ION
Authors:Dym, O., Tawfik, D.S., Yadid, I., Israel Structural Proteomics Center (ISPC)
Deposit date:2009-11-02
Release date:2010-04-28
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Metamorphic proteins mediate evolutionary transitions of structure
Proc.Natl.Acad.Sci.USA, 107, 2010
3KIH
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THE CRYSTAL STRUCTURES OF TWO FRAGMENTS TRUNCATED FROM 5-BLADED BETA-PROPELLER LECTIN, TACHYLECTIN-2 (LIB2-D2-15)
Descriptor:5-bladed beta-propeller lectin, 2-ACETAMIDO-2-DEOXY-D-GLUCONO-1,5-LACTONE
Authors:Dym, O., Tawfik, D.S., Yadid, I., Israel Structural Proteomics Center (ISPC)
Deposit date:2009-11-02
Release date:2010-04-28
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Metamorphic proteins mediate evolutionary transitions of structure
Proc.Natl.Acad.Sci.USA, 107, 2010
3NPU
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION
Descriptor:deoxyribose phosphate aldolase
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Dym, O., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-06-29
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
3NPV
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OPTIMIZATION OF THE IN SILICO DESIGNED KEMP ELIMINASE KE70 BY COMPUTATIONAL DESIGN AND DIRECTED EVOLUTION
Descriptor:deoxyribose phosphate aldolase
Authors:Khersonsky, O., Rothlisberge, D., Wollacott, A.M., Dym, O., Baker, D., Tawfik, D.S., Israel Structural Proteomics Center (ISPC)
Deposit date:2010-06-29
Release date:2011-02-09
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Optimization of the in-silico-designed kemp eliminase KE70 by computational design and directed evolution
J.Mol.Biol., 407, 2011
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