Author results

2QFB
  • Download 2qfb
  • View 2qfb
Molmil generated image of 2qfb
CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF HUMAN RIG-I WITH BOUND ZN
Descriptor:Probable ATP-dependent RNA helicase DDX58, ZINC ION
Authors:Cui, S., Lammens, A., Lammens, K., Hopfner, K.P.
Deposit date:2007-06-27
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.
Mol.Cell, 29, 2008
2QFD
  • Download 2qfd
  • View 2qfd
Molmil generated image of 2qfd
CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF HUMAN RIG-I WITH BOUND HG
Descriptor:Probable ATP-dependent RNA helicase DDX58, MERCURY (II) ION
Authors:Cui, S., Lammens, A., Lammens, K., Hopfner, K.P.
Deposit date:2007-06-27
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.
Mol.Cell, 29, 2008
3EIK
  • Download 3eik
  • View 3eik
Molmil generated image of 3eik
DOUBLE STRANDED DNA BINDING PROTEIN
Descriptor:TATA-box-binding protein, 1,2-ETHANEDIOL
Authors:Cui, S., Wollmann, P., Moldt, M., Hopfner, K.-P.
Deposit date:2008-09-16
Release date:2009-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:structural studies of ecTBP
To be Published
3OCI
  • Download 3oci
  • View 3oci
Molmil generated image of 3oci
CRYSTAL STRUCTURE OF TBP (TATA BOX BINDING PROTEIN)
Descriptor:TRANSCRIPTION INITIATION FACTOR TFIID (TFIID-1), 1,2-ETHANEDIOL
Authors:Cui, S., Wollmann, P., Moldt, M., Hopfner, K.-P.
Deposit date:2010-08-10
Release date:2011-07-13
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.
Nature, 475, 2011
3OSY
  • Download 3osy
  • View 3osy
Molmil generated image of 3osy
HUMAN ENTEROVIRUS 71 3C PROTEASE
Descriptor:3C protease
Authors:Wang, J., Fan, T., Wang, M., Cui, S.
Deposit date:2010-09-10
Release date:2011-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9923 Å)
Cite:Crystal Structure of Human Enterovirus 71 3C Protease.
J.Mol.Biol., 408, 2011
2W4R
  • Download 2w4r
  • View 2w4r
Molmil generated image of 2w4r
CRYSTAL STRUCTURE OF THE REGULATORY DOMAIN OF HUMAN LGP2
Descriptor:PROBABLE ATP-DEPENDENT RNA HELICASE DHX58, MERCURY (II) ION, SULFATE ION
Authors:Pippig, D.A., Hellmuth, J.C., Cui, S., Kirchhofer, A., Lammens, K., Lammens, A., Schmidt, A., Rothenfusser, S., Hopfner, K.P.
Deposit date:2008-12-01
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The Regulatory Domain of the Rig-I Family ATPase Lgp2 Senses Double-Stranded RNA.
Nucleic Acids Res., 37, 2009
3G9A
  • Download 3g9a
  • View 3g9a
Molmil generated image of 3g9a
GREEN FLUORESCENT PROTEIN BOUND TO MINIMIZER NANOBODY
Descriptor:Green fluorescent protein, Minimizer
Authors:Kirchhofer, A., Helma, J., Schmidthals, K., Frauer, C., Cui, S., Karcher, A., Pellis, M., Muyldermans, S., Delucci, C.C., Cardoso, M.C., Leonhardt, H., Hopfner, K.-P., Rothbauer, U.
Deposit date:2009-02-13
Release date:2009-12-08
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (1.614 Å)
Cite:Modulation of protein properties in living cells using nanobodies
Nat.Struct.Mol.Biol., 17, 2010
3K1K
  • Download 3k1k
  • View 3k1k
Molmil generated image of 3k1k
GREEN FLUORESCENT PROTEIN BOUND TO ENHANCER NANOBODY
Descriptor:Green Fluorescent Protein, Enhancer
Authors:Kirchhofer, A., Helma, J., Schmidthals, K., Frauer, C., Cui, S., Karcher, A., Pellis, M., Muyldermans, S., Delucci, C.C., Cardoso, M.C., Leonhardt, H., Hopfner, K.-P., Rothbauer, U.
Deposit date:2009-09-28
Release date:2009-12-08
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Modulation of protein properties in living cells using nanobodies
Nat.Struct.Mol.Biol., 17, 2010
3VGX
  • Download 3vgx
  • View 3vgx
Molmil generated image of 3vgx
STRUCTURE OF GP41 T21/CP621-652
Descriptor:Envelope glycoprotein gp160, ACETIC ACID, GLYCEROL
Authors:Yao, X., Waltersperger, S., Wang, M., Cui, S.
Deposit date:2011-08-22
Release date:2012-04-25
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Discovery of critical residues for viral entry and inhibition through structural Insight of HIV-1 fusion inhibitor CP621-652.
J.Biol.Chem., 287, 2012
3VGY
  • Download 3vgy
  • View 3vgy
Molmil generated image of 3vgy
STRUCTURE OF HIV-1 GP41 NHR/FUSION INHIBITOR COMPLEX P321
Descriptor:Envelope glycoprotein gp160, CP32M, SULFATE ION
Authors:Yao, X., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2011-08-22
Release date:2012-06-13
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.034 Å)
Cite:Structural basis of potent and broad HIV-1 fusion inhibitor CP32M
J.Biol.Chem., 287, 2012
3VH7
  • Download 3vh7
  • View 3vh7
Molmil generated image of 3vh7
STRUCTURE OF HIV-1 GP41 NHR/FUSION INHIBITOR COMPLEX P21
Descriptor:Envelope glycoprotein gp160, CP32M, MAGNESIUM ION
Authors:Yao, X., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2011-08-23
Release date:2012-06-13
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.019 Å)
Cite:Structural basis of potent and broad HIV-1 fusion inhibitor CP32M
J.Biol.Chem., 287, 2012
3VIE
  • Download 3vie
  • View 3vie
Molmil generated image of 3vie
HIV-GP41 FUSION INHIBITOR SIFUVIRTIDE
Descriptor:Envelope glycoprotein gp160, Sifuvirtide
Authors:Yao, X., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2011-09-29
Release date:2012-01-18
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide
J.Biol.Chem., 287, 2012
3VTP
  • Download 3vtp
  • View 3vtp
Molmil generated image of 3vtp
HIV FUSION INHIBITOR MT-C34
Descriptor:Transmembrane protein gp41
Authors:Yao, X., Waltersperger, S., Wang, M., Cui, S.
Deposit date:2012-06-02
Release date:2012-08-22
Last modified:2014-01-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The M-T hook structure is critical for design of HIV-1 fusion inhibitors.
J.Biol.Chem., 287, 2012
3VTQ
  • Download 3vtq
  • View 3vtq
Molmil generated image of 3vtq
NOVEL HIV FUSION INHIBITOR
Descriptor:Envelope glycoprotein gp160, fusion inhibitor MT-Sifuvirtide
Authors:Yao, X., Waltersperger, S., Wang, M., Cui, S.
Deposit date:2012-06-02
Release date:2013-06-26
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Crystal structure of a novel HIV fusion inhibitor
To be Published
3VU5
  • Download 3vu5
  • View 3vu5
Molmil generated image of 3vu5
SHORT PEPTIDE HIV ENTRY INHIBITOR SC22EK
Descriptor:Transmembrane protein gp41, SC22, SULFATE ION, ...
Authors:Yao, X., Chong, H.H., Waltersperger, S., Wang, M.T., He, Y.X., Cui, S.
Deposit date:2012-06-19
Release date:2012-12-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.087 Å)
Cite:Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1
Faseb J., 27, 2013
3VU6
  • Download 3vu6
  • View 3vu6
Molmil generated image of 3vu6
SHORT PEPTIDE HIV ENTRY INHIBITOR MT-SC22EK WITH A M-T HOOK
Descriptor:Transmembrane protein gp41, MTSC22, SULFATE ION
Authors:Yao, X., Chong, H.H., Waltersperger, S., Wang, M.T., He, Y.X., Cui, S.
Deposit date:2012-06-19
Release date:2012-12-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.324 Å)
Cite:Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1
Faseb J., 27, 2013
3VWB
  • Download 3vwb
  • View 3vwb
Molmil generated image of 3vwb
CRYSTAL STRUCTURE OF VIRB CORE DOMAIN (SE-MET DERIVATIVE) COMPLEXED WITH THE CIS-ACTING SITE (5-BRU MODIFICATIONS) UPSTREAM ICSB PROMOTER
Descriptor:Virulence regulon transcriptional activator virB, DNA (26-MER)
Authors:Gao, X.P., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2012-08-21
Release date:2013-08-21
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (2.416 Å)
Cite:Structural insights into VirB-DNA complexes reveal mechanism of transcriptional activation of virulence genes
Nucleic Acids Res., 41, 2013
3W19
  • Download 3w19
  • View 3w19
Molmil generated image of 3w19
POTENT HIV FUSION INHIBITOR CP32M-2
Descriptor:Transmembrane protein gp41, fusion inhibitor CP32M-2
Authors:Yao, X., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2012-11-13
Release date:2013-12-11
Method:X-RAY DIFFRACTION (1.278 Å)
Cite:Optimization of novel anti-HIV fusion inhibitor
To be Published
3W2A
  • Download 3w2a
  • View 3w2a
Molmil generated image of 3w2a
CRYSTAL STRUCTURE OF VIRB CORE DOMAIN COMPLEXED WITH THE CIS-ACTING SITE UPSTREAM ICSP PROMOTER
Descriptor:Virulence regulon transcriptional activator VirB, DNA (31-mer)
Authors:Gao, X.P., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2012-11-27
Release date:2013-09-04
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (2.775 Å)
Cite:Structural insights into VirB-DNA complexes reveal mechanism of transcriptional activation of virulence genes
Nucleic Acids Res., 41, 2013
3W3C
  • Download 3w3c
  • View 3w3c
Molmil generated image of 3w3c
CRYSTAL STRUCTURE OF VIRB CORE DOMAIN COMPLEXED WITH THE CIS-ACTING SITE UPSTREAM ICSB PROMOTER
Descriptor:Virulence regulon transcriptional activator VirB, DNA (26-MER)
Authors:Gao, X.P., Waltersperger, S., Wang, M.T., Cui, S.
Deposit date:2012-12-19
Release date:2013-09-04
Last modified:2013-12-25
Method:X-RAY DIFFRACTION (2.431 Å)
Cite:Structural insights into VirB-DNA complexes reveal mechanism of transcriptional activation of virulence genes
Nucleic Acids Res., 41, 2013
4I2L
  • Download 4i2l
  • View 4i2l
Molmil generated image of 4i2l
NEW HIV ENTRY INHIBITOR MTSFT/T23 COMPLEX
Descriptor:GP41, inhibitor MTSFT
Authors:Yao, X., Chong, H.H., Waltersperger, S., Wang, M.T., He, Y.X., Cui, S.
Deposit date:2012-11-22
Release date:2014-01-22
Method:X-RAY DIFFRACTION (1.426 Å)
Cite:Potent antiviral activity of the novel HIV entry inhibitor MTSFT
To be Published
5GMQ
  • Download 5gmq
  • View 5gmq
Molmil generated image of 5gmq
STRUCTURE OF MERS-COV RBD IN COMPLEX WITH A FULLY HUMAN ANTIBODY MCA1
Descriptor:S protein, MCA1 heavy chain, MCA1 light chain, ...
Authors:Chen, C., Wang, J.M., Zou, T.T., Gao, X.P., Cui, S., Jin, Q.
Deposit date:2016-07-15
Release date:2017-05-31
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset.
J. Infect. Dis., 215, 2017
3OC3
  • Download 3oc3
  • View 3oc3
Molmil generated image of 3oc3
CRYSTAL STRUCTURE OF THE MOT1 N-TERMINAL DOMAIN IN COMPLEX WITH TBP
Descriptor:HELICASE MOT1, TRANSCRIPTION INITIATION FACTOR TFIID (TFIID-1), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Wollmann, P., Cui, S., Viswanathan, R., Berninghausen, O., Wells, M.N., Moldt, M., Witte, G., Butryn, A., Wendler, P., Beckmann, R., Auble, D.T., Hopfner, K.-P.
Deposit date:2010-08-09
Release date:2011-07-13
Last modified:2011-07-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP.
Nature, 475, 2011
3QZQ
  • Download 3qzq
  • View 3qzq
Molmil generated image of 3qzq
HUMAN ENTEROVIRUS 71 3C PROTEASE MUTANT E71D IN COMPLEX WITH RUPINTRIVIR
Descriptor:3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER
Authors:Wang, J., Fan, T., Yao, X., Wu, Z., Guo, L., Lei, X., Wang, J., Wang, M., Jin, Q., Cui, S.
Deposit date:2011-03-07
Release date:2011-08-10
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.7001 Å)
Cite:Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
3QZR
  • Download 3qzr
  • View 3qzr
Molmil generated image of 3qzr
HUMAN ENTEROVIRUS 71 3C PROTEASE MUTANT E71A IN COMPLEX WITH RUPINTRIVIR
Descriptor:3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, 1,2-ETHANEDIOL
Authors:Wang, J., Fan, T., Yao, X., Wu, Z., Guo, L., Lei, X., Wang, J., Wang, M., Jin, Q., Cui, S.
Deposit date:2011-03-07
Release date:2011-08-10
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.039 Å)
Cite:Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues.
J.Virol., 85, 2011
<123>