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1D5M
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X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDE AND SEB
Descriptor:HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ENTEROTOXIN TYPE B, INHIBITOR, ...
Authors:Swain, A.L., Crowther, R., Kammlott, U.
Deposit date:1999-10-07
Release date:2000-06-28
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.
J.Med.Chem., 43, 2000
1D5X
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X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH DIPEPTIDE MIMETIC AND SEB
Descriptor:HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ENTEROTOXIN TYPE B, DIPEPTIDE MIMETIC INHIBITOR
Authors:Swain, A., Crowther, R., Kammlott, U.
Deposit date:1999-10-12
Release date:2000-06-28
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.
J.Med.Chem., 43, 2000
1D5Z
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X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC AND SEB
Descriptor:PROTEIN (HLA CLASS II HISTOCOMPATIBILITY ANTIGEN), PROTEIN (ENTEROTOXIN TYPE B), PROTEIN (PEPTIDOMIMETIC INHIBITOR)
Authors:Swain, A., Crowther, R., Kammlott, U.
Deposit date:1999-10-12
Release date:2000-06-28
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.
J.Med.Chem., 43, 2000
1D6E
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CRYSTAL STRUCTURE OF HLA-DR4 COMPLEX WITH PEPTIDOMIMETIC AND SEB
Descriptor:HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, ENTEROTOXIN TYPE B, PEPTIDOMIMETIC INHIBITOR
Authors:Swain, A., Crowther, R., Kammlott, U.
Deposit date:1999-10-13
Release date:2000-06-28
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.
J.Med.Chem., 43, 2000
1FPP
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PROTEIN FARNESYLTRANSFERASE COMPLEX WITH FARNESYL DIPHOSPHATE
Descriptor:PROTEIN FARNESYLTRANSFERASE, ZINC ION, PHOSPHATE ION, ...
Authors:Dunten, P., Kammlott, U., Crowther, R., Weber, D., Palermo, R., Birktoft, J.
Deposit date:1998-07-10
Release date:1999-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Protein farnesyltransferase: structure and implications for substrate binding.
Biochemistry, 37, 1998
1G4K
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X-RAY STRUCTURE OF A NOVEL MATRIX METALLOPROTEINASE INHIBITOR COMPLEXED TO STROMELYSIN
Descriptor:STROMELYSIN-1, ZINC ION, CALCIUM ION, ...
Authors:Dunten, P., Kammlott, U., Crowther, R., Levin, W., Foley, L.H., Wang, P., Palermo, R.
Deposit date:2000-10-27
Release date:2001-04-25
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of a novel matrix metalloproteinase inhibitor complexed to stromelysin.
Protein Sci., 10, 2001
1KHB
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PEPCK COMPLEX WITH NONHYDROLYZABLE GTP ANALOG, NATIVE DATA
Descriptor:Phosphoenolpyruvate carboxykinase, cytosolic (GTP), MANGANESE (II) ION, ...
Authors:Dunten, P., Belunis, C., Crowther, R., Hollfelder, K., Kammlott, U., Levin, W., Michel, H., Ramsey, G.B., Swain, A., Weber, D., Wertheimer, S.J.
Deposit date:2001-11-29
Release date:2002-02-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.854 Å)
Cite:Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
J.Mol.Biol., 316, 2002
1KHE
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PEPCK COMPLEX WITH NONHYDROLYZABLE GTP ANALOG, MAD DATA
Descriptor:Phosphoenolpyruvate Carboxykinase, cytosolic (GTP), MANGANESE (II) ION, ...
Authors:Dunten, P., Belunis, C., Crowther, R., Hollfelder, K., Kammlott, U., Levin, W., Michel, H., Ramsey, G.B., Swain, A., Weber, D., Wertheimer, S.J.
Deposit date:2001-11-29
Release date:2002-02-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
J.Mol.Biol., 316, 2002
1KHF
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PEPCK COMPLEX WITH PEP
Descriptor:Phosphoenolpyruvate Carboxykinase, cytosolic (GTP), MANGANESE (II) ION, ...
Authors:Dunten, P., Belunis, C., Crowther, R., Hollfelder, K., Kammlott, U., Levin, W., Michel, H., Ramsey, G.B., Swain, A., Weber, D., Wertheimer, S.J.
Deposit date:2001-11-29
Release date:2002-02-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
J.Mol.Biol., 316, 2002
1KHG
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PEPCK
Descriptor:Phosphoenolpyruvate carboxykinase, cytosolic (GTP), MANGANESE (II) ION, ...
Authors:Dunten, P., Belunis, C., Crowther, R., Hollfelder, K., Kammlott, U., Levin, W., Michel, H., Ramsey, G.B., Swain, A., Weber, D., Wertheimer, S.J.
Deposit date:2001-11-29
Release date:2002-02-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site.
J.Mol.Biol., 316, 2002
1M51
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PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR
Descriptor:phosphoenolpyruvate carboxykinase, cytosolic, MANGANESE (II) ION, ...
Authors:Foley, L.H., Wang, P., Dunten, P., Wertheimer, S.J.
Deposit date:2002-07-06
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:X-ray Structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines
Bioorg.Med.Chem.Lett., 13, 2003
1NHX
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PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR
Descriptor:PHOSPHOENOLPYRUVATE CARBOXYKINASE, CYTOSOLIC, MANGANESE (II) ION, ...
Authors:Foley, L.H., Wang, P., Dunten, P., Ramsey, G., Gubler, M.-L., Wertheimer, S.J.
Deposit date:2002-12-19
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-RAY STRUCTURES OF TWO XANTHINE INHIBITORS BOUND TO PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines
Bioorg.Med.Chem.Lett., 13, 2003
2GMV
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PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR
Descriptor:Phosphoenolpyruvate carboxykinase, cytosolic, MANGANESE (II) ION, ...
Authors:Dunten, P.
Deposit date:2006-04-07
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase.
Bioorg.Med.Chem.Lett., 17, 2007
4IPF
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THE 1.7A CRYSTAL STRUCTURE OF HUMANIZED XENOPUS MDM2 WITH RO5045337
Descriptor:E3 ubiquitin-protein ligase Mdm2, [(4S,5R)-2-(4-tert-butyl-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-1-yl]{4-[3-(methylsulfonyl)propyl]piperazin-1-yl}methanone, SULFATE ION
Authors:Graves, B.J., Lukacs, C., Kammlott, R.U., Crowther, R.
Deposit date:2013-01-09
Release date:2013-02-20
Last modified:2013-04-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models.
Cancer Res., 73, 2013
4J3E
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THE 1.9A CRYSTAL STRUCTURE OF HUMANIZED XENOPUS MDM2 WITH NUTLIN-3A
Descriptor:E3 ubiquitin-protein ligase Mdm2, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, SULFATE ION
Authors:Graves, B.J., Lukacs, C.M., Kammlott, R.U., Crowther, R.
Deposit date:2013-02-05
Release date:2013-04-24
Last modified:2014-10-08
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development.
ACS Med Chem Lett, 4, 2013
4J3Y
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN
Descriptor:E3 ubiquitin-protein ligase XIAP, ZINC ION
Authors:Lukacs, C.M., Janson, C.A.
Deposit date:2013-02-06
Release date:2013-09-25
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr.,Sect.D, 69, 2013
4J44
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN WITH AIAV BOUND
Descriptor:E3 ubiquitin-protein ligase XIAP, PEPTIDE (ALA-ILE-ALA-VAL), ZINC ION
Authors:Lukacs, C.M., Janson, C.A.
Deposit date:2013-02-06
Release date:2013-09-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr.,Sect.D, 69, 2013
4J45
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN WITH ATAA BOUND
Descriptor:E3 ubiquitin-protein ligase XIAP, PEPTIDE (ALA-THR-ALA-ALA), ZINC ION
Authors:Lukacs, C.M., Janson, C.A.
Deposit date:2013-02-06
Release date:2013-09-25
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr.,Sect.D, 69, 2013
4J46
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN WITH AVPI BOUND
Descriptor:E3 ubiquitin-protein ligase XIAP, PEPTIDE (ALA-VAL-PRO-ILE), ZINC ION
Authors:Lukacs, C.M., Janson, C.A.
Deposit date:2013-02-06
Release date:2013-09-25
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr.,Sect.D, 69, 2013
4J47
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN WITH SVPI BOUND
Descriptor:E3 ubiquitin-protein ligase XIAP, PEPTIDE (SER-VAL-PRO-ILE), ZINC ION
Authors:Lukacs, C.M., Janson, C.A.
Deposit date:2013-02-06
Release date:2013-09-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr.,Sect.D, 69, 2013
4J48
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CRYSTAL STRUCTURE OF XIAP-BIR2 DOMAIN WITH AMRV BOUND
Descriptor:E3 ubiquitin-protein ligase XIAP, PEPTIDE (ALA-MET-ARG-VAL), ZINC ION, ...
Authors:Gosu, R.
Deposit date:2013-02-06
Release date:2013-09-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr.,Sect.D, 69, 2013