Author results

5XPD
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SUGAR TRANSPORTER OF ATSWEET13 IN INWARD-FACING STATE WITH A SUBSTRATE ANALOG
Descriptor:sugar transporter, 2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE
Authors:Han, L., Zhang, X.J.
Deposit date:2017-06-01
Release date:2017-09-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.788 Å)
Cite:Molecular mechanism of substrate recognition and transport by the AtSWEET13 sugar transporter
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5BK7
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THE STRUCTURE OF MPPP E15A MUTANT SOAKED WITH THE SUBSTRATE L-ARGININE
Descriptor:PLP-Dependent L-Arginine Hydroxylase MppP, (E)-N~2~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-arginine
Authors:Han, L., Silvaggi, N.R.
Deposit date:2018-01-27
Release date:2018-09-05
Method:X-RAY DIFFRACTION (2.196 Å)
Cite:Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase.
Biochemistry, 57, 2018
5HOQ
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APO STRUCTURE OF CALS11, TDP-RHAMNOSE 3'-O-METHYLTRANSFERASE, AN ENZYME IN CALICHEAMICIN BIOSYNTHESIS
Descriptor:TDP-rhamnose 3'-O-methyltransferase (CalS11), SULFATE ION
Authors:Han, L., Helmich, K.E., Singh, S., Thorson, J.S., Bingman, C.A., Phillips Jr., G.N., Enzyme Discovery for Natural Product Biosynthesis
Deposit date:2016-01-19
Release date:2016-03-30
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:Loop dynamics of thymidine diphosphate-rhamnose 3'-O-methyltransferase (CalS11), an enzyme in calicheamicin biosynthesis.
Struct Dyn., 3, 2016
6C8T
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THE STRUCTURE OF MPPP SOAKED WITH THE SUBSTRATE L-ARG
Descriptor:PLP-Dependent L-Arginine Hydroxylase MppP, (E)-N~2~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-arginine, CHLORIDE ION
Authors:Han, L., Silvaggi, N.R.
Deposit date:2018-01-25
Release date:2018-09-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase.
Biochemistry, 57, 2018
6C92
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THE STRUCTURE OF MPPP SOAKED WITH THE PRODUCT 2-KETOARGININE
Descriptor:PLP-Dependent L-Arginine Hydroxylase MppP, (E)-N~2~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-arginine, (4S)-5-carbamimidamido-4-hydroxy-2-oxopentanoic acid
Authors:Han, L., Silvaggi, N.R.
Deposit date:2018-01-25
Release date:2018-09-05
Method:X-RAY DIFFRACTION (1.834 Å)
Cite:Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase.
Biochemistry, 57, 2018
6C9B
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THE STRUCTURE OF MPPP SOAKED WITH THE PRODUCTS 4HKA AND 2KA
Descriptor:PLP-Dependent L-Arginine Hydroxylase MppP, CHLORIDE ION, (4S)-5-carbamimidamido-4-hydroxy-2-oxopentanoic acid
Authors:Han, L., Silvaggi, N.R.
Deposit date:2018-01-26
Release date:2018-04-04
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (1.689 Å)
Cite:Streptomyces wadayamensis MppP is a PLP-Dependent Oxidase, Not an Oxygenase.
Biochemistry, 57, 2018
5EJN
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CRYSTAL STRUCTURE OF JUNO, THE MAMMALIAN EGG RECEPTOR FOR SPERM IZUMO1
Descriptor:Sperm-egg fusion protein Juno, N-ACETYL-D-GLUCOSAMINE
Authors:Nishimura, K., Han, L., Jovine, L.
Deposit date:2015-11-02
Release date:2016-02-24
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes.
Curr.Biol., 26, 2016
5AYW
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STRUCTURE OF A MEMBRANE COMPLEX
Descriptor:Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ...
Authors:Huang, Y., Han, L., Zheng, J.
Deposit date:2015-09-14
Release date:2016-02-24
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.555 Å)
Cite:Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins
Nat.Struct.Mol.Biol., 23, 2016
5DJ1
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STRUCTURE OF THE PLP-DEPENDENT L-ARGININE HYDROXYLASE MPPP HOLOENZYME
Descriptor:PLP-Dependent L-Arginine Hydroxylase MppP, CHLORIDE ION, MAGNESIUM ION
Authors:Silvaggi, N.R., Han, L.
Deposit date:2015-09-01
Release date:2015-11-25
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Streptomyces wadayamensis MppP Is a Pyridoxal 5'-Phosphate-Dependent l-Arginine alpha-Deaminase, gamma-Hydroxylase in the Enduracididine Biosynthetic Pathway.
Biochemistry, 54, 2015
5DJ3
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STRUCTURE OF THE PLP-DEPENDENT L-ARGININE HYDROXYLASE MPPP WITH D-ARGININE BOUND
Descriptor:PLP-Dependent L-Arginine Hydroxylase MppP, (E)-N~2~-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-D-arginine, MAGNESIUM ION
Authors:Silvaggi, N.R., Han, L.
Deposit date:2015-09-01
Release date:2015-11-25
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.227 Å)
Cite:Streptomyces wadayamensis MppP Is a Pyridoxal 5'-Phosphate-Dependent l-Arginine alpha-Deaminase, gamma-Hydroxylase in the Enduracididine Biosynthetic Pathway.
Biochemistry, 54, 2015
5U8M
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A NOVEL FAMILY OF REDOX SENSORS IN THE STREPTOCOCCI EVOLVED FROM TWO-COMPONENT RESPONSE REGULATORS
Descriptor:Response regulator
Authors:Han, L., Silvaggi, N.R.
Deposit date:2016-12-14
Release date:2017-12-20
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization.
PLoS Pathog., 14, 2018
5VFA
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RITR MUTANT - C128D
Descriptor:Response regulator
Authors:Han, L., Silvaggi, N.R.
Deposit date:2017-04-07
Release date:2018-04-11
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (1.452 Å)
Cite:RitR is an archetype for a novel family of redox sensors in the streptococci that has evolved from two-component response regulators and is required for pneumococcal colonization.
PLoS Pathog., 14, 2018
6DA6
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CRYSTAL STRUCTURE OF THE TTND DECARBOXYLASE FROM THE TAUTOMYCETIN BIOSYNTHESIS PATHWAY OF STREPTOMYCES GRISEOCHROMOGENES, APO FORM AT 2.6 A RESOLUTION (P212121)
Descriptor:UbiD-like decarboxylase, MAGNESIUM ION, GLYCEROL, ...
Authors:Han, L., Rudolf, J.D., Chang, C.-Y., Miller, M.D., Soman, J., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2018-05-01
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018
6DA7
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CRYSTAL STRUCTURE OF THE TTND DECARBOXYLASE FROM THE TAUTOMYCETIN BIOSYNTHESIS PATHWAY OF STREPTOMYCES GRISEOCHROMOGENES WITH APO FORM AT 1.83 A RESOLUTION (I222)
Descriptor:UbiD-like decarboxylase, SODIUM ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Han, L., Rudolf, J.D., Chang, C.-Y., Miller, M.D., Soman, J., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2018-05-01
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018
6DA9
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CRYSTAL STRUCTURE OF THE TTND DECARBOXYLASE FROM THE TAUTOMYCETIN BIOSYNTHESIS PATHWAY OF STREPTOMYCES GRISEOCHROMOGENES WITH FMN BOUND AT 2.05 A RESOLUTION
Descriptor:UbiD-like decarboxylase, FLAVIN MONONUCLEOTIDE, MANGANESE (II) ION, ...
Authors:Han, L., Rudolf, J.D., Chang, C.-Y., Miller, M.D., Soman, J., Xu, W., Phillips Jr., G.N., Shen, B., Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2018-05-01
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Biochemical and Structural Characterization of TtnD, a Prenylated FMN-Dependent Decarboxylase from the Tautomycetin Biosynthetic Pathway.
ACS Chem. Biol., 13, 2018
5II6
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CRYSTAL STRUCTURE OF THE ZP-N1 DOMAIN OF MOUSE SPERM RECEPTOR ZP2 AT 0.95 A RESOLUTION
Descriptor:Zona pellucida sperm-binding protein 2
Authors:Dioguardi, E., Han, L., Nishimura, K., De Sanctis, D., Jovine, L.
Deposit date:2016-03-01
Release date:2017-06-14
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Structural Basis of Egg Coat-Sperm Recognition at Fertilization.
Cell, 169, 2017
5B5K
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CRYSTAL STRUCTURE OF IZUMO1, THE MAMMALIAN SPERM LIGAND FOR EGG JUNO
Descriptor:Izumo sperm-egg fusion protein 1, N-ACETYL-D-GLUCOSAMINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Nishimura, K., Han, L., De Sanctis, D., Jovine, L.
Deposit date:2016-05-11
Release date:2016-07-06
Last modified:2016-08-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins.
Curr.Biol., 26, 2016
4FG7
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CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE I 1-293 IN COMPLEX WITH ATP
Descriptor:Calcium/calmodulin-dependent protein kinase type 1, ADENOSINE-5'-TRIPHOSPHATE
Authors:Zha, M., Zhong, C., Ou, Y., Wang, J., Han, L., Ding, J.
Deposit date:2012-06-04
Release date:2013-01-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI.
Plos One, 7, 2012
4FG8
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CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE I 1-315 IN COMPLEX WITH ATP
Descriptor:Calcium/calmodulin-dependent protein kinase type 1, ADENOSINE-5'-TRIPHOSPHATE
Authors:Zha, M., Zhong, C., Ou, Y., Wang, J., Han, L., Ding, J.
Deposit date:2012-06-04
Release date:2013-01-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI.
Plos One, 7, 2012
4FG9
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CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE I 1-320 IN COMPLEX WITH ATP
Descriptor:Calcium/calmodulin-dependent protein kinase type 1, ADENOSINE-5'-TRIPHOSPHATE
Authors:Zha, M., Zhong, C., Ou, Y., Wang, J., Han, L., Ding, J.
Deposit date:2012-06-04
Release date:2013-01-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI.
Plos One, 7, 2012
4FGB
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CRYSTAL STRUCTURE OF HUMAN CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE I APO FORM
Descriptor:Calcium/calmodulin-dependent protein kinase type 1
Authors:Zha, M., Zhong, C., Ou, Y., Wang, J., Han, L., Ding, J.
Deposit date:2012-06-04
Release date:2013-01-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of human CaMKIalpha reveal insights into the regulation mechanism of CaMKI.
Plos One, 7, 2012
4LZL
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STRUCTURE OF THE INACTIVE FORM OF THE REGULATORY DOMAIN FROM THE REPRESSOR OF IRON TRANSPORT REGULATOR (RITR)
Descriptor:Response regulator, GLYCEROL
Authors:Silvaggi, N.R., Han, L., Ulijasz, A.T.
Deposit date:2013-07-31
Release date:2014-09-17
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Defining the Aspartate-Less Receiver (ALR) Domains: Structure and Activation of RitR from Streptococcus pneumoniae
To be Published
4ZA1
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CRYSTAL STRUCTURE OF NOSA INVOLVED IN NOSIHEPTIDE BIOSYNTHESIS
Descriptor:NosA, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Liu, S., Guo, H., Zhang, T., Han, L., Yao, P., Zhang, Y., Rong, N., Yu, Y., Lan, W., Wang, C., Ding, J., Wang, R., Liu, W., Cao, C.
Deposit date:2015-04-13
Release date:2015-08-19
Last modified:2015-09-02
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis
Sci Rep, 5, 2015
5BOE
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ENOLASE IN COMPLEX WITH PEP
Descriptor:Enolase, PHOSPHOENOLPYRUVATE, MAGNESIUM ION, ...
Authors:Wang, C.L., Wu, Y.F., Han, L., Wu, M.H., Zhang, X., Zang, J.Y.
Deposit date:2015-05-27
Release date:2015-12-09
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Octameric structure of Staphylococcus aureus enolase in complex with phosphoenolpyruvate
Acta Crystallogr.,Sect.D, 71, 2015
5BOF
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS ENOLASE
Descriptor:Enolase, MAGNESIUM ION, SULFATE ION
Authors:Wu, Y.F., Wang, C.L., Wu, M.H., Han, L., Zhang, X., Zang, J.Y.
Deposit date:2015-05-27
Release date:2015-12-09
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Octameric structure of Staphylococcus aureus enolase in complex with phosphoenolpyruvate.
Acta Crystallogr.,Sect.D, 71, 2015