1SVV
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4KSR
| Crystal Structure of the Vibrio cholerae ATPase GspE Hexamer | Descriptor: | Type II secretion system protein E, Hemolysin-coregulated protein | Authors: | Hol, W.G, Turley, S, Lu, C.Y, Park, Y.J, Marionni, S.T, Lee, K, Patrick, M, Sandkvist, M, Bush, M, Shah, R. | Deposit date: | 2013-05-17 | Release date: | 2013-09-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Hexamers of the Type II Secretion ATPase GspE from Vibrio cholerae with Increased ATPase Activity. Structure, 21, 2013
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4KSS
| Crystal Structure of Vibrio cholerae ATPase GspsE Hexamer | Descriptor: | Type II secretion system protein E, hemolysin-coregulated protein | Authors: | Hol, W.G, Turley, S, Lu, C.Y, Park, Y.J. | Deposit date: | 2013-05-17 | Release date: | 2013-09-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (7.58 Å) | Cite: | Hexamers of the Type II Secretion ATPase GspE from Vibrio cholerae with Increased ATPase Activity. Structure, 21, 2013
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1RHD
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1HCY
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6TIM
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4TIM
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1GYP
| CRYSTAL STRUCTURE OF GLYCOSOMAL GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE FROM LEISHMANIA MEXICANA: IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN AND A NEW POSITION FOR THE INORGANIC PHOSPHATE BINDING SITE | Descriptor: | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHOSPHATE ION | Authors: | Kim, H, Feil, I.K, Verlinde, C.L.M.J, Petra, P.H, Hol, W.G.J. | Deposit date: | 1995-08-01 | Release date: | 1995-12-07 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site. Biochemistry, 34, 1995
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2A5D
| Structural basis for the activation of cholera toxin by human ARF6-GTP | Descriptor: | ADP-ribosylation factor 6, Cholera enterotoxin, A chain, ... | Authors: | O'Neal, C.J, Jobling, M.G, Holmes, R.K, Hol, W.G.J. | Deposit date: | 2005-06-30 | Release date: | 2005-08-16 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for the activation of cholera toxin by human ARF6-GTP. Science, 309, 2005
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2A5G
| Cholera toxin A1 subunit bound to ARF6(Q67L) | Descriptor: | ADP-ribosylation factor 6, Cholera enterotoxin, A chain, ... | Authors: | O'Neal, C.J, Jobling, M.G, Holmes, R.K, Hol, W.G.J. | Deposit date: | 2005-06-30 | Release date: | 2005-08-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Structural basis for the activation of cholera toxin by human ARF6-GTP. Science, 309, 2005
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3LAD
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2GQ2
| Mycobacterium tuberculosis ThyX-NADP complex | Descriptor: | GLYCEROL, IODIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Sampathkumar, P, Turley, S, Sibley, C.H, Hol, W.G. | Deposit date: | 2006-04-19 | Release date: | 2006-06-27 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design. J.Mol.Biol., 360, 2006
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2AF6
| Crystal structure of Mycobacterium tuberculosis Flavin dependent thymidylate synthase (Mtb ThyX) in the presence of co-factor FAD and substrate analog 5-Bromo-2'-Deoxyuridine-5'-Monophosphate (BrdUMP) | Descriptor: | 5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Sampathkumar, P, Turley, S, Ulmer, J.E, Rhie, H.G, Sibley, C.H, Hol, W.G. | Deposit date: | 2005-07-25 | Release date: | 2005-10-04 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure of the Mycobacterium tuberculosis Flavin Dependent Thymidylate Synthase (MtbThyX) at 2.0A Resolution. J.Mol.Biol., 352, 2005
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2AUC
| Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor | Descriptor: | Myosin A, Myosin A Tail Interacting Protein | Authors: | Bosch, J, Turley, S, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) | Deposit date: | 2005-08-27 | Release date: | 2006-01-17 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2ISY
| Crystal structure of the nickel-activated two-domain iron-dependent regulator (IdeR) | Descriptor: | Iron-dependent repressor ideR, NICKEL (II) ION, PHOSPHATE ION | Authors: | Wisedchaisri, G, Chou, C.J, Wu, M, Roach, C, Rice, A.E, Holmes, R.K, Beeson, C, Hol, W.G. | Deposit date: | 2006-10-18 | Release date: | 2007-02-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.955 Å) | Cite: | Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis Biochemistry, 46, 2007
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2ISZ
| Crystal structure of a two-domain IdeR-DNA complex crystal form I | Descriptor: | Iron-dependent repressor ideR, NICKEL (II) ION, SODIUM ION, ... | Authors: | Wisedchaisri, G, Chou, C.J, Wu, M, Roach, C, Rice, A.E, Holmes, R.K, Beeson, C, Hol, W.G. | Deposit date: | 2006-10-18 | Release date: | 2007-02-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.403 Å) | Cite: | Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis Biochemistry, 46, 2007
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2IT0
| Crystal structure of a two-domain IdeR-DNA complex crystal form II | Descriptor: | ACETATE ION, Iron-dependent repressor ideR, NICKEL (II) ION, ... | Authors: | Wisedchaisri, G, Chou, C.J, Wu, M, Roach, C, Rice, A.E, Holmes, R.K, Beeson, C, Hol, W.G. | Deposit date: | 2006-10-18 | Release date: | 2007-02-13 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis Biochemistry, 46, 2007
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2I6V
| PDZ domain of EpsC from Vibrio cholerae, residues 219-305 | Descriptor: | General secretion pathway protein C | Authors: | Korotkov, K.V, Krumm, B, Bagdasarian, M, Hol, W.G.J. | Deposit date: | 2006-08-29 | Release date: | 2006-10-17 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Structural and Functional Studies of EpsC, a Crucial Component of the Type 2 Secretion System from Vibrio cholerae. J.Mol.Biol., 363, 2006
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2I4S
| PDZ domain of EpsC from Vibrio cholerae, residues 204-305 | Descriptor: | General secretion pathway protein C | Authors: | Korotkov, K.V, Krumm, B, Bagdasarian, M, Hol, W.G.J. | Deposit date: | 2006-08-22 | Release date: | 2006-10-17 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural and Functional Studies of EpsC, a Crucial Component of the Type 2 Secretion System from Vibrio cholerae. J.Mol.Biol., 363, 2006
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5TIM
| REFINED 1.83 ANGSTROMS STRUCTURE OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE, CRYSTALLIZED IN THE PRESENCE OF 2.4 M-AMMONIUM SULPHATE. A COMPARISON WITH THE STRUCTURE OF THE TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE-GLYCEROL-3-PHOSPHATE COMPLEX | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, SULFATE ION, TRIOSEPHOSPHATE ISOMERASE | Authors: | Wierenga, R.K, Hol, W.G.J. | Deposit date: | 1991-04-23 | Release date: | 1992-10-15 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex. J.Mol.Biol., 220, 1991
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2PHH
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2MAD
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3CHB
| CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHOLERA TOXIN, UNKNOWN ATOM OR ION, ... | Authors: | Merritt, E.A, Hol, W.G.J. | Deposit date: | 1998-03-24 | Release date: | 1998-08-12 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site. J.Mol.Biol., 282, 1998
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5TQU
| Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor | Descriptor: | 2-[2-[[3-(1~{H}-benzimidazol-2-ylamino)propylamino]methyl]-4,6-bis(chloranyl)indol-1-yl]ethanol, GLYCEROL, METHIONINE, ... | Authors: | Barros-Alvarez, X, Hol, W.G.J. | Deposit date: | 2016-10-24 | Release date: | 2017-04-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis. ACS Infect Dis, 3, 2017
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5J5A
| Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 70786556) | Descriptor: | METHIONINE, Methionyl-tRNA synthetase, putative, ... | Authors: | Barros-Alvarez, X, Koh, C.Y, Hol, W.G.J. | Deposit date: | 2016-04-01 | Release date: | 2017-01-25 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. Eur J Med Chem, 124, 2016
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