Author results

5HXF
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CRYSTAL STRUCTURE OF 3C PROTEASE FROM A MILD HUMAN ENTEROVIRUS 71 IN COMPLEX WITH RUPINTRIVIR
分子名称:3C protease, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, SULFATE ION
著者Li, B., Yuan, Z., Qin, L., Gu, L.
登録日2016-01-30
公開日2017-02-15
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献Crystal structure of 3C protease from a mild Human enterovirus 71 in complex with rupintrivir
To Be Published
5HXG
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STM1697-FLHD COMPLEX
分子名称:Uncharacterized protein STM1697, Flagellar transcriptional regulator FlhD
著者Li, B., Yuan, Z., Qin, L., Gu, L.
登録日2016-01-30
公開日2017-02-15
実験手法X-RAY DIFFRACTION (1.998 Å)
主引用文献Crystal structure of STM1697-FlhD complex
To Be Published
6A0X
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY 13D4
分子名称:Antibody 13D4, Fab Heavy Chain, Fab Light Chain
著者Li, S., Li, T.
登録日2018-06-06
公開日2018-06-20
最終更新日2018-09-19
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus.
J. Virol., 92, 2018
6A0Z
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CRYSTAL STRUCTURE OF BROADLY NEUTRALIZING ANTIBODY 13D4 BOUND TO H5N1 INFLUENZA HEMAGGLUTININ, HA HEAD REGION
分子名称:Hemagglutinin,Envelope glycoprotein, Antibody 13D4, Fab Heavy Chain, ...
著者Li, S., Li, T.
登録日2018-06-06
公開日2018-06-20
最終更新日2018-09-19
実験手法X-RAY DIFFRACTION (2.329 Å)
主引用文献Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus.
J. Virol., 92, 2018
3J8H
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STRUCTURE OF THE RABBIT RYANODINE RECEPTOR RYR1 IN COMPLEX WITH FKBP12 AT 3.8 ANGSTROM RESOLUTION
分子名称:Ryanodine receptor 1, Peptidyl-prolyl cis-trans isomerase FKBP1A, ZINC ION
著者Yan, Z., Bai, X., Yan, C., Wu, J., Scheres, S.H.W., Shi, Y., Yan, N.
登録日2014-10-26
公開日2014-12-10
最終更新日2018-07-18
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.
Nature, 517, 2015
3JSF
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXYQUINOLINE INHIBITOR 638 AT 1.93A RESOLUTION
分子名称:Macrophage migration inhibitory factor, 7-(2-fluorobenzyl)quinolin-8-ol, SULFATE ION
著者Mclean, L., Zhang, Y.
登録日2009-09-10
公開日2009-11-10
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.
Bioorg.Med.Chem.Lett., 19, 2009
3JSG
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXYQUINOLINE INHIBITOR 707 AT 1.58A RESOLUTION
分子名称:Macrophage migration inhibitory factor, 7-(pyridin-3-ylmethyl)quinolin-8-ol, SULFATE ION
著者Mclean, L., Zhang, Y.
登録日2009-09-10
公開日2009-11-10
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.
Bioorg.Med.Chem.Lett., 19, 2009
3JTU
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CRYSTAL STRUCTURE OF MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF) WITH HYDROXYQUINOLINE INHIBITOR 708 AT 1.86A RESOLUTION
分子名称:Macrophage migration inhibitory factor, 7-(pyridin-2-ylmethyl)quinolin-8-ol, SULFATE ION
著者Mclean, L., Zhang, Y.
登録日2009-09-14
公開日2009-11-10
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.
Bioorg.Med.Chem.Lett., 19, 2009
4I1L
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STRUCTURAL AND BIOLOGICAL FEATURES OF FOXP3 DIMERIZATION RELEVANT TO REGULATORY T CELL FUNCTION
分子名称:Forkhead box protein P3, SULFATE ION, MAGNESIUM ION, ...
著者Song, X.M., Greene, M.I., Zhou, Z.C.
登録日2012-11-21
公開日2012-12-05
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.
Cell Rep, 1, 2012
6K7O
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COMPLEX STRUCTURE OF LILRB4 AND H128-3 ANTIBODY
分子名称:Leukocyte immunoglobulin-like receptor subfamily B member 4, h128-3 Fab heavy chain, h128-3 Fab light chain
著者Song, H., Chai, Y., Xu, X., Gao, F.G.
登録日2019-06-08
公開日2019-07-03
実験手法X-RAY DIFFRACTION (3.004 Å)
主引用文献Disrupting LILRB4/APOE interaction by an efficacious humanized antibody reverses T-cell suppression and blocks AML development.
Cancer Immunol Res, 2019
4GQG
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+
分子名称:Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zhang, L., Zheng, X., Chen, S., Zhai, J., Hu, X.
登録日2012-08-23
公開日2013-08-28
最終更新日2013-12-11
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)
Febs Lett., 587, 2013
4I5X
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND FLUFENAMIC ACID
分子名称:Aldo-keto reductase family 1 member B10, 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zhang, L., Zheng, X., Chen, S., Zhai, J., Zhang, H., Zhao, Y.
登録日2012-11-29
公開日2013-10-23
最終更新日2013-12-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111)
Febs Lett., 587, 2013
4JIH
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND EPALRESTAT
分子名称:Aldo-keto reductase family 1 member B10, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X., Structural Genomics Consortium (SGC)
登録日2013-03-06
公開日2013-10-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
4JII
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CRYSTAL STRUCTURE OF AKR1B10 COMPLEXED WITH NADP+ AND ZOPOLRESTAT
分子名称:Aldo-keto reductase family 1 member B10, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID, ...
著者Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X., Structural Genomics Consortium (SGC)
登録日2013-03-06
公開日2013-10-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
4JIR
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE (AKR1B1) COMPLEXED WITH NADP+ AND EPALRESTAT
分子名称:Aldose reductase, {5-[(2E)-2-methyl-3-phenylprop-2-en-1-ylidene]-4-oxo-2-thioxo-1,3-thiazolidin-3-yl}acetic acid, SULFATE ION, ...
著者Zhang, L., Zheng, X., Zhang, H., Zhao, Y., Chen, K., Zhai, J., Hu, X.
登録日2013-03-06
公開日2013-10-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111).
Febs Lett., 587, 2013
5GS4
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CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA IN COMPLEX WITH A STABILIZED PEPTIDE ANTAGONIST
分子名称:Estrogen receptor, ARG-IAS-ILE-LEU-DNP-ARG-LEU-LEU-GLN, PHOSPHATE ION, ...
著者Xie, M., Wang, T., Li, Z.-G.
登録日2016-08-13
公開日2017-08-30
最終更新日2018-07-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Basis of Inhibition of ER alpha-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides
J. Med. Chem., 60, 2017
5GTR
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ESTROGEN RECEPTOR ALPHA IN COMPLEX WITH A STABILIZED PEPTIDE ANTAGONIST 6
分子名称:Estrogen receptor, ARG-IAS-ILE-0JY-DPP-ARG-0JY-0JY-GLN-NH2, ESTRADIOL
著者Xie, M., Wang, T., Li, Z.-G.
登録日2016-08-23
公開日2017-08-30
最終更新日2017-12-20
実験手法X-RAY DIFFRACTION (2.804 Å)
主引用文献Structural Basis of Inhibition of ER alpha-Coactivator Interaction by High-Affinity N-Terminus Isoaspartic Acid Tethered Helical Peptides
J. Med. Chem., 60, 2017
6IJH
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CRYSTAL STRUCTURE OF PDE10 IN COMPLEX WITH INHIBITOR AF-399/14387019
分子名称:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ...
著者Huang, Y.Y., Yu, Y.F., Zhang, C., Wu, D., Wu, Y., Luo, H.B.
登録日2018-10-10
公開日2019-04-10
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
J. Med. Chem., 62, 2019
6IJI
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CRYSTAL STRUCTURE OF PDE10 IN COMPLEX WITH INHIBITOR 2B
分子名称:cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ...
著者Huang, Y.Y., Yu, Y.F., Zhang, C., Wu, D., Wu, Y., Luo, H.B.
登録日2018-10-10
公開日2019-04-10
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
J. Med. Chem., 62, 2019
4Y9J
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CRYSTAL STRUCTURE OF CAENORHABDITIS ELEGANS ACDH-11 IN COMPLEX WITH C11-COA
分子名称:Protein ACDH-11, isoform b, FLAVIN-ADENINE DINUCLEOTIDE, ...
著者Li, Z.J., Sun, F.
登録日2015-02-17
公開日2015-06-03
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids
Cell, 161, 2015
4Y9L
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CRYSTAL STRUCTURE OF CAENORHABDITIS ELEGANS ACDH-11
分子名称:Protein ACDH-11, isoform b, FLAVIN-ADENINE DINUCLEOTIDE
著者Li, Z.J., Zhai, Y.J., Zhang, K., Sun, F.
登録日2015-02-17
公開日2015-06-03
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids
Cell, 161, 2015
5XS4
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STRUCTURE OF COXSACKIEVIRUS A6 (CVA6) VIRUS A-PARTICLE
分子名称:Genome polyprotein
著者Zheng, Q.B., He, M.Z., Xu, L.F., Yu, H., Li, S.W., Cheng, T.
登録日2017-06-12
公開日2017-09-27
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Nat Commun, 8, 2017
5XS5
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STRUCTURE OF COXSACKIEVIRUS A6 (CVA6) VIRUS PROCAPSID PARTICLE
分子名称:Genome polyprotein
著者Zheng, Q.B., He, M.Z., Xu, L.F., Yu, H., Cheng, T., Li, S.W.
登録日2017-06-12
公開日2017-09-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Nat Commun, 8, 2017
5XS7
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STRUCTURE OF COXSACKIEVIRUS A6 (CVA6) VIRUS A-PARTICLE IN COMPLEX WITH THE NEUTRALIZING ANTIBODY FRAGMENT 1D5
分子名称:Light chain of Fab 1D5, Heavy chain of Fab 1D5, Genome polyprotein
著者Zheng, Q.B., He, M.Z., Xu, L.F., Yu, H., Li, S.W., Cheng, T.
登録日2017-06-12
公開日2017-09-27
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody
Nat Commun, 8, 2017
3ISP
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CRYSTAL STRUCTURE OF ARGP FROM MYCOBACTERIUM TUBERCULOSIS
分子名称:HTH-type transcriptional regulator Rv1985c/MT2039
著者Zhou, X., Lou, Z., Sheng, F., Bartlam, M., Wang, H., Rao, Z.
登録日2009-08-27
公開日2010-02-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structure of ArgP from Mycobacterium tuberculosis Confirms Two Distinct Conformations of Full-length LysR Transcriptional Regulators and Reveals Its Function in DNA Binding and Transcriptional Regulation.
J.Mol.Biol., 2009