Author results

1NVO
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SOLUTION STRUCTURE OF A FOUR-HELIX BUNDLE MODEL, APO-DF1
Descriptor:Homodimeric Alpha2 Four-Helix Bundle
Authors:Maglio, O., Nastri, F., Pavone, V., Lombardi, A., DeGrado, W.F.
Deposit date:2003-02-04
Release date:2003-03-25
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Preorganization of molecular binding sites in designed diiron proteins
Proc.Natl.Acad.Sci.USA, 100, 2003
1U7J
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SOLUTION STRUCTURE OF A DIIRON PROTEIN MODEL
Descriptor:Four-helix bundle model, ZINC ION
Authors:Maglio, O., Nastri, F., Calhoun, J.R., Lahr, S., Pavone, V., DeGrado, W.F., Lombardi, A.
Deposit date:2004-08-04
Release date:2005-03-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Analysis and Design of Turns in alpha-Helical Hairpins
J.Mol.Biol., 346, 2005
1U7M
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SOLUTION STRUCTURE OF A DIIRON PROTEIN MODEL: DUE FERRI(II) TURN MUTANT
Descriptor:Four-helix bundle model, ZINC ION
Authors:Maglio, O., Nastri, F., Calhoun, J.R., Lahr, S., Pavone, V., DeGrado, W.F., Lombardi, A.
Deposit date:2004-08-04
Release date:2005-03-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Analysis and Design of Turns in alpha-Helical Hairpins
J.Mol.Biol., 346, 2005
2HZ8
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QM/MM STRUCTURE REFINED FROM NMR-STRUCTURE OF A SINGLE CHAIN DIIRON PROTEIN
Descriptor:De novo designed diiron protein, ZINC ION
Authors:Calhoun, J.R., Liu, W., Spiegel, K., Dal Peraro, M., Klein, M.L., Wand, A.J., DeGrado, W.F.
Deposit date:2006-08-08
Release date:2007-07-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement.
Structure, 16, 2008
1QP6
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SOLUTION STRUCTURE OF ALPHA2D
Descriptor:PROTEIN (ALPHA2D)
Authors:Hill, R.B., DeGrado, W.F.
Deposit date:1999-06-01
Release date:1999-06-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of Alpha2D, A Nativelike De Novo Designed Protein
J.Am.Chem.Soc., 120, 1998
3AL1
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DESIGNED PEPTIDE ALPHA-1, RACEMIC P1BAR FORM
Descriptor:PROTEIN (D, L-ALPHA-1), (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Patterson, W.R., Anderson, D.H., Degrado, W.F., Cascio, D., Eisenberg, D.
Deposit date:1998-10-26
Release date:1998-11-04
Last modified:2012-03-28
Method:X-RAY DIFFRACTION (0.75 Å)
Cite:Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1.
Protein Sci., 8, 1999
1AL1
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CRYSTAL STRUCTURE OF ALPHA1: IMPLICATIONS FOR PROTEIN DESIGN
Descriptor:ALPHA HELIX PEPTIDE: ELLKKLLEELKG, SULFATE ION
Authors:Hill, C.P., Anderson, D.H., Wesson, L., Degrado, W.F., Eisenberg, D.
Deposit date:1990-07-02
Release date:1991-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of alpha 1: implications for protein design.
Science, 249, 1990
1COI
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DESIGNED TRIMERIC COILED COIL-VALD
Descriptor:COIL-VALD, SULFATE ION
Authors:Ogihara, N.L., Weiss, M.S., Degrado, W.F., Eisenberg, D.
Deposit date:1996-08-10
Release date:1997-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies.
Protein Sci., 6, 1997
1G6U
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CRYSTAL STRUCTURE OF A DOMAIN SWAPPED DIMER
Descriptor:DOMAIN SWAPPED DIMER, SULFATE ION, trifluoroacetic acid
Authors:Ogihara, N.L., Ghirlanda, G., Bryson, J.W., Gingery, M., DeGrado, W.F., Eisenberg, D.
Deposit date:2000-11-07
Release date:2001-02-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Design of three-dimensional domain-swapped dimers and fibrous oligomers.
Proc.Natl.Acad.Sci.USA, 98, 2001
1Y47
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STRUCTURAL STUDIES OF DESIGNED ALPHA-HELICAL HAIRPINS
Descriptor:dueferri (DF2), CADMIUM ION
Authors:Lahr, S.J., Engel, D.E., Stayrook, S.E., Maglio, O., North, B., Geremia, S., Lombardi, A., DeGrado, W.F.
Deposit date:2004-11-30
Release date:2005-03-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Analysis and design of turns in alpha-helical hairpins
J.Mol.Biol., 346, 2005
1YOD
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CRYSTAL STRUCTURE OF A WATER SOLUBLE ANALOG OF PHOSPHOLAMBAN
Descriptor:water-solublized phospholamban
Authors:Slovic, A.M., Stayrook, S.E., North, B., DeGrado, W.F.
Deposit date:2005-01-27
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray structure of a water-soluble analog of the membrane protein phospholamban: sequence determinants defining the topology of tetrameric and pentameric coiled coils.
J.Mol.Biol., 348, 2005
2A3D
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SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D)
Descriptor:PROTEIN (DE NOVO THREE-HELIX BUNDLE)
Authors:Walsh, S.T.R., Cheng, H., Bryson, J.W., Roder, H., Degrado, W.F.
Deposit date:1999-04-01
Release date:1999-05-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and dynamics of a de novo designed three-helix bundle protein.
Proc.Natl.Acad.Sci.USA, 96, 1999
2KQT
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SOLID-STATE NMR STRUCTURE OF THE M2 TRANSMEMBRANE PEPTIDE OF THE INFLUENZA A VIRUS IN DMPC LIPID BILAYERS BOUND TO DEUTERATED AMANTADINE
Descriptor:M2 protein, (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine
Authors:Cady, S.D., Schmidt-Rohr, K., Wang, J., Soto, C.S., DeGrado, W.F., Hong, M.
Deposit date:2009-11-18
Release date:2010-02-09
Last modified:2011-10-26
Method:SOLID-STATE NMR
Cite:Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers
Nature, 463, 2010
2MUZ
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SSNMR STRUCTURE OF A DESIGNED ROCKER PROTEIN
Descriptor:designed rocker protein
Authors:Wang, T., Joh, N., Wu, Y., DeGrado, W.F., Hong, M.
Deposit date:2014-09-18
Release date:2014-12-24
Last modified:2015-01-14
Method:SOLUTION NMR
Cite:De novo design of a transmembrane Zn2+-transporting four-helix bundle.
Science, 346, 2014
3LBW
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HIGH RESOLUTION CRYSTAL STRUCTURE OF TRANSMEMBRANE DOMAIN OF M2
Descriptor:M2 protein, 4-bromobenzoic acid, DI(HYDROXYETHYL)ETHER, ...
Authors:Acharya, R., Polishchuk, A.L., DeGrado, W.F.
Deposit date:2010-01-08
Release date:2010-07-28
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.
Proc.Natl.Acad.Sci.USA, 107, 2010
3S0R
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CRYSTAL STRUCTURE OF DE NOVO DESIGNED HELICAL ASSEMBLY PROTEIN
Descriptor:De novo designed Helical Assembly
Authors:Acharya, R., Grigoryan, G., Kim, Y.H., DeGrado, W.F.
Deposit date:2011-05-13
Release date:2011-06-15
Last modified:2011-08-17
Method:X-RAY DIFFRACTION (2.453 Å)
Cite:Computational design of virus-like protein assemblies on carbon nanotube surfaces.
Science, 332, 2011
4JFX
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STRUCTURE OF PHOSPHOTYROSINE (PTYR) SCAFFOLD BOUND TO PTYR PEPTIDE
Descriptor:Fab light chain, Fab heavy chain, Phosphopeptide, ...
Authors:Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A.
Deposit date:2013-02-28
Release date:2013-09-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
4JFY
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APO STRUCTURE OF PHOSPHOTYROSINE (PYAB) SCAFFOLD
Descriptor:Fab light chain, Fab heavy chain, TETRAETHYLENE GLYCOL
Authors:Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A.
Deposit date:2013-02-28
Release date:2013-08-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
4JFZ
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STRUCTURE OF PHOSPHOSERINE (PSAB) SCAFFOLD BOUND TO PSER PEPTIDE
Descriptor:Fab light chain, Fab heavy chain, Phosphopeptide, ...
Authors:Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A.
Deposit date:2013-02-28
Release date:2013-08-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
4JG0
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STRUCTURE OF PHOSPHOSERINE/THREONINE (PSTAB) SCAFFOLD BOUND TO PSER PEPTIDE
Descriptor:Fab light chain, Fab heavy chain, Phosphopeptide, ...
Authors:Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A.
Deposit date:2013-02-28
Release date:2013-08-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
4JG1
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STRUCTURE OF PHOSPHOSERINE/THREONINE (PSTAB) SCAFFOLD BOUND TO PTHR PEPTIDE
Descriptor:Fab light chain, Fab heavy chain, Phosphopeptide, ...
Authors:Koerber, J.T., Thomsen, N.D., Hannigan, B.T., Degrado, W.F., Wells, J.A.
Deposit date:2013-02-28
Release date:2013-08-28
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Nature-inspired design of motif-specific antibody scaffolds.
Nat.Biotechnol., 31, 2013
4P6J
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CRYSTAL STRUCTURE OF THE COMPUTATIONALLY DESIGNED TRANSMEMBRANE METALLOTRANSPORTER WITH 4-BROMOPHENYLALANINE IN OCTYL GLUCOSIDE
Descriptor:Computationally Designed Transporter of Zn(II) and Proton, SULFATE ION
Authors:Joh, N.H., Acharya, R., DeGrado, W.F.
Deposit date:2014-03-25
Release date:2014-12-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:De novo design of a transmembrane Zn2+-transporting four-helix bundle.
Science, 346, 2014
4P6K
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CRYSTAL STRUCTURE OF THE COMPUTATIONALLY DESIGNED TRANSMEMBRANE METALLOTRANSPORTER WITH 4-BROMOPHENYLALANINE IN LIPIDIC CUBIC PHASE
Descriptor:Computationally Designed Transporter of Zn(II) and Proton
Authors:Joh, N.H., Acharya, R., DeGrado, W.F.
Deposit date:2014-03-25
Release date:2014-12-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:De novo design of a transmembrane Zn2+-transporting four-helix bundle.
Science, 346, 2014
4P6L
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CRYSTAL STRUCTURE OF THE COMPUTATIONALLY DESIGNED TRANSMEMBRANE METALLOTRANSPORTER IN OCTYL GLUCOSIDE
Descriptor:Computationally Designed Transporter of Zn(II) and proton
Authors:Joh, N.H., Acharya, R., DeGrado, W.F.
Deposit date:2014-03-25
Release date:2014-12-24
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.803 Å)
Cite:De novo design of a transmembrane Zn2+-transporting four-helix bundle.
Science, 346, 2014
4QKC
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INFLUENZA A M2 WILD TYPE TM DOMAIN AT LOW PH IN THE LIPIDIC CUBIC PHASE UNDER CRYO DIFFRACTION CONDITIONS
Descriptor:influenza M2 monomer, CALCIUM ION, CHLORIDE ION, ...
Authors:Thomaston, J.L., DeGrado, W.F.
Deposit date:2014-06-05
Release date:2015-11-11
Last modified:2015-12-16
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction.
Proc.Natl.Acad.Sci.USA, 112, 2015