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1SVV
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BU of 1svv by Molmil
Initial Stuctural Analysis of Leishmania major Threonine Aldolase
Descriptor: THREONINE ALDOLASE, UNKNOWN LIGAND
Authors:Hol, W.G.J, Robien, M.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2004-03-30
Release date:2004-08-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Initial Structural Analysis of Leishmania major Threonine Aldolase
To be Published
1RHD
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BU of 1rhd by Molmil
STRUCTURE OF BOVINE LIVER RHODANESE. I. STRUCTURE DETERMINATION AT 2.5 ANGSTROMS RESOLUTION AND A COMPARISON OF THE CONFORMATION AND SEQUENCE OF ITS TWO DOMAINS
Descriptor: RHODANESE
Authors:Hol, W.G.J, Ploegman, J.H, Kalk, K.H, Drent, G.
Deposit date:1977-11-23
Release date:1978-01-16
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of bovine liver rhodanese. I. Structure determination at 2.5 A resolution and a comparison of the conformation and sequence of its two domains.
J.Mol.Biol., 123, 1978
6TIM
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BU of 6tim by Molmil
THE ADAPTABILITY OF THE ACTIVE SITE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE AS OBSERVED IN THE CRYSTAL STRUCTURES OF THREE DIFFERENT COMPLEXES
Descriptor: SN-GLYCEROL-3-PHOSPHATE, TRIOSEPHOSPHATE ISOMERASE
Authors:Noble, M.E.M, Wierenga, R.K, Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes.
Proteins, 10, 1991
1HCY
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BU of 1hcy by Molmil
CRYSTAL STRUCTURE OF HEXAMERIC HAEMOCYANIN FROM PANULIRUS INTERRUPTUS REFINED AT 3.2 ANGSTROMS RESOLUTION
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ARTHROPODAN HEMOCYANIN, COPPER (II) ION
Authors:Volbeda, A, Hol, W.G.J.
Deposit date:1991-05-15
Release date:1994-01-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution.
J.Mol.Biol., 209, 1989
4TIM
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BU of 4tim by Molmil
CRYSTALLOGRAPHIC AND MOLECULAR MODELING STUDIES ON TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE: A CRITICAL ASSESSMENT OF THE PREDICTED AND OBSERVED STRUCTURES OF THE COMPLEX WITH 2-PHOSPHOGLYCERATE
Descriptor: 2-PHOSPHOGLYCERIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:Nobel, M.E.M, Wierenga, R.K, Hol, W.G.J.
Deposit date:1991-04-11
Release date:1992-10-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate.
J.Med.Chem., 34, 1991
1QCB
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BU of 1qcb by Molmil
ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor: PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:Merritt, E.A, Hol, W.G.J.
Deposit date:1999-04-30
Release date:2003-06-10
Last modified:2021-07-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb
To be Published
1QB5
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BU of 1qb5 by Molmil
ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor: PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:Merritt, E.A, Hol, W.G.J.
Deposit date:1999-04-30
Release date:2003-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb
To be Published
6AX8
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BU of 6ax8 by Molmil
Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with methionyl-adenylate
Descriptor: Methionine-tRNA ligase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate
Authors:Barros-Alvarez, X, Hol, W.G.J.
Deposit date:2017-09-06
Release date:2018-04-11
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.
Acta Crystallogr F Struct Biol Commun, 74, 2018
6CML
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BU of 6cml by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 2093)
Descriptor: 1-[(5-chloro-1H-imidazo[4,5-b]pyridin-2-yl)methyl]-4-[(2-chloro-4-methoxyphenyl)methyl]-3-ethyl-1,3-dihydro-2H-imidazol-2-one, GLYCEROL, METHIONINE, ...
Authors:Barros-Alvarez, X, Hol, W.G.J.
Deposit date:2018-03-05
Release date:2019-03-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei
Rsc Med Chem, 11, 2020
6BQM
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BU of 6bqm by Molmil
Secreted serine protease VesC from Vibrio cholerae
Descriptor: serine protease VesC
Authors:Park, Y.J, Korotkov, K.V, Delarosa, J.R, Turley, S, DiMaio, F, Hol, W.G.J.
Deposit date:2017-11-28
Release date:2018-11-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Suppressor Mutations in Type II Secretion Mutants of Vibrio cholerae: Inactivation of the VesC Protease.
Msphere, 5, 2020
5TIM
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BU of 5tim by Molmil
REFINED 1.83 ANGSTROMS STRUCTURE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE, CRYSTALLIZED IN THE PRESENCE OF 2.4 M-AMMONIUM SULPHATE. A COMPARISON WITH THE STRUCTURE OF THE TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE-GLYCEROL-3-PHOSPHATE COMPLEX
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, SULFATE ION, TRIOSEPHOSPHATE ISOMERASE
Authors:Wierenga, R.K, Hol, W.G.J.
Deposit date:1991-04-23
Release date:1992-10-15
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex.
J.Mol.Biol., 220, 1991
2A0U
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BU of 2a0u by Molmil
Crystal structure of the eukaryotic initiation factor 2B from Leishmania major at 2.1 A resolution
Descriptor: SULFATE ION, initiation factor 2B
Authors:Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-06-17
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the eukaryotic initiation factor 2B from Leishmania major at 2.1 A resolution
To be Published
2A0S
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BU of 2a0s by Molmil
Crystal structure of 6-pyruvoyl tetrahydropterin synthase (PTPS) from Plasmodium vivax at 2.2 A resolution
Descriptor: 6-pyruvoyl tetrahydropterin synthase, BIOPTERIN, ZINC ION
Authors:Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-06-16
Release date:2005-07-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of 6-pyruvoyl tetrahydropterin synthase (PTPS) from Plasmodium vivax at 2.2 A resolution
To be Published
2F64
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BU of 2f64 by Molmil
Crystal structure of Nucleoside 2-deoxyribosyltransferase from Trypanosoma brucei at 1.6 A resolution with 1-METHYLQUINOLIN-2(1H)-ONE bound
Descriptor: 1-METHYLQUINOLIN-2(1H)-ONE, GLYCEROL, Nucleoside 2-deoxyribosyltransferase, ...
Authors:Bosch, J, Robien, M.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-11-28
Release date:2005-12-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase.
J.Med.Chem., 49, 2006
6MES
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BU of 6mes by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1907)
Descriptor: 1-[(1H-benzimidazol-2-yl)methyl]-4-[(2,4-dichlorophenyl)methyl]-1,3-dihydro-2H-imidazol-2-one, GLYCEROL, METHIONINE, ...
Authors:Barros-Alvarez, X, Hol, W.G.J.
Deposit date:2018-09-07
Release date:2019-09-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei
Rsc Med Chem, 2020
2PHH
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BU of 2phh by Molmil
THE COENZYME ANALOGUE ADENOSINE 5-DIPHOSPHORIBOSE DISPLACES FAD IN THE ACTIVE SITE OF P-HYDROXYBENZOATE HYDROXYLASE. AN X-RAY CRYSTALLOGRAPHIC INVESTIGATION
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, P-HYDROXYBENZOATE HYDROXYLASE, P-HYDROXYBENZOIC ACID
Authors:Van Derlaan, J.M, Drenth, J, Hol, W.G.J.
Deposit date:1989-06-19
Release date:1990-10-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The coenzyme analogue adenosine 5-diphosphoribose displaces FAD in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation.
Biochemistry, 28, 1989
2MAD
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BU of 2mad by Molmil
THE ACTIVE SITE STRUCTURE OF METHYLAMINE DEHYDROGENASE: HYDRAZINES IDENTIFY C6 AS THE REACTIVE SITE OF THE TRYPTOPHAN DERIVED QUINONE COFACTOR
Descriptor: METHYLAMINE DEHYDROGENASE (HEAVY SUBUNIT), METHYLAMINE DEHYDROGENASE (LIGHT SUBUNIT)
Authors:Huizinga, E.G, Vellieux, F.M.D, Hol, W.G.J.
Deposit date:1992-05-20
Release date:1994-01-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor.
Biochemistry, 31, 1992
3LAD
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BU of 3lad by Molmil
REFINED CRYSTAL STRUCTURE OF LIPOAMIDE DEHYDROGENASE FROM AZOTOBACTER VINELANDII AT 2.2 ANGSTROMS RESOLUTION. A COMPARISON WITH THE STRUCTURE OF GLUTATHIONE REDUCTASE
Descriptor: DIHYDROLIPOAMIDE DEHYDROGENASE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Mattevi, A, Schierbeek, A.J, Hol, W.G.J.
Deposit date:1991-12-11
Release date:1994-01-31
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Refined crystal structure of lipoamide dehydrogenase from Azotobacter vinelandii at 2.2 A resolution. A comparison with the structure of glutathione reductase.
J.Mol.Biol., 220, 1991
3BWC
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BU of 3bwc by Molmil
Crystal structure of spermidine synthase from Trypanosoma cruzi in complex with SAM at 2.3 A resolution
Descriptor: BETA-MERCAPTOETHANOL, S-ADENOSYLMETHIONINE, Spermidine synthase
Authors:Bosch, J, Arakaki, T.L, Le Trong, I, Merritt, E.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-01-09
Release date:2008-04-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of spermidine synthase from Trypanosoma cruzi.
To be Published
5V49
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BU of 5v49 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1917)
Descriptor: GLYCEROL, METHIONINE, Methionyl-tRNA synthetase, ...
Authors:Barros-Alvarez, X, Hol, W.G.J.
Deposit date:2017-03-08
Release date:2017-07-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5USF
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BU of 5usf by Molmil
Leishmania donovani tyrosyl-tRNA synthetase in complex with nanobody and inhibitor
Descriptor: 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, Immunoglobulin heavy chain variable region, Tyrosyl-tRNA synthetase, ...
Authors:Barros-Alvarez, X, Hol, W.G.J.
Deposit date:2017-02-13
Release date:2017-05-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.
Biochimie, 138, 2017
2BP2
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BU of 2bp2 by Molmil
THE STRUCTURE OF BOVINE PANCREATIC PROPHOSPHOLIPASE A2 AT 3.0 ANGSTROMS RESOLUTION
Descriptor: PHOSPHOLIPASE A2
Authors:Dijkstra, B.W, Vannes, G.J.H, Kalk, K.H, Brandenburg, N.P, Hol, W.G.J, Drenth, J.
Deposit date:1981-06-05
Release date:1981-07-16
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Structure of Bovine Pancreatic Prophospholipase A2 at 3.0 Angstroms Resolution
Acta Crystallogr.,Sect.B, 38, 1982
3TEC
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BU of 3tec by Molmil
CALCIUM BINDING TO THERMITASE. CRYSTALLOGRAPHIC STUDIES OF THERMITASE AT 0, 5 AND 100 MM CALCIUM
Descriptor: CALCIUM ION, EGLIN C, THERMITASE
Authors:Gros, P, Kalk, K.H, Hol, W.G.J.
Deposit date:1990-10-26
Release date:1992-01-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Calcium binding to thermitase. Crystallographic studies of thermitase at 0, 5, and 100 mM calcium.
J.Biol.Chem., 266, 1991
3BWB
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BU of 3bwb by Molmil
Crystal structure of the apo form of spermidine synthase from Trypanosoma cruzi at 2.5 A resolution
Descriptor: Spermidine synthase
Authors:Bosch, J, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2008-01-08
Release date:2008-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of spermidine synthase from Trypanosoma cruzi.
To be Published
1PBD
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BU of 1pbd by Molmil
CRYSTAL STRUCTURES OF WILD-TYPE P-HYDROXYBENZOATE HYDROXYLASE COMPLEXED WITH 4-AMINOBENZOATE, 2,4-DIHYDROXYBENZOATE AND 2-HYDROXY-4-AMINOBENZOATE AND OF THE TRY222ALA MUTANT, COMPLEXED WITH 2-HYDROXY-4-AMINOBENZOATE. EVIDENCE FOR A PROTON CHANNEL AND A NEW BINDING MODE OF THE FLAVIN RING
Descriptor: 4-AMINOBENZOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, P-HYDROXYBENZOATE HYDROXYLASE
Authors:Schreuder, H.A, Mattevi, A, Hol, W.G.J.
Deposit date:1994-07-06
Release date:1994-09-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring
Biochemistry, 33, 1994

225158

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