Author results

1ANB
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ANIONIC TRYPSIN MUTANT WITH SER 214 REPLACED BY GLU
Descriptor:ANIONIC TRYPSIN, CALCIUM ION, BENZAMIDINE
Authors:Fletterick, R.J., Mcgrath, M.E.
Deposit date:1994-12-21
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214.
Biochemistry, 31, 1992
1ANC
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ANIONIC TRYPSIN MUTANT WITH SER 214 REPLACED BY LYS
Descriptor:ANIONIC TRYPSIN, CALCIUM ION, BENZAMIDINE
Authors:Fletterick, R.J., Mcgrath, M.E.
Deposit date:1994-12-21
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Perturbing the polar environment of Asp102 in trypsin: consequences of replacing conserved Ser214.
Biochemistry, 31, 1992
1AND
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ANIONIC TRYPSIN MUTANT WITH ARG 96 REPLACED BY HIS
Descriptor:ANIONIC TRYPSIN, COPPER (II) ION, BENZAMIDINE
Authors:Fletterick, R.J., Mcgrath, M.E.
Deposit date:1994-12-21
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of an engineered, metal-actuated switch in trypsin.
Biochemistry, 32, 1993
1ANE
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ANIONIC TRYPSIN WILD TYPE
Descriptor:ANIONIC TRYPSIN, BENZAMIDINE
Authors:Fletterick, R.J., Mcgrath, M.E.
Deposit date:1994-12-21
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of an engineered, metal-actuated switch in trypsin.
Biochemistry, 32, 1993
3F5C
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STRUCTURE OF DAX-1:LRH-1 COMPLEX
Descriptor:Nuclear receptor subfamily 5 group A member 2, Nuclear receptor subfamily 0 group B member 1
Authors:Fletterick, R.J., Sablin, E.P.
Deposit date:2008-11-03
Release date:2008-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
Proc.Natl.Acad.Sci.USA, 105, 2008
1YGP
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PHOSPHORYLATED FORM OF YEAST GLYCOGEN PHOSPHORYLASE WITH PHOSPHATE BOUND IN THE ACTIVE SITE.
Descriptor:YEAST GLYCOGEN PHOSPHORYLASE, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Lin, K., Rath, V.L., Dai, S.C., Fletterick, R.J., Hwang, P.K.
Deposit date:1996-05-30
Release date:1996-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A protein phosphorylation switch at the conserved allosteric site in GP.
Science, 273, 1996
1EWL
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CRYSTAL STRUCTURE OF CRUZAIN BOUND TO WRR-99
Descriptor:CRUZAIN, N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-D-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE
Authors:Brinen, L.S., Gillmor, S.A., Fletterick, R.J.
Deposit date:2000-04-26
Release date:2003-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Cruzain bound to WRR-99
To be Published
1EWM
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THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-112
Descriptor:CRUZAIN, N-[3-CARBOXY-2-HYDROXY-PROPIONYL]-L-HOMOPHENYLALANYL-AMINO-2-METHYLBUTANE
Authors:Brinen, L.S., Gillmor, S.A., Fletterick, R.J.
Deposit date:2000-04-26
Release date:2003-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Cruzain bound to WRR-112
To be Published
1EWO
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THE CYSTEINE PROTEASE CRUZAIN BOUND TO WRR-204
Descriptor:CRUZAIN, N-[N'-BENZYLOXYCARBONYL-PHENYLALANINYL]-3-AMINO-5-PHENYL-PENTANE-1-SULFONIC ACID PHENYL ESTER
Authors:Brinen, L.S., Gillmor, S.A., Fletterick, R.J.
Deposit date:2000-04-26
Release date:2003-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Cruzain bound to WRR-204
To be Published
2AIM
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CRUZAIN INHIBITED WITH BENZOYL-ARGININE-ALANINE-FLUOROMETHYLKETONE
Descriptor:CRUZAIN, BENZOYL-ARGININE-ALANINE-FLUORO-METHYL KETONE
Authors:Gillmor, S.A., Fletterick, R.J.
Deposit date:1997-04-21
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural determinants of specificity in the cysteine protease cruzain.
Protein Sci., 6, 1997
1A0Q
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29G11 COMPLEXED WITH PHENYL [1-(1-N-SUCCINYLAMINO)PENTYL] PHOSPHONATE
Descriptor:29G11 FAB (LIGHT CHAIN), 29G11 FAB (HEAVY CHAIN), ZINC ION, ...
Authors:Buchbinder, J.L., Stephenson, R.C., Scanlan, T.S., Fletterick, R.J.
Deposit date:1997-12-05
Release date:1999-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A comparison of the crystallographic structures of two catalytic antibodies with esterase activity.
J.Mol.Biol., 282, 1998
1AZZ
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FIDDLER CRAB COLLAGENASE COMPLEXED TO ECOTIN
Descriptor:COLLAGENASE, ECOTIN
Authors:Perona, J.J., Fletterick, R.J.
Deposit date:1997-11-24
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of an ecotin-collagenase complex suggests a model for recognition and cleavage of the collagen triple helix.
Biochemistry, 36, 1997
1BF6
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PHOSPHOTRIESTERASE HOMOLOGY PROTEIN FROM ESCHERICHIA COLI
Descriptor:PHOSPHOTRIESTERASE HOMOLOGY PROTEIN, ZINC ION, SULFATE ION, ...
Authors:Buchbinder, J.L., Stephenson, R.C., Scanlan, T.S., Fletterick, R.J.
Deposit date:1998-05-27
Release date:1999-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family.
Biochemistry, 37, 1998
1BRA
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RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
Descriptor:TRYPSIN, CALCIUM ION, BENZAMIDINE
Authors:Perona, J.J., Mcgrath, M.E., Fletterick, R.J.
Deposit date:1992-12-17
Release date:1994-04-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Relocating a negative charge in the binding pocket of trypsin.
J.Mol.Biol., 230, 1993
1BRB
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CRYSTAL STRUCTURES OF RAT ANIONIC TRYPSIN COMPLEXED WITH THE PROTEIN INHIBITORS APPI AND BPTI
Descriptor:TRYPSIN, PANCREATIC TRYPSIN INHIBITOR
Authors:Perona, J.J., Fletterick, R.J.
Deposit date:1992-12-17
Release date:1994-07-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI.
J.Mol.Biol., 230, 1993
1BRC
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RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
Descriptor:TRYPSIN, AMYLOID BETA-PROTEIN PRECURSOR INHIBITOR DOMAIN (APPI)
Authors:Perona, J.J., Fletterick, R.J.
Deposit date:1992-12-17
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Relocating a negative charge in the binding pocket of trypsin.
J.Mol.Biol., 230, 1993
1F29
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CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (I)
Descriptor:CRUZAIN, 3-[[N-[MORPHOLIN-N-YL]-CARBONYL]-PHENYLALANINYL-AMINO]-5- PHENYL-PENTANE-1-SULFONYLBENZENE
Authors:Brinen, L.S., Hansell, E., Roush, W.R., McKerrow, J.H., Fletterick, R.J.
Deposit date:2000-05-23
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure Fold.Des., 8, 2000
1F2A
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CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO A VINYL SULFONE DERIVED INHIBITOR (II)
Descriptor:CRUZAIN, 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONYLMETHYLBENZENE
Authors:Brinen, L.S., Hansell, E., Roush, W.R., McKerrow, J.H., Fletterick, R.J.
Deposit date:2000-05-23
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure Fold.Des., 8, 2000
1F2B
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CRYSTAL STRUCTURE ANALYSIS OF CRUZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (III)
Descriptor:CRUZAIN, 3-[N-[BENZYLOXYCARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID 4-NITRO-PHENYL ESTER
Authors:Brinen, L.S., Hansell, E., Roush, W.R., McKerrow, J.H., Fletterick, R.J.
Deposit date:2000-05-23
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure Fold.Des., 8, 2000
1F2C
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CRYSTAL STRUCTURE ANALYSIS OF CRYZAIN BOUND TO VINYL SULFONE DERIVED INHIBITOR (IV)
Descriptor:CRUZAIN, 3-[[N-[4-METHYL-PIPERAZINYL]CARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID BENZYLOXY-AMIDE
Authors:Brinen, L.S., Hansell, E., Roush, W.R., McKerrow, J.H., Fletterick, R.J.
Deposit date:2000-05-23
Release date:2000-07-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
Structure Fold.Des., 8, 2000
1SLU
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RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN
Descriptor:ECOTIN, ANIONIC TRYPSIN, CALCIUM ION, ...
Authors:Brinen, L.S., Fletterick, R.J.
Deposit date:1996-02-07
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry, 35, 1996
1SLV
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RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN; COPPER-BOUND
Descriptor:ECOTIN, ANIONIC TRYPSIN, CALCIUM ION, ...
Authors:Brinen, L.S., Fletterick, R.J.
Deposit date:1996-02-07
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry, 35, 1996
1SLW
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RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN; NICKEL-BOUND
Descriptor:ECOTIN, ANIONIC TRYPSIN, CALCIUM ION, ...
Authors:Brinen, L.S., Fletterick, R.J.
Deposit date:1996-02-07
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry, 35, 1996
1SLX
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RAT ANIONIC N143H, E151H TRYPSIN COMPLEXED TO A86H ECOTIN; ZINC-BOUND
Descriptor:ECOTIN, ANIONIC TRYPSIN, CALCIUM ION, ...
Authors:Brinen, L.S., Fletterick, R.J.
Deposit date:1996-02-07
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray structures of a designed binding site in trypsin show metal-dependent geometry.
Biochemistry, 35, 1996
1B89
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CLATHRIN HEAVY CHAIN PROXIMAL LEG SEGMENT (BOVINE)
Descriptor:PROTEIN (CLATHRIN HEAVY CHAIN)
Authors:Ybe, J.A., Brodsky, F.M., Hofmann, K., Lin, K., Liu, S.-H., Chen, L., Earnest, T.N., Fletterick, R.J., Hwang, P.K.
Deposit date:1999-05-27
Release date:1999-06-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Clathrin self-assembly is mediated by a tandemly repeated superhelix.
Nature, 399, 1999