Author results

2QEG
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B-DNA WITH 7-DEAZA-DG MODIFICATION
Descriptor:DNA (5'-D(*DCP*DGP*DCP*DGP*DAP*DAP*DTP*DTP*DCP*(7GU)P*DCP*DG)-3')
Authors:Wang, F., Li, F., Ganguly, M., Marky, L.A., Gold, B., Egli, M., Stone, M.P.
Deposit date:2007-06-25
Release date:2008-05-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A bridging water anchors the tethered 5-(3-aminopropyl)-2'-deoxyuridine amine in the DNA major groove proximate to the N+2 C.G base pair: implications for formation of interstrand 5'-GNC-3' cross-links by nitrogen mustards.
Biochemistry, 47, 2008
3OPI
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7-DEAZA-2'-DEOXYADENOSINE MODIFICATION IN B-FORM DNA
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*(7DA)P*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, SODIUM ION
Authors:Kowal, E.A., Ganguly, M., Pallan, P.S., Marky, L.A., Gold, B., Egli, M., Stone, M.P.
Deposit date:2010-09-01
Release date:2011-08-31
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Altering the Electrostatic Potential in the Major Groove: Thermodynamic and Structural Characterization of 7-Deaza-2'-deoxyadenosine:dT Base Pairing in DNA.
J.Phys.Chem.B, 115, 2011
3P4A
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2'FLUORO MODIFIED RNA OCTAMER FA2U2
Descriptor:2'Fluoro modified RNA 8-MER, STRONTIUM ION, MAGNESIUM ION
Authors:Manoharan, M., Akinc, A., Pandey, R.K., Qin, J., Hadwiger, P., John, M., Mills, K., Charisse, K., Maier, M.A., Nechev, L., Greene, E.M., Pallan, P.S., Rozners, E., Rajeev, K.G., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4B
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ALTERNATINGLY MODIFIED 2'FLUORO RNA OCTAMER F/RA2U2-P3
Descriptor:5'-R(*(CFZ)P*GP*(AF2)P*AP*(UFT)P*UP*(CFZ)P*G)-3', BARIUM ION
Authors:Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4C
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ALTERNATINGLY MODIFIED 2'FLUORO RNA OCTAMER F/RA2U2-R32
Descriptor:5'-R(*(CFZ)P*GP*(AF2)P*AP*(UFT)P*UP*(CFZ)P*G)-3', STRONTIUM ION
Authors:Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4D
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ALTERNATINGLY MODIFIED 2'FLUORO RNA OCTAMER F/RC4G4
Descriptor:5'-R(*(CFZ)P*CP*(CFZ)P*CP*(GF2)P*GP*(GF2)P*G)-3'
Authors:Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
468D
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CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
Descriptor:RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3'), MAGNESIUM ION
Authors:Teplova, M., Minasov, G., Tereshko, V., Inamati, G., Cook, P.D., Egli, M.
Deposit date:1999-04-29
Release date:1999-05-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
469D
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CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
Descriptor:RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3'), MAGNESIUM ION
Authors:Teplova, M., Minasov, G., Tereshko, V., Inamati, G., Cook, P.D., Egli, M.
Deposit date:1999-04-29
Release date:1999-05-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
470D
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CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
Descriptor:RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3'), MAGNESIUM ION
Authors:Teplova, M., Minasov, G., Tereshko, V., Inamati, G., Cook, P.D., Egli, M.
Deposit date:1999-04-29
Release date:1999-05-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
471D
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CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA
Descriptor:RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3'), MAGNESIUM ION
Authors:Teplova, M., Minasov, G., Tereshko, V., Inamati, G., Cook, P.D., Egli, M.
Deposit date:1999-04-29
Release date:1999-05-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA.
Nat.Struct.Biol., 6, 1999
4PWM
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CRYSTAL STRUCTURE OF DICKERSON DREW DODECAMER WITH 5-CARBOXYCYTOSINE
Descriptor:5'-[CGCGAATT(5CC)GCG]-3'
Authors:Szulik, M.W., Pallan, P., Banerjee, S., Voehler, M., Egli, M., Stone, M.P.
Deposit date:2014-03-20
Release date:2015-02-11
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Differential stabilities and sequence-dependent base pair opening dynamics of watson-crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Biochemistry, 54, 2015
4RBY
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FIRST X-RAY STRUCTURE OF RNA CONTAINING GUANOSINE PHOSPHORODITHIOATE
Descriptor:5'-R(*CP*GP*CP*(2SG)P*AP*AP*UP*UP*AP*GP*CP*G)-3', STRONTIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4RBZ
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X-RAY STRUCTURE OF RNA CONTAINING ADENOSINE PHOSPHORODITHIOATE
Descriptor:5'-R(*CP*GP*CP*GP*(A2M)P*(ADS)P*UP*UP*AP*GP*CP*G)-3'
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4RC0
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X-RAY STRUCTURE OF RNA CONTAINING GUANOSINE PHOSPHORODITHIOATE
Descriptor:5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*(A2M)P*(2SG)P*CP*G)-3'
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
5D8T
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RNA OCTAMER CONTAINING (S)-5' METHYL, 2'-F U.
Descriptor:RNA oligonucleotide containing (S)-C5'-Me-2'-FU, COBALT HEXAMMINE(III)
Authors:Harp, J.M., Egli, M.
Deposit date:2015-08-17
Release date:2016-06-29
Last modified:2016-07-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5DEK
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RNA OCTAMER CONTAINING DT
Descriptor:RNA oligonucleotide containing dT, COBALT HEXAMMINE(III)
Authors:Harp, J.M., Egli, M.
Deposit date:2015-08-25
Release date:2016-07-20
Method:X-RAY DIFFRACTION (1.993 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5DER
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RNA OLIGONUCLEOTIDE CONTAINING (R)-C5'-ME-2'F U
Descriptor:RNA oligonucleotide containing (R)-C5'-Me-2'-FU
Authors:Harp, J.M., Egli, M.
Deposit date:2015-08-25
Release date:2016-06-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.
J.Org.Chem., 81, 2016
5KT2
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TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA(26-445) INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MG2+
Descriptor:DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.488 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5KT3
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TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA(26-445) INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MN2+
Descriptor:DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5KT4
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TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA R96G INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MG2+
Descriptor:DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5KT5
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TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA R96G INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MN2+
Descriptor:DNA (5'-D(*CP*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.798 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5KT6
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TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA(1-445) INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MG2+
Descriptor:DNA (5'-D(P*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.54 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5KT7
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TERANRY COMPLEX OF HUMAN DNA POLYMERASE IOTA(1-445) INSERTING DCMPNPP OPPOSITE TEMPLATE G IN THE PRESENCE OF MN2+
Descriptor:DNA (5'-D(P*TP*GP*GP*GP*GP*TP*CP*CP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*CP*CP*C)-3'), DNA polymerase iota, ...
Authors:Choi, J.Y., Patra, A., Yeom, M., Lee, Y.S., Zhang, Q., Egli, M., Guengerich, F.P.
Deposit date:2016-07-11
Release date:2016-08-31
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.151 Å)
Cite:Kinetic and Structural Impact of Metal Ions and Genetic Variations on Human DNA Polymerase iota.
J.Biol.Chem., 291, 2016
5V1K
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STRUCTURE OF R-GNA DODECAMER
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*(5BU)P*(8RJ)P*AP*GP*CP*G)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-02
Release date:2017-06-21
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 2017
5V1L
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STRUCTURE OF S-GNA DODECAMER
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*(ZTH)P*AP*GP*CP*G)-3'), STRONTIUM ION, SPERMINE
Authors:Pallan, P.S., Egli, M.
Deposit date:2017-03-02
Release date:2017-06-14
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
J. Am. Chem. Soc., 139, 2017