Author results

1F9E
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CASPASE-8 SPECIFICITY PROBED AT SUBSITE S4: CRYSTAL STRUCTURE OF THE CASPASE-8-Z-DEVD-CHO
Descriptor:CASPASE-8 ALPHA CHAIN, CASPASE-8 BETA CHAIN, (PHQ)DEVD
Authors:Blanchard, H., Donepudi, M., Tschopp, M., Kodandapani, L., Wu, J.C., Grutter, M.G.
Deposit date:2000-07-10
Release date:2001-07-10
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Caspase-8 specificity probed at subsite S(4): crystal structure of the caspase-8-Z-DEVD-cho complex.
J.Mol.Biol., 302, 2000
2DWR
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CRYSTAL STRUCTURE OF THE HUMAN WA ROTAVIRUS VP8* CARBOHYDRATE-RECOGNISING DOMAIN
Descriptor:Outer capsid protein, GLYCEROL, ISOPROPYL ALCOHOL
Authors:Blanchard, H.
Deposit date:2006-08-16
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insight into Host Cell Carbohydrate-recognition by Human and Porcine Rotavirus from Crystal Structures of the Virion Spike Associated Carbohydrate-binding Domain (VP8*)
J.Mol.Biol., 367, 2007
2I2S
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CRYSTAL STRUCTURE OF THE PORCINE CRW-8 ROTAVIRUS VP8* CARBOHYDRATE-RECOGNISING DOMAIN
Descriptor:Outer capsid protein VP4, SULFATE ION, SODIUM ION, ...
Authors:Blanchard, H.
Deposit date:2006-08-16
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insight into Host Cell Carbohydrate-recognition by Human and Porcine Rotavirus from Crystal Structures of the Virion Spike Associated Carbohydrate-binding Domain (VP8*)
J.Mol.Biol., 367, 2007
1QDU
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CRYSTAL STRUCTURE OF THE COMPLEX OF CASPASE-8 WITH THE TRIPEPTIDE KETONE INHIBITOR ZEVD-DCBMK
Descriptor:CASPASE-8 ALPHA-CHAIN, CASPASE-8 BETA-CHAIN, PHQ-GLU-VAL-ASP-DICHLOROMETHYLKETONE INHIBITOR
Authors:Blanchard, H., Grutter, M.G.
Deposit date:1999-07-10
Release date:2000-07-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis.
Structure Fold.Des., 7, 1999
1AJ5
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CALPAIN DOMAIN VI APO
Descriptor:CALPAIN
Authors:Cygler, M., Grochulski, P., Blanchard, H.
Deposit date:1997-05-15
Release date:1998-05-20
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes.
Nat.Struct.Biol., 4, 1997
1DVI
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CALPAIN DOMAIN VI WITH CALCIUM BOUND
Descriptor:CALPAIN, CALCIUM ION
Authors:Cygler, M., Blanchard, H., Grochulski, P.
Deposit date:1997-05-15
Release date:1998-05-27
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes.
Nat.Struct.Biol., 4, 1997
3OY8
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH LACTOBIONIC ACID
Descriptor:Galectin-1, BETA-D-GALACTOSE, GLUCONIC ACID
Authors:Blanchard, H., Collins, P.M.
Deposit date:2010-09-23
Release date:2010-11-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model
CANCER LETT., 2010
3OYW
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH THIODIGALACTOSIDE
Descriptor:Galectin-1, THIODIGALACTOSIDE
Authors:Blanchard, H., Collins, P.M.
Deposit date:2010-09-23
Release date:2010-11-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model
CANCER LETT., 2010
3T1L
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 IN COMPLEX WITH METHYL 2-O-ACETYL-3-O-TOLUOYL-BETA-D-TALOPYRANOSIDE
Descriptor:Galectin-3, CHLORIDE ION, methyl 2-O-acetyl-3-O-(4-methylbenzoyl)-beta-D-talopyranoside
Authors:Blanchard, H., Collins, P.M.
Deposit date:2011-07-22
Release date:2011-12-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Taloside inhibitors of galectin-1 and galectin-3
Chem.Biol.Drug Des., 79, 2012
3T1M
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN IN COMPLEX WITH METHYL 3-DEOXY-2-O-TOLUOYL-3-N-TOLUOYL-BETA-D-TALOPYRANOSIDE
Descriptor:Galectin-3, CHLORIDE ION, methyl 3-deoxy-2-O-(4-methylbenzoyl)-3-[(4-methylbenzoyl)amino]-beta-D-talopyranoside
Authors:Blanchard, H., Collins, P.M.
Deposit date:2011-07-22
Release date:2011-12-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Taloside inhibitors of galectin-1 and galectin-3
Chem.Biol.Drug Des., 79, 2012
3T2T
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 IN COMPLEX WITH METHYL 2-O-ACETYL-3-O-TOLUOYL-BETA-D-TALOPYRANOSIDE
Descriptor:Galectin-1, methyl 2-O-acetyl-3-O-(4-methylbenzoyl)-beta-D-talopyranoside
Authors:Blanchard, H., Collins, P.M.
Deposit date:2011-07-23
Release date:2011-12-28
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Taloside inhibitors of galectin-1 and galectin-3
Chem.Biol.Drug Des., 79, 2012
2NMN
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CARBOHYDRATE-RECOGNISING DOMAIN AT 2.45 ANGSTROM RESOLUTION
Descriptor:Galectin-3, BETA-D-GALACTOSE, BETA-D-GLUCOSE
Authors:Blanchard, H., Collins, P.M.
Deposit date:2006-10-23
Release date:2007-03-06
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols.
Acta Crystallogr.,Sect.D, 63, 2007
2NMO
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CARBOHYDRATE-RECOGNITION DOMAIN AT 1.35 ANGSTROM RESOLUTION
Descriptor:Galectin-3, BETA-D-GALACTOSE, BETA-D-GLUCOSE, ...
Authors:Blanchard, H., Collins, P.M.
Deposit date:2006-10-23
Release date:2007-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols
Acta Crystallogr.,Sect.D, 63, 2007
2NN8
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CARBOHYDRATE-RECOGNITION DOMAIN WITH LACTOSE BOUND, AT 1.35 ANGSTROM RESOLUTION
Descriptor:Galectin-3, BETA-LACTOSE, ALPHA-LACTOSE, ...
Authors:Blanchard, H., Collins, P.M.
Deposit date:2006-10-24
Release date:2007-03-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols.
Acta Crystallogr.,Sect.D, 63, 2007
2P3I
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CRYSTAL STRUCTURE OF RHESUS ROTAVIRUS VP8* AT 295K
Descriptor:VP4, SULFATE ION, 2-O-METHYL-5-N-ACETYL-ALPHA-D- NEURAMINIC ACID
Authors:Blanchard, H.
Deposit date:2007-03-09
Release date:2008-03-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein
Glycobiology, 19, 2009
2P3J
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CRYSTAL STRUCTURE OF THE ARG101ALA MUTANT PROTEIN OF RHESUS ROTAVIRUS VP8*
Descriptor:VP4, SULFATE ION, 2-O-METHYL-5-N-ACETYL-ALPHA-D- NEURAMINIC ACID
Authors:Blanchard, H.
Deposit date:2007-03-09
Release date:2008-03-11
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein
Glycobiology, 19, 2009
2P3K
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CRYSTAL STRUCTURE OF RHESUS ROTAVIRUS VP8* AT 100K
Descriptor:VP4, SULFATE ION, 2-O-METHYL-5-N-ACETYL-ALPHA-D- NEURAMINIC ACID, ...
Authors:Blanchard, H.
Deposit date:2007-03-09
Release date:2008-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Effects on sialic acid recognition of amino acid mutations in the carbohydrate-binding cleft of the rotavirus spike protein
Glycobiology, 19, 2009
3SIS
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CRYSTAL STRUCTURE OF PORCINE CRW-8 ROTAVIRUS VP8* IN COMPLEX WITH ACERAMIDO-GM3_GC
Descriptor:Outer capsid protein VP4, methyl 3,5-dideoxy-5-[(hydroxyacetyl)amino]-D-glycero-alpha-D-galacto-non-2-ulopyranosidonic acid, SODIUM ION, ...
Authors:Blanchard, H., Yu, X.
Deposit date:2011-06-20
Release date:2011-09-28
Last modified:2011-11-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Novel structural insights into rotavirus recognition of ganglioside glycan receptors.
J.Mol.Biol., 413, 2011
3SIT
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CRYSTAL STRUCTURE OF PORCINE CRW-8 ROTAVIRUS VP8* IN COMPLEX WITH ACERAMIDO-GM3
Descriptor:Outer capsid protein VP4, O-SIALIC ACID, BETA-D-GALACTOSE, ...
Authors:Blanchard, H., Yu, X.
Deposit date:2011-06-20
Release date:2011-09-28
Last modified:2011-11-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Novel structural insights into rotavirus recognition of ganglioside glycan receptors.
J.Mol.Biol., 413, 2011
5VWG
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GALECTIN-8 N TERMINAL DOMAIN IN COMPLEX WITH METHYL 3-O-[1-CARBOXYETHYL]-BETA-D-GALACTOPYRANOSIDE
Descriptor:Galectin-8, methyl 3-O-[(1R)-1-carboxyethyl]-beta-D-galactopyranoside
Authors:Bohari, M.H., Yu, X., Blanchard, H.
Deposit date:2017-05-21
Release date:2018-05-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Galectin-8 N terminal domain in complex with Methyl 3-O-[1-carboxyethyl]-beta-D-galactopyranoside
To Be Published
5E88
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH THIENYL-1,2,3-TRIAZOLYL THIODIGALACTOSIDE INHIBITOR
Descriptor:Galectin-3, CHLORIDE ION, 3-deoxy-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-1-thio-3-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranoside
Authors:Collins, P.M., Blanchard, H.
Deposit date:2015-10-13
Release date:2016-08-24
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.
Chembiochem, 17, 2016
5E89
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH 3-FLUOPHENYL-1,2,3-TRIAZOLYL THIODIGALACTOSIDE INHIBITOR
Descriptor:Galectin-3, CHLORIDE ION, 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
Authors:Collins, P.M., Blanchard, H.
Deposit date:2015-10-13
Release date:2016-08-24
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.
Chembiochem, 17, 2016
5E8A
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH 4-FLUOPHENYL-1,2,3-TRIAZOLYL THIODIGALACTOSIDE INHIBITOR
Descriptor:Galectin-3, CHLORIDE ION, 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside
Authors:Collins, P.M., Blanchard, H.
Deposit date:2015-10-13
Release date:2016-08-24
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.
Chembiochem, 17, 2016
5EXO
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CRYSTAL STRUCTURE OF HUMAN GALECTIN-3 CRD IN COMPLEX WITH METHYL 2-O-ACETYL-3-O-(2H-CHROMENE-3-YL-METHYL)-A-D-GALACTOPYRANOSIDE INHIBITOR
Descriptor:Galectin-3, CHLORIDE ION, [(2~{S},3~{R},4~{S},5~{S},6~{R})-6-(hydroxymethyl)-2-methoxy-5-oxidanyl-4-[(2-oxidanylidenechromen-3-yl)methoxy]oxan-3-yl] ethanoate
Authors:Collins, P.M., Blanchard, H.
Deposit date:2015-11-23
Release date:2016-10-05
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:A Selective Galactose-Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model.
J.Med.Chem., 59, 2016
4JC1
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GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN IN COMPLEX WITH THIODIGALACTOSIDE
Descriptor:Galectin-3, CHLORIDE ION, THIODIGALACTOSIDE
Authors:Collins, P.M., Blanchard, H.
Deposit date:2013-02-21
Release date:2013-07-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Investigation into the feasibility of thioditaloside as a novel scaffold for galectin-3-specific inhibitors.
Chembiochem, 14, 2013
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