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1PRE
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BU of 1pre by Molmil
PROAEROLYSIN
Descriptor: PROAEROLYSIN
Authors:Parker, M.W, Buckley, J.T, Postma, J.P.M, Tucker, A.D, Tsernoglou, D.
Deposit date:1995-09-15
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Aeromonas toxin proaerolysin in its water-soluble and membrane-channel states.
Nature, 367, 1994
4QDQ
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BU of 4qdq by Molmil
Physical basis for Nrp2 ligand binding
Descriptor: GLYCEROL, Neuropilin-2, SULFATE ION
Authors:Parker, M.W, Vander Kooi, C.W.
Deposit date:2014-05-14
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
4QDR
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BU of 4qdr by Molmil
Physical basis for Nrp2 ligand binding
Descriptor: Neuropilin-2
Authors:Parker, M.W, Vander Kooi, C.W.
Deposit date:2014-05-14
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
4QDS
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BU of 4qds by Molmil
Physical basis for Nrp2 ligand binding
Descriptor: ACETATE ION, GLYCEROL, Neuropilin-2
Authors:Parker, M.W, Vander Kooi, C.W.
Deposit date:2014-05-14
Release date:2015-04-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form.
Structure, 23, 2015
5DIM
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BU of 5dim by Molmil
Mutant toxin in 'native' space group
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Perfringolysin O
Authors:Parker, M.W, Gorman, M.A, Lawrence, S.L.
Deposit date:2015-09-01
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Structure of mutant toxin at 3.32 Angstrom resolution
To Be Published
5DHL
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BU of 5dhl by Molmil
Crystal structure of Toxin, mutant N197W
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Perfringolysin O
Authors:Parker, M.W, Gorman, M.A, Lawrence, S.L.
Deposit date:2015-08-31
Release date:2016-11-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structure of mutant toxin
To Be Published
1Z52
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BU of 1z52 by Molmil
Proaerolysin Mutant W373L
Descriptor: Aerolysin
Authors:Parker, M.W, Feil, S.C, Tang, J.W.
Deposit date:2005-03-16
Release date:2006-03-07
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal Structure of Proaerolysin at 2.3 A Resolution and Structural Analyses of Single-site Mutants as a Basis for Understanding Membrane Insertion of the Toxin
To be Published
1COL
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BU of 1col by Molmil
REFINED STRUCTURE OF THE PORE-FORMING DOMAIN OF COLICIN A AT 2.4 ANGSTROMS RESOLUTION
Descriptor: COLICIN A
Authors:Parker, M.W, Postma, J.P.M, Pattus, F, Tucker, A.D, Tsernoglou, D.
Deposit date:1991-07-06
Release date:1992-07-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Refined structure of the pore-forming domain of colicin A at 2.4 A resolution.
J.Mol.Biol., 224, 1992
4NKQ
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BU of 4nkq by Molmil
Structure of a Cytokine Receptor Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, ...
Authors:Parker, M.W, Broughton, S.E.
Deposit date:2013-11-13
Release date:2015-09-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
4ZGH
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BU of 4zgh by Molmil
Structure of Sugar Binding Protein Pneumolysin
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GOLD (I) CYANIDE ION, ...
Authors:Parker, M.W, Feil, S.C, Morton, C.
Deposit date:2015-04-23
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.
Sci Rep, 5, 2015
6PRO
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BU of 6pro by Molmil
MnSOD from Geobacillus stearothermophilus
Descriptor: MANGANESE (II) ION, Superoxide dismutase
Authors:Adams, J.J, Morton, C.J, Parker, M.W.
Deposit date:2019-07-10
Release date:2020-05-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.263 Å)
Cite:The Crystal Structure of the Manganese Superoxide Dismutase from Geobacillus stearothermophilus: Parker and Blake (1988) Revisited
Aust.J.Chem., 73, 2020
1EOG
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BU of 1eog by Molmil
CRYSTAL STRUCTURE OF PI CLASS GLUTATHIONE TRANSFERASE
Descriptor: GLUTATHIONE S-TRANSFERASE
Authors:Rossjohn, J, McKinstry, W.J, Oakley, A.J, Parker, M.W, Stenberg, G, Mannervik, B, Dragani, B, Cocco, R, Aceto, A.
Deposit date:2000-03-22
Release date:2000-10-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structures of thermolabile mutants of human glutathione transferase P1-1.
J.Mol.Biol., 302, 2000
1EOH
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BU of 1eoh by Molmil
GLUTATHIONE TRANSFERASE P1-1
Descriptor: GLUTATHIONE S-TRANSFERASE
Authors:Rossjohn, J, McKinstry, W.J, Oakley, A.J, Parker, M.W, Stenberg, G, Mannervik, B, Dragani, B, Cocco, R, Aceto, A.
Deposit date:2000-03-22
Release date:2000-10-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of thermolabile mutants of human glutathione transferase P1-1.
J.Mol.Biol., 302, 2000
3CWM
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BU of 3cwm by Molmil
Crystal structure of alpha-1-antitrypsin complexed with citrate
Descriptor: Alpha-1-antitrypsin, CITRIC ACID
Authors:Morton, C.J, Hansen, G, Feil, S.C, Adams, J.J, Parker, M.W.
Deposit date:2008-04-22
Release date:2008-09-23
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding.
Protein Sci., 17, 2008
3VQ5
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BU of 3vq5 by Molmil
HIV-1 IN core domain in complex with N-METHYL-1-(4-METHYL-2-PHENYL-1,3-THIAZOL-5-YL)METHANAMINE
Descriptor: CADMIUM ION, CHLORIDE ION, N-methyl-1-(4-methyl-2-phenyl-1,3-thiazol-5-yl)methanamine, ...
Authors:Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J.
Deposit date:2012-03-20
Release date:2013-01-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?
J Biomol Screen, 18, 2013
3VQ4
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BU of 3vq4 by Molmil
Fragments bound to HIV-1 integrase
Descriptor: (5-phenyl-1,2-oxazol-3-yl)methanol, CADMIUM ION, POL polyprotein, ...
Authors:Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J.
Deposit date:2012-03-20
Release date:2013-01-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?
J Biomol Screen, 18, 2013
3VQ6
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BU of 3vq6 by Molmil
HIV-1 IN core domain in complex with (1-methyl-5-phenyl-1H-pyrazol-4-yl)methanol
Descriptor: (1-methyl-5-phenyl-1H-pyrazol-4-yl)methanol, CADMIUM ION, POL polyprotein, ...
Authors:Wielens, J, Chalmers, D.K, Parker, M.W, Scanlon, M.J.
Deposit date:2012-03-20
Release date:2013-01-30
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?
J Biomol Screen, 18, 2013
5IMT
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BU of 5imt by Molmil
Toxin receptor complex
Descriptor: CD59 glycoprotein, COPPER (II) ION, Intermedilysin, ...
Authors:Morton, C.J, Lawrence, S.L, Feil, S.C, Parker, M.W.
Deposit date:2016-03-06
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.7001 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
5IMW
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BU of 5imw by Molmil
Trapped Toxin
Descriptor: Intermedilysin
Authors:Lawrence, S.L, Feil, S.C, Morton, C.J, Parker, M.W.
Deposit date:2016-03-07
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.
Structure, 24, 2016
4P8Q
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BU of 4p8q by Molmil
Crystal Structure of Human Insulin Regulated Aminopeptidase with Alanine in Active Site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucyl-cystinyl aminopeptidase, ...
Authors:Hermans, S.J, Ascher, D.B, Hancock, N.C, Holien, J.K, Michell, B, Morton, C.J, Parker, M.W.
Deposit date:2014-03-31
Release date:2014-12-03
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.02 Å)
Cite:Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides.
Protein Sci., 24, 2015
7TBA
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BU of 7tba by Molmil
Pentraxin - ligand complex
Descriptor: C-reactive protein, CALCIUM ION, [3-(dibutylamino)propyl]phosphonic acid
Authors:Shing, K.S.C.T, Morton, C.J, Parker, M.W.
Deposit date:2021-12-21
Release date:2022-10-19
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein.
Embo Mol Med, 15, 2023
6PDG
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BU of 6pdg by Molmil
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 83
Descriptor: 5-ethoxy-2-fluoro-3-methyl-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ...
Authors:Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B.
Deposit date:2019-06-18
Release date:2020-04-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.919 Å)
Cite:Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
6PDA
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BU of 6pda by Molmil
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 74
Descriptor: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyridin-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ...
Authors:Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B.
Deposit date:2019-06-18
Release date:2020-04-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.448 Å)
Cite:Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
6PDE
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BU of 6pde by Molmil
Crystal structure of MYST acetyltransferase domain in complex with inhibitor 40
Descriptor: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-propoxybenzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ...
Authors:Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B.
Deposit date:2019-06-18
Release date:2020-04-01
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J.Med.Chem., 63, 2020
1S3R
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BU of 1s3r by Molmil
Crystal structure of the human-specific toxin intermedilysin
Descriptor: SULFATE ION, intermedilysin
Authors:Polekhina, G, Giddings, K.S, Tweten, R.K, Parker, M.W.
Deposit date:2004-01-14
Release date:2005-01-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into the action of the superfamily of cholesterol-dependent cytolysins from studies of intermedilysin
Proc.Natl.Acad.Sci.Usa, 102, 2005

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