4KSR | | CRYSTAL STRUCTURE OF THE VIBRIO CHOLERAE ATPASE GSPE HEXAMER | | Descriptor: | Type II secretion system protein E, Hemolysin-coregulated protein | | Authors: | Hol, W.G., Turley, S., Lu, C.Y., Park, Y.J., Marionni, S.T., Lee, K., Patrick, M., Sandkvist, M., Bush, M., Shah, R. | | Deposit date: | 2013-05-17 | | Release date: | 2013-09-04 | | Last modified: | 2017-08-23 | | Method: | X-RAY DIFFRACTION (4.2 Å) | | Cite: | Hexamers of the Type II Secretion ATPase GspE from Vibrio cholerae with Increased ATPase Activity.
Structure, 21, 2013
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4KSS | | CRYSTAL STRUCTURE OF VIBRIO CHOLERAE ATPASE GSPSE HEXAMER | | Descriptor: | Type II secretion system protein E, hemolysin-coregulated protein | | Authors: | Hol, W.G., Turley, S., Lu, C.Y., Park, Y.J. | | Deposit date: | 2013-05-17 | | Release date: | 2013-09-04 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (7.58 Å) | | Cite: | Hexamers of the Type II Secretion ATPase GspE from Vibrio cholerae with Increased ATPase Activity.
Structure, 21, 2013
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1RFF | | CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTAPEPTIDE KLNYYDPR, AND TETRANUCLEOTIDE AGTT. | | Descriptor: | 5'-D(*AP*GP*TP*T)-3', Tyrosyl-DNA phosphodiesterase 1, Topoisomerase I-Derived Peptide, ... | | Authors: | Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G. | | Deposit date: | 2003-11-08 | | Release date: | 2004-03-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
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1RFI | | CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, PENTAPEPTIDE KLNYK, AND TETRANUCLEOTIDE AGTC | | Descriptor: | 5'-D(*AP*GP*TP*C)-3', Tyrosyl-DNA phosphodiesterase 1, Topoisomerase I-Derived Peptide, ... | | Authors: | Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G. | | Deposit date: | 2003-11-10 | | Release date: | 2004-03-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
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1RG1 | | CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTT | | Descriptor: | 5'-D(*AP*GP*TP*T)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ... | | Authors: | Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G. | | Deposit date: | 2003-11-10 | | Release date: | 2004-03-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
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1RG2 | | CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTA | | Descriptor: | 5'-D(*AP*GP*TP*A)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ... | | Authors: | Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G. | | Deposit date: | 2003-11-11 | | Release date: | 2004-03-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
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1RGT | | CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTC | | Descriptor: | 5'-D(*AP*GP*TP*C)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ... | | Authors: | Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G. | | Deposit date: | 2003-11-12 | | Release date: | 2004-03-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
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1RGU | | THE CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE, AND TETRANUCLEOTIDE AGTG | | Descriptor: | 5'-D(*AP*GP*TP*G)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ... | | Authors: | Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G. | | Deposit date: | 2003-11-13 | | Release date: | 2004-03-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
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1RH0 | | CRYSTAL STRUCTURE OF HUMAN TYROSYL-DNA PHOSPHODIESTERASE COMPLEXED WITH VANADATE, OCTOPAMINE AND TRINUCLEOTIDE GTT | | Descriptor: | 5'-D(*GP*TP*T)-3', Tyrosyl-DNA phosphodiesterase 1, VANADATE ION, ... | | Authors: | Davies, D.R., Interthal, H., Champoux, J.J., Hol, W.G. | | Deposit date: | 2003-11-13 | | Release date: | 2004-03-02 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Explorations of peptide and oligonucleotide binding sites of tyrosyl-DNA phosphodiesterase using vanadate complexes.
J.Med.Chem., 47, 2004
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1BI0 | | STRUCTURE OF APO-AND HOLO-DIPHTHERIA TOXIN REPRESSOR | | Descriptor: | DIPHTHERIA TOXIN REPRESSOR, ZINC ION, SULFATE ION | | Authors: | Pohl, E., Hol, W.G. | | Deposit date: | 1998-06-21 | | Release date: | 1999-07-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Motion of the DNA-binding domain with respect to the core of the diphtheria toxin repressor (DtxR) revealed in the crystal structures of apo- and holo-DtxR.
J.Biol.Chem., 273, 1998
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1RQC | | CRYSTALS OF PEPTIDE DEFORMYLASE FROM PLASMODIUM FALCIPARUM WITH TEN SUBUNITS PER ASYMMETRIC UNIT REVEAL CRITICAL CHARACTERISTICS OF THE ACTIVE SITE FOR DRUG DESIGN | | Descriptor: | formylmethionine deformylase, COBALT (II) ION | | Authors: | Robien, M.A., Nguyen, K.T., Kumar, A., Hirsh, I., Turley, S., Pei, D., Hol, W.G. | | Deposit date: | 2003-12-04 | | Release date: | 2004-01-20 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | An improved crystal form of Plasmodium falciparum peptide deformylase
Protein Sci., 13, 2004
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1YF5 | | CYTO-EPSL: THE CYTOPLASMIC DOMAIN OF EPSL, AN INNER MEMBRANE COMPONENT OF THE TYPE II SECRETION SYSTEM OF VIBRIO CHOLERAE | | Descriptor: | General secretion pathway protein L | | Authors: | Abendroth, J., Murphy, P., Mushtaq, A., Sandkvist, M., Bagdasarian, M., Hol, W.G. | | Deposit date: | 2004-12-30 | | Release date: | 2005-05-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | The X-ray Structure of the Type II Secretion System Complex Formed by the N-terminal Domain of EpsE and the Cytoplasmic Domain of EpsL of Vibrio cholerae.
J.Mol.Biol., 348, 2005
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2GQ2 | | MYCOBACTERIUM TUBERCULOSIS THYX-NADP COMPLEX | | Descriptor: | Thymidylate synthase thyX, IODIDE ION, POTASSIUM ION, ... | | Authors: | Sampathkumar, P., Turley, S., Sibley, C.H., Hol, W.G. | | Deposit date: | 2006-04-19 | | Release date: | 2006-06-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design.
J.Mol.Biol., 360, 2006
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1A35 | | HUMAN TOPOISOMERASE I/DNA COMPLEX | | Descriptor: | DNA (5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*(BRU)P*(BRU)P*TP*TP*T)-3'), DNA (5'-D(*AP*AP*AP*AP*AP*TP*+UP*+UP*+UP*+UP*CP*+UP*AP*AP*GP*TP*CP*TP*TP*TP*+ UP*T)-3'), PROTEIN (DNA TOPOISOMERASE I) | | Authors: | Redinbo, M.R., Stewart, L., Kuhn, P., Champoux, J.J., Hol, W.G. | | Deposit date: | 1998-01-29 | | Release date: | 1998-08-28 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.
Science, 279, 1998
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1B1B | | IRON DEPENDENT REGULATOR | | Descriptor: | PROTEIN (IRON DEPENDENT REGULATOR), ZINC ION, SULFATE ION | | Authors: | Pohl, E., Holmes, R.K., Hol, W.G. | | Deposit date: | 1998-11-19 | | Release date: | 1999-12-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structure of the iron-dependent regulator (IdeR) from Mycobacterium tuberculosis shows both metal binding sites fully occupied.
J.Mol.Biol., 285, 1999
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1B5S | | DIHYDROLIPOYL TRANSACETYLASE (E.C.2.3.1.12) CATALYTIC DOMAIN (RESIDUES 184-425) FROM BACILLUS STEAROTHERMOPHILUS | | Descriptor: | DIHYDROLIPOAMIDE ACETYLTRANSFERASE | | Authors: | Izard, T., Aevarsson, A., Allen, M.D., Westphal, A.H., Perham, R.N., De Kok, A., Hol, W.G. | | Deposit date: | 1999-01-10 | | Release date: | 1999-02-16 | | Last modified: | 2014-11-19 | | Method: | X-RAY DIFFRACTION (4.4 Å) | | Cite: | Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes.
Proc.Natl.Acad.Sci.USA, 96, 1999
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1C0W | | CRYSTAL STRUCTURE OF THE COBALT-ACTIVATED DIPHTHERIA TOXIN REPRESSOR-DNA COMPLEX REVEALS A METAL BINDING SH-LIKE DOMAIN | | Descriptor: | DNA (5'-D(P*AP*TP*TP*AP*GP*GP*TP*TP*AP*GP*CP*CP*TP*AP*CP*CP*CP*TP*AP*AP*T)-3'), DNA (5'-D(P*AP*TP*TP*AP*GP*GP*TP*TP*AP*GP*GP*CP*TP*AP*CP*CP*CP*TP*AP*AP*T)-3'), DIPHTHERIA TOXIN REPRESSOR, ... | | Authors: | Pohl, E., Holmes, R.K., Hol, W.G. | | Deposit date: | 1999-07-22 | | Release date: | 2000-07-22 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Crystal structure of a cobalt-activated diphtheria toxin repressor-DNA complex reveals a metal-binding SH3-like domain.
J.Mol.Biol., 292, 1999
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1DF7 | | DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND METHOTREXATE | | Descriptor: | DIHYDROFOLATE REDUCTASE, SULFATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G. | | Deposit date: | 1999-11-17 | | Release date: | 2000-03-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
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1DG5 | | DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND TRIMETHOPRIM | | Descriptor: | DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM, ... | | Authors: | Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G. | | Deposit date: | 1999-11-23 | | Release date: | 2000-03-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
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1DG7 | | DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND 4-BROMO WR99210 | | Descriptor: | DIHYDROFOLATE REDUCTASE, 1-[3-(4-BROMO-PHENOXY)-PROPOXY]-6,6-DIMETHYL-1.6-DIHYDRO-[1,3,5]TRIAZINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G. | | Deposit date: | 1999-11-23 | | Release date: | 2000-03-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
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1DG8 | | DIHYDROFOLATE REDUCTASE OF MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH | | Descriptor: | DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCEROL | | Authors: | Li, R., Sirawaraporn, R., Chitnumsub, P., Sirawaraporn, W., Wooden, J., Athappilly, F., Turley, S., Hol, W.G. | | Deposit date: | 1999-11-23 | | Release date: | 2000-03-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs.
J.Mol.Biol., 295, 2000
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1EJ9 | | CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX | | Descriptor: | DNA (5'-D(*C*AP*AP*AP*AP*AP*GP*AP*CP*TP*CP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'), DNA (5'-D(*C*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*GP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), DNA TOPOISOMERASE I | | Authors: | Redinbo, M.R., Champoux, J.J., Hol, W.G. | | Deposit date: | 2000-03-01 | | Release date: | 2000-08-03 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.
Biochemistry, 39, 2000
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1N1G | |
1R49 | | HUMAN TOPOISOMERASE I (TOPO70) DOUBLE MUTANT K532R/Y723F | | Descriptor: | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(P*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I | | Authors: | Interthal, H., Quigley, P.M., Hol, W.G., Champoux, J.J. | | Deposit date: | 2003-10-03 | | Release date: | 2003-12-16 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (3.13 Å) | | Cite: | The role of lysine 532 in the catalytic mechanism of human topoisomerase I.
J.Biol.Chem., 279, 2004
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1R59 | | ENTEROCOCCUS CASSELIFLAVUS GLYCEROL KINASE | | Descriptor: | Glycerol kinase | | Authors: | Yeh, J.I., Charrier, V., Paulo, J., Hou, L., Darbon, E., Claiborne, A., Hol, W.G., Deutscher, J. | | Deposit date: | 2003-10-09 | | Release date: | 2004-10-12 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of Enterococcal Glycerol Kinase in the Absence and Presence of Glycerol: Correlation of conformation to substrate binding and a mechanism of activation by phosphorylation
Biochemistry, 43, 2004
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