Author results

3TE4
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CRYSTAL STRUCTURE OF DOPAMINE N ACETYLTRANSFERASE IN COMPLEX WITH ACETYL-COA FROM DROSOPHILA MELANOGASTER
分子名称:Dopamine N acetyltransferase, isoform A, ACETYL COENZYME *A
著者Cheng, K.C., Huang, S.H., Lyu, P.C.
登録日2011-08-12
公開日2012-07-11
最終更新日2014-03-12
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism
Biochem.J., 446, 2012
5GI7
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CRYSTAL STRUCTURE OF DROSOPHILA MELANOGASTER DOPAMINE N-ACETYLTRANSFERASE IN TERNARY COMPLEX WITH COA AND ACETYL-PHENYLETHYLAMINE
分子名称:Dopamine N-acetyltransferase, COENZYME A, N-(2-phenylethyl)acetamide, ...
著者Yang, Y.C., Lin, S.J., Cheng, K.C., Cheng, H.C., Lyu, P.C.
登録日2016-06-22
公開日2017-07-05
実験手法X-RAY DIFFRACTION (1.201 Å)
主引用文献Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase Bound to CoA and Phenylethylamine
To Be Published
5GI8
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CRYSTAL STRUCTURE OF DROSOPHILA MELANOGASTER DOPAMINE N-ACETYLTRANSFERASE IN TERNARY COMPLEX WITH COA AND ACETYL-DOPAMINE
分子名称:Dopamine N-acetyltransferase, COENZYME A, ~{N}-[2-[3,4-bis(oxidanyl)phenyl]ethyl]ethanamide, ...
著者Yang, Y.C., Lin, S.J., Cheng, K.C., Cheng, H.C., Lyu, P.C.
登録日2016-06-22
公開日2017-07-05
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-dopamine
To Be Published
5GI9
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CRYSTAL STRUCTURE OF DROSOPHILA MELANOGASTER DOPAMINE N-ACETYLTRANSFERASE IN TERNARY COMPLEX WITH COA AND ACETYL-TRYPTAMINE
分子名称:Dopamine N-acetyltransferase, COENZYME A, ~{N}-[2-(1~{H}-indol-3-yl)ethyl]ethanamide, ...
著者Yang, Y.C., Lin, S.J., Cheng, K.C., Cheng, H.C., Lyu, P.C.
登録日2016-06-22
公開日2017-07-05
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-Tryptamine
To Be Published
3HVL
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TETHERED PXR-LBD/SRC-1P COMPLEXED WITH SR-12813
分子名称:Pregnane X receptor, Linker, Steroid receptor coactivator 1, ...
著者Lesburg, C.A., Wang, W., Prosise, W.W., Chen, J., Taremi, S.S., Le, H.V., Madison, V., Cui, X., Thomas, A., Cheng, K.C.
登録日2009-06-16
公開日2009-08-04
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability
Protein Eng.Des.Sel., 21, 2008
4EIB
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CRYSTAL STRUCTURE OF CIRCULAR PERMUTED CBM21 (CP90) GIVES INSIGHT INTO THE ALTERED SELECTIVITY ON CARBOHYDRATE BINDING.
分子名称:Glucoamylase, SULFATE ION, AMMONIUM ION, ...
著者Stephen, P., Cheng, K.C., Lyu, P.C.
登録日2012-04-05
公開日2012-12-12
最終更新日2017-08-23
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Crystal structure of circular permuted RoCBM21 (CP90): dimerisation and proximity of binding sites
Plos One, 7, 2012
3KNX
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HCV NS3 PROTEASE DOMAIN WITH P1-P3 MACROCYCLIC KETOAMIDE INHIBITOR
分子名称:HCV NS3 Protease, HCV NS4a peptide, ZINC ION, ...
著者Venkatraman, S., Velazquez, F., Wu, W., Blackman, M., Chen, K.X., Bogen, S., Nair, L., Tong, X., Chase, R., Hart, A., Agrawal, S., Pichardo, J., Prongay, A., Cheng, K.-C., Girijavallabhan, V., Piwinski, J., Shih, N.-Y., Njoroge, F.G.
登録日2009-11-12
公開日2010-10-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Discovery and structure-activity relationship of P1-P3 ketoamide derived macrocyclic inhibitors of hepatitis C virus NS3 protease.
J.Med.Chem., 52, 2009
3CTB
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TETHERED PXR-LBD/SRC-1P APOPROTEIN
分子名称:Pregnane X receptor, Linker, Steroid receptor coactivator 1
著者Lesburg, C.A.
登録日2008-04-11
公開日2008-12-02
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Construction and characterization of a fully active PXR/SRC-1 tethered protein with increased stability
Protein Eng.Des.Sel., 21, 2008
3KN2
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HCV NS3 PROTEASE DOMAIN WITH KETOAMIDE INHIBITOR
分子名称:HCV NS3 Protease Domain, Peptide KK-NS4A-KK, ZINC ION, ...
著者Nair, L.G., Sannigrahi, M., Pinto, P., Bogen, S., Chen, K.X., Njoroge, G., Prongay, A.
登録日2009-11-11
公開日2010-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献P4 capped amides and lactams as HCV NS3 protease inhibitors with improved potency and DMPK profile.
Bioorg.Med.Chem.Lett., 20, 2010
3LON
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HCV NS3-4A PROTEASE DOMAIN WITH KETOAMIDE INHIBITOR NARLAPREVIR
分子名称:Genome polyprotein, KK-NS4a(21-39)-KK, ZINC ION, ...
著者Prongay, A.J.
登録日2010-02-04
公開日2011-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Candidate selection and preclinical evaluation culminating in the discovery of Narlaprevir (SCH 900518): A potent, selective and orally efficacious second generation HCV NS3 serine protease inhibitor
To be Published
3LOX
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HCV NS3-4A PROTEASE DOMAIN WITH A KETOAMIDE INHIBITOR DERIVATIVE OF BOCEPREVIR BOUND
分子名称:HCV NS3 Protease, HCV NS4a(21-39) peptide, ZINC ION, ...
著者Prongay, A.J.
登録日2010-02-04
公開日2011-02-23
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
Bioorg.Med.Chem.Lett., 20, 2010
3TYQ
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SAR DEVELOPMENT AND DISCOVERY OF POTENT INDOLE-BASED INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE
分子名称:RNA-directed RNA polymerase, 5-ethyl-1-(2-fluoro-5-nitrobenzyl)-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxylic acid, PHOSPHATE ION
著者Lesburg, C.A., Chen, K.X.
登録日2011-09-26
公開日2012-02-01
最終更新日2012-03-21
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors.
J.Med.Chem., 55, 2012
3TYV
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SAR DEVELOPMENT AND DISCOVERY OF POTENT INDOLE-BASED INHIBITORS OF THE HEPATITIS C VIRUS NS5B POLYMERASE
分子名称:RNA-directed RNA polymerase, PHOSPHATE ION, N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide
著者Lesburg, C.A., Chen, K.X.
登録日2011-09-26
公開日2012-02-01
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase.
J.Med.Chem., 55, 2012