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4KSR
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CRYSTAL STRUCTURE OF THE VIBRIO CHOLERAE ATPASE GSPE HEXAMER
Descriptor:Type II secretion system protein E, Hemolysin-coregulated protein
Authors:Hol, W.G., Turley, S., Lu, C.Y., Park, Y.J., Marionni, S.T., Lee, K., Patrick, M., Sandkvist, M., Bush, M., Shah, R.
Deposit date:2013-05-17
Release date:2013-09-04
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Hexamers of the Type II Secretion ATPase GspE from Vibrio cholerae with Increased ATPase Activity.
Structure, 21, 2013
4KSS
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CRYSTAL STRUCTURE OF VIBRIO CHOLERAE ATPASE GSPSE HEXAMER
Descriptor:Type II secretion system protein E, hemolysin-coregulated protein
Authors:Hol, W.G., Turley, S., Lu, C.Y., Park, Y.J.
Deposit date:2013-05-17
Release date:2013-09-04
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (7.58 Å)
Cite:Hexamers of the Type II Secretion ATPase GspE from Vibrio cholerae with Increased ATPase Activity.
Structure, 21, 2013
1RFF
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CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTAPEPTIDE KLNYYDPR, AND TETRANUCLEOTIDE AGTT.
Descriptor:5'-D(*AP*GP*TP*T)-3', Tyrosyl-DNA phosphodiesterase 1, Topoisomerase I-Derived Peptide, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-08
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RFI
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CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, PENTAPEPTIDE KLNYK, AND TETRANUCLEOTIDE AGTC
Descriptor:5'-D(*AP*GP*TP*C)-3', Tyrosyl-DNA phosphodiesterase 1, Topoisomerase I-Derived Peptide, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-10
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RG1
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CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTT
Descriptor:5'-D(*AP*GP*TP*T)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-10
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RG2
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CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTA
Descriptor:5'-D(*AP*GP*TP*A)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-11
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RGT
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CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTC
Descriptor:5'-D(*AP*GP*TP*C)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-12
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RGU
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THE CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTG
Descriptor:5'-D(*AP*GP*TP*G)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-13
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1RH0
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CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE AND TRINUCLEOTIDE GTT
Descriptor:5'-D(*GP*TP*T)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ...
Authors:Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G.
Deposit date:2003-11-13
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
1BI0
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STRUCTURE OF APO-AND HOLO-DIPHTHERIA TOXIN REPRESSOR
Descriptor:DIPHTHERIA TOXIN REPRESSOR, ZINC ION, SULFATE ION
Authors:Pohl, E., Hol, W.G.
Deposit date:1998-06-21
Release date:1999-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Motion of the DNA-binding domain with respect to the core of the diphtheria toxin repressor (DtxR) revealed in the crystal structures of apo- and holo-DtxR.
J.Biol.Chem., 273, 1998
1RQC
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CRYSTALS OF PEPTIDE DEFORMYLASE FROM PLASMODIUM FALCIPARUM WITH TEN SUBUNITS PER ASYMMETRIC UNIT REVEAL CRITICAL CHARACTERISTICS OF THE ACTIVE SITE FOR DRUG DESIGN
Descriptor:formylmethionine deformylase, COBALT (II) ION
Authors:Robien, M.A., Nguyen, K.T., Kumar, A., Hirsh, I., Turley, S., Pei, D., Hol, W.G.
Deposit date:2003-12-04
Release date:2004-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:An improved crystal form of Plasmodium falciparum peptide deformylase
Protein Sci., 13, 2004
1YF5
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CYTO-EPSL: THE CYTOPLASMIC DOMAIN OF EPSL, AN INNER MEMBRANE COMPONENT OF THE TYPE II SECRETION SYSTEM OF VIBRIO CHOLERAE
Descriptor:General secretion pathway protein L
Authors:Abendroth, J., Murphy, P., Mushtaq, A., Sandkvist, M., Bagdasarian, M., Hol, W.G.
Deposit date:2004-12-30
Release date:2005-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The X-ray Structure of the Type II Secretion System Complex Formed by the N-terminal Domain of EpsE and the Cytoplasmic Domain of EpsL of Vibrio cholerae.
J.Mol.Biol., 348, 2005
2GQ2
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MYCOBACTERIUM TUBERCULOSIS THYX-NADP COMPLEX
Descriptor:Thymidylate synthase thyX, IODIDE ION, POTASSIUM ION, ...
Authors:Sampathkumar, P., Turley, S., Sibley, C.H., Hol, W.G.
Deposit date:2006-04-19
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design.
J.Mol.Biol., 360, 2006
1A35
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HUMAN TOPOISOMERASE I/DNA COMPLEX
Descriptor:DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3'), PROTEIN (DNA TOPOISOMERASE I)
Authors:Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., Hol, W.G.
Deposit date:1998-01-29
Release date:1998-08-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
1B1B
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IRON DEPENDENT REGULATOR
Descriptor:PROTEIN (IRON DEPENDENT REGULATOR), ZINC ION, SULFATE ION
Authors:Pohl, E., Holmes, R.K., Hol, W.G.
Deposit date:1998-11-19
Release date:1999-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the iron-dependent regulator (IdeR) from Mycobacterium tuberculosis shows both metal binding sites fully occupied.
J.Mol.Biol., 285, 1999
1B5S
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DIHYDROLIPOYL TRANSACETYLASE (E.C.2.3.1.12) CATALYTIC DOMAIN (RESIDUES 184-425) FROM BACILLUS STEAROTHERMOPHILUS
Descriptor:DIHYDROLIPOAMIDE ACETYLTRANSFERASE
Authors:Izard, T., Aevarsson, A., Allen, M.D., Westphal, A.H., Perham, R.N., De Kok, A., Hol, W.G.
Deposit date:1999-01-10
Release date:1999-02-16
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes.
Proc.Natl.Acad.Sci.USA, 96, 1999
1C0W
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CRYSTAL STRUCTURE OF THE COBALT-ACTIVATED DIPHTHERIA TOXIN REPRESSOR-DNA COMPLEX REVEALS A METAL BINDING SH-LIKE DOMAIN
Descriptor:DNA (5'-D(P*AP*TP*TP*AP*GP*GP*TP*TP*AP*GP*CP*CP*TP*AP*CP*CP*CP*TP*AP*AP*T)-3'), DNA (5'-D(P*AP*TP*TP*AP*GP*GP*TP*TP*AP*GP*GP*CP*TP*AP*CP*CP*CP*TP*AP*AP*T)-3'), DIPHTHERIA TOXIN REPRESSOR, ...
Authors:Pohl, E., Holmes, R.K., Hol, W.G.
Deposit date:1999-07-22
Release date:2000-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a cobalt-activated diphtheria toxin repressor-DNA complex reveals a metal-binding SH3-like domain.
J.Mol.Biol., 292, 1999
1DF7
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DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE
Descriptor:DIHYDROFOLATE REDUCTASE, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.
Deposit date:1999-11-17
Release date:2000-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1DG5
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DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND TRIMETHOPRIM
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM, ...
Authors:Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.
Deposit date:1999-11-23
Release date:2000-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1DG7
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DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210
Descriptor:DIHYDROFOLATE REDUCTASE, 1-[3-(4-BROMO-PHENOXY)-PROPOXY]-6,6-DIMETHYL-1.6-DIHYDRO-[1,3,5]TRIAZINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.
Deposit date:1999-11-23
Release date:2000-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1DG8
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DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH
Descriptor:DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL
Authors:Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G.
Deposit date:1999-11-23
Release date:2000-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
1EJ9
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CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
Descriptor:DNA (5'-D(*C*AP*AP*AP*AP*AP*GP*AP*CP*TP*CP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'), DNA (5'-D(*C*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*GP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), DNA TOPOISOMERASE I
Authors:Redinbo, M.R., Champoux, J.J., Hol, W.G.
Deposit date:2000-03-01
Release date:2000-08-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.
Biochemistry, 39, 2000
1N1G
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CRYSTAL STRUCTURE OF LEISHMANIA MEXICANA GLYCEROL-3-PHOSPHATE DEHYDROGENASE WITH INHIBITOR BCP
Descriptor:glycerol-3-phosphate dehydrogenase, 2-BROMO-6-CHLORO-PURINE, PALMITIC ACID
Authors:Choe, J., Hol, W.G.
Deposit date:2002-10-17
Release date:2003-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase.
Chem.Biol., 9, 2002
1R49
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HUMAN TOPOISOMERASE I (TOPO70) DOUBLE MUTANT K532R/Y723F
Descriptor:5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I
Authors:Interthal, H., Quigley, P.M., Hol, W.G., Champoux, J.J.
Deposit date:2003-10-03
Release date:2003-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.13 Å)
Cite:The role of lysine 532 in the catalytic mechanism of human topoisomerase I.
J.Biol.Chem., 279, 2004
1R59
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ENTEROCOCCUS CASSELIFLAVUS GLYCEROL KINASE
Descriptor:Glycerol kinase
Authors:Yeh, J.I., Charrier, V., Paulo, J., Hou, L., Darbon, E., Claiborne, A., Hol, W.G., Deutscher, J.
Deposit date:2003-10-09
Release date:2004-10-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of Enterococcal Glycerol Kinase in the Absence and Presence of Glycerol: Correlation of conformation to substrate binding and a mechanism of activation by phosphorylation
Biochemistry, 43, 2004