Author results

1ULA
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APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS
Descriptor:PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION
Authors:Ealick, S.E., Rule, S.A., Carter, D.C., Greenhough, T.J., Babu, Y.S., Cook, W.J., Habash, J., Helliwell, J.R., Stoeckler, J.D., Parksjunior, R.E., Chen, S.-F., Bugg, C.E.
Deposit date:1991-11-05
Release date:1993-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proc.Natl.Acad.Sci.USA, 88, 1991
1ULB
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APPLICATION OF CRYSTALLOGRAPHIC AND MODELING METHODS IN THE DESIGN OF PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITORS
Descriptor:PURINE NUCLEOSIDE PHOSPHORYLASE, SULFATE ION, GUANINE
Authors:Ealick, S.E., Rule, S.A., Carter, D.C., Greenhough, T.J., Babu, Y.S., Cook, W.J., Habash, J., Helliwell, J.R., Stoeckler, J.D., Parksjunior, R.E., Chen, S.-F., Bugg, C.E.
Deposit date:1991-11-05
Release date:1993-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Application of crystallographic and modeling methods in the design of purine nucleoside phosphorylase inhibitors.
Proc.Natl.Acad.Sci.USA, 88, 1991
1HIG
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THREE-DIMENSIONAL STRUCTURE OF RECOMBINANT HUMAN INTERFERON-GAMMA.
Descriptor:INTERFERON-GAMMA
Authors:Ealick, S.E., Cook, W.J., Vijay-Kumar, S., Carson, M., Nagabhushan, T.L., Trotta, P.P., Bugg, C.E.
Deposit date:1991-10-03
Release date:1992-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Three-dimensional structure of recombinant human interferon-gamma.
Science, 252, 1991
1OTX
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PURINE NUCLEOSIDE PHOSPHORYLASE M64V MUTANT
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, W.B., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-23
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OTY
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NATIVE PNP +ALLO
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION, 6-METHYLPURINE
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, W.B., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-23
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OU4
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NATIVE PNP +TALO
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION, 6-METHYLPURINE
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, W.B., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-24
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OUM
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M64V PNP +TALO
Descriptor:Purine nucleoside phosphorylase, 9-(6-DEOXY-ALPHA-L-TALOFURANOSYL)-6-METHYLPURINE, PHOSPHATE ION
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, W.B., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-24
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OV6
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M64V PNP + ALLO
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION, 9-(6-DEOXY-BETA-D-ALLOFURANOSYL)-6-METHYLPURINE
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, P.W., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-25
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OVG
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M64V PNP +MEPDR
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION, 9-(2-DEOXY-BETA-D-RIBOFURANOSYL)-6-METHYLPURINE
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, P.W., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-26
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1QCZ
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CRYSTAL STRUCTURE OF E. COLI PURE, AN UNUSUAL MUTASE THAT CATALYZES THE CONVERSION OF N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE (N5-CAIR) TO 4-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE (CAIR) IN THE PURINE BIOSYNTHETIC PATHWAY
Descriptor:N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE
Authors:Ealick, S.E., Mathews, I.I.
Deposit date:1999-05-10
Release date:1999-11-10
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway.
Structure Fold.Des., 7, 1999
1T3T
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STRUCTURE OF FORMYLGLYCINAMIDE SYNTHETASE
Descriptor:Phosphoribosylformylglycinamidine synthase, MAGNESIUM ION, SULFATE ION, ...
Authors:Ealick, S.E., Anand, R., Hoskin, A.A., Stubbe, J.
Deposit date:2004-04-27
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Domain Organization of Salmonella typhimurium Formylglycinamide Ribonucleotide Amidotransferase Revealed by X-ray crystallography
Biochemistry, 43, 2004
1ZUD
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STRUCTURE OF THIS-THIF PROTEIN COMPLEX
Descriptor:Adenylyltransferase thiF, ThiS protein, ZINC ION, ...
Authors:Ealick, S.E., Lehmann, C.
Deposit date:2005-05-30
Release date:2006-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structure of the Escherichia coli ThiS-ThiF Complex, a Key Component of the Sulfur Transfer System in Thiamin Biosynthesis.
Biochemistry, 45, 2006
2HRU
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T. MARITIMA PURL COMPLEXED WITH ADP
Descriptor:Phosphoribosylformylglycinamidine synthase II, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Ealick, S.E., Morar, M.
Deposit date:2006-07-20
Release date:2007-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006
2HRY
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T. MARITIMA PURL COMPLEXED WITH AMPPCP
Descriptor:Phosphoribosylformylglycinamidine synthase II, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Ealick, S.E., Morar, M.
Deposit date:2006-07-20
Release date:2007-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006
2HS0
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T. MARITIMA PURL COMPLEXED WITH ATP
Descriptor:Phosphoribosylformylglycinamidine synthase II, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
Authors:Ealick, S.E., Morar, M.
Deposit date:2006-07-20
Release date:2007-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006
2HS3
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T. MARITIMA PURL COMPLEXED WITH FGAR
Descriptor:Phosphoribosylformylglycinamidine synthase II, PHOSPHATE ION, N-(N-FORMYLGLYCYL)-5-O-PHOSPHONO-BETA-D-RIBOFURANOSYLAMINE
Authors:Ealick, S.E., Morar, M.
Deposit date:2006-07-21
Release date:2007-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006
2HS4
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T. MARITIMA PURL COMPLEXED WITH FGAR AND AMPPCP
Descriptor:Phosphoribosylformylglycinamidine synthase II, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Ealick, S.E., Morar, M.
Deposit date:2006-07-21
Release date:2007-01-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily
Biochemistry, 45, 2006
2NSH
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E. COLI PURE H45Q MUTANT COMPLEXED WITH NITRO-AIR
Descriptor:Phosphoribosylaminoimidazole carboxylase catalytic subunit, ((2R,3S,4R,5R)-5-(5-AMINO-4-NITRO-1H-IMIDAZOL-1-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL DIHYDROGEN PHOSPHATE
Authors:Ealick, S.E., Morar, M.
Deposit date:2006-11-04
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
2NSJ
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E. COLI PURE H45Q MUTANT COMPLEXED WITH CAIR
Descriptor:Phosphoribosylaminoimidazole carboxylase catalytic subunit, 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID
Authors:Ealick, S.E., Morar, M.
Deposit date:2006-11-04
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
2NSL
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E. COLI PURE H45N MUTANT COMPLEXED WITH CAIR
Descriptor:Phosphoribosylaminoimidazole carboxylase catalytic subunit, 5-AMINO-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID
Authors:Ealick, S.E., Morar, M.
Deposit date:2006-11-04
Release date:2007-04-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:N(5)-CAIR Mutase: Role of a CO(2) Binding Site and Substrate Movement in Catalysis.
Biochemistry, 46, 2007
2QJG
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M. JANNASCHII ADH SYNTHASE COMPLEXED WITH F1,6P
Descriptor:Putative aldolase MJ0400, 1,6-DI-O-PHOSPHONO-D-ALLITOL
Authors:Ealick, S.E., Morar, M.
Deposit date:2007-07-07
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry, 46, 2007
2QJH
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M. JANNASCHII ADH SYNTHASE COVALENTLY BOUND TO DIHYDROXYACETONE PHOSPHATE
Descriptor:Putative aldolase MJ0400, 1,3-DIHYDROXYACETONEPHOSPHATE
Authors:Ealick, S.E., Morar, M.
Deposit date:2007-07-07
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry, 46, 2007
2QJI
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M. JANNASCHII ADH SYNTHASE COMPLEXED WITH DIHYDROXYACETONE PHOSPHATE AND GLYCEROL
Descriptor:Putative aldolase MJ0400, 1,3-DIHYDROXYACETONEPHOSPHATE, GLYCEROL
Authors:Ealick, S.E., Morar, M.
Deposit date:2007-07-07
Release date:2007-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid synthase, a catalyst in the archaeal pathway for the biosynthesis of aromatic amino acids.
Biochemistry, 46, 2007
2QQC
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E109Q MUTANT OF PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE FROM METHANOCOCCUS JANNASHII
Descriptor:Pyruvoyl-dependent arginine decarboxylase (EC 4.1.1.19) (PvlArgDC), AGMATINE, PYRUVIC ACID, ...
Authors:Ealick, S.E., Soriano, E.S.
Deposit date:2007-07-26
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii.
Acta Crystallogr.,Sect.D, 64, 2008
2QQD
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N47A MUTANT OF PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE FROM METHANOCOCCUS JANNASHII
Descriptor:Pyruvoyl-dependent arginine decarboxylase (EC 4.1.1.19) (PvlArgDC), AGMATINE, PYRUVIC ACID, ...
Authors:Ealick, S.E., Soriano, E.S.
Deposit date:2007-07-26
Release date:2008-03-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the N47A and E109Q mutant proteins of pyruvoyl-dependent arginine decarboxylase from Methanococcus jannaschii.
Acta Crystallogr.,Sect.D, 64, 2008