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4BY3
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD IN APO- FORM OBTAINED RECOMBINANTLY FROM E. COLI.
Descriptor:DIHYDROOROTASE, ZINC ION, FORMIC ACID
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-07-17
Release date:2014-05-28
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structure, Functional Characterization, and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6B
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD WITH INCOMPLETE ACTIVE SITE, OBTAINED RECOMBINANTLY FROM E. COLI.
Descriptor:CAD PROTEIN, FORMIC ACID, GLYCEROL
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.656 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6C
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD IN APO- FORM OBTAINED RECOMBINANTLY FROM HEK293 CELLS.
Descriptor:CAD PROTEIN, ZINC ION, FORMIC ACID
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-01-08
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.451 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6D
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD BOUND TO SUBSTRATE AT PH 6.0
Descriptor:CAD PROTEIN, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, N-CARBAMOYL-L-ASPARTATE, ...
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.298 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6E
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD BOUND TO SUBSTRATE AT PH 5.5
Descriptor:DIHYDROOROTASE, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, N-CARBAMOYL-L-ASPARTATE, ...
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.263 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6F
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD BOUND TO SUBSTRATE AT PH 6.5
Descriptor:DIHYDROOROTASE, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, N-CARBAMOYL-L-ASPARTATE, ...
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.261 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6I
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD BOUND TO SUBSTRATE AT PH 7.0
Descriptor:CAD PROTEIN, ZINC ION, FORMIC ACID, ...
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-01-08
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6J
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD BOUND TO SUBSTRATE AT PH 7.5
Descriptor:CAD PROTEIN, ZINC ION, (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ...
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.299 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6K
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD BOUND TO SUBSTRATE AT PH 8.0
Descriptor:CAD PROTEIN, ZINC ION, N-CARBAMOYL-L-ASPARTATE, ...
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.478 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6L
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD BOUND TO THE INHIBITOR FLUOROOROTATE AT PH 6.0
Descriptor:CAD PROTEIN, ZINC ION, FORMIC ACID, ...
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6M
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD BOUND TO THE INHIBITOR FLUOROOROTATE AT PH 7.0
Descriptor:CAD PROTEIN, ZINC ION, FORMIC ACID, ...
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-01-08
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6N
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD E1637T MUTANT BOUND TO SUBSTRATE AT PH 6.0
Descriptor:CAD PROTEIN, ZINC ION, FORMIC ACID, ...
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6O
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD C1613S MUTANT IN APO-FORM AT PH 6.0
Descriptor:CAD PROTEIN, ZINC ION, FORMIC ACID
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6P
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD C1613S MUTANT IN APO-FORM AT PH 7.0
Descriptor:CAD PROTEIN, ZINC ION, FORMIC ACID
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.518 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
4C6Q
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN OF HUMAN CAD C1613S MUTANT BOUND TO SUBSTRATE AT PH 7.0
Descriptor:CAD PROTEIN, OROTIC ACID, ZINC ION, ...
Authors:Ramon-Maiques, S., Lallous, N., Grande-Garcia, A.
Deposit date:2013-09-18
Release date:2014-02-05
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.659 Å)
Cite:Structure, Functional Characterization and Evolution of the Dihydroorotase Domain of Human Cad.
Structure, 22, 2014
5G1N
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ASPARTATE TRANSCARBAMOYLASE DOMAIN OF HUMAN CAD BOUND TO PALA
Descriptor:CAD PROTEIN, N-(PHOSPHONACETYL)-L-ASPARTIC ACID, 1,2-ETHANEDIOL
Authors:Ruiz-Ramos, A., Grande-Garcia, A., Moreno-Morcillo, M.D., Ramon-Maiques, S.
Deposit date:2016-03-29
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala.
Structure, 24, 2016
5G1O
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ASPARTATE TRANSCARBAMOYLASE DOMAIN OF HUMAN CAD IN APO FORM
Descriptor:CAD PROTEIN, 1,2-ETHANEDIOL, GLYCEROL
Authors:Ruiz-Ramos, A., Grande-Garcia, A., Moreno-Morcillo, M.D., Ramon-Maiques, S.
Deposit date:2016-03-29
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala.
Structure, 24, 2016
5G1P
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ASPARTATE TRANSCARBAMOYLASE DOMAIN OF HUMAN CAD BOUND TO CARBAMOYL PHOSPHATE
Descriptor:CAD PROTEIN, PHOSPHORIC ACID MONO(FORMAMIDE)ESTER
Authors:Ruiz-Ramos, A., Grande-Garcia, A., Moreno-Morcillo, M.D., Ramon-Maiques, S.
Deposit date:2016-03-29
Release date:2016-06-22
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-Tumoral Drug Pala.
Structure, 24, 2016
5NNN
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ASPARTATE TRANSCARBAMOYLASE FROM CHAETOMIUM THERMOPHILUM CAD-LIKE
Descriptor:ctATC, GLYCEROL
Authors:Moreno-Morcillo, M., Grande-Garcia, A., Ramon-Maiques, S.
Deposit date:2017-04-10
Release date:2017-06-07
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis.
Structure, 25, 2017
5NNQ
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ASPARTATE TRANSCARBAMOYLASE FROM CHAETOMIUM THERMOPHILUM CAD-LIKE BOUND TO CARBAMOYL PHOSPHATE
Descriptor:ctATC, GLYCEROL
Authors:Moreno-Morcillo, M., Grande-Garcia, A., Ramon-Maiques, S.
Deposit date:2017-04-10
Release date:2017-06-07
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis.
Structure, 25, 2017
5NNL
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INACTIVE DIHYDROOROTASE-LIKE DOMAIN OF CHAETOMIUM THERMOPHILUM CAD-LIKE MULTIFUNCTIONAL PROTEIN
Descriptor:Inactive dihydroorotase-like domain
Authors:Ramon-Maiques, S., Moreno-Morcillo, M., Grande-Garcia, A.
Deposit date:2017-04-10
Release date:2017-06-07
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis.
Structure, 25, 2017
6HFD
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HUMAN DIHYDROOROTASE MUTANT F1563L APO STRUCTURE
Descriptor:CAD protein, ZINC ION, FORMIC ACID
Authors:Ramon-Maiques, S., Grande Garcia, A.
Deposit date:2018-08-21
Release date:2018-10-24
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.869968 Å)
Cite:Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD.
J. Biol. Chem., 293, 2018
6HFE
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HUMAN DIHYDROOROTASE MUTANT F1563T APO STRUCTURE
Descriptor:CAD protein, ZINC ION, FORMIC ACID
Authors:Ramon-Maiques, S., Grande Garcia, A.
Deposit date:2018-08-21
Release date:2018-10-24
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.479974 Å)
Cite:Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD.
J. Biol. Chem., 293, 2018
6HFF
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HUMAN DIHYDROOROTASE MUTANT F1563Y APO STRUCTURE
Descriptor:CAD protein, ZINC ION, FORMIC ACID
Authors:Ramon-Maiques, S., Grande Garcia, A.
Deposit date:2018-08-21
Release date:2018-10-24
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.510001 Å)
Cite:Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD.
J. Biol. Chem., 293, 2018
6HFH
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HUMAN DIHYDROOROTASE MUTANT F1563A CO-CRYSTALLIZED WITH CARBAMOYL ASPARTATE AT PH 7.0
Descriptor:CAD protein, ZINC ION, FORMIC ACID, ...
Authors:Ramon-Maiques, S., Grande Garcia, A.
Deposit date:2018-08-21
Release date:2018-10-24
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.448713 Å)
Cite:Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD.
J. Biol. Chem., 293, 2018
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